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Last Name
Institution

Francine Grodstein, SC.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham & Women's Hospital
Channing Division of Network Medicine
181 Longwood Ave
Boston MA 02115
Phone617/525-2748
Fax617/525-2008
Other Positions
TitleProfessor in the Department of Epidemiology
InstitutionHarvard School of Public Health
DepartmentEpidemiology


 Overview 
 overview
My research focuses on healthy aging, particularly in women. My primary research base is the Nurses’ Health Study (NHS). During the past 10 years, I have independently established a study of cognitive function among elderly participants of the Nurses’ Health Study. This has developed into one of the largest existing studies of cognition, with several repeated measures of function in 20,000 women aged 70 years and over. In addition, the success of this project led to funding to incorporate cognitive testing into three large-scale randomized clinical trials of cardiovascular disease prevention (the Women’s Health Study, the Women’s Antioxidant Cardiovascular Study, and Physicians’ Health Study II with a total of 16,000 participants in the cognitive cohort). This work encompasses a large variety of research topics, from identifying lifestyle and dietary factors that influence cognition to exploring biomarkers to predict eventual risk of cognitive impairment. Major publications from this work (in JAMA, New England Journal of Medicine, British Medical Journal) have made substantial contributions to the field.

Numerous trainees have developed their research careers via this cognitive study. Specifically, I am currently mentoring one doctoral student, one postdoctoral fellow, and two junior faculty members in evaluating the effects on cognition of plasma insulin, plasma amyloid beta, plasma IGF, genetic factors, and folate. In addition, one doctoral student who completed her training with me is currently a postdoctoral fellow (at HSPPH) and two postdoctoral fellows who completed their training with me have progressed to junior faculty positions (at the University of Colorado School of Medicine, and at HMS).

I have also initiated a study of risk factors for incontinence in the Nurses’ Health Study. Incontinence is a common problem in older women, with important public health consequences, yet little is known about its epidemiology or prevention. I have designed a self-reported questionnaire to identify urinary incontinence in the NHS participants and have received funding from NIH to conduct this investigation. A postdoctoral fellow and a doctoral student are exploring risk factors for incontinence, such as body mass index, type 2 diabetes , cigarette smoking, and is also examining incidence rates of incontinence, which have not been tracked in any large population-based studies.


 Mentoring 
 completed student projects
Comparison of risk factors for cognitive decline across cancer survivors and women with no cancer history in the Nurses' Health Study
Summer, 06/18/12 - 08/20/12

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Snyder HM, Carrillo MC, Grodstein F, Henriksen K, Jeromin A, Lovestone S, Mielke MM, O'Bryant S, Sarasa M, Sjøgren M, Soares H, Teeling J, Trushina E, Ward M, West T, Bain LJ, Shineman DW, Weiner M, Fillit HM. Developing novel blood-based biomarkers for Alzheimer's disease. Alzheimers Dement. 2014 Jan; 10(1):109-14.
    View in: PubMed
  2. Ley SH, Sun Q, Willett WC, Eliassen AH, Wu K, Pan A, Grodstein F, Hu FB. Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. Am J Clin Nutr. 2014 Feb; 99(2):352-60.
    View in: PubMed
  3. Samieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, Stampfer M, Grodstein F. The association between dietary patterns at midlife and health in aging: an observational study. Ann Intern Med. 2013 Nov 5; 159(9):584-91.
    View in: PubMed
  4. Arkema EV, Goldstein BL, Robinson W, Sokolove J, Wagner CA, Malspeis S, Rosner B, Grodstein F, Karlson EW, Costenbader KH. Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case-control study. Arthritis Res Ther. 2013; 15(5):R159.
    View in: PubMed
  5. Devore EE, Grodstein F, Schernhammer ES. Shift work and cognition in the nurses' health study. Am J Epidemiol. 2013 Oct 15; 178(8):1296-300.
    View in: PubMed
  6. O'Brien J, Jackson JW, Grodstein F, Blacker D, Weuve J. Postmenopausal hormone therapy is not associated with risk of all-cause dementia and Alzheimer's disease. Epidemiol Rev. 2014; 36(1):83-103.
    View in: PubMed
  7. Matthews CA, Whitehead WE, Townsend MK, Grodstein F. Risk factors for urinary, fecal, or dual incontinence in the nurses' health study. Obstet Gynecol. 2013 Sep; 122(3):539-45.
    View in: PubMed
  8. Grodstein F. Hormone therapy in younger women and cognitive health. JAMA Intern Med. 2013 Aug 12; 173(15):1437-8.
    View in: PubMed
  9. Samieri C, Grodstein F, Rosner BA, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI. Mediterranean diet and cognitive function in older age. Epidemiology. 2013 Jul; 24(4):490-9.
    View in: PubMed
  10. Devore EE, Minassian VA, Grodstein F. Factors associated with persistent urinary incontinence. Am J Obstet Gynecol. 2013 Aug; 209(2):145.e1-6.
    View in: PubMed
  11. Minassian VA, Devore E, Hagan K, Grodstein F. Severity of urinary incontinence and effect on quality of life in women by incontinence type. Obstet Gynecol. 2013 May; 121(5):1083-90.
    View in: PubMed
  12. Kim DH, Grodstein F, Rosner B, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI. Seafood Types and Age-Related Cognitive Decline in the Women's Health Study. J Gerontol A Biol Sci Med Sci. 2013 Oct; 68(10):1255-62.
    View in: PubMed
  13. Okereke OI, Grodstein F. Phobic anxiety and cognitive performance over 4 years among community-dwelling older women in the nurses' health study. Am J Geriatr Psychiatry. 2013 Nov; 21(11):1125-34.
    View in: PubMed
  14. Arkema EV, Hart JE, Bertrand KA, Laden F, Grodstein F, Rosner BA, Karlson EW, Costenbader KH. Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study. Ann Rheum Dis. 2013 Apr; 72(4):506-11.
    View in: PubMed
  15. Grodstein F. You are only as old as you think. Am J Psychiatry. 2013 Feb 1; 170(2):143-5.
    View in: PubMed
  16. Samieri C, Okereke OI, E Devore E, Grodstein F. Long-term adherence to the mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr. 2013 Apr; 143(4):493-9.
    View in: PubMed
  17. Devore EE, Kang JH, Stampfer MJ, Grodstein F. The association of antioxidants and cognition in the nurses' health study. Am J Epidemiol. 2013 Jan 1; 177(1):33-41.
    View in: PubMed
  18. Weuve J, Press DZ, Grodstein F, Wright RO, Hu H, Weisskopf MG. Cumulative exposure to lead and cognition in persons with Parkinson's disease. Mov Disord. 2013 Feb; 28(2):176-82.
    View in: PubMed
  19. Townsend MK, Matthews CA, Whitehead WE, Grodstein F. Risk factors for fecal incontinence in older women. Am J Gastroenterol. 2013 Jan; 108(1):113-9.
    View in: PubMed
  20. Okereke OI, Willett WC, Grodstein F. Reply. Ann Neurol. 2012 Oct; 72(4):626-7.
    View in: PubMed
  21. Devore EE, Townsend MK, Resnick NM, Grodstein F. The epidemiology of urinary incontinence in women with type 2 diabetes. J Urol. 2012 Nov; 188(5):1816-21.
    View in: PubMed
  22. Townsend MK, Devore EE, Resnick NM, Grodstein F. Acidic fruit intake in relation to incidence and progression of urinary incontinence. Int Urogynecol J. 2013 Apr; 24(4):605-12.
    View in: PubMed
  23. Rist PM, Kang JH, Buring JE, Glymour MM, Grodstein F, Kurth T. Migraine and cognitive decline among women: prospective cohort study. BMJ. 2012; 345:e5027.
    View in: PubMed
  24. Koyama A, Okereke OI, Yang T, Blacker D, Selkoe DJ, Grodstein F. Plasma amyloid-ß as a predictor of dementia and cognitive decline: a systematic review and meta-analysis. Arch Neurol. 2012 Jul; 69(7):824-31.
    View in: PubMed
  25. Vercambre MN, Grodstein F, Berr C, Kang JH. Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors. J Acad Nutr Diet. 2012 Jun; 112(6):816-23.
    View in: PubMed
  26. Okereke OI, Rosner BA, Kim DH, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Grodstein F. Dietary fat types and 4-year cognitive change in community-dwelling older women. Ann Neurol. 2012 Jul; 72(1):124-34.
    View in: PubMed
  27. Sun Q, Grodstein F. Healthy ageing in women: is moderate drinking the secret ingredient? Maturitas. 2012 Jul; 72(3):173-4.
    View in: PubMed
  28. Townsend MK, Resnick NM, Grodstein F. Caffeine intake and risk of urinary incontinence progression among women. Obstet Gynecol. 2012 May; 119(5):950-7.
    View in: PubMed
  29. Devore EE, Kang JH, Breteler MM, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol. 2012 Jul; 72(1):135-43.
    View in: PubMed
  30. Weuve J, Puett RC, Schwartz J, Yanosky JD, Laden F, Grodstein F. Exposure to particulate air pollution and cognitive decline in older women. Arch Intern Med. 2012 Feb 13; 172(3):219-27.
    View in: PubMed
  31. Sajjad I, Grodstein F, Kang JH, Curhan GC, Lin J. Kidney dysfunction and cognitive decline in women. Clin J Am Soc Nephrol. 2012 Mar; 7(3):437-43.
    View in: PubMed
  32. Townsend MK, Okereke OI, Xia W, Yang T, Selkoe DJ, Grodstein F. Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study. Alzheimer Dis Assoc Disord. 2012 Jan; 26(1):50-4.
    View in: PubMed
  33. Amariglio RE, Townsend MK, Grodstein F, Sperling RA, Rentz DM. Specific subjective memory complaints in older persons may indicate poor cognitive function. J Am Geriatr Soc. 2011 Sep; 59(9):1612-7.
    View in: PubMed
  34. Sun Q, Townsend MK, Okereke OI, Rimm EB, Hu FB, Stampfer MJ, Grodstein F. Alcohol consumption at midlife and successful ageing in women: a prospective cohort analysis in the nurses' health study. PLoS Med. 2011 Sep; 8(9):e1001090.
    View in: PubMed
  35. Vercambre MN, Grodstein F, Manson JE, Stampfer MJ, Kang JH. Physical activity and cognition in women with vascular conditions. Arch Intern Med. 2011 Jul 25; 171(14):1244-50.
    View in: PubMed
  36. Okereke OI, Selkoe DJ, Grodstein F. Plasma beta-amyloid level, cognitive reserve, and cognitive decline. JAMA. 2011 Apr 27; 305(16):1655; author reply 1655-6.
    View in: PubMed
  37. Townsend MK, Curhan GC, Resnick NM, Grodstein F. Original research: rates of remission, improvement, and progression of urinary incontinence in Asian, Black, and White women. Am J Nurs. 2011 Apr; 111(4):26-33; quiz 34-5.
    View in: PubMed
  38. Snowden M, Steinman L, Mochan K, Grodstein F, Prohaska TR, Thurman DJ, Brown DR, Laditka JN, Soares J, Zweiback DJ, Little D, Anderson LA. Effect of exercise on cognitive performance in community-dwelling older adults: review of intervention trials and recommendations for public health practice and research. J Am Geriatr Soc. 2011 Apr; 59(4):704-16.
    View in: PubMed
  39. Jura YH, Townsend MK, Curhan GC, Resnick NM, Grodstein F. Caffeine intake, and the risk of stress, urgency and mixed urinary incontinence. J Urol. 2011 May; 185(5):1775-80.
    View in: PubMed
  40. Townsend MK, Jura YH, Curhan GC, Resnick NM, Grodstein F. Fluid intake and risk of stress, urgency, and mixed urinary incontinence. Am J Obstet Gynecol. 2011 Jul; 205(1):73.e1-6.
    View in: PubMed
  41. Devore EE, Prescott J, De Vivo I, Grodstein F. Relative telomere length and cognitive decline in the Nurses' Health Study. Neurosci Lett. 2011 Mar 29; 492(1):15-8.
    View in: PubMed
  42. Grodstein F. How early can cognitive decline be detected? BMJ. 2012; 344:d7652.
    View in: PubMed
  43. Evans DA, Grodstein F, Loewenstein D, Kaye J, Weintraub S. Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 2. Alzheimers Dement. 2011 Jan; 7(1):110-23.
    View in: PubMed
  44. Kang JH, Grodstein F. Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline. Neurobiol Aging. 2012 Jul; 33(7):1129-37.
    View in: PubMed
  45. Devore EE, Kang JH, Stampfer MJ, Grodstein F. Total antioxidant capacity of diet in relation to cognitive function and decline. Am J Clin Nutr. 2010 Nov; 92(5):1157-64.
    View in: PubMed
  46. Vercambre MN, Grodstein F, Kang JH. Dietary fat intake in relation to cognitive change in high-risk women with cardiovascular disease or vascular factors. Eur J Clin Nutr. 2010 Oct; 64(10):1134-40.
    View in: PubMed
  47. Sun Q, Hu FB, Grodstein F. Invited commentary--Physical activity benefits various aspects of healthy aging: Comment on "Physical activity at midlife and health-related quality of life in older men". Arch Intern Med. 2010 Jul 12; 170(13):1172-3.
    View in: PubMed
  48. Devore EE, Grodstein F, van Rooij FJ, Hofman A, Stampfer MJ, Witteman JC, Breteler MM. Dietary antioxidants and long-term risk of dementia. Arch Neurol. 2010 Jul; 67(7):819-25.
    View in: PubMed
  49. Okereke OI, Kurth T, Pollak MN, Gaziano JM, Grodstein F. Fasting plasma insulin, C-peptide and cognitive change in older men without diabetes: results from the Physicians' Health Study II. Neuroepidemiology. 2010; 34(4):200-7.
    View in: PubMed
  50. Sun Q, Townsend MK, Okereke OI, Franco OH, Hu FB, Grodstein F. Physical activity at midlife in relation to successful survival in women at age 70 years or older. Arch Intern Med. 2010 Jan 25; 170(2):194-201.
    View in: PubMed
  51. Townsend MK, Curhan GC, Resnick NM, Grodstein F. The incidence of urinary incontinence across Asian, black, and white women in the United States. Am J Obstet Gynecol. 2010 Apr; 202(4):378.e1-7.
    View in: PubMed
  52. Phelan S, Grodstein F, Brown JS. Clinical research in diabetes and urinary incontinence: what we know and need to know. J Urol. 2009 Dec; 182(6 Suppl):S14-7.
    View in: PubMed
  53. Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Arch Neurol. 2009 Oct; 66(10):1247-53.
    View in: PubMed
  54. Sun Q, Townsend MK, Okereke OI, Franco OH, Hu FB, Grodstein F. Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort study. BMJ. 2009; 339:b3796.
    View in: PubMed
  55. Devore EE, Kang JH, Okereke O, Grodstein F. Physical activity levels and cognition in women with type 2 diabetes. Am J Epidemiol. 2009 Oct 15; 170(8):1040-7.
    View in: PubMed
  56. Townsend MK, Devore E, Kang JH, Grodstein F. The relation between moderate alcohol consumption and cognitive function in older women with type 2 diabetes. Diabetes Res Clin Pract. 2009 Sep; 85(3):322-7.
    View in: PubMed
  57. Hak AE, Curhan GC, Grodstein F, Choi HK. Menopause, postmenopausal hormone use and risk of incident gout. Ann Rheum Dis. 2010 Jul; 69(7):1305-9.
    View in: PubMed
  58. Devore EE, Grodstein F, van Rooij FJ, Hofman A, Rosner B, Stampfer MJ, Witteman JC, Breteler MM. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr. 2009 Jul; 90(1):170-6.
    View in: PubMed
  59. Kang JH, Cook NR, Manson JE, Buring JE, Albert CM, Grodstein F. Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular Study. Circulation. 2009 Jun 2; 119(21):2772-80.
    View in: PubMed
  60. Devore EE, Stampfer MJ, Breteler MM, Rosner B, Kang JH, Okereke O, Hu FB, Grodstein F. Dietary fat intake and cognitive decline in women with type 2 diabetes. Diabetes Care. 2009 Apr; 32(4):635-40.
    View in: PubMed
  61. Townsend MK, Curhan GC, Resnick NM, Grodstein F. Oral contraceptive use and incident urinary incontinence in premenopausal women. J Urol. 2009 May; 181(5):2170-5.
    View in: PubMed
  62. Okereke OI, Selkoe DJ, Pollak MN, Stampfer MJ, Hu FB, Hankinson SE, Grodstein F. A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation. Int J Geriatr Psychiatry. 2009 Feb; 24(2):177-82.
    View in: PubMed
  63. Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis. 2009; 16(2):277-85.
    View in: PubMed
  64. Weuve J, Korrick SA, Weisskopf MG, Weisskopf MA, Ryan LM, Schwartz J, Nie H, Grodstein F, Hu H. Cumulative exposure to lead in relation to cognitive function in older women. Environ Health Perspect. 2009 Apr; 117(4):574-80.
    View in: PubMed
  65. Kang JH, Cook N, Manson J, Buring JE, Albert CM, Grodstein F. A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am J Clin Nutr. 2008 Dec; 88(6):1602-10.
    View in: PubMed
  66. Townsend MK, Curhan GC, Resnick NM, Grodstein F. Postmenopausal hormone therapy and incident urinary incontinence in middle-aged women. Am J Obstet Gynecol. 2009 Jan; 200(1):86.e1-5.
    View in: PubMed
  67. Danforth KN, Townsend MK, Curhan GC, Resnick NM, Grodstein F. Type 2 diabetes mellitus and risk of stress, urge and mixed urinary incontinence. J Urol. 2009 Jan; 181(1):193-7.
    View in: PubMed
  68. Hernán MA, Alonso A, Logan R, Grodstein F, Michels KB, Willett WC, Manson JE, Robins JM. Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease. Epidemiology. 2008 Nov; 19(6):766-79.
    View in: PubMed
  69. Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, Fischl B, Buckner RL. The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex. 2009 Mar; 19(3):497-510.
    View in: PubMed
  70. Utian WH, Archer DF, Bachmann GA, Gallagher C, Grodstein Fn, Heiman JR, Henderson VW, Hodis HN, Karas RH, Lobo RA, Manson JE, Reid RL, Schmidt PJ, Stuenkel CA. Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society. Menopause. 2008 Jul-Aug; 15(4 Pt 1):584-602.
    View in: PubMed
  71. Arvanitakis Z, Grodstein F, Bienias JL, Schneider JA, Wilson RS, Kelly JF, Evans DA, Bennett DA. Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology. Neurology. 2008 Jun 3; 70(23):2219-25.
    View in: PubMed
  72. Lifford KL, Townsend MK, Curhan GC, Resnick NM, Grodstein F. The epidemiology of urinary incontinence in older women: incidence, progression, and remission. J Am Geriatr Soc. 2008 Jul; 56(7):1191-8.
    View in: PubMed
  73. Grodstein F, Manson JE, Stampfer MJ, Rexrode K. Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy. Arch Intern Med. 2008 Apr 28; 168(8):861-6.
    View in: PubMed
  74. van Oijen M, Okereke OI, Kang JH, Pollak MN, Hu FB, Hankinson SE, Grodstein F. Fasting insulin levels and cognitive decline in older women without diabetes. Neuroepidemiology. 2008; 30(3):174-9.
    View in: PubMed
  75. Okereke OI, Kang JH, Cook NR, Gaziano JM, Manson JE, Buring JE, Grodstein F. Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults. J Am Geriatr Soc. 2008 Jun; 56(6):1028-36.
    View in: PubMed
  76. Townsend MK, Curhan GC, Resnick NM, Grodstein F. BMI, waist circumference, and incident urinary incontinence in older women. Obesity (Silver Spring). 2008 Apr; 16(4):881-6.
    View in: PubMed
  77. Grodstein F, van Oijen M, Irizarry MC, Rosas HD, Hyman BT, Growdon JH, De Vivo I. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS One. 2008; 3(2):e1590.
    View in: PubMed
  78. Grodstein F, Skarupski KA, Bienias JL, Wilson RS, Bennett DA, Evans DA. Anti-inflammatory agents and cognitive decline in a bi-racial population. Neuroepidemiology. 2008; 30(1):45-50.
    View in: PubMed
  79. Okereke OI, Pollak MN, Hu FB, Hankinson SE, Selkoe DJ, Grodstein F. Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes. Psychoneuroendocrinology. 2008 May; 33(4):455-61.
    View in: PubMed
  80. Townsend MK, Danforth KN, Rosner B, Curhan GC, Resnick NM, Grodstein F. Physical activity and incident urinary incontinence in middle-aged women. J Urol. 2008 Mar; 179(3):1012-6; discussion 1016-7.
    View in: PubMed
  81. Grodstein F, Kang JH, Glynn RJ, Cook NR, Gaziano JM. A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II. Arch Intern Med. 2007 Nov 12; 167(20):2184-90.
    View in: PubMed
  82. Townsend MK, Danforth KN, Rosner B, Curhan GC, Resnick NM, Grodstein F. Body mass index, weight gain, and incident urinary incontinence in middle-aged women. Obstet Gynecol. 2007 Aug; 110(2 Pt 1):346-53.
    View in: PubMed
  83. Townsend MK, Danforth KN, Lifford KL, Rosner B, Curhan GC, Resnick NM, Grodstein F. Incidence and remission of urinary incontinence in middle-aged women. Am J Obstet Gynecol. 2007 Aug; 197(2):167.e1-5.
    View in: PubMed
  84. Kang JH, Cook N, Manson J, Buring JE, Grodstein F. Low dose aspirin and cognitive function in the women's health study cognitive cohort. BMJ. 2007 May 12; 334(7601):987.
    View in: PubMed
  85. Weisskopf MG, Grodstein F, Ascherio A. Smoking and cognitive function in Parkinson's disease. Mov Disord. 2007 Apr 15; 22(5):660-5.
    View in: PubMed
  86. Kang JH, Grodstein F. Plasma carotenoids and tocopherols and cognitive function: a prospective study. Neurobiol Aging. 2008 Sep; 29(9):1394-403.
    View in: PubMed
  87. Grodstein F. Cardiovascular risk factors and cognitive function. Alzheimers Dement. 2007 Apr; 3(2 Suppl):S16-22.
    View in: PubMed
  88. Danforth KN, Shah AD, Townsend MK, Lifford KL, Curhan GC, Resnick NM, Grodstein F. Physical activity and urinary incontinence among healthy, older women. Obstet Gynecol. 2007 Mar; 109(3):721-7.
    View in: PubMed
  89. Grodstein F. Cardiovascular risk factors and cognitive function. Alz and Dem. 2007; in press.
  90. Harrington M, Grodstein F. Antioxidant vitamins and Alzheimer's disease: A review of the epidemiologic literature. Aging Health. 2007; in press.
  91. Okereke O, Kang JH, Gaziano JM, Ma J, Stampfer MJ, Grodstein F. Plasma C-peptide and cognitive performance in older men without diabetes. Am J Geriatr Psychiatry. 2006 Dec; 14(12):1041-50.
    View in: PubMed
  92. Kang JH, Cook N, Manson J, Buring JE, Grodstein F. A randomized trial of vitamin E supplementation and cognitive function in women. Arch Intern Med. 2006 Dec 11-25; 166(22):2462-8.
    View in: PubMed
  93. Kang JH, Irizarry MC, Grodstein F. Prospective study of plasma folate, vitamin B12, and cognitive function and decline. Epidemiology. 2006 Nov; 17(6):650-7.
    View in: PubMed
  94. Okereke OI, Kang JH, Ma J, Gaziano JM, Grodstein F. Midlife plasma insulin-like growth factor I and cognitive function in older men. J Clin Endocrinol Metab. 2006 Nov; 91(11):4306-12.
    View in: PubMed
  95. Willett WC, Manson JE, Grodstein F, Stampfer MJ, Colditz GA. Re: "combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the women's health initiative clinical trial". Am J Epidemiol. 2006 Jun 1; 163(11):1067-8; author reply 1068-9.
    View in: PubMed
  96. Weuve J, Ridker PM, Cook NR, Buring JE, Grodstein F. High-sensitivity C-reactive protein and cognitive function in older women. Epidemiology. 2006 Mar; 17(2):183-9.
    View in: PubMed
  97. Danforth KN, Townsend MK, Lifford K, Curhan GC, Resnick NM, Grodstein F. Risk factors for urinary incontinence among middle-aged women. Am J Obstet Gynecol. 2006 Feb; 194(2):339-45.
    View in: PubMed
  98. Grodstein F, Manson JE, Stampfer MJ. Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation. J Womens Health (Larchmt). 2006 Jan-Feb; 15(1):35-44.
    View in: PubMed
  99. Okereke OI, Kang JH, Ma J, Gaziano JM, Grodstein F. Mid-life Plasma Insulin-like Growth Factor I and Cognitive Function in Older Men. J Clin Endocrinal Metab. 2006; 91:4306-12.
  100. Tworoger SS, Lee S, Schernhammer ES, Grodstein F. The association of self-reported sleep duration, difficulty sleeping, and snoring with cognitive function in older women. Alzheimer Dis Assoc Disord. 2006 Jan-Mar; 20(1):41-8.
    View in: PubMed
  101. Lee S, Buring JE, Cook NR, Grodstein F. The relation of education and income to cognitive function among professional women. Neuroepidemiology. 2006; 26(2):93-101.
    View in: PubMed
  102. Okereke O, Kang JH, Ma J, Hankinson SE, Pollak MN, Grodstein F. Plasma IGF-I levels and cognitive performance in older women. Neurobiol Aging. 2007 Jan; 28(1):135-42.
    View in: PubMed
  103. Lifford KL, Curhan GC, Hu FB, Barbieri RL, Grodstein F. Type 2 diabetes mellitus and risk of developing urinary incontinence. J Am Geriatr Soc. 2005 Nov; 53(11):1851-7.
    View in: PubMed
  104. Okereke O, Hankinson SE, Hu FB, Grodstein F. Plasma C peptide level and cognitive function among older women without diabetes mellitus. Arch Intern Med. 2005 Jul 25; 165(14):1651-6.
    View in: PubMed
  105. Kang JH, Ascherio A, Grodstein F. Fruit and vegetable consumption and cognitive decline in aging women. Ann Neurol. 2005 May; 57(5):713-20.
    View in: PubMed
  106. Kang JH, Logroscino G, De Vivo I, Hunter D, Grodstein F. Apolipoprotein E, cardiovascular disease and cognitive function in aging women. Neurobiol Aging. 2005 Apr; 26(4):475-84.
    View in: PubMed
  107. Stampfer MJ, Kang JH, Chen J, Cherry R, Grodstein F. Effects of moderate alcohol consumption on cognitive function in women. N Engl J Med. 2005 Jan 20; 352(3):245-53.
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  108. Atri A, Locascio JJ, Lin JM, Yap L, Dickerson BC, Grodstein F, Irizarry MC, Growdon JH, Greenberg SM. Prevalence and effects of lobar microhemorrhages in early-stage dementia. Neurodegener Dis. 2005; 2(6):305-12.
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  109. Karlson EW, Mandl LA, Hankinson SE, Grodstein F. Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health Study. Arthritis Rheum. 2004 Nov; 50(11):3458-67.
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  110. Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F. Physical activity, including walking, and cognitive function in older women. JAMA. 2004 Sep 22; 292(12):1454-61.
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  111. Kang JH, Weuve J, Grodstein F. Postmenopausal hormone therapy and risk of cognitive decline in community-dwelling aging women. Neurology. 2004 Jul 13; 63(1):101-7.
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  112. Lee S, Cho E, Grodstein F, Kawachi I, Hu FB, Colditz GA. Effects of marital transitions on changes in dietary and other health behaviours in US women. Int J Epidemiol. 2005 Feb; 34(1):69-78.
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  113. Grodstein F, Manson JE, Stampfer MJ, Willett WC. The discrepancy between observational studies and randomized trials of menopausal hormone therapy. Ann Intern Med. 2004 May 4; 140(9):764-5; author reply 765-6.
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  114. Barr RG, Wentowski CC, Grodstein F, Somers SC, Stampfer MJ, Schwartz J, Speizer FE, Camargo CA. Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary disease. Arch Intern Med. 2004 Feb 23; 164(4):379-86.
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  115. Logroscino G, Kang JH, Grodstein F. Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years. BMJ. 2004 Mar 6; 328(7439):548.
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  116. Grodstein F, Lifford K, Resnick NM, Curhan GC. Postmenopausal hormone therapy and risk of developing urinary incontinence. Obstet Gynecol. 2004 Feb; 103(2):254-60.
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  117. Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F. Physical activity, including walking, and cognitive function in older women. J Amer Med Assoc. 2004; 292:1454-61.
  118. Lee S, Kawachi I, Grodstein F. Does caregiving stress affect cognitive function in older women? J Nerv Ment Dis. 2004 Jan; 192(1):51-7.
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  119. Karlson EW, Mandl LA, Aweh GN, Grodstein F. Coffee consumption and risk of rheumatoid arthritis. Arthritis Rheum. 2003 Nov; 48(11):3055-60.
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  120. Grodstein F, Fretts R, Lifford K, Resnick N, Curhan G. Association of age, race, and obstetric history with urinary symptoms among women in the Nurses' Health Study. Am J Obstet Gynecol. 2003 Aug; 189(2):428-34.
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  121. Grodstein F, Chen J, Hankinson SE. Cataract extraction and cognitive function in older women. Epidemiology. 2003 Jul; 14(4):493-7.
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  122. Kang JH, Grodstein F. Regular use of nonsteroidal anti-inflammatory drugs and cognitive function in aging women. Neurology. 2003 May 27; 60(10):1591-7.
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  123. Mattix Kramer HJ, Grodstein F, Stampfer MJ, Curhan GC. Menopause and postmenopausal hormone use and risk of incident kidney stones. J Am Soc Nephrol. 2003 May; 14(5):1272-7.
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  124. Grodstein F, Manson JE, Stampfer MJ. Postmenopausal hormone replacement therapy. Ann Intern Med. 2003 Apr 15; 138(8):688; author reply 688-9.
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  125. Lee S, Kawachi I, Berkman LF, Grodstein F. Education, other socioeconomic indicators, and cognitive function. Am J Epidemiol. 2003 Apr 15; 157(8):712-20.
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  126. Albert CM, Chae CU, Grodstein F, Rose LM, Rexrode KM, Ruskin JN, Stampfer MJ, Manson JE. Prospective study of sudden cardiac death among women in the United States. Circulation. 2003 Apr 29; 107(16):2096-101.
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  127. Grodstein F, Chen J, Willett WC. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr. 2003 Apr; 77(4):975-84.
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  128. Grodstein F, Clarkson TB, Manson JE. Understanding the divergent data on postmenopausal hormone therapy. N Engl J Med. 2003 Feb 13; 348(7):645-50.
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  129. Karlson EW, Mandl LA, Aweh GN, Sangha O, Liang MH, Grodstein F. Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors. Am J Med. 2003 Feb 1; 114(2):93-8.
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  130. Grodstein F, Manson JE. Relationship between hormone replacement therapy, socioeconomic status, and coronary heart disease. JAMA. 2003 Jan 1; 289(1):44-5; author reply 45.
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  131. Karlson EW, Mandl LA, Aweh GN, Sangha, O, Liang MH, Grodstein F. Obesity as a risk facotr for severe hip osteoarthritis in a large female cohort study. Am J Med. 2003; 114:93-8.
  132. Stampfer MJ, Grodstein F. Can homocysteine be related to physical functioning? Am J Med. 2002 Nov; 113(7):610-1.
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  133. Hu FB, Grodstein F. Postmenopausal hormone therapy and the risk of cardiovascular disease: the epidemiologic evidence. Am J Cardiol. 2002 Jul 3; 90(1A):26F-29F.
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  134. Grodstein F, Manson JE, Stampfer MJ. Postmenopausal hormone use and secondary prevention of coronary events in the nurses' health study. a prospective, observational study. Ann Intern Med. 2001 Jul 3; 135(1):1-8.
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  135. Grodstein F, Chen J, Wilson RS, Manson JE. Type 2 diabetes and cognitive function in community-dwelling elderly women. Diabetes Care. 2001 Jun; 24(6):1060-5.
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  136. Grodstein F. Response to comments on 'A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease'. Maturitas. 2001 May 30; 38(3):239-41.
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  137. Grodstein F, Manson JE, Colditz GA, Willett WC, Speizer FE, Stampfer MJ. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med. 2000 Dec 19; 133(12):933-41.
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  138. Hu FB, Stampfer MJ, Manson JE, Grodstein F, Colditz GA, Speizer FE, Willett WC. Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. N Engl J Med. 2000 Aug 24; 343(8):530-7.
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  139. Grodstein F, Chen J, Pollen DA, Albert MS, Wilson RS, Folstein MF, Evans DA, Stampfer MJ. Postmenopausal hormone therapy and cognitive function in healthy older women. J Am Geriatr Soc. 2000 Jul; 48(7):746-52.
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  140. Grodstein F, Mayeux R, Stampfer MJ. Tofu and cognitive function: food for thought. J Am Coll Nutr. 2000 Apr; 19(2):207-9.
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  141. Leitzmann MF, Rimm EB, Willett WC, Spiegelman D, Grodstein F, Stampfer MJ, Colditz GA, Giovannucci E. Recreational physical activity and the risk of cholecystectomy in women. N Engl J Med. 1999 Sep 9; 341(11):777-84.
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  142. Grodstein F, Stampfer MJ, Falkeborn M, Naessen T, Persson I. Postmenopausal hormone therapy and risk of cardiovascular disease and hip fracture in a cohort of Swedish women. Epidemiology. 1999 Sep; 10(5):476-80.
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  143. Hu FB, Grodstein F, Hennekens CH, Colditz GA, Johnson M, Manson JE, Rosner B, Stampfer MJ. Age at natural menopause and risk of cardiovascular disease. Arch Intern Med. 1999 May 24; 159(10):1061-6.
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  144. Grodstein F, Newcomb PA, Stampfer MJ. Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. Am J Med. 1999 May; 106(5):574-82.
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  145. Grodstein F, Newcomb PA, Stampfer MJ . Postmenopausal hormone therapy and the risk of colorectal cancer: A review and meta-analysis. Am J Med 106:574-82. 1999; 106:574-82.
  146. Stampfer MJ, Grodstein F . Role of Hormone Replacement in Cardiovascular Disease. Lobo RA, editor. Treatment of the Postmenopausal Woman: Basic and Clinical Access Lippincott Williams & Wilkins, Philadelphia 1999;361-7. 1999; 361-7.
  147. Grodstein F, Stampfer MJ. Estrogen for women at varying risk of coronary disease. Maturitas. 1998 Sep 20; 30(1):19-26.
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  148. Grodstein F, Martinez ME, Platz EA, Giovannucci E, Colditz GA, Kautzky M, Fuchs C, Stampfer MJ. Postmenopausal hormone use and risk for colorectal cancer and adenoma. Ann Intern Med. 1998 May 1; 128(9):705-12.
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  149. Patel SR, Parker JA, Grodstein F, Goldhaber SZ. Similarity in Presentation and Response to Thrombolysis Among Women and Men with Pulmonary Embolism. J Thromb Thrombolysis. 1998 May; 5(2):95-100.
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  150. Grodstein F, Colditz GA, Stampfer MJ. Tooth loss and hormone use in postmenopausal women. Compend Contin Educ Dent Suppl. 1998; (22):S9-16.
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  151. Platz EA, Martinez ME, Grodstein F, Fuchs CS, Colditz GA, Stampfer MJ, Giovannucci E. Parity and other reproductive factors and risk of adenomatous polyps of the distal colorectum (United States). Cancer Causes Control. 1997 Nov; 8(6):894-903.
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  152. Mikkola KM, Patel SR, Parker JA, Grodstein F, Goldhaber SZ. Attenuation over 24 hours of the efficacy of thrombolysis of pulmonary embolism among patients with cancer. Am Heart J. 1997 Oct; 134(4):603-7.
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  153. Daniels LB, Parker JA, Patel SR, Grodstein F, Goldhaber SZ. Relation of duration of symptoms with response to thrombolytic therapy in pulmonary embolism. Am J Cardiol. 1997 Jul 15; 80(2):184-8.
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  154. Mikkola KM, Patel SR, Parker JA, Grodstein F, Goldhaber SZ. Increasing age is a major risk factor for hemorrhagic complications after pulmonary embolism thrombolysis. Am Heart J. 1997 Jul; 134(1):69-72.
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  155. Grodstein F, Stampfer MJ, Colditz GA, Willett WC, Manson JE, Joffe M, Rosner B, Fuchs C, Hankinson SE, Hunter DJ, Hennekens CH, Speizer FE. Postmenopausal hormone therapy and mortality. N Engl J Med. 1997 Jun 19; 336(25):1769-75.
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  156. Camargo CA, Stampfer MJ, Glynn RJ, Grodstein F, Gaziano JM, Manson JE, Buring JE, Hennekens CH. Moderate alcohol consumption and risk for angina pectoris or myocardial infarction in U.S. male physicians. Ann Intern Med. 1997 Mar 1; 126(5):372-5.
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  157. Goldhaber SZ, Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Willett WC, Hennekens CH. A prospective study of risk factors for pulmonary embolism in women. JAMA. 1997 Feb 26; 277(8):642-5.
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  158. Martínez ME, Grodstein F, Giovannucci E, Colditz GA, Speizer FE, Hennekens C, Rosner B, Willett WC, Stampfer MJ. A prospective study of reproductive factors, oral contraceptive use, and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 1997 Jan; 6(1):1-5.
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  159. Grodstein F, Stampfer MJ, Goldhaber SZ, Manson JE, Colditz GA, Speizer FE, Willett WC, Hennekens CH. Prospective study of exogenous hormones and risk of pulmonary embolism in women. Lancet. 1996 Oct 12; 348(9033):983-7.
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  160. Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Rosner B, Speizer FE, Hennekens CH. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 1996 Aug 15; 335(7):453-61.
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  161. Grodstein F, Levine R, Troy L, Spencer T, Colditz GA, Stampfer MJ. Three-year follow-up of participants in a commercial weight loss program. Can you keep it off? Arch Intern Med. 1996 Jun 24; 156(12):1302-6.
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  162. Grodstein F. Invited commentary: can selection bias explain the cardiovascular benefits of estrogen replacement therapy? Am J Epidemiol. 1996 May 15; 143(10):979-82; discussion 983-4.
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  163. Grodstein F, Colditz GA, Stampfer MJ. Post-menopausal hormone use and tooth loss: a prospective study. J Am Dent Assoc. 1996 Mar; 127(3):370-7, quiz 392.
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  164. Grodstein F . Can selection bias explain the cardiovascular benefits of estrogen replacement therapy?. Am J Epidemiology. 1996; 143:979-82.
  165. Grodstein F, Stampfer MJ . Indications du traitement hormonal après la ménopause. Réalités Cardiologiques. 1996; 94:19-28.
  166. Grodstein F, Stampfer MJ . Selection bias and studies of hormone replacement therapy. European Consensus Development Conference on Menopause. 1996; 151-5.
  167. Grodstein F, Manson JE, Stampfer MJ . Postmenopausal Hormone Therapy. Manson J, Hennekens CH, Ridker P, Gaziano M, editors. Prevention of Myocardial Infarction. 1996; 413-29.
  168. Grodstein F, Stampfer MJ. Cardiovascular disease: impact of sex steroid replacement. Adashi EY, Rock JA, Rosenwaks Z, editors. Reproductive Endocrinology, Surgery, and Technology. 1996; 1852-66.
  169. Grodstein F, Stampfer M. The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women. Prog Cardiovasc Dis. 1995 Nov-Dec; 38(3):199-210.
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  170. Grodstein F, Speizer FE, Hunter DJ. A prospective study of incident squamous cell carcinoma of the skin in the nurses' health study. J Natl Cancer Inst. 1995 Jul 19; 87(14):1061-6.
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  171. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, Buring J, Hennekens CH. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med. 1995 Mar 16; 332(11):706-11.
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  172. Gann PH, Hennekens CH, Longcope C, Verhoek-Oftedahl W, Grodstein F, Stampfer MJ. A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia. Prostate. 1995 Jan; 26(1):40-9.
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  173. Grodstein F, Hennekens CH, Colditz GA, Hunter DJ, Stampfer MJ. A prospective study of permanent hair dye use and hematopoietic cancer. J Natl Cancer Inst. 1994 Oct 5; 86(19):1466-70.
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  174. Stampfer M, Grodstein F. Cardioprotective effect of hormone replacement therapy. Is not due to selection bias. BMJ. 1994 Sep 24; 309(6957):808-9.
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  175. Stampfer MJ, Grodstein F, Bechtel S. Postmenopausal estrogen and cardiovascular disease. Contemp Intern Med. 1994 Sep; 6(9):47-56, 59.
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  176. Grodstein F, Goldman MB, Cramer DW. Infertility in women and moderate alcohol use. Am J Public Health. 1994 Sep; 84(9):1429-32.
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  177. Grodstein F, Colditz GA, Hunter DJ, Manson JE, Willett WC, Stampfer MJ. A prospective study of symptomatic gallstones in women: relation with oral contraceptives and other risk factors. Obstet Gynecol. 1994 Aug; 84(2):207-14.
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  178. Grodstein F, Goldman MB, Cramer DW. Body mass index and ovulatory infertility. Epidemiology. 1994 Mar; 5(2):247-50.
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  179. Grodstein F, Rothman KJ. Epidemiology of pelvic inflammatory disease. Epidemiology. 1994 Mar; 5(2):234-42.
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  180. Gann PH, Hennekens CH, Sacks FM, Grodstein F, Giovannucci EL, Stampfer MJ. Prospective study of plasma fatty acids and risk of prostate cancer. J Natl Cancer Inst. 1994 Feb 16; 86(4):281-6.
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  181. Stampfer MJ, Grodstein F . Role of hormone replacement in cardiovascular disease. Lobo R, editor. Treatment of the Postmenopausal Woman. 1994; 233.
  182. Wechsler H, Isaac NE, Grodstein F, Sellers DE. Continuation and initiation of alcohol use from the first to the second year of college. J Stud Alcohol. 1994 Jan; 55(1):41-5.
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  183. Grodstein F, Colditz GA, Stampfer MJ. Postmenopausal hormone use and cholecystectomy in a large prospective study. Obstet Gynecol. 1994 Jan; 83(1):5-11.
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  184. Grodstein F, Goldman MB, Ryan L, Cramer DW. Relation of female infertility to consumption of caffeinated beverages. Am J Epidemiol. 1993 Jun 15; 137(12):1353-60.
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  185. Grodstein F, Goldman MB, Cramer DW. Relation of tubal infertility to history of sexually transmitted diseases. Am J Epidemiol. 1993 Mar 1; 137(5):577-84.
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  186. Grodstein F, Goldman MB, Ryan L, Cramer DW. Self-reported use of pharmaceuticals and primary ovulatory infertility. Epidemiology. 1993 Mar; 4(2):151-6.
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  187. Grodstein F, Goldman MB, Ryan L, Cramer DW. Pharmaceutical use and ovulatory infertility. Epidemiology. 1993; 4:151-56.
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