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Last Name
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Nathan Ivan Shapiro, M.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Emergency Med - CCW-2nd Floor
330 Brookline Ave
Boston MA 02215
Phone617/667-5398
Fax617/264-6848

 Mentoring 
 completed student projects
Non-Invasive Doppler Ultrasound Hemodynamic Cardiac Output Monitoring: Predicting Fluid Responsiveness in Patients in the Emergency Department
Summer, 06/19/06 - 08/11/06

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang HE, Donnelly JP, Shapiro NI, Hohmann SF, Levitan EB. Hospital Variations in Severe Sepsis Mortality. Am J Med Qual. 2014 May 9.
    View in: PubMed
  2. Muroya T, Kannan L, Ghiran IC, Shevkoplyas SS, Paz Z, Tsokos M, Dalle Lucca JJ, Shapiro NI, Tsokos GC. C4d Deposits on the Surface of RBCs in Trauma Patients and Interferes With Their Function*. Crit Care Med. 2014 May; 42(5):e364-72.
    View in: PubMed
  3. Skibsted S, Shapiro NI. Transcriptomics may pave the biomarker road in sepsis*. Crit Care Med. 2014 Apr; 42(4):974-5.
    View in: PubMed
  4. Chiu DT, Shapiro NI, Sun BC, Mottley JL, Grossman SA. Are echocardiography, telemetry, ambulatory electrocardiography monitoring, and cardiac enzymes in emergency department patients presenting with syncope useful tests? A preliminary investigation. J Emerg Med. 2014 Jul; 47(1):113-8.
    View in: PubMed
  5. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014 May 1; 370(18):1683-93.
    View in: PubMed
  6. Peitz GW, Troyer J, Jones AE, Shapiro NI, Nelson RD, Hernandez J, Kline JA. Association of body mass index with increased cost of care and length of stay for emergency department patients with chest pain and dyspnea. Circ Cardiovasc Qual Outcomes. 2014 Mar 1; 7(2):292-8.
    View in: PubMed
  7. Zonneveld R, Martinelli R, Shapiro NI, Kuijpers TW, Plötz FB, Carman CV. Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults. Crit Care. 2014; 18(1):204.
    View in: PubMed
  8. Kennedy M, Enander RA, Tadiri SP, Wolfe RE, Shapiro NI, Marcantonio ER. Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. J Am Geriatr Soc. 2014 Mar; 62(3):462-9.
    View in: PubMed
  9. Filbin MR, Hou PC, Massey M, Barche A, Kao E, Bracey A, Skibsted S, Chang Y, Shapiro NI. The microcirculation is preserved in emergency department low-acuity sepsis patients without hypotension. Acad Emerg Med. 2014 Feb; 21(2):154-62.
    View in: PubMed
  10. Wang HE, Szychowski JM, Griffin R, Safford MM, Shapiro NI, Howard G. Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study. BMJ Open. 2014; 4(1):e004283.
    View in: PubMed
  11. Wiener Z, Chiu DT, Shapiro NI, Grossman SA. Substance abuse in emergency department patients with unexplained syncope. Intern Emerg Med. 2014 Apr; 9(3):331-4.
    View in: PubMed
  12. Kline JA, Jones AE, Shapiro NI, Hernandez J, Hogg MM, Troyer J, Nelson RD. Multicenter, randomized trial of quantitative pretest probability to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Circ Cardiovasc Imaging. 2014 Jan 1; 7(1):66-73.
    View in: PubMed
  13. Kline JA, Shapiro NI, Jones AE, Hernandez J, Hogg MM, Troyer J, Nelson RD. Outcomes and Radiation Exposure of Emergency Department Patients With Chest Pain and Shortness of Breath and Ultralow Pretest Probability: A Multicenter Study. Ann Emerg Med. 2014 Mar; 63(3):281-8.
    View in: PubMed
  14. Skibsted S, Bhasin MK, Aird WC, Shapiro NI. Bench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach. Crit Care. 2013 Oct 4; 17(5):231.
    View in: PubMed
  15. Shapiro NI, Angus DC. A review of therapeutic attempts to recruit the microcirculation in patients with sepsis. Minerva Anestesiol. 2014 Feb; 80(2):225-35.
    View in: PubMed
  16. Massey MJ, Larochelle E, Najarro G, Karmacharla A, Arnold R, Trzeciak S, Angus DC, Shapiro NI. The microcirculation image quality score: Development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care. 2013 Dec; 28(6):913-7.
    View in: PubMed
  17. Grossman SA, Chiu D, Lipsitz L, Mottley JL, Shapiro NI. Can elderly patients without risk factors be discharged home when presenting to the emergency department with syncope? Arch Gerontol Geriatr. 2014 Jan-Feb; 58(1):110-4.
    View in: PubMed
  18. Wang HE, Shapiro NI, Safford MM, Griffin R, Judd S, Rodgers JB, Warnock DG, Cushman M, Howard G. High-sensitivity C-reactive protein and risk of sepsis. PLoS One. 2013; 8(7):e69232.
    View in: PubMed
  19. Omar YG, Massey M, Andersen LW, Giberson TA, Berg K, Cocchi MN, Shapiro NI, Donnino MW. Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation. 2013 Dec; 84(12):1717-22.
    View in: PubMed
  20. Wang HE, Griffin R, Judd S, Shapiro NI, Safford MM. Obesity and risk of sepsis: A population-based cohort study. Obesity (Silver Spring). 2013 Dec; 21(12):E762-9.
    View in: PubMed
  21. Skibsted S, Arnold R, Sherwin R, Singh S, Lundy D, Nelson T, Puskarich MA, Trzeciak S, Jones AE, Shapiro NI. The association of near infrared spectroscopy-derived StO2 measurements and biomarkers of endothelial activation in sepsis. Intern Emerg Med. 2013 Sep; 8(6):529-36.
    View in: PubMed
  22. Sterling SA, Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Summers RL, Jones AE. Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock. 2013 Jul; 40(1):11-4.
    View in: PubMed
  23. Traub SJ, Mitchell AM, Jones AE, Tang A, O'Connor J, Nelson T, Kellum J, Shapiro NI. N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. Ann Emerg Med. 2013 Nov; 62(5):511-520.e25.
    View in: PubMed
  24. Puskarich MA, Trzeciak S, Shapiro NI, Albers AB, Heffner AC, Kline JA, Jones AE. Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest. 2013 Jun; 143(6):1548-53.
    View in: PubMed
  25. Zhang G, Yang L, Kim GS, Ryan K, Lu S, O'Donnell RK, Spokes K, Shapiro N, Aird WC, Kluk MJ, Yano K, Sanchez T. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood. 2013 Jul 18; 122(3):443-55.
    View in: PubMed
  26. Ginde AA, Moss M, Shapiro NI, Schwartz RS. Impact of older age and nursing home residence on clinical outcomes of US emergency department visits for severe sepsis. J Crit Care. 2013 Oct; 28(5):606-11.
    View in: PubMed
  27. Wiener Z, Shapiro NI, Chiu DT, Grossman SA. The prevalence of psychiatric disease in emergency department patients with unexplained syncope. Intern Emerg Med. 2013 Aug; 8(5):427-30.
    View in: PubMed
  28. Skibsted S, Jones AE, Puskarich MA, Arnold R, Sherwin R, Trzeciak S, Schuetz P, Aird WC, Shapiro NI. Biomarkers of endothelial cell activation in early sepsis. Shock. 2013 May; 39(5):427-32.
    View in: PubMed
  29. Arnold RC, Sherwin R, Shapiro NI, O'Connor JL, Glaspey L, Singh S, Medado P, Trzeciak S, Jones AE. Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department. Acad Emerg Med. 2013 May; 20(5):433-40.
    View in: PubMed
  30. Odom SR, Howell MD, Silva GS, Nielsen VM, Gupta A, Shapiro NI, Talmor D. Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg. 2013 Apr; 74(4):999-1004.
    View in: PubMed
  31. Berger T, Green J, Horeczko T, Hagar Y, Garg N, Suarez A, Panacek E, Shapiro N. Shock index and early recognition of sepsis in the emergency department: pilot study. West J Emerg Med. 2013 Mar; 14(2):168-74.
    View in: PubMed
  32. Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Inflammatory and endothelial activation biomarkers and risk of sepsis: a nested case-control study. J Crit Care. 2013 Oct; 28(5):549-55.
    View in: PubMed
  33. Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, Davison DL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, Haase M, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, Rimmelé T, Shapiro NI, Shaw AD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care. 2013 Feb 6; 17(1):R25.
    View in: PubMed
  34. Traub SJ, Kellum JA, Tang A, Cataldo L, Kancharla A, Shapiro NI. Risk factors for radiocontrast nephropathy after emergency department contrast-enhanced computerized tomography. Acad Emerg Med. 2013 Jan; 20(1):40-5.
    View in: PubMed
  35. Volz KA, Canham L, Kaplan E, Sanchez LD, Shapiro NI, Grossman SA. Identifying patients with cellulitis who are likely to require inpatient admission after a stay in an ED observation unit. Am J Emerg Med. 2013 Feb; 31(2):360-4.
    View in: PubMed
  36. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41.
    View in: PubMed
  37. Grossman SA, Babineau M, Kulchycki L, Mottley L, Kancharla A, Nencioni A, Shapiro N. Further thoughts on whether outcomes of near syncope parallel syncope. Am J Emerg Med. 2012 Nov; 30(9):2064.
    View in: PubMed
  38. Wang HE, Shapiro NI, Griffin R, Safford MM, Judd S, Howard G. Chronic medical conditions and risk of sepsis. PLoS One. 2012; 7(10):e48307.
    View in: PubMed
  39. Mahler SA, Miller CD, Hollander JE, Nagurney JT, Birkhahn R, Singer AJ, Shapiro NI, Glynn T, Nowak R, Safdar B, Peberdy M, Counselman FL, Chandra A, Kosowsky J, Neuenschwander J, Schrock JW, Plantholt S, Diercks DB, Peacock WF. Identifying patients for early discharge: performance of decision rules among patients with acute chest pain. Int J Cardiol. 2013 Sep 30; 168(2):795-802.
    View in: PubMed
  40. Singer AJ, Thode HC, Peacock WF, Hollander JE, Diercks D, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller C, Lewandrowski E, Nagurney J. The association between self-reported exercise intensity and acute coronary syndrome in emergency department chest pain patients. J Emerg Med. 2013 Jan; 44(1):17-22.
    View in: PubMed
  41. Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Jones AE. Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock. 2012 Oct; 38(4):337-40.
    View in: PubMed
  42. Grossman SA, Babineau M, Burke L, Kancharla A, Mottley L, Nencioni A, Shapiro NI. Applying the Boston syncope criteria to near syncope. J Emerg Med. 2012 Dec; 43(6):958-63.
    View in: PubMed
  43. Chase M, Klasco RS, Joyce NR, Donnino MW, Wolfe RE, Shapiro NI. Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med. 2012 Nov; 30(9):1691-7.
    View in: PubMed
  44. Schuetz P, Kennedy M, Lucas JM, Howell MD, Aird WC, Yealy DM, Shapiro NI. Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med. 2012 Jul; 125(7):670-8.
    View in: PubMed
  45. Arnold RC, Dellinger RP, Parrillo JE, Chansky ME, Lotano VE, McCoy JV, Jones AE, Shapiro NI, Hollenberg SM, Trzeciak S. Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability. J Crit Care. 2012 Oct; 27(5):531.e1-7.
    View in: PubMed
  46. Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J, Ince C. Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients. Crit Care Res Pract. 2012; 2012:121752.
    View in: PubMed
  47. van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8.
    View in: PubMed
  48. Roberson RS, Lockhart E, Shapiro NI, Bandarenko N, McMahon TJ, Massey MJ, White WD, Bennett-Guerrero E. Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion. 2012 Nov; 52(11):2459-64.
    View in: PubMed
  49. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Heffner AC, Kline JA, Jones AE. Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med. 2012 Mar; 19(3):252-8.
    View in: PubMed
  50. Kilgannon JH, Trzeciak S, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Jones AE, Shapiro NI. Reply to letters regarding article, "relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest". Circulation. 2012 Jan 24; 125(3):e289.
    View in: PubMed
  51. Diercks DB, Peacock WF, Hollander JE, Singer AJ, Birkhahn R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller CD, Lewandrowski E, Nagurney JT. Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain. Am Heart J. 2012 Jan; 163(1):74-80.e4.
    View in: PubMed
  52. Wang HE, Shapiro NI, Yealy DM. Characteristics of out-of-hospital shock care. Crit Care Med. 2011 Nov; 39(11):2431-9.
    View in: PubMed
  53. Peacock WF, Nagurney J, Birkhahn R, Singer A, Shapiro N, Hollander J, Glynn T, Nowak R, Safdar B, Miller C, Peberdy M, Counselman F, Chandra A, Kosowsky J, Neuenschwander J, Schrock J, Plantholt S, Lewandrowski E, Wong V, Kupfer K, Diercks D. Myeloperoxidase in the diagnosis of acute coronary syndromes: the importance of spectrum. Am Heart J. 2011 Nov; 162(5):893-9.
    View in: PubMed
  54. Shapiro NI, Arnold R, Sherwin R, O'Connor J, Najarro G, Singh S, Lundy D, Nelson T, Trzeciak SW, Jones AE. The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis. Crit Care. 2011; 15(5):R223.
    View in: PubMed
  55. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med. 2011 Sep; 39(9):2066-71.
    View in: PubMed
  56. Schuetz P, Jones AE, Aird WC, Shapiro NI. Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock. 2011 Aug; 36(2):104-8.
    View in: PubMed
  57. Grossman SA, Shapiro NI, Mottley JL, Sanchez L, Ullman E, Wolfe RE. Is telemetry useful in evaluating chest pain patients in an observation unit? Intern Emerg Med. 2011 Dec; 6(6):543-6.
    View in: PubMed
  58. Puskarich MA, Trzeciak S, Shapiro NI, Heffner AC, Kline JA, Jones AE. Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation. 2011 Oct; 82(10):1289-93.
    View in: PubMed
  59. Schuetz P, Jones AE, Howell MD, Trzeciak S, Ngo L, Younger JG, Aird W, Shapiro NI. Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med. 2011 Nov; 58(5):438-44.
    View in: PubMed
  60. Kilgannon JH, Jones AE, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Shapiro NI, Trzeciak S. Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation. 2011 Jun 14; 123(23):2717-22.
    View in: PubMed
  61. McGillicuddy DC, O'Connell FJ, Shapiro NI, Calder SA, Mottley LJ, Roberts JC, Sanchez LD. Emergency department abnormal vital sign "triggers" program improves time to therapy. Acad Emerg Med. 2011 May; 18(5):483-7.
    View in: PubMed
  62. Ginde AA, Camargo CA, Shapiro NI. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med. 2011 May; 18(5):551-4.
    View in: PubMed
  63. Grossman SA, Bar J, Fischer C, Lipsitz LA, Mottley L, Sands K, Zimetbaum P, Shapiro NI. Reducing admissions utilizing the Boston Syncope Criteria. J Emerg Med. 2012 Mar; 42(3):345-52.
    View in: PubMed
  64. Shapiro NI, Aird WC. Sepsis and the broken endothelium. Crit Care. 2011; 15(2):135.
    View in: PubMed
  65. Schuetz P, Castro P, Shapiro NI. Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care. 2011 Mar; 34(3):771-8.
    View in: PubMed
  66. Schuetz P, Yano K, Sorasaki M, Ngo L, St Hilaire M, Lucas JM, Aird W, Shapiro NI. Influence of diabetes on endothelial cell response during sepsis. Diabetologia. 2011 May; 54(5):996-1003.
    View in: PubMed
  67. Howell MD, Talmor D, Schuetz P, Hunziker S, Jones AE, Shapiro NI. Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med. 2011 Feb; 39(2):322-7.
    View in: PubMed
  68. Perman SM, Chang AM, Hollander JE, Gaieski DF, Trzeciak S, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Goyal M, Cairns CB, Ngo L, Rivers EP, Shapiro NI. Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Acad Emerg Med. 2011 Feb; 18(2):219-22.
    View in: PubMed
  69. Grossman SA, Babineau M, Burke L, Kancharla A, Mottley L, Nencioni A, Shapiro NI. Do outcomes of near syncope parallel syncope? Am J Emerg Med. 2012 Jan; 30(1):203-6.
    View in: PubMed
  70. Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE. RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. Am J Pathol. 2011 Jan; 178(1):245-52.
    View in: PubMed
  71. Green JP, Berger T, Garg N, Shapiro NI. Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection. Ann Emerg Med. 2011 Mar; 57(3):291-5.
    View in: PubMed
  72. McGillicuddy DC, de La Pena J, Goudie JS, Fisher J, Shapiro N, Sanchez LD. Adherence to dose of succinylcholine and etomidate in the emergency department. West J Emerg Med. 2010 Dec; 11(5):432-4.
    View in: PubMed
  73. Kaji AH, Lewis RJ, Beavers-May T, Berg R, Bulger E, Cairns C, Callaway C, Camargo CA, Carcillo J, DeBiasi R, Diaz T, Ducharme F, Glickman S, Heilpern K, Hickey R, Hoek TV, Hollander J, Janson S, Jurkovich G, Kellermann A, Kingsmore S, Kline J, Kuppermann N, Lowe R, McLario D, Nathanson L, Nichol G, Peitzman A, Richardson L, Sanders A, Shah M, Shapiro N, Silverman R, Than M, Wilber S, Yealy DM. Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009. Ann Emerg Med. 2010 Nov; 56(5):522-37.
    View in: PubMed
  74. Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care. 2010; 14(5):R182.
    View in: PubMed
  75. Kennedy M, Joyce N, Howell MD, Lawrence Mottley J, Shapiro NI. Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer. Acad Emerg Med. 2010 Oct; 17(10):1080-5.
    View in: PubMed
  76. Seigel TA, Cocchi MN, Salciccioli J, Shapiro NI, Howell M, Tang A, Donnino MW. Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection. J Emerg Med. 2012 Mar; 42(3):254-9.
    View in: PubMed
  77. Fischer CM, Yano K, Aird WC, Shapiro NI. Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection. J Emerg Med. 2012 Feb; 42(2):127-32.
    View in: PubMed
  78. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 1; 185(1):517-24.
    View in: PubMed
  79. Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010 Jun 2; 303(21):2165-71.
    View in: PubMed
  80. Shapiro NI, Bates DW. Response: The Unacceptable Costs of Trying to Achieve "Diagnostic Certainty" J Emerg Med. 2010 Apr 22.
    View in: PubMed
  81. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, Gaieski DF, Goyal M, Cairns CB, Kupfer K, Lee SW, Rivers EP. The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med. 2010 Jul; 56(1):52-59.e1.
    View in: PubMed
  82. Trzeciak S, Jones AE, Shapiro NI, Pusateri AE, Arnold RC, Rizzuto M, Arora T, Parrillo JE, Dellinger RP. A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation. Crit Care Med. 2010 Apr; 38(4):1092-100.
    View in: PubMed
  83. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010 Feb 24; 303(8):739-46.
    View in: PubMed
  84. Wang HE, Weaver MD, Shapiro NI, Yealy DM. Opportunities for Emergency Medical Services care of sepsis. Resuscitation. 2010 Feb; 81(2):193-7.
    View in: PubMed
  85. Grossman SA, Fischer C, Kancharla A, Lipsitz LA, Mottley L, Zimetbaum P, Shapiro NI. Can benign etiologies predict benign outcomes in high-risk syncope patients? J Emerg Med. 2011 May; 40(5):592-7.
    View in: PubMed
  86. Trzeciak S, Jones AE, Kilgannon JH, Milcarek B, Hunter K, Shapiro NI, Hollenberg SM, Dellinger P, Parrillo JE. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009 Nov; 37(11):2895-903; quiz 2904.
    View in: PubMed
  87. Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med. 2010 Jan; 55(1):40-46.e1.
    View in: PubMed
  88. Shapiro NI, Fisher C, Donnino M, Cataldo L, Tang A, Trzeciak S, Horowitz G, Wolfe RE. The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. J Emerg Med. 2010 Jul; 39(1):89-94.
    View in: PubMed
  89. Nencioni A, Trzeciak S, Shapiro NI. The microcirculation as a diagnostic and therapeutic target in sepsis. Intern Emerg Med. 2009 Oct; 4(5):413-8.
    View in: PubMed
  90. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock. 2009 Jul; 32(1):35-9.
    View in: PubMed
  91. Arnold RC, Parrillo JE, Phillip Dellinger R, Chansky ME, Shapiro NI, Lundy DJ, Trzeciak S, Hollenberg SM. Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med. 2009 Oct; 35(10):1761-6.
    View in: PubMed
  92. Caterino JM, Kulchycki LK, Fischer CM, Wolfe RE, Shapiro NI. Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc. 2009 Jul; 57(7):1184-90.
    View in: PubMed
  93. Singer AJ, Thode HC, Green GB, Birkhahn R, Shapiro NI, Cairns C, Baumann BM, Aghababian R, Char D, Hollander JE. The incremental benefit of a shortness-of-breath biomarker panel in emergency department patients with dyspnea. Acad Emerg Med. 2009 Jun; 16(6):488-94.
    View in: PubMed
  94. Shapiro NI, Yano K, Sorasaki M, Fischer C, Shih SC, Aird WC. Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis. J Vasc Res. 2009; 46(5):495-502.
    View in: PubMed
  95. Callaway DW, Shapiro NI, Donnino MW, Baker C, Rosen CL. Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma. 2009 Apr; 66(4):1040-4.
    View in: PubMed
  96. Donnino MW, Cocchi MN, Howell M, Clardy P, Talmor D, Cataldo L, Chase M, Al-Marshad A, Ngo L, Shapiro NI. Statin therapy is associated with decreased mortality in patients with infection. Acad Emerg Med. 2009 Mar; 16(3):230-4.
    View in: PubMed
  97. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP. A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med. 2009 Jan; 37(1):96-104.
    View in: PubMed
  98. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multi-Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis. Shock. 2008 Dec 22.
    View in: PubMed
  99. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP. Multi-Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis. Shock. 2008 Dec 4.
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  100. Jones AE, Brown MD, Trzeciak S, Shapiro NI, Garrett JS, Heffner AC, Kline JA. The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med. 2008 Oct; 36(10):2734-9.
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  101. Berkman M, Ufberg J, Nathanson LA, Shapiro NI. Anion gap as a screening tool for elevated lactate in patients with an increased risk of developing sepsis in the Emergency Department. J Emerg Med. 2009 May; 36(4):391-4.
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  102. Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008 Dec; 34(12):2210-7.
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  103. Shapiro NI, Wolfe RE, Wright SB, Moore R, Bates DW. Who needs a blood culture? A prospectively derived and validated prediction rule. J Emerg Med. 2008 Oct; 35(3):255-64.
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  104. Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM. Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med. 2008 May; 15(5):399-413.
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  105. McGillicuddy DC, Tang A, Cataldo L, Gusev J, Shapiro NI. Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med. 2009 Feb; 4(1):41-4.
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  106. Talmor D, Greenberg D, Howell MD, Lisbon A, Novack V, Shapiro N. The costs and cost-effectiveness of an integrated sepsis treatment protocol. Crit Care Med. 2008 Apr; 36(4):1168-74.
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  107. Shapiro NI, Yano K, Okada H, Fischer C, Howell M, Spokes KC, Ngo L, Angus DC, Aird WC. A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis. Shock. 2008 Apr; 29(4):452-7.
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  108. Jones AE, Shapiro NI, Kilgannon JH, Trzeciak S. Goal-directed hemodynamic optimization in the post-cardiac arrest syndrome: a systematic review. Resuscitation. 2008 Apr; 77(1):26-9.
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  109. Wang HE, Shapiro NI, Angus DC, Yealy DM. National estimates of severe sepsis in United States emergency departments. Crit Care Med. 2007 Aug; 35(8):1928-36.
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  110. Jones AE, Shapiro NI, Roshon M. Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med. 2007 Nov; 14(11):1072-8.
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  111. Howell MD, Donnino M, Clardy P, Talmor D, Shapiro NI. Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med. 2007 Nov; 33(11):1892-9.
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  112. Grossman SA, Fischer C, Lipsitz LA, Mottley L, Sands K, Thompson S, Zimetbaum P, Shapiro NI. Predicting adverse outcomes in syncope. J Emerg Med. 2007 Oct; 33(3):233-9.
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  113. Howell MD, Donnino MW, Talmor D, Clardy P, Ngo L, Shapiro NI. Performance of severity of illness scoring systems in emergency department patients with infection. Acad Emerg Med. 2007 Aug; 14(8):709-14.
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  114. Kelly SP, Shapiro N, Woodruff M, Corrigan K, Sanchez LD, Wolfe RE. The effects of clinical workload on teaching in the emergency department. Acad Emerg Med. 2007 Jun; 14(6):526-31.
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  115. Talmor D, Jones AE, Rubinson L, Howell MD, Shapiro NI. Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med. 2007 May; 35(5):1251-6.
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  116. Howell MD, Shapiro NI. Surviving sepsis outside the intensive care unit. Crit Care Med. 2007 May; 35(5):1422-3.
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  117. Grossman SA, Fischer C, Bar JL, Lipsitz LA, Mottley L, Sands K, Thompson S, Zimetbaum P, Shapiro NI. The yield of head CT in syncope: a pilot study. Intern Emerg Med. 2007 Mar; 2(1):46-9.
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  118. Shapiro NI, Howell MD, Talmor D, Donnino M, Ngo L, Bates DW. Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortality. Crit Care Med. 2007 Jan; 35(1):192-8.
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  119. Shapiro N, Howell MD, Bates DW, Angus DC, Ngo L, Talmor D. The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med. 2006 Nov; 48(5):583-90, 590.e1.
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  120. Reuben AD, Appelboam AV, Higginson I, Lloyd JG, Shapiro NI. Early goal-directed therapy: a UK perspective. Emerg Med J. 2006 Nov; 23(11):828-32.
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  121. Talmor D, Shapiro N, Greenberg D, Stone PW, Neumann PJ. When is critical care medicine cost-effective? A systematic review of the cost-effectiveness literature. Crit Care Med. 2006 Nov; 34(11):2738-47.
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  122. Strehlow MC, Emond SD, Shapiro NI, Pelletier AJ, Camargo CA. National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med. 2006 Sep; 48(3):326-31, 331.e1-3.
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  123. Shapiro NI, Howell MD, Talmor D, Lahey D, Ngo L, Buras J, Wolfe RE, Weiss JW, Lisbon A. Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med. 2006 Apr; 34(4):1025-32.
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  124. Murray SB, Bates DW, Ngo L, Ufberg JW, Shapiro NI. Charlson Index is associated with one-year mortality in emergency department patients with suspected infection. Acad Emerg Med. 2006 May; 13(5):530-6.
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  125. Shapiro NI, Talmor D. Predicting mortality in the intensive care unit: man against machine. Crit Care Med. 2006 Mar; 34(3):932-3.
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  126. Sanchez LD, Imperato J, Delapena JE, Shapiro N, Tian L. Accuracy of weight estimation by ED personnel. Am J Emerg Med. 2005 Nov; 23(7):915-6.
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  127. Shapiro NI, Donnino MW. Sepsis: the changing times. Crit Care Med. 2005 Nov; 33(11):2700-1.
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  128. Grossman SA, Shapiro NI, Van Epp S, Kohen R, Arnold R, Moore R, Lee L, Wolfe RE, Lipsitz LA. Sex differences in the emergency department evaluation of elderly patients with syncope. J Gerontol A Biol Sci Med Sci. 2005 Sep; 60(9):1202-5.
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  129. Kennedy M, Bates DW, Wright SB, Ruiz R, Wolfe RE, Shapiro NI. Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med. 2005 Nov; 46(5):393-400.
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  130. McGillicuddy DC, Walker O, Shapiro NI, Edlow JA. Guillain-Barré syndrome in the emergency department. Ann Emerg Med. 2006 Apr; 47(4):390-3.
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  131. Shapiro N, Howell MD. Sick? Or, not sick? Crit Care Med. 2005 May; 33(5):1151-3.
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  132. Shapiro NI, Howell MD, Talmor D, Nathanson LA, Lisbon A, Wolfe RE, Weiss JW. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med. 2005 May; 45(5):524-8.
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  133. Shapiro NI, Howell M, Talmor D. A blueprint for a sepsis protocol. Acad Emerg Med. 2005 Apr; 12(4):352-9.
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  134. Shapiro NI, Spear J, Sheehy S, Brown J, Edlow JA. Barriers to the use of outpatient enoxaparin therapy in patients with deep venous thrombosis. Am J Emerg Med. 2005 Jan; 23(1):30-4.
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  135. Grossman SA, Van Epp S, Arnold R, Moore R, Lee L, Shapiro NI, Wolfe RE, Lipsitz LA. The value of cardiac enzymes in elderly patients presenting to the emergency department with syncope. J Gerontol A Biol Sci Med Sci. 2003 Nov; 58(11):1055-8.
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  136. Pozner CN, Levine M, Shapiro N, Hanrahan JP. Concordance of field and emergency department assessment in the prehospital management of patients with dyspnea. Prehosp Emerg Care. 2003 Oct-Dec; 7(4):440-4.
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  137. Shapiro NI, Kociszewski C, Harrison T, Chang Y, Wedel SK, Thomas SH. Isolated prehospital hypotension after traumatic injuries: a predictor of mortality? J Emerg Med. 2003 Aug; 25(2):175-9.
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  138. Shapiro NI, Wolfe RE, Moore RB, Smith E, Burdick E, Bates DW. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003 Mar; 31(3):670-5.
    View in: PubMed
  139. Small SD, Wuerz RC, Simon R, Shapiro N, Conn A, Setnik G. Demonstration of high-fidelity simulation team training for emergency medicine. Acad Emerg Med. 1999 Apr; 6(4):312-23.
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  140. Shapiro NI, Karras DJ, Leech SH, Heilpern KL. Absolute lymphocyte count as a predictor of CD4 count. Ann Emerg Med. 1998 Sep; 32(3 Pt 1):323-8.
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