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Last Name
Institution

Guillermo Garcia-Cardena, PH.D.

TitleAssociate Professor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressHarvard Medical School
Center for Excellence in Vascular Biology, NRB-730C
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4302
Fax617/525-4330

 Mentoring 
 completed student projects
Control of Endothelial and Graft Function by the Mechano-activated Gene KLF2 during Organ Transplantation
Summer, 06/04/07 - 08/24/07
The Role of Ephrin-B2 in Tumor Angiogenesis
Full Time, 01/03/05 - 06/01/05
Role of Transcription Factor KLF2 in Lineage Specification of hiPSC-derived Hematopoietic Stem Cell Progenitors
Part Time, 02/01/12 - 12/31/12
Atheroprotective Effects of Statins on Vascular Endothelium
Summer, 06/01/05 - 08/31/05

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13.
    View in: PubMed
  2. Koo A, Nordsletten D, Umeton R, Yankama B, Ayyadurai S, García-Cardeña G, Dewey CF. In Silico Modeling of Shear-Stress-Induced Nitric Oxide Production in Endothelial Cells through Systems Biology. Biophys J. 2013 May 21; 104(10):2295-306.
    View in: PubMed
  3. Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-ß Autocrine Signaling to Promote Monocyte Recruitment. Immunity. 2013 May 23; 38(5):1025-37.
    View in: PubMed
  4. Timsit MO, Adams WJ, Laguna-Fernandez A, Ichimura T, Bonventre JV, García-Cardeña G, Tullius SG. Flow is Critical for Maintaining a Protective Phenotype in Renal Proximal Tubular Cells. Am J Transplant. 2013 Jun; 13(6):1617-8.
    View in: PubMed
  5. Giantsos-Adams KM, Koo AJ, Song S, Sakai J, Sankaran J, Shin JH, Garcia-Cardena G, Dewey CF. Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation. Cell Mol Bioeng. 2013 Jun; 6(2):160-174.
    View in: PubMed
  6. Koo A, Dewey CF, García-Cardeña G. Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells. Am J Physiol Cell Physiol. 2013 Jan; 304(2):C137-46.
    View in: PubMed
  7. Marrone G, Russo L, Rosado E, Hide D, García-Cardeña G, García-Pagán JC, Bosch J, Gracia-Sancho J. The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins. J Hepatol. 2013 Jan; 58(1):98-103.
    View in: PubMed
  8. Adams WJ, García-Cardeña G. Novel stem cell-based drug discovery platforms for cardiovascular disease. J Biomol Screen. 2012 Oct; 17(9):1117-27.
    View in: PubMed
  9. Gimbrone MA, García-Cardeña G. Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc Pathol. 2013 Jan; 22(1):9-15.
    View in: PubMed
  10. Timsit MO, García-Cardeña G. Flow-dependent endothelial function and kidney dysfunction. Semin Nephrol. 2012 Mar; 32(2):185-91.
    View in: PubMed
  11. Russo L, Gracia-Sancho J, García-Calderó H, Marrone G, García-Pagán JC, García-Cardeña G, Bosch J. Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers. Hepatology. 2012 Mar; 55(3):921-30.
    View in: PubMed
  12. Adamo L, García-Cardeña G. The vascular origin of hematopoietic cells. Dev Biol. 2012 Feb 1; 362(1):1-10.
    View in: PubMed
  13. Wu W, Xiao H, Laguna-Fernandez A, Villarreal G, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy JY. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 2011 Aug 2; 124(5):633-41.
    View in: PubMed
  14. Gracia-Sancho J, Russo L, García-Calderó H, García-Pagán JC, García-Cardeña G, Bosch J. Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver. Gut. 2011 Apr; 60(4):517-24.
    View in: PubMed
  15. Gracia-Sancho J, Villarreal G, Zhang Y, Yu JX, Liu Y, Tullius SG, García-Cardeña G. Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention. Transplantation. 2010 Jul 27; 90(2):142-9.
    View in: PubMed
  16. Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH. Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses. J Clin Invest. 2010 Jun; 120(6):1961-70.
    View in: PubMed
  17. Borenstein JT, Tupper MM, Mack PJ, Weinberg EJ, Khalil AS, Hsiao J, García-Cardeña G. Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate. Biomed Microdevices. 2010 Feb; 12(1):71-9.
    View in: PubMed
  18. Yuan X, Theruvath AJ, Ge X, Floerchinger B, Jurisch A, García-Cardeña G, Tullius SG. Machine perfusion or cold storage in organ transplantation: indication, mechanisms, and future perspectives. Transpl Int. 2010 Jun; 23(6):561-70.
    View in: PubMed
  19. Villarreal G, Zhang Y, Larman HB, Gracia-Sancho J, Koo A, García-Cardeña G. Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. Biochem Biophys Res Commun. 2010 Jan 1; 391(1):984-9.
    View in: PubMed
  20. Gracia-Sancho J, Villarreal G, Zhang Y, García-Cardeña G. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res. 2010 Feb 1; 85(3):514-9.
    View in: PubMed
  21. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8.
    View in: PubMed
  22. Adamo L, Naveiras O, Wenzel PL, McKinney-Freeman S, Mack PJ, Gracia-Sancho J, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, García-Cardeña G, Daley GQ. Biomechanical forces promote embryonic haematopoiesis. Nature. 2009 Jun 25; 459(7250):1131-5.
    View in: PubMed
  23. Adamo L, Zhang Y, García-Cardeña G. AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts. BMC Pharmacol. 2009; 9:2.
    View in: PubMed
  24. Tullius SG, García-Cardeña G. Organ procurement and perfusion before transplantation. N Engl J Med. 2009 Jan 1; 360(1):78-80.
    View in: PubMed
  25. Mack PJ, Zhang Y, Chung S, Vickerman V, Kamm RD, García-Cardeña G. Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling. J Biol Chem. 2009 Mar 27; 284(13):8412-20.
    View in: PubMed
  26. Liu M, Kluger MS, D'Alessio A, García-Cardeña G, Pober JS. Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context. Am J Pathol. 2008 Apr; 172(4):1088-99.
    View in: PubMed
  27. Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res. 2007 Aug 3; 101(3):234-47.
    View in: PubMed
  28. Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res. 2007 Sep 28; 101(7):723-33.
    View in: PubMed
  29. Abeles D, Kwei S, Stavrakis G, Zhang Y, Wang ET, García-Cardeña G. Gene expression changes evoked in a venous segment exposed to arterial flow. J Vasc Surg. 2006 Oct; 44(4):863-70.
    View in: PubMed
  30. García-Cardeña G, Gimbrone MA. Biomechanical modulation of endothelial phenotype: implications for health and disease. Handb Exp Pharmacol. 2006; (176 Pt 2):79-95.
    View in: PubMed
  31. Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA, García-Cardeña G. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest. 2006 Jan; 116(1):49-58.
    View in: PubMed
  32. Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA, García-Cardeña G. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem. 2005 Jul 22; 280(29):26714-9.
    View in: PubMed
  33. Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA, Balasubramanian V, García-Cardeña G, Jain MK. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005 Mar 18; 96(5):e48-57.
    View in: PubMed
  34. Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, Gimbrone MA. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14871-6.
    View in: PubMed
  35. Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ. Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site. J Thorac Cardiovasc Surg. 2004 Oct; 128(4):552-61.
    View in: PubMed
  36. Chang LK, Garcia-Cardeña G, Farnebo F, Fannon M, Chen EJ, Butterfield C, Moses MA, Mulligan RC, Folkman J, Kaipainen A. Dose-dependent response of FGF-2 for lymphangiogenesis. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11658-63.
    View in: PubMed
  37. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15.
    View in: PubMed
  38. Comander J, Natarajan S, Gimbrone MA, García-Cardeña G. Improving the statistical detection of regulated genes from microarray data using intensity-based variance estimation. BMC Genomics. 2004 Feb 27; 5(1):17.
    View in: PubMed
  39. Papapetropoulos A, Fulton D, Lin MI, Fontana J, McCabe TJ, Zoellner S, García-Cardeña G, Zhou Z, Gratton JP, Sessa WC. Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein. Mol Pharmacol. 2004 Feb; 65(2):407-15.
    View in: PubMed
  40. Kwei S, Stavrakis G, Takahas M, Taylor G, Folkman MJ, Gimbrone MA, García-Cardeña G. Early adaptive responses of the vascular wall during venous arterialization in mice. Am J Pathol. 2004 Jan; 164(1):81-9.
    View in: PubMed
  41. Kiely JM, Hu Y, García-Cardeña G, Gimbrone MA. Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma. J Immunol. 2003 Sep 15; 171(6):3216-24.
    View in: PubMed
  42. Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA, Luscinskas FW. Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May; 162(5):1591-601.
    View in: PubMed
  43. Takayama K, García-Cardena G, Sukhova GK, Comander J, Gimbrone MA, Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem. 2002 Nov 15; 277(46):44147-54.
    View in: PubMed
  44. Blackman BR, García-Cardeña G, Gimbrone MA. A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J Biomech Eng. 2002 Aug; 124(4):397-407.
    View in: PubMed
  45. García-Cardeña G, Comander JI, Blackman BR, Anderson KR, Gimbrone MA. Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis? Ann N Y Acad Sci. 2001 Dec; 947:1-6.
    View in: PubMed
  46. Comander J, Weber GM, Gimbrone MA, García-Cardeña G. Argus--a new database system for Web-based analysis of multiple microarray data sets. Genome Res. 2001 Sep; 11(9):1603-10.
    View in: PubMed
  47. Garcia-Cardeña G, Comander J, Anderson KR, Blackman BR, Gimbrone MA. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4478-85.
    View in: PubMed
  48. Kuo CJ, LaMontagne KR, Garcia-Cardeña G, Ackley BD, Kalman D, Park S, Christofferson R, Kamihara J, Ding YH, Lo KM, Gillies S, Folkman J, Mulligan RC, Javaherian K. Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain. J Cell Biol. 2001 Mar 19; 152(6):1233-46.
    View in: PubMed
  49. Shin D, Garcia-Cardena G, Hayashi S, Gerety S, Asahara T, Stavrakis G, Isner J, Folkman J, Gimbrone MA, Anderson DJ. Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 2001 Feb 15; 230(2):139-50.
    View in: PubMed
  50. Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem. 2000 Jul 21; 275(29):22268-72.
    View in: PubMed
  51. Gimbrone MA, Topper JN, Nagel T, Anderson KR, Garcia-Cardeña G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci. 2000 May; 902:230-9; discussion 239-40.
    View in: PubMed
  52. García-Cardeña G, Anderson KR, Mauri L, Gimbrone MA. Distinct mechanical stimuli differentially regulate the PI3K/Akt survival pathway in endothelial cells. Ann N Y Acad Sci. 2000 May; 902:294-7.
    View in: PubMed
  53. Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann RJ, Sessa WC. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. Am J Physiol. 1999 Aug; 277(2 Pt 1):G463-8.
    View in: PubMed
  54. Papapetropoulos A, García-Cardeña G, Dengler TJ, Maisonpierre PC, Yancopoulos GD, Sessa WC. Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab Invest. 1999 Feb; 79(2):213-23.
    View in: PubMed
  55. Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science. 1998 Sep 11; 281(5383):1683-6.
    View in: PubMed
  56. García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998 Apr 23; 392(6678):821-4.
    View in: PubMed
  57. García-Cardeña G, Folkman J. Is there a role for nitric oxide in tumor angiogenesis? J Natl Cancer Inst. 1998 Apr 15; 90(8):560-1.
    View in: PubMed
  58. Woodard AS, García-Cardeña G, Leong M, Madri JA, Sessa WC, Languino LR. The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration. J Cell Sci. 1998 Feb; 111 ( Pt 4):469-78.
    View in: PubMed
  59. Shah V, García-Cardeña G, Sessa WC, Groszmann RJ. The hepatic circulation in health and disease: report of a single-topic symposium. Hepatology. 1998 Jan; 27(1):279-88.
    View in: PubMed
  60. Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest. 1997 Dec 15; 100(12):3131-9.
    View in: PubMed
  61. Shah V, Haddad FG, Garcia-Cardena G, Frangos JA, Mennone A, Groszmann RJ, Sessa WC. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest. 1997 Dec 1; 100(11):2923-30.
    View in: PubMed
  62. Caulin-Glaser T, García-Cardeña G, Sarrel P, Sessa WC, Bender JR. 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 1997 Nov; 81(5):885-92.
    View in: PubMed
  63. García-Cardeña G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem. 1997 Oct 10; 272(41):25437-40.
    View in: PubMed
  64. Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. Am J Pathol. 1997 May; 150(5):1835-44.
    View in: PubMed
  65. Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest. 1997 Jan 1; 99(1):110-6.
    View in: PubMed
  66. Atucha NM, Shah V, García-Cardeña G, Sessa WE, Groszmann RJ. Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis. Gastroenterology. 1996 Dec; 111(6):1627-32.
    View in: PubMed
  67. García-Cardeña G, Fan R, Stern DF, Liu J, Sessa WC. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem. 1996 Nov 1; 271(44):27237-40.
    View in: PubMed
  68. Liu J, García-Cardeña G, Sessa WC. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization. Biochemistry. 1996 Oct 15; 35(41):13277-81.
    View in: PubMed
  69. García-Cardeña G, Oh P, Liu J, Schnitzer JE, Sessa WC. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6448-53.
    View in: PubMed
  70. Liu J, García-Cardeña G, Sessa WC. Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. Biochemistry. 1995 Sep 26; 34(38):12333-40.
    View in: PubMed
  71. Sessa WC, García-Cardeña G, Liu J, Keh A, Pollock JS, Bradley J, Thiru S, Braverman IM, Desai KM. The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J Biol Chem. 1995 Jul 28; 270(30):17641-4.
    View in: PubMed
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