Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Ole Isacson, Dr.Med.Sci, M.B.

TitleProfessor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMclean Hospital
MRC 130, Center for Neuroregeneration Research
115 Mill St
Belmont MA 02478
Phone617/855-3283
Fax617/855-3284

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, Schüle B. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction. Neurobiol Dis. 2014 Feb; 62:381-6.
    View in: PubMed
  2. Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O. Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons. Stem Cells. 2013 Aug; 31(8):1548-62.
    View in: PubMed
  3. Olanow CW, Isacson O. Stem cells for Parkinson's disease: Advancing science but protecting patients. Mov Disord. 2012 Oct; 27(12):1475-7.
    View in: PubMed
  4. Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, Marti-Masso JF, Preza E, Barker S, Sutherland M, Corriveau RA, D'Andrea M, Schapira AH, Uitti RJ, Guttman M, Opala G, Jasinska-Myga B, Puschmann A, Nilsson C, Espay AJ, Slawek J, Gutmann L, Boeve BF, Boylan K, Stoessl AJ, Ross OA, Maragakis NJ, Van Gerpen J, Gerstenhaber M, Gwinn K, Dawson TM, Isacson O, Marder KS, Clark LN, Przedborski SE, Finkbeiner S, Rothstein JD, Wszolek ZK, Rossor MN, Hardy J. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS One. 2012; 7(8):e43099.
    View in: PubMed
  5. Smith GA, Isacson O, Dunnett SB. The search for genetic mouse models of prodromal Parkinson's disease. Exp Neurol. 2012 Oct; 237(2):267-73.
    View in: PubMed
  6. Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012 Jul 4; 4(141):141ra90.
    View in: PubMed
  7. Hallett PJ, McLean JR, Kartunen A, Langston JW, Isacson O. a-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits. Neurobiol Dis. 2012 Aug; 47(2):258-67.
    View in: PubMed
  8. Deleidi M, Isacson O. Viral and inflammatory triggers of neurodegenerative diseases. Sci Transl Med. 2012 Feb 15; 4(121):121ps3.
    View in: PubMed
  9. Lindvall O, Barker RA, Brüstle O, Isacson O, Svendsen CN. Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell. 2012 Feb 3; 10(2):151-5.
    View in: PubMed
  10. Cooper O, Parmar M, Isacson O. Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy. Prog Brain Res. 2012; 200:265-76.
    View in: PubMed
  11. Cooper O, Hallett P, Isacson O. Using stem cells and iPS cells to discover new treatments for Parkinson's disease. Parkinsonism Relat Disord. 2012 Jan; 18 Suppl 1:S14-6.
    View in: PubMed
  12. McLean JR, Hallett PJ, Cooper O, Stanley M, Isacson O. Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression. Mol Cell Neurosci. 2012 Feb; 49(2):230-9.
    View in: PubMed
  13. Deleidi M, Hargus G, Hallett P, Osborn T, Isacson O. Development of histocompatible primate-induced pluripotent stem cells for neural transplantation. Stem Cells. 2011 Jul; 29(7):1052-63.
    View in: PubMed
  14. Deleidi M, Cooper O, Hargus G, Levy A, Isacson O. Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons. PLoS One. 2011; 6(5):e19926.
    View in: PubMed
  15. Tsui A, Isacson O. Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease. J Neurol. 2011 Aug; 258(8):1393-405.
    View in: PubMed
  16. Deleidi M, Hallett PJ, Koprich JB, Chung CY, Isacson O. The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. J Neurosci. 2010 Dec 1; 30(48):16091-101.
    View in: PubMed
  17. Isacson O, Mendez I. Being too inclusive about synuclein inclusions. Nat Med. 2010 Sep; 16(9):960-1; author reply 961.
    View in: PubMed
  18. Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A. 2010 Sep 7; 107(36):15921-6.
    View in: PubMed
  19. Seo H, Isacson O. The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome. J Neurochem. 2010 Sep; 114(6):1819-26.
    View in: PubMed
  20. Hedlund E, Karlsson M, Osborn T, Ludwig W, Isacson O. Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. Brain. 2010 Aug; 133(Pt 8):2313-30.
    View in: PubMed
  21. Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson O. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci. 2010 Nov; 45(3):258-66.
    View in: PubMed
  22. Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain. 2010 Jul; 133(Pt 7):2022-31.
    View in: PubMed
  23. Lin Z, Zhao Y, Chung CY, Zhou Y, Xiong N, Glatt CE, Isacson O. High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. FASEB J. 2010 Jul; 24(7):2191-200.
    View in: PubMed
  24. Chung CY, Koprich JB, Hallett PJ, Isacson O. Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22474-9.
    View in: PubMed
  25. Chung S, Leung A, Han BS, Chang MY, Moon JI, Kim CH, Hong S, Pruszak J, Isacson O, Kim KS. Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell. 2009 Dec 4; 5(6):646-58.
    View in: PubMed
  26. Pruszak J, Ludwig W, Blak A, Alavian K, Isacson O. CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells. 2009 Dec; 27(12):2928-40.
    View in: PubMed
  27. Pruszak J, Just L, Isacson O, Nikkhah G. Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. Curr Protoc Stem Cell Biol. 2009 Dec; Chapter 2:Unit 2D.5.
    View in: PubMed
  28. Isacson O. Cell therapy ahead for Parkinson's disease. Science. 2009 Nov 20; 326(5956):1060.
    View in: PubMed
  29. Hallett PJ, Cooper O, Isacson O. No evidence for disease-like processes in fetal transplants. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):E104; author reply E105.
    View in: PubMed
  30. Cooper O, Astradsson A, Hallett P, Robertson H, Mendez I, Isacson O. Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients. J Neurol. 2009 Aug; 256 Suppl 3:310-6.
    View in: PubMed
  31. Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51.
    View in: PubMed
  32. Chung CY, Koprich JB, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci. 2009 Mar 18; 29(11):3365-73.
    View in: PubMed
  33. Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009 Mar 6; 136(5):964-77.
    View in: PubMed
  34. Zhang J, Xu TX, Hallett PJ, Watanabe M, Grant SG, Isacson O, Yao WD. PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. J Neurosci. 2009 Mar 4; 29(9):2948-60.
    View in: PubMed
  35. Lin L, Lesnick TG, Maraganore DM, Isacson O. Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics. Trends Neurosci. 2009 Mar; 32(3):142-9.
    View in: PubMed
  36. Pruszak J, Isacson O. Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy. Adv Exp Med Biol. 2009; 651:112-23.
    View in: PubMed
  37. Hedlund E, Isacson O. ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 4; 3(6):575-6.
    View in: PubMed
  38. Isacson O, Kordower JH. Future of cell and gene therapies for Parkinson's disease. Ann Neurol. 2008 Dec; 64 Suppl 2:S122-38.
    View in: PubMed
  39. Vinuela A, Hallett PJ, Reske-Nielsen C, Patterson M, Sotnikova TD, Caron MG, Gainetdinov RR, Isacson O. Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. Brain. 2008 Dec; 131(Pt 12):3361-79.
    View in: PubMed
  40. Sanchez-Pernaute R, Lee H, Patterson M, Reske-Nielsen C, Yoshizaki T, Sonntag KC, Studer L, Isacson O. Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain. 2008 Aug; 131(Pt 8):2127-39.
    View in: PubMed
  41. Seo H, Kim W, Isacson O. Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Hum Mol Genet. 2008 Oct 15; 17(20):3144-53.
    View in: PubMed
  42. de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isacson O. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells. 2008 Sep; 26(9):2349-60.
    View in: PubMed
  43. Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 2008 Aug 1; 42(1):248-51.
    View in: PubMed
  44. Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5856-61.
    View in: PubMed
  45. Mendez I, Viñuela A, Astradsson A, Mukhida K, Hallett P, Robertson H, Tierney T, Holness R, Dagher A, Trojanowski JQ, Isacson O. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med. 2008 May; 14(5):507-9.
    View in: PubMed
  46. Hedlund E, Pruszak J, Lardaro T, Ludwig W, Viñuela A, Kim KS, Isacson O. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem Cells. 2008 Jun; 26(6):1526-36.
    View in: PubMed
  47. Viaro R, Sanchez-Pernaute R, Marti M, Trapella C, Isacson O, Morari M. Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism. Neurobiol Dis. 2008 Jun; 30(3):430-8.
    View in: PubMed
  48. Koprich JB, Reske-Nielsen C, Mithal P, Isacson O. Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation. 2008; 5:8.
    View in: PubMed
  49. Astradsson A, Cooper O, Vinuela A, Isacson O. Recent advances in cell-based therapy for Parkinson disease. Neurosurg Focus. 2008; 24(3-4):E6.
    View in: PubMed
  50. Hong S, Kang UJ, Isacson O, Kim KS. Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. J Neurochem. 2008 Jan; 104(2):316-24.
    View in: PubMed
  51. Hedlund E, Hefferan MP, Marsala M, Isacson O. Cell therapy and stem cells in animal models of motor neuron disorders. Eur J Neurosci. 2007 Oct; 26(7):1721-37.
    View in: PubMed
  52. Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A. 2007 Sep 4; 104(36):14430-5.
    View in: PubMed
  53. Redmond DE, Vinuela A, Kordower JH, Isacson O. Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease. Neurobiol Dis. 2008 Jan; 29(1):103-16.
    View in: PubMed
  54. Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. PLoS Med. 2007 Aug; 4(8):e262.
    View in: PubMed
  55. Chung CY, Koprich JB, Endo S, Isacson O. An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. J Neurosci. 2007 Aug 1; 27(31):8314-23.
    View in: PubMed
  56. Brunlid G, Pruszak J, Holmes B, Isacson O, Sonntag KC. Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system. Stem Cells. 2007 Oct; 25(10):2551-8.
    View in: PubMed
  57. Hong S, Hwang DY, Yoon S, Isacson O, Ramezani A, Hawley RG, Kim KS. Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells. Mol Ther. 2007 Sep; 15(9):1630-9.
    View in: PubMed
  58. Pruszak J, Sonntag KC, Aung MH, Sanchez-Pernaute R, Isacson O. Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells. 2007 Sep; 25(9):2257-68.
    View in: PubMed
  59. Sánchez-Pernaute R, Jenkins BG, Choi JK, Iris Chen YC, Isacson O. In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiol Dis. 2007 Aug; 27(2):220-7.
    View in: PubMed
  60. Isacson O. Ole Isacson: development of new therapies for Parkinson's disease (interview). J Vis Exp. 2007; (3):189.
    View in: PubMed
  61. Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD. Inhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem. 2007 May 25; 282(21):15778-89.
    View in: PubMed
  62. Seo H, Sonntag KC, Kim W, Cattaneo E, Isacson O. Proteasome activator enhances survival of Huntington's disease neuronal model cells. PLoS One. 2007; 2(2):e238.
    View in: PubMed
  63. Hedlund E, Pruszak J, Ferree A, Viñuela A, Hong S, Isacson O, Kim KS. Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations. Stem Cells. 2007 May; 25(5):1126-35.
    View in: PubMed
  64. Karki S, Pruszak J, Isacson O, Sonntag KC. ES cell-derived neuroepithelial cell cultures. J Vis Exp. 2006 Dec; (1):118.
    View in: PubMed
  65. Baker KL, Daniels SB, Lennington JB, Lardaro T, Czap A, Notti RQ, Cooper O, Isacson O, Frasca S, Conover JC. Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse. J Comp Neurol. 2006 Oct 20; 498(6):747-61.
    View in: PubMed
  66. Sonntag KC, Pruszak J, Yoshizaki T, van Arensbergen J, Sanchez-Pernaute R, Isacson O. Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells. 2007 Feb; 25(2):411-8.
    View in: PubMed
  67. Ferrari D, Sanchez-Pernaute R, Lee H, Studer L, Isacson O. Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft. Eur J Neurosci. 2006 Oct; 24(7):1885-96.
    View in: PubMed
  68. Isacson O. What are the long-term effects of neural grafting in patients with Huntington's disease? Nat Clin Pract Neurol. 2006 Sep; 2(9):470-1.
    View in: PubMed
  69. Kelly BB, Hedlund E, Kim C, Ishiguro H, Isacson O, Chikaraishi DM, Kim KS, Feng G. A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. Neuroscience. 2006 Oct 13; 142(2):343-54.
    View in: PubMed
  70. Lin L, Isacson O. Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem Cells. 2006 Nov; 24(11):2504-13.
    View in: PubMed
  71. Chung S, Shin BS, Hedlund E, Pruszak J, Ferree A, Kang UJ, Isacson O, Kim KS. Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. J Neurochem. 2006 Jun; 97(5):1467-80.
    View in: PubMed
  72. Chung S, Shin BS, Hwang M, Lardaro T, Kang UJ, Isacson O, Kim KS. Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Stem Cells. 2006 Jun; 24(6):1583-93.
    View in: PubMed
  73. Krichevsky AM, Sonntag KC, Isacson O, Kosik KS. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells. 2006 Apr; 24(4):857-64.
    View in: PubMed
  74. Sánchez-Pernaute R, Brownell AL, Jenkins BG, Isacson O. Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging. Toxicol Appl Pharmacol. 2005 Sep 1; 207(2 Suppl):251-6.
    View in: PubMed
  75. Kim DW, Chung S, Hwang M, Ferree A, Tsai HC, Park JJ, Chung S, Nam TS, Kang UJ, Isacson O, Kim KS. Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells. 2006 Mar; 24(3):557-67.
    View in: PubMed
  76. Sánchez-Pernaute R, Studer L, Ferrari D, Perrier A, Lee H, Viñuela A, Isacson O. Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem Cells. 2005 Aug; 23(7):914-22.
    View in: PubMed
  77. Seo H, Isacson O. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Exp Neurol. 2005 Jun; 193(2):469-80.
    View in: PubMed
  78. Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson O. Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum Mol Genet. 2005 Jul 1; 14(13):1709-25.
    View in: PubMed
  79. Mendez I, Sanchez-Pernaute R, Cooper O, Viñuela A, Ferrari D, Björklund L, Dagher A, Isacson O. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain. 2005 Jul; 128(Pt 7):1498-510.
    View in: PubMed
  80. Sonntag KC, Simantov R, Isacson O. Stem cells may reshape the prospect of Parkinson's disease therapy. Brain Res Mol Brain Res. 2005 Mar 24; 134(1):34-51.
    View in: PubMed
  81. Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson O. Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci. 2005 Mar; 28(3):417-29.
    View in: PubMed
  82. Lin L, Rao Y, Isacson O. Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Mol Cell Neurosci. 2005 Mar; 28(3):547-55.
    View in: PubMed
  83. Chung S, Hedlund E, Hwang M, Kim DW, Shin BS, Hwang DY, Kang UJ, Isacson O, Kim KS. The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons. Mol Cell Neurosci. 2005 Feb; 28(2):241-52.
    View in: PubMed
  84. Kakinohana O, Cizkova D, Tomori Z, Hedlund E, Marsala S, Isacson O, Marsala M. Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study. Exp Neurol. 2004 Nov; 190(1):122-32.
    View in: PubMed
  85. Jenkins BG, Sanchez-Pernaute R, Brownell AL, Chen YC, Isacson O. Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. J Neurosci. 2004 Oct 27; 24(43):9553-60.
    View in: PubMed
  86. Cooper O, Isacson O. Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. J Neurosci. 2004 Oct 13; 24(41):8924-31.
    View in: PubMed
  87. Seo H, Sonntag KC, Isacson O. Generalized brain and skin proteasome inhibition in Huntington's disease. Ann Neurol. 2004 Sep; 56(3):319-28.
    View in: PubMed
  88. Isacson O. Problems and solutions for circuits and synapses in Parkinson's disease. Neuron. 2004 Jul 22; 43(2):165-8.
    View in: PubMed
  89. Sánchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL, Isacson O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J Neuroinflammation. 2004 May 17; 1(1):6.
    View in: PubMed
  90. Sonntag KC, Simantov R, Kim KS, Isacson O. Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation. Eur J Neurosci. 2004 Mar; 19(5):1141-52.
    View in: PubMed
  91. Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti F, Sanchez-Pernaute R, Isacson O. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. Neuroimage. 2003 Oct; 20(2):1064-75.
    View in: PubMed
  92. Isacson O. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurol. 2003 Jul; 2(7):417-24.
    View in: PubMed
  93. Kim KS, Kim CH, Hwang DY, Seo H, Chung S, Hong SJ, Lim JK, Anderson T, Isacson O. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. J Neurochem. 2003 May; 85(3):622-34.
    View in: PubMed
  94. Hunter CL, Isacson O, Nelson M, Bimonte-Nelson H, Seo H, Lin L, Ford K, Kindy MS, Granholm AC. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neurosci Res. 2003 Apr; 45(4):437-45.
    View in: PubMed
  95. Cicchetti F, Fodor W, Deacon TW, van Horne C, Rollins S, Burton W, Costantini LC, Isacson O. Immune parameters relevant to neural xenograft survival in the primate brain. Xenotransplantation. 2003 Jan; 10(1):41-9.
    View in: PubMed
  96. Isacson O, Bjorklund LM, Schumacher JM. Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells. Ann Neurol. 2003; 53 Suppl 3:S135-46; discussion S146-8.
    View in: PubMed
  97. Granholm AC, Sanders L, Seo H, Lin L, Ford K, Isacson O. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. 2003; 13(8):905-14.
    View in: PubMed
  98. McNaught KS, Belizaire R, Isacson O, Jenner P, Olanow CW. Altered proteasomal function in sporadic Parkinson's disease. Exp Neurol. 2003 Jan; 179(1):38-46.
    View in: PubMed
  99. Chung S, Sonntag KC, Andersson T, Bjorklund LM, Park JJ, Kim DW, Kang UJ, Isacson O, Kim KS. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. Eur J Neurosci. 2002 Nov; 16(10):1829-38.
    View in: PubMed
  100. Cicchetti F, Costantini L, Belizaire R, Burton W, Isacson O, Fodor W. Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brain. Exp Neurol. 2002 Oct; 177(2):376-84.
    View in: PubMed
  101. Sánchez-Pernaute R, Brownell AL, Isacson O. Functional imaging of the dopamine system: in vivo evaluation of dopamine deficiency and restoration. Neurotoxicology. 2002 Oct; 23(4-5):469-78.
    View in: PubMed
  102. McNaught KS, Björklund LM, Belizaire R, Isacson O, Jenner P, Olanow CW. Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport. 2002 Aug 7; 13(11):1437-41.
    View in: PubMed
  103. Bimonte HA, Granholm AC, Seo H, Isacson O. Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats. Neurosci Lett. 2002 Aug 2; 328(1):50-4.
    View in: PubMed
  104. McNaught KS, Belizaire R, Jenner P, Olanow CW, Isacson O. Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease. Neurosci Lett. 2002 Jul 5; 326(3):155-8.
    View in: PubMed
  105. Isacson O. Models of repair mechanisms for future treatment modalities of Parkinson's disease. Brain Res Bull. 2002 Apr; 57(6):839-46.
    View in: PubMed
  106. Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KS. A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. J Neurochem. 2002 Mar; 80(5):905-16.
    View in: PubMed
  107. Cicchetti F, Brownell AL, Williams K, Chen YI, Livni E, Isacson O. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci. 2002 Mar; 15(6):991-8.
    View in: PubMed
  108. Isacson O, Seo H, Lin L, Albeck D, Granholm AC. Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends Neurosci. 2002 Feb; 25(2):79-84.
    View in: PubMed
  109. Seo H, Ferree AW, Isacson O. Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. Eur J Neurosci. 2002 Feb; 15(3):498-506.
    View in: PubMed
  110. Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2344-9.
    View in: PubMed
  111. Chung S, Andersson T, Sonntag KC, Björklund L, Isacson O, Kim KS. Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines. Stem Cells. 2002; 20(2):139-45.
    View in: PubMed
  112. Costantini LC, Fraefel C, Breakefield XO, Isacson O. Herpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use. Methods Mol Med. 2002; 69:461-79.
    View in: PubMed
  113. Björklund LM, Isacson O. Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease. Prog Brain Res. 2002; 138:411-20.
    View in: PubMed
  114. Williams-Johnso M, Isacson O. Therapeutic approaches: session XI summary and research needs. Neurotoxicology. 2001 Dec; 22(6):855-8.
    View in: PubMed
  115. Moore AE, Cicchetti F, Hennen J, Isacson O. Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat. Exp Neurol. 2001 Dec; 172(2):363-76.
    View in: PubMed
  116. Hwang DY, Carlezon WA, Isacson O, Kim KS. A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Hum Gene Ther. 2001 Sep 20; 12(14):1731-40.
    View in: PubMed
  117. McNaught KS, Olanow CW, Halliwell B, Isacson O, Jenner P. Failure of the ubiquitin-proteasome system in Parkinson's disease. Nat Rev Neurosci. 2001 Aug; 2(8):589-94.
    View in: PubMed
  118. Isacson O, Costantini L, Schumacher JM, Cicchetti F, Chung S, Kim K. Cell implantation therapies for Parkinson's disease using neural stem, transgenic or xenogeneic donor cells. Parkinsonism Relat Disord. 2001 Jul; 7(3):205-212.
    View in: PubMed
  119. Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O. Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits. Exp Neurol. 2001 Jul; 170(1):36-47.
    View in: PubMed
  120. Isacson O, Bjorklund L, Pernaute RS. Parkinson's disease: interpretations of transplantation study are erroneous. Nat Neurosci. 2001 Jun; 4(6):553.
    View in: PubMed
  121. Costantini LC, Cole D, Chaturvedi P, Isacson O. Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease. Eur J Neurosci. 2001 Mar; 13(6):1085-92.
    View in: PubMed
  122. Holm KH, Cicchetti F, Bjorklund L, Boonman Z, Tandon P, Costantini LC, Deacon TW, Huang X, Chen DF, Isacson O. Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum. Neuroscience. 2001; 104(2):397-405.
    View in: PubMed
  123. Isacson O, van Horne C, Schumacher JM, Brownell AL. Improved surgical cell therapy in Parkinson's disease. Physiological basis and new transplantation methodology. Adv Neurol. 2001; 86:447-54.
    View in: PubMed
  124. Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, Saporta S, Isacson O. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13877-82.
    View in: PubMed
  125. Haque NS, Isacson O. Neurotrophic factors NGF and FGF-2 alter levels of huntingtin (IT15) in striatal neuronal cell cultures. Cell Transplant. 2000 Sep-Oct; 9(5):623-7.
    View in: PubMed
  126. Costantini LC, Isacson O. Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture. Exp Neurol. 2000 Jul; 164(1):60-70.
    View in: PubMed
  127. Emilien G, Ponchon M, Caldas C, Isacson O, Maloteaux JM. Impact of genomics on drug discovery and clinical medicine. QJM. 2000 Jul; 93(7):391-423.
    View in: PubMed
  128. Schumacher JM, Ellias SA, Palmer EP, Kott HS, Dinsmore J, Dempsey PK, Fischman AJ, Thomas C, Feldman RG, Kassissieh S, Raineri R, Manhart C, Penney D, Fink JS, Isacson O. Transplantation of embryonic porcine mesencephalic tissue in patients with PD. Neurology. 2000 Mar 14; 54(5):1042-50.
    View in: PubMed
  129. Fink JS, Schumacher JM, Ellias SL, Palmer EP, Saint-Hilaire M, Shannon K, Penn R, Starr P, VanHorne C, Kott HS, Dempsey PK, Fischman AJ, Raineri R, Manhart C, Dinsmore J, Isacson O. Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results. Cell Transplant. 2000 Mar-Apr; 9(2):273-8.
    View in: PubMed
  130. Costantini LC, Bakowska JC, Breakefield XO, Isacson O. Gene therapy in the CNS. Gene Ther. 2000 Jan; 7(2):93-109.
    View in: PubMed
  131. Costantini LC, Isacson O. Neuroimmunophilin ligand enhances neurite outgrowth and effect of fetal dopamine transplants. Neuroscience. 2000; 100(3):515-20.
    View in: PubMed
  132. Kordower JH, Isacson O, Leventhal L, Emerich DF. Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? Prog Brain Res. 2000; 127:414-30.
    View in: PubMed
  133. Isacson O, Lin L. Cholinergic modulation of amyloid processing and dementia in animal models of Alzheimer's disease. Ann N Y Acad Sci. 2000; 920:309-14.
    View in: PubMed
  134. Lin L, Georgievska B, Mattsson A, Isacson O. Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):12108-13.
    View in: PubMed
  135. Costantini LC, Jacoby DR, Wang S, Fraefel C, Breakefield XO, Isacson O. Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors. Hum Gene Ther. 1999 Oct 10; 10(15):2481-94.
    View in: PubMed
  136. Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 1999 Sep 29; 10(14):2881-6.
    View in: PubMed
  137. Isacson O, Sladek JR. Cellular and molecular treatments of neurological diseases. Exp Neurol. 1999 Sep; 159(1):1-3.
    View in: PubMed
  138. Kordower JH, Isacson O, Emerich DF. Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? Exp Neurol. 1999 Sep; 159(1):4-20.
    View in: PubMed
  139. Isacson O. The neurobiology and neurogenetics of stem cells. Brain Pathol. 1999 Jul; 9(3):495-8.
    View in: PubMed
  140. Holm K, Isacson O. Factors intrinsic to the neuron can induce and maintain its ability to promote axonal outgrowth: a role for BCL2? Trends Neurosci. 1999 Jun; 22(6):269-73.
    View in: PubMed
  141. Brownell AL, Jenkins BG, Isacson O. Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease. Biomed Pharmacother. 1999 Apr; 53(3):131-40.
    View in: PubMed
  142. Boonman Z, Isacson O. Apoptosis in neuronal development and transplantation: role of caspases and trophic factors. Exp Neurol. 1999 Mar; 156(1):1-15.
    View in: PubMed
  143. Deacon T, Whatley B, LeBlanc C, Lin L, Isacson O. Pig fetal septal neurons implanted into the hippocampus of aged or cholinergic deafferented rats grow axons and form cross-species synapses in appropriate target regions. Cell Transplant. 1999 Jan-Feb; 8(1):111-29.
    View in: PubMed
  144. LeBlanc CJ, Deacon TW, Whatley BR, Dinsmore J, Lin L, Isacson O. Morris water maze analysis of 192-IgG-saporin-lesioned rats and porcine cholinergic transplants to the hippocampus. Cell Transplant. 1999 Jan-Feb; 8(1):131-42.
    View in: PubMed
  145. Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson O. Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. Nat Med. 1998 Nov; 4(11):1308-12.
    View in: PubMed
  146. Costantini LC, Chaturvedi P, Armistead DM, McCaffrey PG, Deacon TW, Isacson O. A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease. Neurobiol Dis. 1998 Aug; 5(2):97-106.
    View in: PubMed
  147. Brownell AL, Livni E, Galpern W, Isacson O. In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants. Ann Neurol. 1998 Mar; 43(3):387-90.
    View in: PubMed
  148. Lin L, LeBlanc CJ, Deacon TW, Isacson O. Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system. Neuroreport. 1998 Feb 16; 9(3):547-52.
    View in: PubMed
  149. Deacon T, Dinsmore J, Costantini LC, Ratliff J, Isacson O. Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation. Exp Neurol. 1998 Jan; 149(1):28-41.
    View in: PubMed
  150. Isacson O, Deacon T. Neural transplantation studies reveal the brain's capacity for continuous reconstruction. Trends Neurosci. 1997 Oct; 20(10):477-82.
    View in: PubMed
  151. Isacson O, Breakefield XO. Benefits and risks of hosting animal cells in the human brain. Nat Med. 1997 Sep; 3(9):964-9.
    View in: PubMed
  152. Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med. 1997 Sep; 38(3):389-98.
    View in: PubMed
  153. Costantini LC, Lin L, Isacson O. Medial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts. Neuroreport. 1997 Jul 7; 8(9-10):2253-7.
    View in: PubMed
  154. Schumacher JM, Isacson O. Neuronal xenotransplantation in Parkinson's disease. Nat Med. 1997 May; 3(5):474-5.
    View in: PubMed
  155. Freed WJ, Isacson O. A special issue based on the third annual conference of the American Society for Neural Transplantation, 1996. Cell Transplant. 1997 May-Jun; 6(3):201-2.
    View in: PubMed
  156. Haque NS, LeBlanc CJ, Isacson O. Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons. Cell Transplant. 1997 May-Jun; 6(3):239-48.
    View in: PubMed
  157. Haque NS, Borghesani P, Isacson O. Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder. Mol Med Today. 1997 Apr; 3(4):175-83.
    View in: PubMed
  158. Haque N, Isacson O. Antisense gene therapy for neurodegenerative disease? Exp Neurol. 1997 Mar; 144(1):139-46.
    View in: PubMed
  159. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med. 1997 Mar; 3(3):350-3.
    View in: PubMed
  160. Isacson O, Deacon TW. Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat. Neuroscience. 1996 Dec; 75(3):827-37.
    View in: PubMed
  161. Galpern WR, Matthews RT, Beal MF, Isacson O. NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. Neuroreport. 1996 Nov 4; 7(15-17):2639-42.
    View in: PubMed
  162. Galpern WR, Burns LH, Deacon TW, Dinsmore J, Isacson O. Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology. Exp Neurol. 1996 Jul; 140(1):1-13.
    View in: PubMed
  163. Dinsmore JH, Pakzaban P, Deacon TW, Burns L, Isacson O. Survival of transplanted porcine neural cells treated with F(ab')2 antibody fragments directed against donor MHC class-I in a rodent model. Transplant Proc. 1996 Apr; 28(2):817-8.
    View in: PubMed
  164. Dinsmore J, Ratliff J, Deacon T, Pakzaban P, Jacoby D, Galpern W, Isacson O. Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation. Cell Transplant. 1996 Mar-Apr; 5(2):131-43.
    View in: PubMed
  165. Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O. Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell Transplant. 1996 Mar-Apr; 5(2):225-32.
    View in: PubMed
  166. Isacson O, Deacon TW, Pakzaban P, Galpern WR, Dinsmore J, Burns LH. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres. Nat Med. 1995 Nov; 1(11):1189-94.
    View in: PubMed
  167. Freeman TB, Sanberg PR, Isacson O. Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease. Cell Transplant. 1995 Nov-Dec; 4(6):539-45.
    View in: PubMed
  168. Garcia AR, Deacon TW, Dinsmore J, Isacson O. Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex. Cell Transplant. 1995 Sep-Oct; 4(5):515-27.
    View in: PubMed
  169. Isacson O. Behavioral effects and gene delivery in a rat model of Parkinson's disease. Science. 1995 Aug 11; 269(5225):856-7.
    View in: PubMed
  170. Tatter SB, Galpern WR, Hoogeveen AT, Isacson O. Effects of striatal excitotoxicity on huntingtin-like immunoreactivity. Neuroreport. 1995 May 30; 6(8):1125-9.
    View in: PubMed
  171. Pakzaban P, Deacon TW, Burns LH, Dinsmore J, Isacson O. A novel mode of immunoprotection of neural xenotransplants: masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system. Neuroscience. 1995 Apr; 65(4):983-96.
    View in: PubMed
  172. Burns LH, Pakzaban P, Deacon TW, Brownell AL, Tatter SB, Jenkins BG, Isacson O. Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease. Neuroscience. 1995 Feb; 64(4):1007-17.
    View in: PubMed
  173. Isacson O, Frim DM, Galpern WR, Tatter SB, Breakefield XO, Schumacher JM. Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra. Restor Neurol Neurosci. 1995 Jan 1; 8(1):59-61.
    View in: PubMed
  174. Deacon TW, Pakzaban P, Isacson O. The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence. Brain Res. 1994 Dec 30; 668(1-2):211-9.
    View in: PubMed
  175. Deacon TW, Pakzaban P, Burns LH, Dinsmore J, Isacson O. Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats. Exp Neurol. 1994 Nov; 130(1):151-67.
    View in: PubMed
  176. Pakzaban P, Isacson O. Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers. Neuroscience. 1994 Oct; 62(4):989-1001.
    View in: PubMed
  177. Andersen JK, Frim DM, Isacson O, Beal MF, Breakefield XO. Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Brain Res. 1994 Sep 5; 656(1):108-14.
    View in: PubMed
  178. Frim DM, Wüllner U, Beal MF, Isacson O. Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum. Exp Neurol. 1994 Aug; 128(2):172-80.
    View in: PubMed
  179. Pakzaban P, Geller AI, Isacson O. Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain. Hum Gene Ther. 1994 Aug; 5(8):987-95.
    View in: PubMed
  180. Frim DM, Uhler TA, Galpern WR, Beal MF, Breakefield XO, Isacson O. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5104-8.
    View in: PubMed
  181. Isacson O. Clinical and preclinical PET correlates of parkinsonism with 11C-WIN 35,428. Ann Neurol. 1994 Mar; 35(3):377-8.
    View in: PubMed
  182. Uhler TA, Frim DM, Pakzaban P, Isacson O. The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum. Neurosurgery. 1994 Jan; 34(1):122-7; discussion 127-8.
    View in: PubMed
  183. Andersen JK, Frim DM, Isacson O, Breakefield XO. Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter. Cell Mol Neurobiol. 1993 Oct; 13(5):503-15.
    View in: PubMed
  184. Burns LH, Sato K, Wüllner U, Isacson O. Intra-nigra infusion of AMPA attenuates dopamine-dependent rotation in the rat. Neuroreport. 1993 Sep; 4(9):1075-8.
    View in: PubMed
  185. Isacson O. On neuronal health. Trends Neurosci. 1993 Aug; 16(8):306-8.
    View in: PubMed
  186. Frim DM, Simpson J, Uhler TA, Short MP, Bossi SR, Breakefield XO, Isacson O. Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF. J Neurosci Res. 1993 Jul 1; 35(4):452-8.
    View in: PubMed
  187. Wüllner U, Brouillet E, Isacson O, Young AB, Penney JB. Glutamate receptor binding sites in MPTP-treated mice. Exp Neurol. 1993 Jun; 121(2):284-7.
    View in: PubMed
  188. Frim DM, Yee WM, Isacson O. NGF reduces striatal excitotoxic neuronal loss without affecting concurrent neuronal stress. Neuroreport. 1993 Jun; 4(6):655-8.
    View in: PubMed
  189. Simpson JR, Isacson O. Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum. Exp Neurol. 1993 May; 121(1):57-64.
    View in: PubMed
  190. Frim DM, Uhler TA, Short MP, Ezzedine ZD, Klagsbrun M, Breakefield XO, Isacson O. Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions. Neuroreport. 1993 Apr; 4(4):367-70.
    View in: PubMed
  191. Frim DM, Short MP, Rosenberg WS, Simpson J, Breakefield XO, Isacson O. Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum. J Neurosurg. 1993 Feb; 78(2):267-73.
    View in: PubMed
  192. Pakzaban P, Deacon TW, Burns LH, Isacson O. Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence. Exp Brain Res. 1993; 97(1):13-22.
    View in: PubMed
  193. Bossi SR, Simpson JR, Isacson O. Age dependence of striatal neuronal death caused by mitochondrial dysfunction. Neuroreport. 1993 Jan; 4(1):73-6.
    View in: PubMed
  194. Yee WM, Frim DM, Isacson O. Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex. Exp Brain Res. 1993; 94(2):193-202.
    View in: PubMed
  195. Rosenberg WS, Breakefield XO, DeAntonio C, Isacson O. Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods. Brain Res Mol Brain Res. 1992 Dec; 16(3-4):311-5.
    View in: PubMed
  196. Hantraye P, Leroy-Willig A, Denys A, Riche D, Isacson O, Maziere M, Syrota A. Magnetic resonance imaging to monitor pathology of caudate-putamen after excitotoxin-induced neuronal loss in the nonhuman primate brain. Exp Neurol. 1992 Oct; 118(1):18-23.
    View in: PubMed
  197. Isacson O, Sofroniew MV. Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems. Exp Neurol. 1992 Aug; 117(2):151-75.
    View in: PubMed
  198. Beal MF, Swartz KJ, Isacson O. Developmental changes in brain kynurenic acid concentrations. Brain Res Dev Brain Res. 1992 Jul 24; 68(1):136-9.
    View in: PubMed
  199. Hantraye P, Riche D, Maziere M, Isacson O. Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease. Proc Natl Acad Sci U S A. 1992 May 1; 89(9):4187-91.
    View in: PubMed
  200. Hantraye P, Brownell AL, Elmaleh D, Spealman RD, Wüllner U, Brownell GL, Madras BK, Isacson O. Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism. Neuroreport. 1992 Mar; 3(3):265-8.
    View in: PubMed
  201. Hantraye P, Loc'H C, Maziere B, Khalili-Varasteh M, Crouzel C, Fournier D, Yorke JC, Stulzaft O, Riche D, Isacson O, et al. 6-[18F]fluoro-L-dopa uptake and [76Br]bromolisuride binding in the excitotoxically lesioned caudate-putamen of nonhuman primates studied using positron emission tomography. Exp Neurol. 1992 Feb; 115(2):218-27.
    View in: PubMed
  202. Schumacher JM, Hantraye P, Brownell AL, Riche D, Madras BK, Davenport PD, Maziere M, Elmaleh DR, Brownell GL, Isacson O. A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures. Cell Transplant. 1992; 1(4):313-22.
    View in: PubMed
  203. Isacson O, Peschanski M. Is there capacity for anatomical and functional repair in the adult somatosensory thalamus? Exp Neurol. 1992 Jan; 115(1):173-6.
    View in: PubMed
  204. Levisohn LF, Isacson O. Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task. Brain Res. 1991 Nov 15; 564(2):230-44.
    View in: PubMed
  205. Schumacher JM, Short MP, Hyman BT, Breakefield XO, Isacson O. Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids. Neuroscience. 1991; 45(3):561-70.
    View in: PubMed
  206. Hantraye P, Riche D, Maziere M, Isacson O. A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon. Exp Neurol. 1990 May; 108(2):91-104.
    View in: PubMed
  207. O'Brien TS, Svendsen CN, Isacson O, Sofroniew MV. Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons. Brain Res. 1990 Feb 5; 508(2):249-56.
    View in: PubMed
  208. Sofroniew MV, Galletly NP, Isacson O, Svendsen CN. Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science. 1990 Jan 19; 247(4940):338-42.
    View in: PubMed
  209. Isacson O, Hantraye P, Maziere M, Sofroniew MV, Riche D. Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates. Prog Brain Res. 1990; 82:523-33.
    View in: PubMed
  210. Sofroniew MV, Dunnett SB, Isacson O. Remodelling of intrinsic and afferent systems in neocortex with cortical transplants. Prog Brain Res. 1990; 82:313-20.
    View in: PubMed
  211. Dusart I, Isacson O, Nothias F, Gumpel M, Peschanski M. Presence of Schwann cells in neurodegenerative lesions of the central nervous system. Neurosci Lett. 1989 Nov 6; 105(3):246-50.
    View in: PubMed
  212. Dunnett S, Isacson O. Trophic mechanisms are not enough. Trends Neurosci. 1989 Jul; 12(7):257.
    View in: PubMed
  213. Sofroniew MV, Isacson O, O'Brien TS. Nerve growth factor receptor immunoreactivity in the rat suprachiasmatic nucleus. Brain Res. 1989 Jan 9; 476(2):358-62.
    View in: PubMed
  214. Isacson O, Riche D, Hantraye P, Sofroniew MV, Maziere M. A primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen. Exp Brain Res. 1989; 75(1):213-20.
    View in: PubMed
  215. Wictorin K, Simerly RB, Isacson O, Swanson LW, Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--III. Efferent projecting graft neurons and their relation to host afferents within the grafts. Neuroscience. 1989; 30(2):313-30.
    View in: PubMed
  216. Lams BE, Isacson O, Sofroniew MV. Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons. Brain Res. 1988 Dec 20; 475(2):401-6.
    View in: PubMed
  217. Wictorin K, Isacson O, Fischer W, Nothias F, Peschanski M, Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--I. Subcortical afferents. Neuroscience. 1988 Nov; 27(2):547-62.
    View in: PubMed
  218. Sofroniew MV, Isacson O. Distribution of degeneration of cholinergic neurons in the septum following axotomy in different portions of the fimbria-fornix: a correlation between degree of cell loss and proximity of neuronal somata to the lesion. J Chem Neuroanat. 1988 Nov-Dec; 1(6):327-37.
    View in: PubMed
  219. Nothias F, Wictorin K, Isacson O, Björklund A, Peschanski M. Morphological alteration of thalamic afferents in the excitotoxically lesioned striatum. Brain Res. 1988 Oct 4; 461(2):349-54.
    View in: PubMed
  220. Peschanski M, Isacson O. Fetal homotypic transplant in the excitotoxically neuron-depleted thalamus: light microscopy. J Comp Neurol. 1988 Aug 15; 274(3):449-63.
    View in: PubMed
  221. Brundin P, Barbin G, Strecker RE, Isacson O, Prochiantz A, Björklund A. Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro. Brain Res. 1988 Apr 1; 467(2):233-43.
    View in: PubMed
  222. Clarke DJ, Dunnett SB, Isacson O, Sirinathsinghji DJ, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway. Neuroscience. 1988 Mar; 24(3):791-801.
    View in: PubMed
  223. Dunnett SB, Isacson O, Sirinathsinghji DJ, Clarke DJ, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions--III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience. 1988 Mar; 24(3):813-20.
    View in: PubMed
  224. Sirinathsinghji DJ, Dunnett SB, Isacson O, Clarke DJ, Kendrick K, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. 1988 Mar; 24(3):803-11.
    View in: PubMed
  225. Fischer W, Wictorin K, Isacson O, Björklund A. Trophic effects on cholinergic striatal interneurons by submaxillary gland transplants. Prog Brain Res. 1988; 78:409-12.
    View in: PubMed
  226. Gage FH, Brundin P, Strecker R, Dunnett SB, Isacson O, Bjorklund A. Intracerebral neuronal grafting in experimental animal models of age-related motor dysfunction. Ann N Y Acad Sci. 1988; 515:383-94.
    View in: PubMed
  227. Wictorin K, Isacson O, Fischer W, Nothias F, Peschanski M, Björklund A. Studies on host afferent inputs to fetal striatal transplants in the excitotoxically lesioned striatum. Prog Brain Res. 1988; 78:55-60.
    View in: PubMed
  228. Isacson O, Wictorin K, Fischer W, Sofroniew MV, Björklund A. Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: anatomical and neurochemical studies of trophic interactions. Prog Brain Res. 1988; 78:13-26.
    View in: PubMed
  229. Peschanski M, Rudin M, Isacson O, Delepierre M, Roques BP. Magnetic resonance imaging of intracerebral neural grafts. Prog Brain Res. 1988; 78:619-24.
    View in: PubMed
  230. Clarke DJ, Dunnett SB, Isacson O, Björklund A. Striatal grafts in the ibotenic acid-lesioned neostriatum: ultrastructural and immunocytochemical studies. Prog Brain Res. 1988; 78:47-53.
    View in: PubMed
  231. Dunnett SB, Isacson O, Sirinathsinghji DJ, Clarke DJ, Björklund A. Striatal grafts in the ibotenic acid-lesioned neostriatum: functional studies. Prog Brain Res. 1988; 78:39-45.
    View in: PubMed
  232. Björklund A, Brundin P, Isacson O. Neuronal replacement by intracerebral neural implants in animal models of neurodegenerative disease. Adv Neurol. 1988; 47:455-92.
    View in: PubMed
  233. Isacson O, Dawbarn D, Brundin P, Gage FH, Emson PC, Björklund A. Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography. Neuroscience. 1987 Aug; 22(2):481-97.
    View in: PubMed
  234. Isacson O, Fischer W, Wictorin K, Dawbarn D, Björklund A. Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat. Neuroscience. 1987 Mar; 20(3):1043-56.
    View in: PubMed
  235. Isacson O, Pritzel M, Dawbarn D, Brundin P, Kelly PA, Wiklund L, Emson PC, Gage FH, Dunnett SB, Björklund A. Striatal neural transplants in the ibotenic acid-lesioned rat neostriatum. Cellular and functional aspects. Ann N Y Acad Sci. 1987; 495:537-55.
    View in: PubMed
  236. Brundin P, Strecker RE, Lindvall O, Isacson O, Nilsson OG, Barbin G, Prochiantz A, Forni C, Nieoullon A, Widner H, et al. Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease. Ann N Y Acad Sci. 1987; 495:473-96.
    View in: PubMed
  237. Sofroniew MV, Isacson O, Björklund A. Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage. Brain Res. 1986 Jul 23; 378(2):409-15.
    View in: PubMed
  238. Dunnett SB, Whishaw IQ, Jones GH, Isacson O. Effects of dopamine-rich grafts on conditioned rotation in rats with unilateral 6-hydroxydopamine lesions. Neurosci Lett. 1986 Jul 11; 68(1):127-33.
    View in: PubMed
  239. Isacson O, Dunnett SB, Björklund A. Graft-induced behavioral recovery in an animal model of Huntington disease. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2728-32.
    View in: PubMed
  240. Brundin P, Isacson O, Gage FH, Prochiantz A, Björklund A. The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting. Brain Res. 1986 Feb 26; 366(1-2):346-9.
    View in: PubMed
  241. Zetterström T, Brundin P, Gage FH, Sharp T, Isacson O, Dunnett SB, Ungerstedt U, Björklund A. In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis. Brain Res. 1986 Jan 8; 362(2):344-9.
    View in: PubMed
  242. Brundin P, Isacson O, Gage FH, Björklund A. Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells. Brain Res. 1986 Jan; 389(1-2):77-84.
    View in: PubMed
  243. Pritzel M, Isacson O, Brundin P, Wiklund L, Björklund A. Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats. Exp Brain Res. 1986; 65(1):112-26.
    View in: PubMed
  244. Sofroniew MV, Pearson RC, Isacson O, Björklund A. Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons. Prog Brain Res. 1986; 70:363-89.
    View in: PubMed
  245. Isacson O, Brundin P, Gage FH, Björklund A. Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting. Neuroscience. 1985 Dec; 16(4):799-817.
    View in: PubMed
  246. Brundin P, Barbin G, Isacson O, Mallat M, Chamak B, Prochiantz A, Gage FH, Björklund A. Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro. Neurosci Lett. 1985 Oct 24; 61(1-2):79-84.
    View in: PubMed
  247. Gage FH, Brundin P, Isacson O, Björklund A. Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage. Neurosci Lett. 1985 Sep 30; 60(2):133-7.
    View in: PubMed
  248. Brundin P, Isacson O, Björklund A. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Res. 1985 Apr 8; 331(2):251-9.
    View in: PubMed
  249. Emson PC, Dawbarn D, Rossor MN, Rehfeld JF, Brundin P, Isacson O, Björklund A. Cholecystokinin content in the basal ganglia in Huntington's disease. The expression of cholecystokinin immunoreactivity in striatal grafts to ibotenic acid-lesioned rat striatum. Ann N Y Acad Sci. 1985; 448:488-94.
    View in: PubMed
  250. Isacson O, Brundin P, Kelly PA, Gage FH, Björklund A. Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum. Nature. 1984 Oct 4-10; 311(5985):458-60.
    View in: PubMed
  251. Gage FH, Dunnett SB, Brundin P, Isacson O, Björklund A. Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application. Dev Neurosci. 1983-1984; 6(3):137-51.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Isacson's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_