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Keywords
Last Name
Institution

Bruce Michael Spiegelman, PH.D.

TitleStanley J. Korsmeyer Professor of Cell Biology and Medicine
InstitutionDana-Farber Cancer Institute
DepartmentCell Biology
AddressDana Farber Cancer Institute
Department of Cancer Biology, CLS11145
44 Binney St
Boston MA 02115
Phone617/632-3567
Fax617/632-5363
Other Positions
TitleStanley J. Korsmeyer Professor of Cell Biology and Medicine
InstitutionDana-Farber Cancer Institute
DepartmentMedicine


 Mentoring 
 completed student projects
Assessing PRDM16 Protein Stability in Adipose Tissue
Summer, 05/17/10 - 08/06/10

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014 Jan 16; 156(1-2):20-44.
    View in: PubMed
  2. Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch. Cell. 2014 Jan 16; 156(1-2):304-16.
    View in: PubMed
  3. Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. ß-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic ß-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors. Cell Metab. 2014 Jan 7; 19(1):96-108.
    View in: PubMed
  4. Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. Exercise Induces Hippocampal BDNF through a PGC-1a/FNDC5 Pathway. Cell Metab. 2013 Nov 5; 18(5):649-59.
    View in: PubMed
  5. Goswami D, Devarakonda S, Chalmers MJ, Pascal BD, Spiegelman BM, Griffin PR. Time Window Expansion for HDX Analysis of an Intrinsically Disordered Protein. J Am Soc Mass Spectrom. 2013 Oct; 24(10):1584-92.
    View in: PubMed
  6. Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12480-5.
    View in: PubMed
  7. Spiegelman BM. Banting lecture 2012: regulation of adipogenesis: toward new therapeutics for metabolic disease. Diabetes. 2013 Jun; 62(6):1774-82.
    View in: PubMed
  8. Adamovich Y, Shlomai A, Tsvetkov P, Umansky KB, Reuven N, Estall JL, Spiegelman BM, Shaul Y. The Protein Level of PGC-1a, a Key Metabolic Regulator, Is Controlled by NADH-NQO1. Mol Cell Biol. 2013 Jul; 33(13):2603-13.
    View in: PubMed
  9. Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P. PGC1a Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress. Cancer Cell. 2013 Mar 18; 23(3):287-301.
    View in: PubMed
  10. Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes Dev. 2013 Feb 1; 27(3):234-50.
    View in: PubMed
  11. Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A PGC-1a Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy. Cell. 2012 Dec 7; 151(6):1319-31.
    View in: PubMed
  12. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110.
    View in: PubMed
  13. Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012 Jul 20; 150(2):366-76.
    View in: PubMed
  14. Glass DJ, Spiegelman BM. Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science. Skelet Muscle. 2012; 2(1):11.
    View in: PubMed
  15. Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Development of insulin resistance in mice lacking PGC-1a in adipose tissues. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9635-40.
    View in: PubMed
  16. Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 2; 15(5):778-86.
    View in: PubMed
  17. Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. A novel therapeutic approach to treating obesity through modulation of TGFß signaling. Endocrinology. 2012 Jul; 153(7):3133-46.
    View in: PubMed
  18. Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK. A chemical screen probing the relationship between mitochondrial content and cell size. PLoS One. 2012; 7(3):e33755.
    View in: PubMed
  19. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012 Mar 7; 15(3):395-404.
    View in: PubMed
  20. Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012 Feb 8; 15(2):230-9.
    View in: PubMed
  21. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012 Feb 1; 26(3):271-81.
    View in: PubMed
  22. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 26; 481(7382):463-8.
    View in: PubMed
  23. Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011 Dec 7; 14(6):739-45.
    View in: PubMed
  24. Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 2011 Dec; 11(12):886-95.
    View in: PubMed
  25. Spiegelman BM. QnAs with Bruce M. Spiegelman. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19121.
    View in: PubMed
  26. Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM. Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1a/ERR? complex. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18678-83.
    View in: PubMed
  27. Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidovic D, Shulman GI, Spiegelman BM, Griffin PR. Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation. Nature. 2011 Sep 22; 477(7365):477-81.
    View in: PubMed
  28. Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011 Aug; 152(8):2996-3004.
    View in: PubMed
  29. Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev. 2011 Jun 15; 25(12):1232-44.
    View in: PubMed
  30. Handschin C, Spiegelman BM. PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell Metab. 2011 Apr 6; 13(4):351; author reply 352.
    View in: PubMed
  31. Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex. Cell Metab. 2011 Feb 2; 13(2):160-9.
    View in: PubMed
  32. Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010 Dec 23; 143(7):1072-83.
    View in: PubMed
  33. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011 Jan; 121(1):96-105.
    View in: PubMed
  34. Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21866-71.
    View in: PubMed
  35. Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR. Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. Development. 2010 Oct; 137(20):3489-99.
    View in: PubMed
  36. Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 2010 Jul 22; 466(7305):451-6.
    View in: PubMed
  37. Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T. NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc Natl Acad Sci U S A. 2010 Jul 6; 107(27):12317-22.
    View in: PubMed
  38. Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metab. 2010 Apr 7; 11(4):257-62.
    View in: PubMed
  39. Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010 Mar 25; 464(7288):619-23.
    View in: PubMed
  40. Pandorf CE, Caiozzo VJ, Haddad F, Baldwin KM. A rationale for SDS-PAGE of MHC isoforms as a gold standard for determining contractile phenotype. J Appl Physiol. 2010 Jan; 108(1):222-2; author reply 226.
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  41. Handschin C, Summermatter S, LeBrasseur NK, Lin J, Spiegelman BM. For a pragmatic approach to exercise studies. J Appl Physiol. 2010 Jan; 108(1):223-3; author reply 226.
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  42. Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22510-5.
    View in: PubMed
  43. Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20405-10.
    View in: PubMed
  44. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27; 460(7259):1154-8.
    View in: PubMed
  45. Kleiner S, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z. PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function. J Biol Chem. 2009 Jul 10; 284(28):18624-33.
    View in: PubMed
  46. Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 2009 Jul; 58(7):1499-508.
    View in: PubMed
  47. Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev. 2009 Apr 1; 23(7):788-97.
    View in: PubMed
  48. Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19926-31.
    View in: PubMed
  49. Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK. Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. Clin Cancer Res. 2008 Oct 15; 14(20):6478-86.
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  50. Wenz T, Diaz F, Spiegelman BM, Moraes CT. Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab. 2008 Sep; 8(3):249-56.
    View in: PubMed
  51. Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7.
    View in: PubMed
  52. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21; 454(7207):961-7.
    View in: PubMed
  53. Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature. 2008 Jul 24; 454(7203):463-9.
    View in: PubMed
  54. Walkey CJ, Spiegelman BM. A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis. J Biol Chem. 2008 Sep 5; 283(36):24290-4.
    View in: PubMed
  55. Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15; 22(10):1397-409.
    View in: PubMed
  56. Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4721-6.
    View in: PubMed
  57. Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 2008 Feb 21; 451(7181):1008-12.
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  58. Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, Stevenson SC, Rangwala SM. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol. 2008 May; 104(5):1304-12.
    View in: PubMed
  59. Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem. 2008; 77:289-312.
    View in: PubMed
  60. Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 2007 Nov; 117(11):3463-74.
    View in: PubMed
  61. Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem. 2007 Oct 12; 282(41):30014-21.
    View in: PubMed
  62. Jäger S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12017-22.
    View in: PubMed
  63. Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007 Jul; 6(1):38-54.
    View in: PubMed
  64. Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM. Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell. 2007 May; 11(5):395-406.
    View in: PubMed
  65. Rohas LM, St-Pierre J, Uldry M, Jäger S, Handschin C, Spiegelman BM. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):7933-8.
    View in: PubMed
  66. Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev. 2007 Apr 1; 21(7):770-83.
    View in: PubMed
  67. Spiegelman BM. Transcriptional control of energy homeostasis through the PGC1 coactivators. Novartis Found Symp. 2007; 286:3-6; discusssion 6-12, 162-3, 196-203.
    View in: PubMed
  68. Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM. The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007 Jan; 5(1):35-46.
    View in: PubMed
  69. Spiegelman BM. Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Novartis Found Symp. 2007; 287:60-3; discussion 63-9.
    View in: PubMed
  70. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006 Dec 14; 444(7121):847-53.
    View in: PubMed
  71. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev. 2006 Dec; 58(4):726-41.
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  72. Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006 Dec; 4(6):453-64.
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  73. Spiegelman BM, Enerbäck S. "The adipocyte: a multifunctional cell". Cell Metab. 2006 Dec; 4(6):425-7.
    View in: PubMed
  74. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006 Oct 20; 127(2):397-408.
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  75. Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM. PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16260-5.
    View in: PubMed
  76. Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev. 2006 Nov 1; 20(21):2996-3009.
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  77. Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006 Dec; 27(7):728-35.
    View in: PubMed
  78. Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14379-84.
    View in: PubMed
  79. Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM. Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):10086-91.
    View in: PubMed
  80. Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 2006 May; 3(5):333-41.
    View in: PubMed
  81. Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM. Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. J Biol Chem. 2006 May 26; 281(21):14683-90.
    View in: PubMed
  82. Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005 Oct; 2(4):227-38.
    View in: PubMed
  83. Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 2005 Aug 26; 122(4):505-15.
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  84. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005 Aug 12; 309(5737):1074-8.
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  85. Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005 Jun; 1(6):361-70.
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  86. Andersen G, Wegner L, Yanagisawa K, Rose CS, Lin J, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Hansen T, Spiegelman BM, Pedersen O. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. J Med Genet. 2005 May; 42(5):402-7.
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  87. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005 Apr; 1(4):259-71.
    View in: PubMed
  88. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 3; 434(7029):113-8.
    View in: PubMed
  89. Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Kia X, Shivdasani RA, Spiegelman BM. Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 1; 19(3):362-75.
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  90. Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab. 2005 Feb; 1(2):93-106.
    View in: PubMed
  91. Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 2005 Jan 28; 120(2):261-73.
    View in: PubMed
  92. Spiegelman BM, Heinrich R. Biological control through regulated transcriptional coactivators. Cell. 2004 Oct 15; 119(2):157-67.
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  196. Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 1996 Apr 15; 10(8):974-84.
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  197. Honrado GI, Johnson RS, Golombek DA, Spiegelman BM, Papaioannou VE, Ralph MR. The circadian system of c-fos deficient mice. J Comp Physiol A. 1996 Apr; 178(4):563-70.
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  198. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996 Feb 2; 271(5249):665-8.
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  199. Saez E, Oppenheim H, Smoluk J, Andersen JW, Van Etten RA, Spiegelman BM. c-fos is not essential for v-abl-induced lymphomagenesis. Cancer Res. 1995 Dec 15; 55(24):6196-9.
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  200. Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest. 1995 Dec; 96(6):2914-23.
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  201. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 1995 Dec 1; 83(5):803-12.
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  202. Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9856-60.
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  203. Tontonoz P, Hu E, Spiegelman BM. Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. Curr Opin Genet Dev. 1995 Oct; 5(5):571-6.
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  204. Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM. c-fos is required for malignant progression of skin tumors. Cell. 1995 Sep 8; 82(5):721-32.
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  205. Ross SR, Graves RA, Choy L, Soleveva V, Spiegelman BM. Transgenic mouse models of disease: altering adipose tissue function in vivo. Ann N Y Acad Sci. 1995 Jun 30; 758:297-313.
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  206. Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC, Spiegelman BM. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol. 1995 May; 15(5):2582-8.
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  207. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995 May; 95(5):2409-15.
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  208. Claffey KP, Senger DR, Spiegelman BM. Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF. Biochim Biophys Acta. 1995 Jan 5; 1246(1):1-9.
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  209. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol. 1995 Jan; 15(1):351-7.
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  210. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994 Dec 30; 79(7):1147-56.
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  211. Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res. 1994 Dec 25; 22(25):5628-34.
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  212. Platt KA, Claffey KP, Wilkison WO, Spiegelman BM, Ross SR. Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice. J Biol Chem. 1994 Nov 18; 269(46):28558-62.
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  213. Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. 1994 Nov; 43(11):1271-8.
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  214. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest. 1994 Oct; 94(4):1543-9.
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  215. Paylor R, Johnson RS, Papaioannou V, Spiegelman BM, Wehner JM. Behavioral assessment of c-fos mutant mice. Brain Res. 1994 Jul 18; 651(1-2):275-82.
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  216. Hu E, Mueller E, Oliviero S, Papaioannou VE, Johnson R, Spiegelman BM. Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. EMBO J. 1994 Jul 1; 13(13):3094-103.
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  217. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4854-8.
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  218. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 1994 May 15; 8(10):1224-34.
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  219. Jain J, Nalefski EA, McCaffrey PG, Johnson RS, Spiegelman BM, Papaioannou V, Rao A. Normal peripheral T-cell function in c-Fos-deficient mice. Mol Cell Biol. 1994 Mar; 14(3):1566-74.
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  220. Klaus S, Choy L, Champigny O, Cassard-Doulcier AM, Ross S, Spiegelman B, Ricquier D. Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression. J Cell Sci. 1994 Jan; 107 ( Pt 1):313-9.
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  221. Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 1994 Jan; 134(1):264-70.
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  222. Halvorsen YD, Bursell SE, Wilkison WO, Clermont AC, Brittis M, McGovern TJ, Spiegelman BM. Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes. J Clin Invest. 1993 Dec; 92(6):2872-6.
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  223. Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol. 1993 Aug; 13(8):4753-9.
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  224. Ross SR, Graves RA, Spiegelman BM. Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Dev. 1993 Jul; 7(7B):1318-24.
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  225. Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 1993 Jul; 7(7B):1309-17.
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  226. Pascual M, Catana E, White T, Spiegelman BM, Schifferli JA. Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D. Eur J Immunol. 1993 Jun; 23(6):1389-92.
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  227. Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity, and TNF alpha. Cell. 1993 May 21; 73(4):625-7.
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  228. Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem. 1993 Apr 5; 268(10):6823-6.
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  229. Wilkison WO, Spiegelman BM. Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol. J Biol Chem. 1993 Feb 5; 268(4):2844-9.
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  230. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993 Jan 1; 259(5091):87-91.
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  231. Johnson RS, Spiegelman BM, Papaioannou V. Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell. 1992 Nov 13; 71(4):577-86.
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  232. Field SJ, Johnson RS, Mortensen RM, Papaioannou VE, Spiegelman BM, Greenberg ME. Growth and differentiation of embryonic stem cells that lack an intact c-fos gene. Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19):9306-10.
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  233. Oliviero S, Robinson GS, Struhl K, Spiegelman BM. Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation. Genes Dev. 1992 Sep; 6(9):1799-809.
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  234. Ross SR, Choy L, Graves RA, Fox N, Solevjeva V, Klaus S, Ricquier D, Spiegelman BM. Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7561-5.
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  235. Claffey KP, Wilkison WO, Spiegelman BM. Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. J Biol Chem. 1992 Aug 15; 267(23):16317-22.
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  236. Graves RA, Tontonoz P, Platt KA, Ross SR, Spiegelman BM. Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression. J Cell Biochem. 1992 Jul; 49(3):219-24.
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  237. Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol. 1992 Jul; 12(7):3313.
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  238. Choy LN, Rosen BS, Spiegelman BM. Adipsin and an endogenous pathway of complement from adipose cells. J Biol Chem. 1992 Jun 25; 267(18):12736-41.
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  239. White RT, Damm D, Hancock N, Rosen BS, Lowell BB, Usher P, Flier JS, Spiegelman BM. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem. 1992 May 5; 267(13):9210-3.
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  240. Distel RJ, Robinson GS, Spiegelman BM. Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms. J Biol Chem. 1992 Mar 25; 267(9):5937-41.
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  241. Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol. 1992 Mar; 12(3):1202-8.
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  242. Wilkison WO, Choy L, Spiegelman BM. Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity. J Biol Chem. 1991 Sep 5; 266(25):16886-91.
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  243. Graves RA, Tontonoz P, Ross SR, Spiegelman BM. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. Genes Dev. 1991 Mar; 5(3):428-37.
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  244. Ross SR, Graves RA, Greenstein A, Platt KA, Shyu HL, Mellovitz B, Spiegelman BM. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9590-4.
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  245. Herrera R, Agarwal S, Walton K, Satterberg B, Distel RJ, Goodman R, Spiegelman BM, Roberts TM. A direct role for c-fos in AP-1-dependent gene transcription. Cell Growth Differ. 1990 Oct; 1(10):483-90.
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  246. Johnson PR, Spiegelman B, Rosen B, Turkenkopf I, Ree H, Greenwood MR. Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats. Am J Physiol. 1990 Jul; 259(1 Pt 2):R184-8.
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  247. Dobson DE, Kambe A, Block E, Dion T, Lu H, Castellot JJ, Spiegelman BM. 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Cell. 1990 Apr 20; 61(2):223-30.
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  248. Allegretto EA, Smeal T, Angel P, Spiegelman BM, Karin M. DNA-binding activity of Jun is increased through its interaction with Fos. J Cell Biochem. 1990 Apr; 42(4):193-206.
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  249. Lowell BB, Napolitano A, Usher P, Dulloo AG, Rosen BS, Spiegelman BM, Flier JS. Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine. Endocrinology. 1990 Mar; 126(3):1514-20.
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  250. Wilkison WO, Min HY, Claffey KP, Satterberg BL, Spiegelman BM. Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA. J Biol Chem. 1990 Jan 5; 265(1):477-82.
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  251. Distel RJ, Spiegelman BM. Protooncogene c-fos as a transcription factor. Adv Cancer Res. 1990; 55:37-55.
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  252. Herrera R, Ro HS, Robinson GS, Xanthopoulos KG, Spiegelman BM. A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation. Mol Cell Biol. 1989 Dec; 9(12):5331-9.
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  253. Kitagawa K, Rosen BS, Spiegelman BM, Lienhard GE, Tanner LI. Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes. Biochim Biophys Acta. 1989 Oct 30; 1014(1):83-9.
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  254. Platt KA, Min HY, Ross SR, Spiegelman BM. Obesity-linked regulation of the adipsin gene promoter in transgenic mice. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7490-4.
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  255. Johnson RS, Sheng M, Greenberg ME, Kolodner RD, Papaioannou VE, Spiegelman BM. Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science. 1989 Sep 15; 245(4923):1234-6.
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  256. Rosen BS, Cook KS, Yaglom J, Groves DL, Volanakis JE, Damm D, White T, Spiegelman BM. Adipsin and complement factor D activity: an immune-related defect in obesity. Science. 1989 Jun 23; 244(4911):1483-7.
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  257. Spiegelman BM, Lowell B, Napolitano A, Dubuc P, Barton D, Francke U, Groves DL, Cook KS, Flier JS. Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice. J Biol Chem. 1989 Jan 25; 264(3):1811-5.
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  258. Flier JS, Lowell B, Napolitano A, Usher P, Rosen B, Cook KS, Spiegelman B. Adipsin: regulation and dysregulation in obesity and other metabolic states. Recent Prog Horm Res. 1989; 45:567-80; discussion 580-1.
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  259. Spiegelman BM, Distel RJ, Ro HS, Rosen BS, Satterberg B. fos protooncogene and the regulation of gene expression in adipocyte differentiation. J Cell Biol. 1988 Sep; 107(3):829-32.
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  260. Spiegelman BM. Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function. Trends Genet. 1988 Jul; 4(7):203-7.
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  261. Cherington V, Brown M, Paucha E, St Louis J, Spiegelman BM, Roberts TM. Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation. Mol Cell Biol. 1988 Mar; 8(3):1380-4.
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  262. Rauscher FJ, Sambucetti LC, Curran T, Distel RJ, Spiegelman BM. Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell. 1988 Feb 12; 52(3):471-80.
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  263. Distel RJ, Spiegelman BM. Involvement of fos as a trans-acting factor in adipogenic gene expression. Prog Clin Biol Res. 1988; 284:187-209.
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  264. Cook KS, Min HY, Johnson D, Chaplinsky RJ, Flier JS, Hunt CR, Spiegelman BM. Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science. 1987 Jul 24; 237(4813):402-5.
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  265. Flier JS, Cook KS, Usher P, Spiegelman BM. Severely impaired adipsin expression in genetic and acquired obesity. Science. 1987 Jul 24; 237(4813):405-8.
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  266. Distel RJ, Ro HS, Rosen BS, Groves DL, Spiegelman BM. Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell. 1987 Jun 19; 49(6):835-44.
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  267. Dobson DE, Groves DL, Spiegelman BM. Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation. J Biol Chem. 1987 Feb 5; 262(4):1804-9.
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  268. Min HY, Spiegelman BM. Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor. Nucleic Acids Res. 1986 Nov 25; 14(22):8879-92.
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  269. Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM. Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3786-90.
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  270. Cherington V, Morgan B, Spiegelman BM, Roberts TM. Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4307-11.
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  271. Castellot JJ, Kambe AM, Dobson DE, Spiegelman BM. Heparin potentiation of 3T3-adipocyte stimulated angiogenesis: mechanisms of action on endothelial cells. J Cell Physiol. 1986 May; 127(2):323-9.
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  272. Spiegelman BM, Cook KS, Hunt CR. Regulation of gene expression during the differentiation of 3T3-adipocytes. Prog Clin Biol Res. 1986; 226:445-54.
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  273. Cook KS, Groves DL, Min HY, Spiegelman BM. A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue. Proc Natl Acad Sci U S A. 1985 Oct; 82(19):6480-4.
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  274. Cook KS, Hunt CR, Spiegelman BM. Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control. J Cell Biol. 1985 Feb; 100(2):514-20.
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  275. Spiegelman BM, Ginty CA. Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell. 1983 Dec; 35(3 Pt 2):657-66.
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  276. Spiegelman BM, Frank M, Green H. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem. 1983 Aug 25; 258(16):10083-9.
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  277. Castellot JJ, Karnovsky MJ, Spiegelman BM. Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes. Proc Natl Acad Sci U S A. 1982 Sep; 79(18):5597-601.
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  278. Spiegelman BM, Farmer SR. Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes. Cell. 1982 May; 29(1):53-60.
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  279. Spiegelman BM, Green H. Cyclic AMP-mediated control of lipogenic enzyme synthesis during adipose differentiation of 3T3 cells. Cell. 1981 May; 24(2):503-10.
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  280. Castellot JJ, Karnovsky MJ, Spiegelman BM. Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):6007-11.
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  281. Spiegelman BM, Green H. Control of specific protein biosynthesis during the adipose conversion of 3T3 cells. J Biol Chem. 1980 Sep 25; 255(18):8811-18.
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  282. Cleveland DW, Spiegelman BM, Kirschner MW. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. J Biol Chem. 1979 Dec 25; 254(24):12670-8.
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  283. Spiegelman BM, Lopata MA, Kirschner MW. Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells. Cell. 1979 Feb; 16(2):253-63.
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  284. Spiegelman BM, Lopata MA, Kirschner MW. Multiple sites for the initiation of microtubule assembly in mammalian cells. Cell. 1979 Feb; 16(2):239-52.
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  285. Spiegelman BM, Penningroth SM, Kirschner MW. Turnover of tubulin and the N site GTP in Chinese hamster ovary cells. Cell. 1977 Nov; 12(3):587-600.
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  286. Spiegelman BM, Coursen BW. Age-related changes associated with the induction of o-pyrocatechuic acid carboxylase in Aspergillus ornatus. Arch Microbiol. 1975 Jun 20; 104(1):33-7.
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