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Last Name
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Mark Poznansky, PH.D., M.B.,CH.B.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Partners AIDS Research Center and Infectious Diseases
149 13th Street
Charlestown MA 02129
Phone617/724-6375
Fax617/726-4691

 Mentoring 
 current student opportunities
Available: 10/30/12, Expires: 10/31/14

The two student projects available at the Vaccine and Immunotherapy Center at Massachusetts General Hospital involve the development of new therapeutics for cancer, infectious diseases and immune mediated diseases based on the discovery of fugetaxis or the repulsion of immune cells from a specific agent. Ovarian cancer is known to produce large amounts of a immune cell repellent protein that can subdue the anti-cancer immune response. We are working on novel ways to overcome this immune suppressive action with small molecule antagonists of receptors. The student would learn this basic and applied science including techniques which quantitate immune cell migration and function in this context. The second project involves the finding that chemorepellent agents can be used to protect a transplated graft from rejection by impeding recipient immune cell infiltration into the donor tissue. Here we coat islet transplants for the treatment of type I diabetes with a chemorepellent to achieve our desired effect. Preclinical studies in both ovarian cancer and Type I diabetes have been encouraging and the student would become involved in these ongoing studies to help move a discovery (T cell fugetaxis) from bench to bedside.

Available: 08/01/12, Expires: 11/01/14

Join a lab in which students get hands on experience in both experimental work and design in the context of vaccine development in HIV and for ovarian cancer. Also be a part of a new Vaccine and Immunotherapy Center at Massachusetts General Hospital which sets as its goal the acceleration of the development of new agents for the prevention and treatment of infectious diseases and cancer.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17561-6.
    View in: PubMed
  2. Leblanc PR, Yuan J, Brauns T, Gelfand JA, Poznansky MC. Accelerated vaccine development against emerging infectious diseases. Hum Vaccin Immunother. 2012 Jul; 8(7):1010-2.
    View in: PubMed
  3. Zhang J, Poznansky M, Crumpacker C. Naive and memory CD4? T cells in HIV eradication and immunization. J Infect Dis. 2012 Aug 15; 206(4):617-8; author reply 618.
    View in: PubMed
  4. Kotton CN, Poznansky MC. Vaccination of oncology patients: an effective tool and an opportunity not to be missed. Oncologist. 2012; 17(1):1-2.
    View in: PubMed
  5. Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc P, Ingraham R, Forbes B, Edelblute B, Collette B, Xing D, Kowalski M, Mingari MC, Vianello F, Birrer M, Orsulic S, Dranoff G, Poznansky MC. CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer. Cancer Res. 2011 Aug 15; 71(16):5522-34.
    View in: PubMed
  6. Santosuosso M, Righi E, Hill ED, Leblanc PR, Kodish B, Mylvaganam HN, Siddappa NB, Stevceva L, Hu SL, Ghebremichael M, Chenine AL, Hovav AH, Ruprecht RM, Poznansky MC. R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes. PLoS One. 2011; 6(4):e18465.
    View in: PubMed
  7. Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM. R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models. PLoS One. 2010; 5(7):e11689.
    View in: PubMed
  8. Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM. Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes. J Infect Dis. 2010 Apr 15; 201(8):1155-63.
    View in: PubMed
  9. Vianello F, Righi E, Poznansky MC. Methods for quantitation of leukocyte chemotaxis and fugetaxis. Methods Mol Biol. 2010; 616:115-24.
    View in: PubMed
  10. Lee JY, Buzney CD, Poznansky MC, Sackstein R. Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukoc Biol. 2009 Dec; 86(6):1285-94.
    View in: PubMed
  11. Santosuosso M, Righi E, Lindstrom V, Leblanc PR, Poznansky MC. HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection. J Infect Dis. 2009 Oct 1; 200(7):1050-3.
    View in: PubMed
  12. Goodchild TT, Robinson KA, Pang W, Tondato F, Cui J, Arrington J, Godwin L, Ungs M, Carlesso N, Weich N, Poznansky MC, Chronos NA. Bone marrow-derived B cells preserve ventricular function after acute myocardial infarction. JACC Cardiovasc Interv. 2009 Oct; 2(10):1005-16.
    View in: PubMed
  13. Jaafar F, Righi E, Lindstrom V, Linton C, Nohadani M, Van Noorden S, Lloyd T, Poznansky J, Stamp G, Dina R, Coleman DV, Poznansky MC. Correlation of CXCL12 expression and FoxP3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer. Am J Pathol. 2009 Oct; 175(4):1525-35.
    View in: PubMed
  14. Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC. X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens. J Virol. 2009 Nov; 83(21):10941-50.
    View in: PubMed
  15. Stevceva L, Yoon V, Carville A, Pacheco B, Santosuosso M, Korioth-Schmitz B, Mansfield K, Poznansky MC. The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo. J Immunol. 2008 Oct 15; 181(8):5510-21.
    View in: PubMed
  16. Huttenlocher A, Poznansky MC. Reverse leukocyte migration can be attractive or repulsive. Trends Cell Biol. 2008 Jun; 18(6):298-306.
    View in: PubMed
  17. Papeta N, Chen T, Vianello F, Gererty L, Malik A, Mok YT, Tharp WG, Bagley J, Zhao G, Stevceva L, Yoon V, Sykes M, Sachs D, Iacomini J, Poznansky MC. Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent. Transplantation. 2007 Jan 27; 83(2):174-83.
    View in: PubMed
  18. Vianello F, Poznansky MC. Generation of a tissue-engineered thymic organoid. Methods Mol Biol. 2007; 380:163-70.
    View in: PubMed
  19. Stevceva L, Yoon V, Anastasiades D, Poznansky MC. Immune responses to HIV Gp120 that facilitate viral escape. Curr HIV Res. 2007 Jan; 5(1):47-54.
    View in: PubMed
  20. Goodchild T, Pang W, Tondato F, Cui J, Otsuka Y, Frowein S, Ungs M, Robinson K, Poznansky M, Chronos N. Safety of intramyocardial injection of autologous bone marrow cells to treat myocardial ischemia in pigs. Cardiovasc Revasc Med. 2006 Jul-Sep; 7(3):136-45.
    View in: PubMed
  21. Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palù G, Irimia D, Toner M, Weissleder R, Poznansky MC. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol. 2006 Mar 1; 176(5):2902-14.
    View in: PubMed
  22. Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature. 2006 Feb 2; 439(7076):599-603.
    View in: PubMed
  23. Irimia D, Liu SY, Tharp WG, Samadani A, Toner M, Poznansky MC. Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip. 2006 Feb; 6(2):191-8.
    View in: PubMed
  24. Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu SY, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG, Poznansky MC. Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol. 2006 Mar; 79(3):539-54.
    View in: PubMed
  25. Vianello F, Kraft P, Mok YT, Hart WK, White N, Poznansky MC. A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus. J Immunol. 2005 Oct 15; 175(8):5115-25.
    View in: PubMed
  26. Vianello F, Olszak IT, Poznansky MC. Fugetaxis: active movement of leukocytes away from a chemokinetic agent. J Mol Med (Berl). 2005 Oct; 83(10):752-63.
    View in: PubMed
  27. Brainard DM, Tharp WG, Granado E, Miller N, Trocha AK, Ren XH, Conrad B, Terwilliger EF, Wyatt R, Walker BD, Poznansky MC. Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. J Virol. 2004 May; 78(10):5184-93.
    View in: PubMed
  28. Antohe F, Lin L, Kao GY, Poznansky MJ, Allen TM. Transendothelial movement of liposomes in vitro mediated by cancer cells, neutrophils or histamine. J Liposome Res. 2004; 14(1-2):1-25.
    View in: PubMed
  29. Robertson P, Poznansky MC. T-lymphocyte development and models of thymopoietic reconstitution. Transpl Infect Dis. 2003 Mar; 5(1):38-42.
    View in: PubMed
  30. Adams GB, Chabner KT, Foxall RB, Weibrecht KW, Rodrigues NP, Dombkowski D, Fallon R, Poznansky MC, Scadden DT. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood. 2003 Jan 1; 101(1):45-51.
    View in: PubMed
  31. Poznansky MC, Olszak IT, Evans RH, Wang Z, Foxall RB, Olson DP, Weibrecht K, Luster AD, Scadden DT. Thymocyte emigration is mediated by active movement away from stroma-derived factors. J Clin Invest. 2002 Apr; 109(8):1101-10.
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  32. Segal R, Poznansky MC, Connors L, Sands K, Barlam T. Changing patterns of presentations of patients with HIV-related disease at a tertiary referral centre and its implications for physician training. Int J STD AIDS. 2001 Jul; 12(7):453-9.
    View in: PubMed
  33. Poznansky MC, Olszak IT, Foxall RB, Piascik A, Adams GB, Evans RH, Cheng T, Scadden DT. Tissue source dictates lineage outcome of human fetal CD34(+)CD38(-) cells. Exp Hematol. 2001 Jun; 29(6):766-74.
    View in: PubMed
  34. Poznansky MC, Evans RH, Foxall RB, Olszak IT, Piascik AH, Hartman KE, Brander C, Meyer TH, Pykett MJ, Chabner KT, Kalams SA, Rosenzweig M, Scadden DT. Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat Biotechnol. 2000 Jul; 18(7):729-34.
    View in: PubMed
  35. Olszak IT, Poznansky MC, Evans RH, Olson D, Kos C, Pollak MR, Brown EM, Scadden DT. Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo. J Clin Invest. 2000 May; 105(9):1299-305.
    View in: PubMed
  36. Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, Scadden DT. Active movement of T cells away from a chemokine. Nat Med. 2000 May; 6(5):543-8.
    View in: PubMed
  37. Poznansky MC, La Vecchio J, Silva-Arietta S, Porter-Brooks J, Brody K, Olszak IT, Adams GB, Ramstedt U, Marasco WA, Scadden DT. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and monocytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat. Hum Gene Ther. 1999 Oct 10; 10(15):2505-14.
    View in: PubMed
  38. Adams GB, McMullen M, Turner S, Olszak IT, Scadden DT, McClure MO, Poznansky MC. Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors. J Acquir Immune Defic Syndr. 1999 May 1; 21(1):1-8.
    View in: PubMed
  39. Adams GB, Pym AS, Poznansky MC, McClure MO, Weber JN. The in vivo effects of combination antiretroviral drug therapy on peripheral blood CD34+ cell colony-forming units from HIV type 1-infected patients. AIDS Res Hum Retroviruses. 1999 Apr 10; 15(6):551-9.
    View in: PubMed
  40. Poznansky MC, Foxall R, Mhashilkar A, Coker R, Jones S, Ramstedt U, Marasco W. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat. Hum Gene Ther. 1998 Mar 1; 9(4):487-96.
    View in: PubMed
  41. el Oakley RM, Brand NJ, Burton PB, McMullen MC, Adams GB, Poznansky MC, Barton PJ, Yacoub MH. Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts. J Thorac Cardiovasc Surg. 1998 Jan; 115(1):1-8.
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  42. Landau R, Coker R, Vermeulen E, Touquet R, Fothergill J, Poznansky MC. Patients unaware of their HIV status present to inner city accident and emergency department with respiratory complications. J Accid Emerg Med. 1997 Sep; 14(5):304-6.
    View in: PubMed
  43. Coker R, Poznansky M. Survival and treatment of AIDS patients 1984-1993. Genitourin Med. 1997 Apr; 73(2):148.
    View in: PubMed
  44. Poznansky MC, Adams GB. The development of a gene therapy for HIV infection. Int J STD AIDS. 1997 Mar; 8(3):145-7; quiz 148-9.
    View in: PubMed
  45. Poznansky MC, Walters J, Cruikshank A, Pollock R, Dendrowskyj P, Lewis K, Parry JV, Fothergill J, Weber J. The rising prevalence of HIV-1 infection in patients attending an inner city accident and emergency department. J Accid Emerg Med. 1996 Nov; 13(6):424-5.
    View in: PubMed
  46. Coker RJ, Poznansky MC. Physicians' experience and survival in patients with AIDS. N Engl J Med. 1996 Aug 1; 335(5):349; author reply 350-1.
    View in: PubMed
  47. Poznansky MC, Coker R, Skinner C, Hill A, Bailey S, Whitaker L, Renton A, Weber J. HIV positive patients first presenting with an AIDS defining illness: characteristics and survival. BMJ. 1995 Jul 15; 311(6998):156-8.
    View in: PubMed
  48. Coker RJ, Desmond N, Poznansky M, Smith C, Shafi MS, Bell D, Riordan JF, Murphy S. Experience of HIV disease in a London District General Hospital. Int J STD AIDS. 1995 Jan-Feb; 6(1):47-9.
    View in: PubMed
  49. Poznansky MC, Torkington J, Turner G, Bankes MJ, Parry JV, Connell JA, Touquet R, Weber J. Prevalence of HIV infection in patients attending an inner city accident and emergency department. BMJ. 1994 Mar 5; 308(6929):636.
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  50. Langhoff E, Terwilliger EF, Bos HJ, Kalland KH, Poznansky MC, Bacon OM, Haseltine WA. Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):7998-8002.
    View in: PubMed
  51. Poznansky M, Lever A, Bergeron L, Haseltine W, Sodroski J. Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector. J Virol. 1991 Jan; 65(1):532-6.
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  52. Poznansky MC, Walker B, Haseltine WA, Sodroski J, Langhoff E. A rapid method for quantitating the frequency of peripheral blood cells containing HIV-1 DNA. J Acquir Immune Defic Syndr. 1991; 4(4):368-73.
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  53. Poznansky MC, Clissold PM, Lachmann PJ. The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha chain of the complement component, C3. J Immunol. 1989 Dec 1; 143(11):3860-2.
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  54. Poznansky MC, Clissold PM, Lachmann PJ. The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3. J Immunol. 1989 Aug 15; 143(4):1254-8.
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  55. Gruber B, Poznansky M, Boss E, Partin J, Gorevic P, Kaplan AP. Characterization and functional studies of rheumatoid synovial mast cells. Activation by secretagogues, anti-IgE, and a histamine-releasing lymphokine. Arthritis Rheum. 1986 Aug; 29(8):944-55.
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  56. Poznansky MC, Gordon AC, Grant IW, Wyllie AH. A cellular abnormality in glucocorticoid resistant asthma. Clin Exp Immunol. 1985 Jul; 61(1):135-42.
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  57. Poznansky MC, Gordon AC, Douglas JG, Krajewski AS, Wyllie AH, Grant IW. Resistance to methylprednisolone in cultures of blood mononuclear cells from glucocorticoid-resistant asthmatic patients. Clin Sci (Lond). 1984 Dec; 67(6):639-45.
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  58. Poznansky MJ, Shandling M, Salkie MA, Elliott JF, Lau E. Advantages in the use of L-asparaginase-albumin polymer as an antitumor agent. Cancer Res. 1982 Mar; 42(3):1020-5.
    View in: PubMed
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