Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Jochen Daniel Muehlschlegel, M.D.

TitleAssistant Professor of Anaesthesia
InstitutionBrigham and Women's Hospital
DepartmentAnaesthesia
AddressBrigham and Womens Hospital
C W N, L1, L111
75 Francis St
Boston MA 02115
Phone617/525-8156
Fax617/730-2813

 Biography 
 awards and honors
2006 - 2007Anesthesiology Fellow of the Year
2008 - 2010Mercedes Concepcion Faculty Development Fellowship
2008 - 2010Scholar in Translational Anesthesia Research (STAR)
2009 - Wellcome Burroughs Travel Award
2009 - Vivien Thomas Young Investigator Finalist
2010 - Valedictorian, Scholars in Clinical Science Program

 Overview 
 overview
Research goals
My research centers on the impact of genetic variation upon adverse cardiovascular events, and their significance on a functional level. The patients of my clinical practice of cardiac anesthesia are also my research subjects, as they are a group that is profoundly transcriptionally-upregulated, making examination of genetic variation in transcription more readily apparent. I am an investigator in the CABG Genomics study group created by Drs. Body, Shernan, and Collard in 2001 and also the principal investigator of the TRANSCRIBE (transcriptomic analysis of left ventricular gene expression) study, initiated by myself in 2009. Both studies aim to determine the relationship between genetic variation and perioperative myocardial injury in patients undergoing cardiac surgery. In TRANSCRIBE, my goals are to identify differential expression in human left ventricular myocardium upon exposure to ischemia, examine genetic variants that determine expression changes, and characterize these changes among different disease states.

Clinical Contributions:
I am a Cardiac Anesthesiologist in the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital. With extensive subspecialty training in all aspects of cardiac disease and transesophageal echocardiography, I see myself as a perioperative physician guiding the care of very sick patients with cardiovascular disease. While the spectrum of cardiovascular intervention might be shifting from the more invasive operating room to the less invasive catheter-based technologies, as a perioperative cardiovascular physician I see myself involved in all aspects of the care of these dynamic patients for many years to come.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Christodoulou DC, Wakimoto H, Onoue K, Eminaga S, Gorham JM, Depalma SR, Herman DS, Teekakirikul P, Conner DA, McKean DM, Domenighetti AA, Aboukhalil A, Chang S, Srivastava G, McDonough B, De Jager PL, Chen J, Bulyk ML, Muehlschlegel JD, Seidman CE, Seidman JG. 5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy. J Clin Invest. 2014 Feb 10.
    View in: PubMed
  2. Hilberath JN, Muehlschlegel JD. Noteworthy Articles in 2013 for Cardiothoracic Anesthesiologists. Semin Cardiothorac Vasc Anesth. 2013 Dec 16.
    View in: PubMed
  3. Qi L, Qi Q, Prudente S, Mendonca C, Andreozzi F, di Pietro N, Sturma M, Novelli V, Mannino GC, Formoso G, Gervino EV, Hauser TH, Muehlschlegel JD, Niewczas MA, Krolewski AS, Biolo G, Pandolfi A, Rimm E, Sesti G, Trischitta V, Hu F, Doria A. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA. 2013 Aug 28; 310(8):821-8.
    View in: PubMed
  4. Fox AA, Nascimben L, Body SC, Collard CD, Mitani AA, Liu KY, Muehlschlegel JD, Shernan SK, Marcantonio ER. Increased perioperative b-type natriuretic peptide associates with heart failure hospitalization or heart failure death after coronary artery bypass graft surgery. Anesthesiology. 2013 Aug; 119(2):284-94.
    View in: PubMed
  5. Lampert SM, Michaud GF, Couper GS, Muehlschlegel JD. Epicardial cryoablation resulting in precipitous left ventricular dysfunction. J Thorac Cardiovasc Surg. 2013 Apr; 145(4):e41-2.
    View in: PubMed
  6. Urdaneta F, Muehlschlege JD, Chawla LS, Palacios JM, Janelle GM. Roundtable discussion: status asthmaticus in a patient with an anterior mediastinal mass. Semin Cardiothorac Vasc Anesth. 2012 Dec; 16(4):243-9.
    View in: PubMed
  7. Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Smith SA, Lichtner P, Collard CD, Shernan SK, Hartwig JH, Body SC, Hoffmeister KM. Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury. Am J Hematol. 2012 Feb; 87(2):161-6.
    View in: PubMed
  8. Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PLoS One. 2011; 6(9):e24593.
    View in: PubMed
  9. Fox AA, Marcantonio ER, Collard CD, Thoma M, Perry TE, Shernan SK, Muehlschlegel JD, Body SC. Increased peak postoperative B-type natriuretic peptide predicts decreased longer-term physical function after primary coronary artery bypass graft surgery. Anesthesiology. 2011 Apr; 114(4):807-16.
    View in: PubMed
  10. Muehlschlegel JD. If a troponin falls in a forest but no one measures it, does it really matter? Anesthesiology. 2011 Apr; 114(4):732-3.
    View in: PubMed
  11. Lipman PJ, Liu KY, Muehlschlegel JD, Body S, Lange C. Inferring genetic causal effects on survival data with associated endo-phenotypes. Genet Epidemiol. 2011 Feb; 35(2):119-24.
    View in: PubMed
  12. Lipman PJ, Liu KY, Muehlschlegel JD, Body S, Lange C. Inferring genetic causal effects on survival data with associated endo-phenotypes. Genet Epidemiol. 2010 Dec 31.
    View in: PubMed
  13. Muehlschlegel JD, Shernan SK, Body SC. From creatine kinase-MB to troponin: do we really need to differentiate between myocardial injury and infarction? Anesthesiology. 2010 Dec; 113(6):1479-80.
    View in: PubMed
  14. Muehlschlegel JD, Liu KY, Perry TE, Fox AA, Collard CD, Shernan SK, Body SC. Chromosome 9p21 variant predicts mortality after coronary artery bypass graft surgery. Circulation. 2010 Sep 14; 122(11 Suppl):S60-5.
    View in: PubMed
  15. Herman SC, Muehlschlegel JD, Couper GS, Kelly E. Colonic perforation from left ventricular assist device: a rare complication. Interact Cardiovasc Thorac Surg. 2010 Sep; 11(3):369-70.
    View in: PubMed
  16. Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC. Heart-type fatty acid binding protein is an independent predictor of death and ventricular dysfunction after coronary artery bypass graft surgery. Anesth Analg. 2010 Nov; 111(5):1101-9.
    View in: PubMed
  17. Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Shernan SK, Body SC. Plasma neutrophil gelatinase-associated lipocalin and acute postoperative kidney injury in adult cardiac surgical patients. Anesth Analg. 2010 Jun 1; 110(6):1541-7.
    View in: PubMed
  18. Fox AA, Muehlschlegel JD, Body SC, Shernan SK, Liu KY, Perry TE, Aranki SF, Cook EF, Marcantonio ER, Collard CD. Comparison of the utility of preoperative versus postoperative B-type natriuretic peptide for predicting hospital length of stay and mortality after primary coronary artery bypass grafting. Anesthesiology. 2010 Apr; 112(4):842-51.
    View in: PubMed
  19. Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK. Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting. Anesthesiology. 2010 Mar; 112(3):607-13.
    View in: PubMed
  20. Garvin S, Fitzgerald D, Muehlschlegel JD, Perry TE, Fox AA, Shernan SK, Collard CD, Aranki S, Body SC. Heparin dose response is independent of preoperative antithrombin activity in patients undergoing coronary artery bypass graft surgery using low heparin concentrations. Anesth Analg. 2010 Oct; 111(4):856-61.
    View in: PubMed
  21. Liu KY, Muehlschlegel JD, Perry TE, Fox AA, Collard CD, Body SC, Shernan SK. Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2010 Feb; 139(2):483-8, 488.e1-2.
    View in: PubMed
  22. Garvin S, Muehlschlegel JD, Perry TE, Chen J, Liu KY, Fox AA, Collard CD, Aranki SF, Shernan SK, Body SC. Postoperative activity, but not preoperative activity, of antithrombin is associated with major adverse cardiac events after coronary artery bypass graft surgery. Anesth Analg. 2010 Oct; 111(4):862-9.
    View in: PubMed
  23. Litofe T, Muehlschlegel J, Peng Y, Sidi A, Bleiweis MS. The diagnostic process and perioperative and anesthetic management of an undiagnosed congenital cyanotic cardiac defect in an adult for trauma surgery. J Clin Anesth. 2009 Sep; 21(6):454-8.
    View in: PubMed
  24. Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet. 2009 Oct; 2(5):499-506.
    View in: PubMed
  25. Perry TE, Muehlschlegel JD, Liu KY, Fox AA, Collard CD, Body SC, Shernan SK. C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. BMC Med Genet. 2009; 10:38.
    View in: PubMed
  26. Muehlschlegel JD, Perry TE, Liu KY, Nascimben L, Fox AA, Collard CD, Avery EG, Aranki SF, D'Ambra MN, Shernan SK, Body SC. Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting. Eur Heart J. 2009 Jul; 30(13):1574-83.
    View in: PubMed
  27. Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 2009 Apr; 110(4):738-47.
    View in: PubMed
  28. Perry TE, Muehlschlegel JD, Body SC. Genomics: risk and outcomes in cardiac surgery. Anesthesiol Clin. 2008 Sep; 26(3):399-417.
    View in: PubMed
  29. Muehlschlegel JD, Body SC. Impact of genetic variation on perioperative bleeding. Am J Hematol. 2008 Sep; 83(9):732-7.
    View in: PubMed
  30. Sidi A, Naik B, Urdaneta F, Muehlschlegel JD, Kirby DS, Lobato EB. Treatment of ethanol-induced acute pulmonary hypertension and right ventricular dysfunction in pigs, by sildenafil analogue (UK343-664) or nitroglycerin. Ann Card Anaesth. 2008 Jul-Dec; 11(2):97-104.
    View in: PubMed
  31. Muehlschlegel JD, Peng YG, Lobato EB, Hess PJ, Martin TD, Klodell CT. Temporary biventricular pacing postcardiopulmonary bypass in patients with reduced ejection fraction. J Card Surg. 2008 Jul-Aug; 23(4):324-30.
    View in: PubMed
  32. Sidi A, Naik B, Muehlschlegel JD, Kirby DS, Lobato EB. Ethanol-induced acute pulmonary hypertension and right ventricular dysfunction in pigs. Br J Anaesth. 2008 Apr; 100(4):568-9.
    View in: PubMed
  33. Robinson AR, Robinson MS, Martin TD, Muehlschlegel JD, Peng YG. Intraoperative transesophageal echocardiography alters the surgical course for patients undergoing ascending aortic aneurysm repair. J Cardiothorac Vasc Anesth. 2009 Feb; 23(1):71-4.
    View in: PubMed
  34. Urdaneta F, Lobato EB, Beaver T, Muehlschlegel JD, Kirby DS, Klodell C, Sidi A. Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog. Perfusion. 2008 Mar; 23(2):117-25.
    View in: PubMed
  35. Sidi A, Muehlschlegel JD, Kirby DS, Lobato EB. Administration of milrinone before ischemia, in the presence of beta-blockade, to treat metabolic impairment and myocardial stunning in pigs. Acta Anaesthesiol Scand. 2008 Mar; 52(3):397-405.
    View in: PubMed
  36. Collard CD, Muehlschlegel JD. Literature Review. J Cardiothorac Vasc Anesth. 2008; 22(1):162-64.
  37. Neuman MD, Fox JA, Muehlschlegel JD. Incidental discovery of a large patent ductus arteriosus in an adult during aortic reconstruction: echocardiographic findings and diagnostic dilemmas. Anesth Analg. 2007 Nov; 105(5):1227-8.
    View in: PubMed
  38. Lobato EB, Muehlschlegel JD. Echocardiography in the ICU. A Practical Approach to Transesophageal Echocardiography, Albert C Perrino Jr., MD Scott T Reeves MD, MBA, FACC. 2007.
  39. Muehlschlegel JD, Dobija N, Lobato EB. Acute Pulmonary Hypertension and Right Ventricular Failure. Complications in Anesthesiology. 2007.
  40. Muehlschlegel JD, Lobato EB, Kirby DS, Arnaoutakis G, Sidi A. Inhaled amyl nitrite effectively reverses acute catastrophic thromboxane-mediated pulmonary hypertension in pigs. Ann Card Anaesth. 2007 Jul; 10(2):113-20.
    View in: PubMed
  41. Sidi A, Muehlschlegel JD, Kirby DS, Kirby RR, Lobato EB. Treating ischemic left ventricular dysfunction with hypertonic saline administered after coronary occlusion in pigs. J Cardiothorac Vasc Anesth. 2007 Jun; 21(3):400-5.
    View in: PubMed
  42. Sidi A, Muehlschlegel JD, Muehschlegel JD, Kirby DS, Lobato EB. Treating metabolic impairment and myocardial stunning with phosphodiesterase inhibitor type III, milrinone, administered prior to coronary artery occlusion in the presence of calcium channel blockade in pigs. Ann Card Anaesth. 2007 Jan; 10(1):34-41.
    View in: PubMed
  43. Muehlschlegel JD, Alomar-Melero E, Staples ED, Janelle GM. Acute high-output failure from an aortoventricular fistula due to a ruptured sinus of Valsalva aneurysm after blunt chest trauma. Anesth Analg. 2006 Dec; 103(6):1408-9.
    View in: PubMed
  44. Sidi A, Muehlschlegel JD, Kirby DS, Lobato EB. Treatment of ischaemic left ventricular dysfunction with milrinone or dobutamine administered during coronary artery stenosis in the presence of beta blockade in pigs. Br J Anaesth. 2006 Dec; 97(6):799-807.
    View in: PubMed
  45. Lobato EB, Beaver T, Muehlschlegel J, Kirby DS, Klodell C, Sidi A. Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension. Br J Anaesth. 2006 Mar; 96(3):317-22.
    View in: PubMed
  46. Kirchner EA, Mols G, Hermle G, Muehlschlegel JD, Geiger KK, Guttmann J, Pahl HL. Reduced activation of immunomodulatory transcription factors during positive end-expiratory pressure adjustment based on volume-dependent compliance in isolated perfused rabbit lungs. Br J Anaesth. 2005 Apr; 94(4):530-5.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Muehlschlegel's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_