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David Z. Rudner, Ph.D.

TitleAssociate Professor of Microbiology and Immunobiology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Inst of Medicine
Microbiology and Immunobiology, Room 1025
4 Blackfan Cir
Boston MA 02115
Phone617/432-4455

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T. CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis. Cell. 2013 Oct 24; 155(3):647-58.
    View in: PubMed
  2. Rodrigues CD, Marquis KA, Meisner J, Rudner DZ. Peptidoglycan hydrolysis is required for assembly and activity of the transenvelope secretion complex during sporulation in Bacillus subtilis. Mol Microbiol. 2013 Sep; 89(6):1039-52.
    View in: PubMed
  3. Meisner J, Montero Llopis P, Sham LT, Garner E, Bernhardt TG, Rudner DZ. FtsEX is required for CwlO peptidoglycan hydrolase activity during cell wall elongation in Bacillus subtilis. Mol Microbiol. 2013 Sep; 89(6):1069-83.
    View in: PubMed
  4. Wang X, Llopis PM, Rudner DZ. Organization and segregation of bacterial chromosomes. Nat Rev Genet. 2013 Feb 12; 14(3):191-203.
    View in: PubMed
  5. Doan T, Coleman J, Marquis KA, Meeske AJ, Burton BM, Karatekin E, Rudner DZ. FisB mediates membrane fission during sporulation in Bacillus subtilis. Genes Dev. 2013 Feb 1; 27(3):322-34.
    View in: PubMed
  6. Yardimci H, Wang X, Loveland AB, Tappin I, Rudner DZ, Hurwitz J, van Oijen AM, Walter JC. Bypass of a protein barrier by a replicative DNA helicase. Nature. 2012 Dec 13; 492(7428):205-9.
    View in: PubMed
  7. Jackson D, Wang X, Rudner DZ. Spatio-temporal organization of replication in bacteria and eukaryotes (nucleoids and nuclei). Cold Spring Harb Perspect Biol. 2012 Aug; 4(8):a010389.
    View in: PubMed
  8. Wagner-Herman JK, Bernard R, Dunne R, Bisson-Filho AW, Kumar K, Nguyen T, Mulcahy L, Koullias J, Gueiros-Filho FJ, Rudner DZ. RefZ facilitates the switch from medial to polar division during spore formation in Bacillus subtilis. J Bacteriol. 2012 Sep; 194(17):4608-18.
    View in: PubMed
  9. Garner EC, Bernard R, Wang W, Zhuang X, Rudner DZ, Mitchison T. Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science. 2011 Jul 8; 333(6039):222-5.
    View in: PubMed
  10. Bernard R, Marquis KA, Rudner DZ. Nucleoid occlusion prevents cell division during replication fork arrest in Bacillus subtilis. Mol Microbiol. 2010 Nov; 78(4):866-82.
    View in: PubMed
  11. Rudner DZ, Losick R. Protein subcellular localization in bacteria. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a000307.
    View in: PubMed
  12. Morlot C, Uehara T, Marquis KA, Bernhardt TG, Rudner DZ. A highly coordinated cell wall degradation machine governs spore morphogenesis in Bacillus subtilis. Genes Dev. 2010 Feb 15; 24(4):411-22.
    View in: PubMed
  13. Wagner JK, Marquis KA, Rudner DZ. SirA enforces diploidy by inhibiting the replication initiator DnaA during spore formation in Bacillus subtilis. Mol Microbiol. 2009 Sep; 73(5):963-74.
    View in: PubMed
  14. Doan T, Morlot C, Meisner J, Serrano M, Henriques AO, Moran CP, Rudner DZ. Novel secretion apparatus maintains spore integrity and developmental gene expression in Bacillus subtilis. PLoS Genet. 2009 Jul; 5(7):e1000566.
    View in: PubMed
  15. Sullivan NL, Marquis KA, Rudner DZ. Recruitment of SMC by ParB-parS organizes the origin region and promotes efficient chromosome segregation. Cell. 2009 May 15; 137(4):697-707.
    View in: PubMed
  16. Marquis KA, Burton BM, Nollmann M, Ptacin JL, Bustamante C, Ben-Yehuda S, Rudner DZ. SpoIIIE strips proteins off the DNA during chromosome translocation. Genes Dev. 2008 Jul 1; 22(13):1786-95.
    View in: PubMed
  17. Burton BM, Marquis KA, Sullivan NL, Rapoport TA, Rudner DZ. The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell. 2007 Dec 28; 131(7):1301-12.
    View in: PubMed
  18. Campo N, Marquis KA, Rudner DZ. SpoIIQ anchors membrane proteins on both sides of the sporulation septum in Bacillus subtilis. J Biol Chem. 2008 Feb 22; 283(8):4975-82.
    View in: PubMed
  19. Campo N, Rudner DZ. SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2007 Aug; 189(16):6021-7.
    View in: PubMed
  20. Doan T, Rudner DZ. Perturbations to engulfment trigger a degradative response that prevents cell-cell signalling during sporulation in Bacillus subtilis. Mol Microbiol. 2007 Apr; 64(2):500-11.
    View in: PubMed
  21. Straight PD, Fischbach MA, Walsh CT, Rudner DZ, Kolter R. A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 2; 104(1):305-10.
    View in: PubMed
  22. Tiyanont K, Doan T, Lazarus MB, Fang X, Rudner DZ, Walker S. Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):11033-8.
    View in: PubMed
  23. Campo N, Rudner DZ. A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis. Mol Cell. 2006 Jul 7; 23(1):25-35.
    View in: PubMed
  24. Ben-Yehuda S, Fujita M, Liu XS, Gorbatyuk B, Skoko D, Yan J, Marko JF, Liu JS, Eichenberger P, Rudner DZ, Losick R. Defining a centromere-like element in Bacillus subtilis by Identifying the binding sites for the chromosome-anchoring protein RacA. Mol Cell. 2005 Mar 18; 17(6):773-82.
    View in: PubMed
  25. Doan T, Marquis KA, Rudner DZ. Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum. Mol Microbiol. 2005 Mar; 55(6):1767-81.
    View in: PubMed
  26. Eichenberger P, Fujita M, Jensen ST, Conlon EM, Rudner DZ, Wang ST, Ferguson C, Haga K, Sato T, Liu JS, Losick R. The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis. PLoS Biol. 2004 Oct; 2(10):e328.
    View in: PubMed
  27. Ben-Yehuda S, Rudner DZ, Losick R. Assembly of the SpoIIIE DNA translocase depends on chromosome trapping in Bacillus subtilis. Curr Biol. 2003 Dec 16; 13(24):2196-200.
    View in: PubMed
  28. Pan Q, Losick R, Rudner DZ. A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2003 Oct; 185(20):6051-6.
    View in: PubMed
  29. Ben-Yehuda S, Rudner DZ, Losick R. RacA, a bacterial protein that anchors chromosomes to the cell poles. Science. 2003 Jan 24; 299(5606):532-6.
    View in: PubMed
  30. Rudner DZ, Pan Q, Losick RM. Evidence that subcellular localization of a bacterial membrane protein is achieved by diffusion and capture. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8701-6.
    View in: PubMed
  31. Rudner DZ, Losick R. A sporulation membrane protein tethers the pro-sigmaK processing enzyme to its inhibitor and dictates its subcellular localization. Genes Dev. 2002 Apr 15; 16(8):1007-18.
    View in: PubMed
  32. Rudner DZ, Losick R. Morphological coupling in development: lessons from prokaryotes. Dev Cell. 2001 Dec; 1(6):733-42.
    View in: PubMed
  33. Rudner DZ, Fawcett P, Losick R. A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14765-70.
    View in: PubMed
  34. Cline TW, Rudner DZ, Barbash DA, Bell M, Vutien R. Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf(+) gene dose effects. Proc Natl Acad Sci U S A. 1999 Dec 7; 96(25):14451-8.
    View in: PubMed
  35. Rudner DZ, Breger KS, Kanaar R, Adams MD, Rio DC. RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Mol Cell Biol. 1998 Jul; 18(7):4004-11.
    View in: PubMed
  36. Rudner DZ, Kanaar R, Breger KS, Rio DC. Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo. Mol Cell Biol. 1998 Apr; 18(4):1765-73.
    View in: PubMed
  37. Rudner DZ, Breger KS, Rio DC. Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo. Genes Dev. 1998 Apr 1; 12(7):1010-21.
    View in: PubMed
  38. Hammond LE, Rudner DZ, Kanaar R, Rio DC. Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo. Mol Cell Biol. 1997 Dec; 17(12):7260-7.
    View in: PubMed
  39. Lee AL, Volkman BF, Robertson SA, Rudner DZ, Barbash DA, Cline TW, Kanaar R, Rio DC, Wemmer DE. Chemical shift mapping of the RNA-binding interface of the multiple-RBD protein sex-lethal. Biochemistry. 1997 Nov 25; 36(47):14306-17.
    View in: PubMed
  40. Rudner DZ, Kanaar R, Breger KS, Rio DC. Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10333-7.
    View in: PubMed
  41. Adams MD, Rudner DZ, Rio DC. Biochemistry and regulation of pre-mRNA splicing. Curr Opin Cell Biol. 1996 Jun; 8(3):331-9.
    View in: PubMed
  42. Kanaar R, Lee AL, Rudner DZ, Wemmer DE, Rio DC. Interaction of the sex-lethal RNA binding domains with RNA. EMBO J. 1995 Sep 15; 14(18):4530-9.
    View in: PubMed
  43. Ireton K, Rudner DZ, Siranosian KJ, Grossman AD. Integration of multiple developmental signals in Bacillus subtilis through the Spo0A transcription factor. Genes Dev. 1993 Feb; 7(2):283-94.
    View in: PubMed
  44. Lowell JE, Rudner DZ, Sachs AB. 3'-UTR-dependent deadenylation by the yeast poly(A) nuclease. Genes Dev. 1992 Nov; 6(11):2088-99.
    View in: PubMed
  45. Rudner DZ, LeDeaux JR, Ireton K, Grossman AD. The spo0K locus of Bacillus subtilis is homologous to the oligopeptide permease locus and is required for sporulation and competence. J Bacteriol. 1991 Feb; 173(4):1388-98.
    View in: PubMed
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