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Last Name
Institution

Kenneth Marc Kaye, M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham & Women's Hospital
Infectious Disease
181 Longwood Ave
Boston MA 02115
Phone617/525-4256
Fax617/525-4251

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Dheekollu J, Chen HS, Kaye KM, Lieberman PM. Timeless-Dependent DNA Replication-Coupled Recombination Promotes Kaposi's Sarcoma-Associated Herpesvirus Episome Maintenance and Terminal Repeat Stability. J Virol. 2013 Apr; 87(7):3699-709.
    View in: PubMed
  2. Habison AC, Beauchemin C, Simas JP, Usherwood EJ, Kaye KM. Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence. J Virol. 2012 Nov; 86(21):11863-76.
    View in: PubMed
  3. Ballestas ME, Kaye KM. The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency. Future Microbiol. 2011 Dec; 6(12):1399-413.
    View in: PubMed
  4. Bazan JA, Martin SI, Kaye KM. Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Med Clin North Am. 2011 Jul; 95(4):743-60, viii.
    View in: PubMed
  5. De León Vázquez E, Kaye KM. The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence. J Virol. 2011 Aug; 85(15):7622-33.
    View in: PubMed
  6. De León Vázquez E, Kaye KM. Rapid and quantitative assessment of KSHV LANA-mediated DNA replication. Arch Virol. 2011 Aug; 156(8):1323-33.
    View in: PubMed
  7. Bazan JA, Martin SI, Kaye KM. Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Infect Dis Clin North Am. 2009 Dec; 23(4):983-96, ix.
    View in: PubMed
  8. Kelley-Clarke B, De Leon-Vazquez E, Slain K, Barbera AJ, Kaye KM. Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence. J Virol. 2009 May; 83(9):4326-37.
    View in: PubMed
  9. Barbera AJ, Kaye KM. KSHV LANA's expanding bag of tricks. Blood. 2008 May 1; 111(9):4425-6.
    View in: PubMed
  10. Chodaparambil JV, Barbera AJ, Lu X, Kaye KM, Hansen JC, Luger K. A charged and contoured surface on the nucleosome regulates chromatin compaction. Nat Struct Mol Biol. 2007 Nov; 14(11):1105-7.
    View in: PubMed
  11. Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C. Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J Virol. 2007 May; 81(9):4904-8.
    View in: PubMed
  12. Kelley-Clarke B, Ballestas ME, Srinivasan V, Barbera AJ, Komatsu T, Harris TA, Kazanjian M, Kaye KM. Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding. J Virol. 2007 Apr; 81(8):4348-56.
    View in: PubMed
  13. Kelley-Clarke B, Ballestas ME, Komatsu T, Kaye KM. Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes. Virology. 2007 Jan 20; 357(2):149-57.
    View in: PubMed
  14. You J, Srinivasan V, Denis GV, Harrington WJ, Ballestas ME, Kaye KM, Howley PM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006 Sep; 80(18):8909-19.
    View in: PubMed
  15. Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Luger K, Kaye KM. Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome. Cell Cycle. 2006 May; 5(10):1048-52.
    View in: PubMed
  16. Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM. The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science. 2006 Feb 10; 311(5762):856-61.
    View in: PubMed
  17. Srinivasan V, Komatsu T, Ballestas ME, Kaye KM. Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA. J Virol. 2004 Dec; 78(24):14033-8.
    View in: PubMed
  18. Martin SI, Kaye KM. Beta-lactam antibiotics: newer formulations and newer agents. Infect Dis Clin North Am. 2004 Sep; 18(3):603-19, ix.
    View in: PubMed
  19. Komatsu T, Ballestas ME, Barbera AJ, Kelley-Clarke B, Kaye KM. KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology. 2004 Feb 20; 319(2):225-36.
    View in: PubMed
  20. Barbera AJ, Ballestas ME, Kaye KM. The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence. J Virol. 2004 Jan; 78(1):294-301.
    View in: PubMed
  21. Li H, Komatsu T, Dezube BJ, Kaye KM. The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter. J Virol. 2002 Dec; 76(23):11880-8.
    View in: PubMed
  22. Komatsu T, Ballestas ME, Barbera AJ, Kaye KM. The KSHV latency-associated nuclear antigen: a multifunctional protein. Front Biosci. 2002 Mar 1; 7:d726-30.
    View in: PubMed
  23. Ballestas ME, Kaye KM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA. J Virol. 2001 Apr; 75(7):3250-8.
    View in: PubMed
  24. Komatsu T, Barbera AJ, Ballestas ME, Kaye KM. The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen. Viral Immunol. 2001; 14(4):311-7.
    View in: PubMed
  25. Fisman DN, Kaye KM. Once-daily dosing of aminoglycoside antibiotics. Infect Dis Clin North Am. 2000 Jun; 14(2):475-87.
    View in: PubMed
  26. Kaye KM, Izumi KM, Li H, Johannsen E, Davidson D, Longnecker R, Kieff E. An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation. J Virol. 1999 Dec; 73(12):10525-30.
    View in: PubMed
  27. Lee H, Choi JK, Li M, Kaye K, Kieff E, Jung JU. Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP. J Virol. 1999 May; 73(5):3913-9.
    View in: PubMed
  28. Ballestas ME, Chatis PA, Kaye KM. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science. 1999 Apr 23; 284(5414):641-4.
    View in: PubMed
  29. Jones D, Ballestas ME, Kaye KM, Gulizia JM, Winters GL, Fletcher J, Scadden DT, Aster JC. Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998 Aug 13; 339(7):444-9.
    View in: PubMed
  30. Eliopoulos AG, Stack M, Dawson CW, Kaye KM, Hodgkin L, Sihota S, Rowe M, Young LS. Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors. Oncogene. 1997 Jun 19; 14(24):2899-916.
    View in: PubMed
  31. Izumi KM, Kaye KM, Kieff ED. The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1447-52.
    View in: PubMed
  32. Devergne O, Hatzivassiliou E, Izumi KM, Kaye KM, Kleijnen MF, Kieff E, Mosialos G. Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation. Mol Cell Biol. 1996 Dec; 16(12):7098-108.
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  33. Ansieau S, Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss HJ. Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14053-8.
    View in: PubMed
  34. Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G. Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. Proc Natl Acad Sci U S A. 1996 Oct 1; 93(20):11085-90.
    View in: PubMed
  35. Zuckerman JM, Kaye KM. The newer macrolides. Azithromycin and clarithromycin. Infect Dis Clin North Am. 1995 Sep; 9(3):731-45.
    View in: PubMed
  36. Kaye ET, Kaye KM. Topical antibacterial agents. Infect Dis Clin North Am. 1995 Sep; 9(3):547-59.
    View in: PubMed
  37. Kaye KM, Izumi KM, Mosialos G, Kieff E. The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues. J Virol. 1995 Feb; 69(2):675-83.
    View in: PubMed
  38. Izumi KM, Kaye KM, Kieff ED. Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation. J Virol. 1994 Jul; 68(7):4369-76.
    View in: PubMed
  39. Kaye KM, Izumi KM, Kieff E. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1993 Oct 1; 90(19):9150-4.
    View in: PubMed
  40. Kaye KM, Macone A, Kazanjian PH. Catheter infection caused by Methylobacterium in immunocompromised hosts: report of three cases and review of the literature. Clin Infect Dis. 1992 May; 14(5):1010-4.
    View in: PubMed
  41. Kaye KM, McKusick KA, Eagle KA. Pulmonary embolism masquerading as coronary insufficiency: clues to the diagnosis by exercise-thallium stress test. Am Heart J. 1989 May; 117(5):1169-71.
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  42. Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL. Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol. 1986 Jul; 59(1):90-7.
    View in: PubMed
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