Mark Poznansky, PH.D., M.B.,CH.B.
|Title||Associate Professor of Medicine|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Partners AIDS Research Center and Infectious Diseases
149 13th Street
Charlestown MA 02129
Available: 10/30/12, Expires: 10/31/14
The two student projects available at the Vaccine and Immunotherapy Center at Massachusetts General Hospital involve the development of new therapeutics for cancer, infectious diseases and immune mediated diseases based on the discovery of fugetaxis or the repulsion of immune cells from a specific agent. Ovarian cancer is known to produce large amounts of a immune cell repellent protein that can subdue the anti-cancer immune response. We are working on novel ways to overcome this immune suppressive action with small molecule antagonists of receptors. The student would learn this basic and applied science including techniques which quantitate immune cell migration and function in this context. The second project involves the finding that chemorepellent agents can be used to protect a transplated graft from rejection by impeding recipient immune cell infiltration into the donor tissue. Here we coat islet transplants for the treatment of type I diabetes with a chemorepellent to achieve our desired effect. Preclinical studies in both ovarian cancer and Type I diabetes have been encouraging and the student would become involved in these ongoing studies to help move a discovery (T cell fugetaxis) from bench to bedside.
Available: 08/01/12, Expires: 11/01/14
Join a lab in which students get hands on experience in both experimental work and design in the context of vaccine development in HIV and for ovarian cancer. Also be a part of a new Vaccine and Immunotherapy Center at Massachusetts General Hospital which sets as its goal the acceleration of the development of new agents for the prevention and treatment of infectious diseases and cancer.
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