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Deborah Tan Hung, M.D., Ph.D.

TitleAssociate Professor of Microbiology and Immunobiology
InstitutionMassachusetts General Hospital
DepartmentMicrobiology and Immunobiology
AddressMassachusetts General Hospital
Simches Building, 7208
185 Cambridge St
Boston MA 02114
Phone617/643-3117
Fax617/726-6893
Other Positions
TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
DivisionInfectious Disease


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT. Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorg Med Chem Lett. 2013 Nov 15; 23(22):6052-9.
    View in: PubMed
  2. Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT. Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model. ACS Chem Biol. 2013 Oct 18; 8(10):2224-34.
    View in: PubMed
  3. Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Schmidt Grant S, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci U S A. 2013 Jul 9; 110(28):11565-70.
    View in: PubMed
  4. Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9932-7.
    View in: PubMed
  5. Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun; 9(6):398-405.
    View in: PubMed
  6. Grant SS, Hung DT. Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence. 2013 May 15; 4(4):273-83.
    View in: PubMed
  7. Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. ACS Chem Biol. 2013 Apr 19; 8(4):812-22.
    View in: PubMed
  8. Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP. Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):E3629-30.
    View in: PubMed
  9. Chand NS, Clatworthy AE, Hung DT. The Two-Component Sensor KinB Acts as a Phosphatase To Regulate Pseudomonas aeruginosa Virulence. J Bacteriol. 2012 Dec; 194(23):6537-47.
    View in: PubMed
  10. McMahon TC, Stanley S, Kazyanskaya E, Hung D, Wood JL. The first synthesis of an epidiselenodiketopiperazine. Org Lett. 2012 Sep 7; 14(17):4534-6.
    View in: PubMed
  11. Grant SS, Kaufmann BB, Chand NS, Haseley N, Hung DT. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12147-52.
    View in: PubMed
  12. Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012 Aug 17; 7(8):1377-84.
    View in: PubMed
  13. Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6217-22.
    View in: PubMed
  14. Weiner B, Gomez J, Victor TC, Warren RM, Sloutsky A, Plikaytis BB, Posey JE, van Helden PD, Gey van Pittius NC, Koehrsen M, Sisk P, Stolte C, White J, Gagneux S, Birren B, Hung D, Murray M, Galagan J. Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region. PLoS One. 2012; 7(2):e26038.
    View in: PubMed
  15. Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, Abouelleil A, Bochicchio J, Chauvin S, Desmet T, Gujja S, McCowan C, Montmayeur A, Steelman S, Frimodt-Møller J, Petersen AM, Struve C, Krogfelt KA, Bingen E, Weill FX, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3065-70.
    View in: PubMed
  16. Chindelevitch L, Stanley S, Hung D, Regev A, Berger B. MetaMerge: scaling up genome-scale metabolic reconstructions with application to Mycobacterium tuberculosis. Genome Biol. 2012; 13(1):r6.
    View in: PubMed
  17. Wivagg CN, Hung DT. Resuscitation-promoting factors are required for ß-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Mar; 56(3):1591-4.
    View in: PubMed
  18. Liu X, Bolla K, Ashforth EJ, Zhuo Y, Gao H, Huang P, Stanley SA, Hung DT, Zhang L. Systematics-guided bioprospecting for bioactive microbial natural products. Antonie Van Leeuwenhoek. 2012 Jan; 101(1):55-66.
    View in: PubMed
  19. Chand NS, Hung DT. The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection. Virulence. 2011 Nov-Dec; 2(6):553-8.
    View in: PubMed
  20. Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR. GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol. 2011 Sep; 81(5):1390-401.
    View in: PubMed
  21. Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT. The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. J Bacteriol. 2011 Jun; 193(12):2989-99.
    View in: PubMed
  22. Gomez JE, Clatworthy A, Hung DT. Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches. Crit Rev Biochem Mol Biol. 2011 Feb; 46(1):41-66.
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  23. Kaufmann BB, Hung DT. The fast track to multidrug resistance. Mol Cell. 2010 Feb 12; 37(3):297-8.
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  24. Hett EC, Hung DT. Targeting multiple biofilm pathways. Chem Biol. 2009 Dec 24; 16(12):1216-8.
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  25. Stanley SA, Hung DT. Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells. Sci Transl Med. 2009 Dec 16; 1(11):11ps13.
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  26. Stanley SA, Hung DT. Chemical tools for dissecting bacterial physiology and virulence. Biochemistry. 2009 Sep 22; 48(37):8776-86.
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  27. Barczak AK, Hung DT. Productive steps toward an antimicrobial targeting virulence. Curr Opin Microbiol. 2009 Oct; 12(5):490-6.
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  28. Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT. Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infect Immun. 2009 Apr; 77(4):1293-303.
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  29. Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB. Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nat Methods. 2009 Jan; 6(1):67-9.
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  30. Clatworthy AE, Pierson E, Hung DT. Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol. 2007 Sep; 3(9):541-8.
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  31. Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ. Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2372-7.
    View in: PubMed
  32. Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006 Aug; 10(4):321-6.
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  33. Hung DT, Zhu J, Sturtevant D, Mekalanos JJ. Bile acids stimulate biofilm formation in Vibrio cholerae. Mol Microbiol. 2006 Jan; 59(1):193-201.
    View in: PubMed
  34. Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005 Oct 28; 310(5748):670-4.
    View in: PubMed
  35. Hung DT, Mekalanos JJ. Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):3028-33.
    View in: PubMed
  36. Hung, D.T.; Lilly, C.M. Hemodynamic monitoring in the intensive care unit. Journal of Critical Illness. 2003; 18((5)):196-297.
  37. Hung, D.T.; Baden L.R. A new era for sepsis treatment? Understanding sepsis as a consequence of host immune response. Expert Opin. Ther. Patents. 2002; 12((2), ):181-192.
  38. Laham RJ, Rezaee M, Post M, Novicki D, Sellke FW, Pearlman JD, Simons M, Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther. 2000 Feb; 292(2):795-802.
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  39. Laham RJ, Rezaee M, Post M, Sellke FW, Braeckman RA, Hung D, Simons M. Intracoronary and intravenous administration of basic fibroblast growth factor: myocardial and tissue distribution. Drug Metab Dispos. 1999 Jul; 27(7):821-6.
    View in: PubMed
  40. Laham RJ, Simons M, Hung D. Subxyphoid access of the normal pericardium: a novel drug delivery technique. Catheter Cardiovasc Interv. 1999 May; 47(1):109-11.
    View in: PubMed
  41. Laham RJ, Hung D, Simons M. Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery. Clin Cardiol. 1999 Jan; 22(1 Suppl 1):I6-9.
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  42. Laham RJ, Simons M, Tofukuji M, Hung D, Sellke FW. Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: insight into ischemia-induced reduction in endothelium-dependent vasodilatation. J Thorac Cardiovasc Surg. 1998 Dec; 116(6):1022-8.
    View in: PubMed
  43. Hung DT, Jamison TF, Schreiber SL. Understanding and controlling the cell cycle with natural products. Chem Biol. 1996 Aug; 3(8):623-39.
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  44. Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol. 1996 Apr; 3(4):287-93.
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  45. Hung, D.T.; Nerenberg, J.B.; Schreiber, S.L. Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization. J. Am. Chem. Soc. 1996; 118:11054-11080.
  46. Liang, J.; Hung, D.T.; Schreiber, S.L.; Clardy, J. Structure of the Human 25 kDa FK506 Binding Protein Complexed with Rapamycin. J. Am. Chem. Soc. 1996; 118:1231.
  47. Hung DT, Nerenberg JB, Schreiber SL. Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chem Biol. 1994 Sep; 1(1):67-71.
    View in: PubMed
  48. Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol. 1993 Aug; 13(8):4760-9.
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  49. Nerenberg, J.B.; Hung, D.T.; Schreiber, S.L. . Total synthesis of the Immunosuppressive Agent (-)-Discodermolide. J. Am. Chem. Soc.,. 1993; 115:12621.
  50. Hung DT, Wong YH, Vu TK, Coughlin SR. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem. 1992 Oct 15; 267(29):20831-4.
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  51. Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR. Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem. 1992 Jul 5; 267(19):13146-9.
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  52. Hung DT, Schreiber SL. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. Biochem Biophys Res Commun. 1992 Apr 30; 184(2):733-8.
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  53. Garboczi DN, Hung DT, Wiley DC. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3429-33.
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  54. Hung DT, Vu TH, Nelken NA, Coughlin SR. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J Cell Biol. 1992 Feb; 116(3):827-32.
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  55. Coughlin SR, Scarborough RM, Vu TK, Hung DT. Thrombin receptor structure and function. Cold Spring Harb Symp Quant Biol. 1992; 57:149-54.
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  56. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991 Mar 22; 64(6):1057-68.
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  57. Evans, D.A.; Chapman, K.T.; Hung, D.T.; Kawaguchi, A.T. . Transition State ?-solvation by Aromatic Rings: An Electronic Contribution to Diels-Alder Reaction Diastereoselectivity. Angew. Chemie, Intl. Ed:. 1987; 26,:1184.
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