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Takaharu Ichimura, PH.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
HIM-550, Renal Division
4 Blackfan Cir
Boston MA 02115
Phone617/525-5961
Fax617/525-5965

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Abu-Saleh N, Awad H, Khamaisi M, Armaly Z, Karram T, Heyman SN, Kaballa A, Ichimura T, Holman J, Abassi Z. Nephroprotective effects of TVP1022, a non-MAO inhibitor S-isomer of rasagiline, in an experimental model of diabetic renal ischemic injury. Am J Physiol Renal Physiol. 2014 Jan; 306(1):F24-33.
    View in: PubMed
  2. Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest. 2013 Sep 3; 123(9):4023-35.
    View in: PubMed
  3. Timsit MO, Adams WJ, Laguna-Fernandez A, Ichimura T, Bonventre JV, García-Cardeña G, Tullius SG. Flow is Critical for Maintaining a Protective Phenotype in Renal Proximal Tubular Cells. Am J Transplant. 2013 Jun; 13(6):1617-8.
    View in: PubMed
  4. Nishihara K, Masuda S, Shinke H, Ozawa A, Ichimura T, Yonezawa A, Nakagawa S, Inui K, Bonventre JV, Matsubara K. Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity. Biochem Pharmacol. 2013 Feb 15; 85(4):570-82.
    View in: PubMed
  5. Milwid JM, Ichimura T, Li M, Jiao Y, Lee J, Yarmush JS, Parekkadan B, Tilles AW, Bonventre JV, Yarmush ML. Secreted factors from bone marrow stromal cells upregulate IL-10 and reverse acute kidney injury. Stem Cells Int. 2012; 2012:392050.
    View in: PubMed
  6. Havasi A, Haegele JA, Gall JM, Blackmon S, Ichimura T, Bonegio RG, Panchenko MV. Histone Acetyl Transferase (HAT) HBO1 and JADE1 in Epithelial Cell Regeneration. Am J Pathol. 2013 Jan; 182(1):152-62.
    View in: PubMed
  7. Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12105-10.
    View in: PubMed
  8. Ichimura T, Brooks CR, Bonventre JV. Kim-1/Tim-1 and immune cells: shifting sands. Kidney Int. 2012 May; 81(9):809-11.
    View in: PubMed
  9. Grgic I, Campanholle G, Bijol V, Wang C, Sabbisetti VS, Ichimura T, Humphreys BD, Bonventre JV. Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int. 2012 Jul; 82(2):172-83.
    View in: PubMed
  10. Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener. 2012; 7:2.
    View in: PubMed
  11. Qin Y, Alderliesten MC, Stokman G, Pennekamp P, Bonventre JV, de Heer E, Ichimura T, de Graauw M, Price LS, van de Water B. Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion. Am J Pathol. 2011 Dec; 179(6):2766-78.
    View in: PubMed
  12. Azzi J, Tang L, Moore R, Tong R, El Haddad N, Akiyoshi T, Mfarrej B, Yang S, Jurewicz M, Ichimura T, Lindeman N, Cheng J, Abdi R. Polylactide-cyclosporin A nanoparticles for targeted immunosuppression. FASEB J. 2010 Oct; 24(10):3927-38.
    View in: PubMed
  13. Jurewicz M, Takakura A, Augello A, Naini SM, Ichimura T, Zandi-Nejad K, Abdi R. Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation. J Immunol. 2010 Mar 15; 184(6):2939-48.
    View in: PubMed
  14. Nishihara K, Masuda S, Nakagawa S, Yonezawa A, Ichimura T, Bonventre JV, Inui K. Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats. Am J Physiol Renal Physiol. 2010 Apr; 298(4):F923-34.
    View in: PubMed
  15. Ichimura T, Mou S. Kidney injury molecule-1 in acute kidney injury and renal repair: a review. Zhong Xi Yi Jie He Xue Bao. 2008 May; 6(5):533-8.
    View in: PubMed
  16. Ichimura T, Asseldonk EJ, Humphreys BD, Gunaratnam L, Duffield JS, Bonventre JV. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest. 2008 May; 118(5):1657-68.
    View in: PubMed
  17. Rennert PD, Ichimura T, Sizing ID, Bailly V, Li Z, Rennard R, McCoon P, Pablo L, Miklasz S, Tarilonte L, Bonventre JV. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J Immunol. 2006 Oct 1; 177(7):4311-21.
    View in: PubMed
  18. Vaidya VS, Ramirez V, Ichimura T, Bobadilla NA, Bonventre JV. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol. 2006 Feb; 290(2):F517-29.
    View in: PubMed
  19. Asmellash S, Stevens JL, Ichimura T. Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivo. Toxicol Sci. 2005 Dec; 88(2):576-84.
    View in: PubMed
  20. Schachter AD, Ichimura T, Kohane IS. Chromosomes 18 and X are quantitative trait loci for nephrotic-range proteinuria in rats. Pediatr Nephrol. 2005 Dec; 20(12):1717-23.
    View in: PubMed
  21. Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, Bonventre JV. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest. 2005 Jul; 115(7):1743-55.
    View in: PubMed
  22. Ichimura T, Hung CC, Yang SA, Stevens JL, Bonventre JV. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol. 2004 Mar; 286(3):F552-63.
    View in: PubMed
  23. Hung CC, Ichimura T, Stevens JL, Bonventre JV. Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. J Biol Chem. 2003 Aug 1; 278(31):29317-26.
    View in: PubMed
  24. Shimada M, Saito M, Katakai T, Shimizu A, Ichimura T, Omata S, Horigome T. Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150. J Biochem. 1999 Dec; 126(6):1033-42.
    View in: PubMed
  25. Gohshi T, Shimada M, Kawahire S, Imai N, Ichimura T, Omata S, Horigome T. Molecular cloning of mouse p47, a second group mammalian RuvB DNA helicase-like protein: homology with those from human and Saccharomyces cerevisiae. J Biochem. 1999 May; 125(5):939-46.
    View in: PubMed
  26. Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, Sanicola M. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem. 1998 Feb 13; 273(7):4135-42.
    View in: PubMed
  27. Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T. 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. J Biol Chem. 1997 Oct 3; 272(40):25267-74.
    View in: PubMed
  28. Kawahire S, Takeuchi M, Gohshi T, Sasagawa S, Shimada M, Takahashi M, Abe TK, Ueda T, Kuwano R, Hikawa A, Ichimura T, Omata S, Horigome T. cDNA cloning of nuclear localization signal binding protein NBP60, a rat homologue of lamin B receptor, and identification of binding sites of human lamin B receptor for nuclear localization signals and chromatin. J Biochem. 1997 May; 121(5):881-9.
    View in: PubMed
  29. Kashimoto K, Nagano Y, Suitani Y, Hamanaka K, Mizumoto T, Tomizaki K, Takahata H, Nagamoto A, Ohata A, Yoshihara S, Ichimura T. Structure-activity relationship studies of PACAP-27 and VIP analogues. Ann N Y Acad Sci. 1996 Dec 26; 805:505-10.
    View in: PubMed
  30. Ichimura T, Finch PW, Zhang G, Kan M, Stevens JL. Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair. Am J Physiol. 1996 Nov; 271(5 Pt 2):F967-76.
    View in: PubMed
  31. Ichimura T, Uchiyama J, Kunihiro O, Ito M, Horigome T, Omata S, Shinkai F, Kaji H, Isobe T. Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase. J Biol Chem. 1995 Dec 1; 270(48):28515-8.
    View in: PubMed
  32. Ichimura T, Maier JA, Maciag T, Zhang G, Stevens JL. FGF-1 in normal and regenerating kidney: expression in mononuclear, interstitial, and regenerating epithelial cells. Am J Physiol. 1995 Nov; 269(5 Pt 2):F653-62.
    View in: PubMed
  33. Matsuoka K, Taoka M, Satozawa N, Nakayama H, Ichimura T, Takahashi N, Yamakuni T, Song SY, Isobe T. A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9670-4.
    View in: PubMed
  34. Watanabe M, Isobe T, Ichimura T, Kuwano R, Takahashi Y, Kondo H, Inoue Y. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Brain Res Mol Brain Res. 1994 Aug; 25(1-2):113-21.
    View in: PubMed
  35. Lu G, de Vetten NC, Sehnke PC, Isobe T, Ichimura T, Fu H, van Heusden GP, Ferl RJ. A single Arabidopsis GF14 isoform possesses biochemical characteristics of diverse 14-3-3 homologues. Plant Mol Biol. 1994 Jul; 25(4):659-67.
    View in: PubMed
  36. Zhang G, Sato JD, Herley MT, Tsang MW, Ye H, Liu H, Ichimura T, Yan G, McKeehan WL, Stevens JL. Stable and temperature-sensitive transformation of rat kidney epithelial cells suppresses expression of acidic fibroblast growth factor 1 but activates secretion of fibroblast growth factor 3 (int-2) and vascular endothelial growth factor. Cell Growth Differ. 1994 Apr; 5(4):349-57.
    View in: PubMed
  37. Ohsumi T, Ichimura T, Sugano H, Omata S, Isobe T, Kuwano R. Ribosome-binding protein p34 is a member of the leucine-rich-repeat-protein superfamily. Biochem J. 1993 Sep 1; 294 ( Pt 2):465-72.
    View in: PubMed
  38. Zhang G, Ichimura T, Maier JA, Maciag T, Stevens JL. A role for fibroblast growth factor type-1 in nephrogenic repair. Autocrine expression in rat kidney proximal tubule epithelial cells in vitro and in the regenerating epithelium following nephrotoxic damage by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine in vivo. J Biol Chem. 1993 Jun 5; 268(16):11542-7.
    View in: PubMed
  39. Watanabe M, Isobe T, Ichimura T, Kuwano R, Takahashi Y, Kondo H. Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system. Brain Res Mol Brain Res. 1993 Jan; 17(1-2):135-46.
    View in: PubMed
  40. Hayden PJ, Ichimura T, McCann DJ, Pohl LR, Stevens JL. Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts. J Biol Chem. 1991 Oct 5; 266(28):18415-8.
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  41. Zhang GH, Ichimura T, Wallin A, Kan M, Stevens JL. Regulation of rat proximal tubule epithelial cell growth by fibroblast growth factors, insulin-like growth factor-1 and transforming growth factor-beta, and analysis of fibroblast growth factors in rat kidney. J Cell Physiol. 1991 Aug; 148(2):295-305.
    View in: PubMed
  42. Watanabe M, Isobe T, Okuyama T, Ichimura T, Kuwano R, Takahashi Y, Kondo H. Molecular cloning of cDNA to rat 14-3-3 eta chain polypeptide and the neuronal expression of the mRNA in the central nervous system. Brain Res Mol Brain Res. 1991 May; 10(2):151-8.
    View in: PubMed
  43. Isobe T, Ichimura T, Sunaya T, Okuyama T, Takahashi N, Kuwano R, Takahashi Y. Distinct forms of the protein kinase-dependent activator of tyrosine and tryptophan hydroxylases. J Mol Biol. 1991 Jan 5; 217(1):125-32.
    View in: PubMed
  44. Ichimura T, Isobe T, Okuyama T, Takahashi N, Araki K, Kuwano R, Takahashi Y. Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7084-8.
    View in: PubMed
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