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Quan Zhu, PH.D.

TitleInstructor in Medicine
InstitutionDana-Farber Cancer Institute
DepartmentMedicine
AddressDana Farber Cancer Institute
Cia, Room Jf824
44 Binney St
Boston MA 02115
Phone617/632-2067
Fax617/632-3113

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Han T, Abdel-Motal UM, Chang DK, Sui J, Muvaffak A, Campbell J, Zhu Q, Kupper TS, Marasco WA. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma. PLoS One. 2012; 7(9):e44455.
    View in: PubMed
  2. Braun SE, Taube R, Zhu Q, Wong FE, Murakami A, Kamau E, Dwyer M, Qiu G, Daigle J, Carville A, Johnson RP, Marasco WA. In vivo selection of CD4(+) T cells transduced with a gamma-retroviral vector expressing a single-chain intrabody targeting HIV-1 tat. Hum Gene Ther. 2012 Sep; 23(9):917-31.
    View in: PubMed
  3. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA. Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells. Mol Cancer Ther. 2012 Nov; 11(11):2451-61.
    View in: PubMed
  4. Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 2011 Dec; 134(4):419-33.
    View in: PubMed
  5. Abdel-Motal UM, Sarkis PT, Han T, Pudney J, Anderson DJ, Zhu Q, Marasco WA. Anti-gp120 minibody gene transfer to female genital epithelial cells protects against HIV-1 virus challenge in vitro. PLoS One. 2011; 6(10):e26473.
    View in: PubMed
  6. Han T, Sui J, Bennett AS, Liddington RC, Donis RO, Zhu Q, Marasco WA. Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display. Biochem Biophys Res Commun. 2011 Jun 3; 409(2):253-9.
    View in: PubMed
  7. Xu C, Lo A, Yammanuru A, Tallarico AS, Brady K, Murakami A, Barteneva N, Zhu Q, Marasco WA. Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS One. 2010; 5(3):e9625.
    View in: PubMed
  8. Nakase K, Cheng J, Zhu Q, Marasco WA. Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells. J Leukoc Biol. 2009 Jan; 85(1):165-74.
    View in: PubMed
  9. Sui J, Aird DR, Tamin A, Murakami A, Yan M, Yammanuru A, Jing H, Kan B, Liu X, Zhu Q, Yuan QA, Adams GP, Bellini WJ, Xu J, Anderson LJ, Marasco WA. Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway. PLoS Pathog. 2008 Nov; 4(11):e1000197.
    View in: PubMed
  10. Taube R, Zhu Q, Xu C, Diaz-Griffero F, Sui J, Kamau E, Dwyer M, Aird D, Marasco WA. Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles. PLoS One. 2008; 3(9):e3181.
    View in: PubMed
  11. Sui J, Zhu QK, Muvaffak A, Lo A, Marasco WA. Humanized Monoclonal Antibodies And Methods Of Use. 2008.
  12. Lo AS, Zhu Q, Marasco WA. Intracellular antibodies (intrabodies) and their therapeutic potential. Handb Exp Pharmacol. 2008; (181):343-73.
    View in: PubMed
  13. Taube R, Zhu Q, Xu C, Diaz-Griffero F, Sui J, Aird D, Dwyer MR and Marasco WA. . Lentivirus display: Stable expression of human antibodies on the surface of human cells and virus particles. (Under second review). Nature Biotech. 2008.
  14. Xu C, Sui J, Tao H, Zhu Q, Marasco WA. Human anti-CXCR4 antibodies undergo VH replacement, exhibit functional V-region sulfation, and define CXCR4 antigenic heterogeneity. J Immunol. 2007 Aug 15; 179(4):2408-18.
    View in: PubMed
  15. Cheng J, Kydd AR, Nakase K, Noonan KM, Murakami A, Tao H, Dwyer M, Xu C, Zhu Q, Marasco WA. Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. Blood. 2007 Sep 15; 110(6):2110-20.
    View in: PubMed
  16. Lo A, Zhu Q, Marasco WA. Intracellular antibodies (intrabodies) and their therapeutic potential. Eds. Y. Chernajovsky and A. Nissim. Handbook of Experimental Pharmacology: Therapeutic Antibodies. 2007; 181:333-63.
  17. Nakase K, Cheng J, Zhu Q, Marasco WA. . Transcriptional Regulation of the SHP-1, a candidate tumor suppressor gene in hematological malignancies. . The 48th Annual Meeting of American Society of Hematology. Orlando, FL. Published in Blood, American Society of Hematology 48th Annual Meeting. Orlando, FL. 2006. Abstract #4346 published in Blood, Volume 108, issue 11, November 16, 2006 . 2006; 108(11):Abstract #4346 .
  18. Zhu QK, Marasco WA. Vectors and Uses Thereof. 2004.
  19. Zhu Q, Maitra U, Johnston D, Lozano M, Dudley JP. The homeodomain protein CDP regulates mammary-specific gene transcription and tumorigenesis. Mol Cell Biol. 2004 Jun; 24(11):4810-23.
    View in: PubMed
  20. Zhu Q, Ricardo RR, Zhang L, Ogueta S, Agrawal R, Dzau V, and Marasco WA. . Development of constitutive and inducible SIN lentiviral vectors and their application in cardiovascular gene transfer. Gene Ther Mol Biol. 2004; 8:91-102.
  21. Zhu Q, Marasco WA. Intracellular targeting of antibodies in mammalian cells. New Comprehensive Biochemistry: Gene Transfer and Expression in Mammalian Cells. Ed. Savvas C. Makrides. 2003; 38:573-87.
  22. Lecerf JM, Shirley TL, Zhu Q, Kazantsev A, Amersdorfer P, Housman DE, Messer A, Huston JS. Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4764-9.
    View in: PubMed
  23. Powell CM, Rudge TL, Zhu Q, Johnson LF, Hansen U. Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression. EMBO J. 2000 Sep 1; 19(17):4665-75.
    View in: PubMed
  24. Huston JS, Zhu QK, et al. Bioengineered vehicles for targeted nucleic acid delivery. 2000.
  25. Lecerf JM, Shirley TL, Zhu Q, Messer A, Huston JS. . Anti-huntingtin single-chain Fv intrabody blocks aggregation of co-transfected huntingtin protein. The 10th IBC International Conference on Antibody Engineering. La Jolla, CA. 1999.
  26. Zhu Q, Zeng C, Huhalov A, Yao J, Turi TG, Danley D, Hynes T, Cong Y, DiMattia D, Kennedy S, Daumy G, Schaeffer E, Marasco WA and Huston JS. Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, Capase-7. J Immuno Meth. 1999; 231:207-22.
  27. Volker JL, Rameh LE, Zhu Q, DeCaprio J, Hansen U. Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes Dev. 1997 Jun 1; 11(11):1435-46.
    View in: PubMed
  28. Jones SD, Zhu Q, VanHaight C, Huhalov A. . Non-viral vectors used for delivery of genes encoding toxin molecules. Keystone Symposium. . 1997.
  29. Zhu Q, Courtney RJ. Chemical cross-linking of virion envelope and tegument proteins of herpes simplex virus type 1. Virology. 1994 Nov 1; 204(2):590-9.
    View in: PubMed
  30. Shirra MK, Zhu Q, Huang HC, Pallas D, Hansen U. One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. Mol Cell Biol. 1994 Aug; 14(8):5076-87.
    View in: PubMed
  31. Zhu, QK. Chemical cross-linking studies of herpes simplex virus type 1 glycoproteins. 1991.
  32. Zhu QL, Smith TF, Lathrop RH, Figge J. Acid helix-turn activator motif. Proteins. 1990; 8(2):156-63.
    View in: PubMed
  33. Zhu Q, Courtney RJ. Chemical crosslinking of glycoproteins on the envelope of herpes simplex virus. Virology. 1988 Dec; 167(2):377-84.
    View in: PubMed
  34. Zhu Q, Courtney RJ. Chemical cross-linking study of the herpes simplex virus glycoprotein oligomerization on the virion envelope. The 13th International Herpesvirus Workshop. Irvine CA. 1988.
  35. Zhu Q, Courtney RJ. . Chemical cross-linking of the HSV-specific glycoproteins on the envelope of HSV-1 virions. ASM South Central Branch and Louisiana Biochemistry Society joint meeting. Shreveport, LA. 1986.
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