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Kevin Struhl, PH.D.

TitleDavid Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
Address240 Longwood Ave, C2-315
Bcmp
240 Longwood Ave
Boston MA 02115
Phone617/432-2104
Fax617/432-2529

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Struhl K, Segal E. Determinants of nucleosome positioning. Nat Struct Mol Biol. 2013 Mar 5; 20(3):267-73.
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  2. Hirsch HA, Iliopoulos D, Struhl K. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):972-7.
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  3. Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, Epstein CB, Frietze S, Harrow J, Kaul R, Khatun J, Lajoie BR, Landt SG, Lee BK, Pauli F, Rosenbloom KR, Sabo P, Safi A, Sanyal A, Shoresh N, Simon JM, Song L, Trinklein ND, Altshuler RC, Birney E, Brown JB, Cheng C, Djebali S, Dong X, Dunham I, Ernst J, Furey TS, Gerstein M, Giardine B, Greven M, Hardison RC, Harris RS, Herrero J, Hoffman MM, Iyer S, Kelllis M, Khatun J, Kheradpour P, Kundaje A, Lassman T, Li Q, Lin X, Marinov GK, Merkel A, Mortazavi A, Parker SC, Reddy TE, Rozowsky J, Schlesinger F, Thurman RE, Wang J, Ward LD, Whitfield TW, Wilder SP, Wu W, Xi HS, Yip KY, Zhuang J, Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M, Pazin MJ, Lowdon RF, Dillon LA, Adams LB, Kelly CJ, Zhang J, Wexler JR, Green ED, Good PJ, Feingold EA, Bernstein BE, Birney E, Crawford GE, Dekker J, Elinitski L, Farnham PJ, Gerstein M, Giddings MC, Gingeras TR, Green ED, Guigó R, Hardison RC, Hubbard TJ, Kellis M, Kent WJ, Lieb JD, Margulies EH, Myers RM, Snyder M, Starnatoyannopoulos JA, Tennebaum SA, Weng Z, White KP, Wold B, Khatun J, Yu Y, Wrobel J, Risk BA, Gunawardena HP, Kuiper HC, Maier CW, Xie L, Chen X, Giddings MC, Bernstein BE, Epstein CB, Shoresh N, Ernst J, Kheradpour P, Mikkelsen TS, Gillespie S, Goren A, Ram O, Zhang X, Wang L, Issner R, Coyne MJ, Durham T, Ku M, Truong T, Ward LD, Altshuler RC, Eaton ML, Kellis M, Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov GK, Khatun J, Williams BA, Zaleski C, Rozowsky J, Röder M, Kokocinski F, Abdelhamid RF, Alioto T, Antoshechkin I, Baer MT, Batut P, Bell I, Bell K, Chakrabortty S, Chen X, Chrast J, Curado J, Derrien T, Drenkow J, Dumais E, Dumais J, Duttagupta R, Fastuca M, Fejes-Toth K, Ferreira P, Foissac S, Fullwood MJ, Gao H, Gonzalez D, Gordon A, Gunawardena HP, Howald C, Jha S, Johnson R, Kapranov P, King B, Kingswood C, Li G, Luo OJ, Park E, Preall JB, Presaud K, Ribeca P, Risk BA, Robyr D, Ruan X, Sammeth M, Sandu KS, Schaeffer L, See LH, Shahab A, Skancke J, Suzuki AM, Takahashi H, Tilgner H, Trout D, Walters N, Wang H, Wrobel J, Yu Y, Hayashizaki Y, Harrow J, Gerstein M, Hubbard TJ, Reymond A, Antonarakis SE, Hannon GJ, Giddings MC, Ruan Y, Wold B, Carninci P, Guigó R, Gingeras TR, Rosenbloom KR, Sloan CA, Learned K, Malladi VS, Wong MC, Barber GP, Cline MS, Dreszer TR, Heitner SG, Karolchik D, Kent WJ, Kirkup VM, Meyer LR, Long JC, Maddren M, Raney BJ, Furey TS, Song L, Grasfeder LL, Giresi PG, Lee BK, Battenhouse A, Sheffield NC, Simon JM, Showers KA, Safi A, London D, Bhinge AA, Shestak C, Schaner MR, Kim SK, Zhang ZZ, Mieczkowski PA, Mieczkowska JO, Liu Z, McDaniell RM, Ni Y, Rashid NU, Kim MJ, Adar S, Zhang Z, Wang T, Winter D, Keefe D, Birney E, Iyer VR, Lieb JD, Crawford GE, Li G, Sandhu KS, Zheng M, Wang P, Luo OJ, Shahab A, Fullwood MJ, Ruan X, Ruan Y, Myers RM, Pauli F, Williams BA, Gertz J, Marinov GK, Reddy TE, Vielmetter J, Partridge EC, Trout D, Varley KE, Gasper C, Bansal A, Pepke S, Jain P, Amrhein H, Bowling KM, Anaya M, Cross MK, King B, Muratet MA, Antoshechkin I, Newberry KM, McCue K, Nesmith AS, Fisher-Aylor KI, Pusey B, DeSalvo G, Parker SL, Balasubramanian S, Davis NS, Meadows SK, Eggleston T, Gunter C, Newberry JS, Levy SE, Absher DM, Mortazavi A, Wong WH, Wold B, Blow MJ, Visel A, Pennachio LA, Elnitski L, Margulies EH, Parker SC, Petrykowska HM, Abyzov A, Aken B, Barrell D, Barson G, Berry A, Bignell A, Boychenko V, Bussotti G, Chrast J, Davidson C, Derrien T, Despacio-Reyes G, Diekhans M, Ezkurdia I, Frankish A, Gilbert J, Gonzalez JM, Griffiths E, Harte R, Hendrix DA, Howald C, Hunt T, Jungreis I, Kay M, Khurana E, Kokocinski F, Leng J, Lin MF, Loveland J, Lu Z, Manthravadi D, Mariotti M, Mudge J, Mukherjee G, Notredame C, Pei B, Rodriguez JM, Saunders G, Sboner A, Searle S, Sisu C, Snow C, Steward C, Tanzer A, Tapanan E, Tress ML, van Baren MJ, Walters N, Washieti S, Wilming L, Zadissa A, et al. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 6; 489(7414):57-74.
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  4. Polytarchou C, Iliopoulos D, Struhl K. An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci U S A. 2012 Sep 4; 109(36):14470-5.
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  5. Hughes AL, Jin Y, Rando OJ, Struhl K. A Functional Evolutionary Approach to Identify Determinants of Nucleosome Positioning: A Unifying Model for Establishing the Genome-wide Pattern. Mol Cell. 2012 Oct 12; 48(1):5-15.
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  6. Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012 Jul 5; 487(7405):114-8.
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  7. Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA. Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes. Cell Rep. 2012 Feb 23; 1(2):83-90.
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  8. Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. An HNF4a-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 9; 147(6):1233-47.
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  9. Wong KH, Struhl K. The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein. Genes Dev. 2011 Dec 1; 25(23):2525-39.
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  10. Lee JJ, Drakaki A, Iliopoulos D, Struhl K. MiR-27b targets PPAR? to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. Oncogene. 2012 Aug 16; 31(33):3818-25.
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  11. Krebs AR, Karmodiya K, Lindahl-Allen M, Struhl K, Tora L. SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers. Mol Cell. 2011 Nov 4; 44(3):410-23.
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  12. Miotto B, Struhl K. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol Cell. 2011 Oct 7; 44(1):62-71.
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  13. Tirosh I, Wong KH, Barkai N, Struhl K. Extensive divergence of yeast stress responses through transitions between induced and constitutive activation. Proc Natl Acad Sci U S A. 2011 Oct 4; 108(40):16693-8.
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  14. Iliopoulos D, Rotem A, Struhl K. Inhibition of miR-193a expression by Max and RXRa activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 2011 Aug 1; 71(15):5144-53.
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  15. Esberg A, Moqtaderi Z, Fan X, Lu J, Struhl K, Byström A. Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae. PLoS One. 2011; 6(6):e20829.
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  16. Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN. Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res. 2011 Jul 1; 71(13):4720-31.
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  17. Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 2011 May 1; 71(9):3196-201.
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  18. Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1397-402.
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  19. Katan-Khaykovich Y, Struhl K. Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1296-301.
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  20. Locke G, Tolkunov D, Moqtaderi Z, Struhl K, Morozov AV. High-throughput sequencing reveals a simple model of nucleosome energetics. Proc Natl Acad Sci U S A. 2010 Dec 7; 107(49):20998-1003.
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  21. Fan X, Moqtaderi Z, Jin Y, Zhang Y, Liu XS, Struhl K. Nucleosome depletion at yeast terminators is not intrinsic and can occur by a transcriptional mechanism linked to 3'-end formation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):17945-50.
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  22. Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell. 2010 Sep 10; 39(5):761-72.
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  23. Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell. 2010 Aug 27; 39(4):493-506.
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  24. Yang A, Zhu Z, Kettenbach A, Kapranov P, McKeon F, Gingeras TR, Struhl K. Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo. PLoS One. 2010; 5(7):e11572.
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  25. Moqtaderi Z, Wang J, Raha D, White RJ, Snyder M, Weng Z, Struhl K. Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells. Nat Struct Mol Biol. 2010 May; 17(5):635-40.
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  26. Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger SA, Bulyk M, Tsichlis PN, Shirley Liu X, Struhl K. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell. 2010 Apr 13; 17(4):348-61.
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  27. Raha D, Wang Z, Moqtaderi Z, Wu L, Zhong G, Gerstein M, Struhl K, Snyder M. Close association of RNA polymerase II and many transcription factors with Pol III genes. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3639-44.
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  28. Miotto B, Struhl K. HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin. Mol Cell. 2010 Jan 15; 37(1):57-66.
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  29. Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell. 2009 Nov 13; 139(4):693-706.
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  30. Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal. 2009; 2(92):ra62.
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  31. Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009 Oct 1; 69(19):7507-11.
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  32. Auerbach RK, Euskirchen G, Rozowsky J, Lamarre-Vincent N, Moqtaderi Z, Lefrançois P, Struhl K, Gerstein M, Snyder M. Mapping accessible chromatin regions using Sono-Seq. Proc Natl Acad Sci U S A. 2009 Sep 1; 106(35):14926-31.
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  33. Zhang Y, Moqtaderi Z, Rattner BP, Euskirchen G, Snyder M, Kadonaga JT, Liu XS, Struhl K. Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo. Nat Struct Mol Biol. 2009 Aug; 16(8):847-52.
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  34. Fan X, Struhl K. Where does mediator bind in vivo? PLoS One. 2009; 4(4):e5029.
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  35. Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K. Epigenomics: a roadmap, but to where? Science. 2008 Oct 3; 322(5898):43-4.
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  36. Miotto B, Struhl K. HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. Genes Dev. 2008 Oct 1; 22(19):2633-8.
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  37. Struhl K. The hisB463 mutation and expression of a eukaryotic protein in Escherichia coli. Genetics. 2008 Oct; 180(2):709-14.
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  38. Fan X, Lamarre-Vincent N, Wang Q, Struhl K. Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments. Nucleic Acids Res. 2008 Nov; 36(19):e125.
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  39. Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature. 2008 Apr 3; 452(7187):604-9.
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  40. Moqtaderi Z, Struhl K. Expanding the repertoire of plasmids for PCR-mediated epitope tagging in yeast. Yeast. 2008 Apr; 25(4):287-92.
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  41. Wade JT, Struhl K. The transition from transcriptional initiation to elongation. Curr Opin Genet Dev. 2008 Apr; 18(2):130-6.
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  42. Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N, Green RD, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JD, Liu XS. Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res. 2008 Mar; 18(3):393-403.
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  43. Struhl K. Kevin Struhl. Interview. Curr Biol. 2008 Jan 8; 18(1):R7-9.
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  44. Ghosh S, Hirsch HA, Sekinger EA, Kapranov P, Struhl K, Gingeras TR. Differential analysis for high density tiling microarray data. BMC Bioinformatics. 2007; 8:359.
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  45. Schwabish MA, Struhl K. The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo. Mol Cell Biol. 2007 Oct; 27(20):6987-95.
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  46. Miotto B, Struhl K. [Histone H4 lysine 16 acetylation: from genome regulation to tumoral progression]. Med Sci (Paris). 2007 Aug-Sep; 23(8-9):735-40.
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  47. Peckham HE, Thurman RE, Fu Y, Stamatoyannopoulos JA, Noble WS, Struhl K, Weng Z. Nucleosome positioning signals in genomic DNA. Genome Res. 2007 Aug; 17(8):1170-7.
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  48. Wade JT, Struhl K, Busby SJ, Grainger DC. Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization. Mol Microbiol. 2007 Jul; 65(1):21-6.
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  49. Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VV, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJ. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14; 447(7146):799-816.
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  50. Struhl K. Transcriptional noise and the fidelity of initiation by RNA polymerase II. Nat Struct Mol Biol. 2007 Feb; 14(2):103-5.
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  51. Reppas NB, Wade JT, Church GM, Struhl K. The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting. Mol Cell. 2006 Dec 8; 24(5):747-57.
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  52. Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR, Struhl K. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell. 2006 Nov 17; 24(4):593-602.
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  53. Pascual-Ahuir A, Struhl K, Proft M. Genome-wide location analysis of the stress-activated MAP kinase Hog1 in yeast. Methods. 2006 Nov; 40(3):272-8.
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  54. Ghosh S, Hirsch HA, Sekinger E, Struhl K, Gingeras TR. Rank-statistics based enrichment-site prediction algorithm developed for chromatin immunoprecipitation on chip experiments. BMC Bioinformatics. 2006; 7:434.
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  55. Wade JT, Castro Roa D, Grainger DC, Hurd D, Busby SJ, Struhl K, Nudler E. Extensive functional overlap between sigma factors in Escherichia coli. Nat Struct Mol Biol. 2006 Sep; 13(9):806-14.
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  56. Miotto B, Struhl K. Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains. Mol Cell Biol. 2006 Aug; 26(16):5969-82.
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  57. Proft M, Mas G, de Nadal E, Vendrell A, Noriega N, Struhl K, Posas F. The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress. Mol Cell. 2006 Jul 21; 23(2):241-50.
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  58. Schwabish MA, Struhl K. Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II. Mol Cell. 2006 May 5; 22(3):415-22.
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  59. Hall DB, Wade JT, Struhl K. An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae. Mol Cell Biol. 2006 May; 26(9):3672-9.
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  60. Fan X, Chou DM, Struhl K. Activator-specific recruitment of Mediator in vivo. Nat Struct Mol Biol. 2006 Feb; 13(2):117-20.
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  61. Joshi AA, Struhl K. Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol Cell. 2005 Dec 22; 20(6):971-8.
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  62. Wade JT, Reppas NB, Church GM, Struhl K. Genomic analysis of LexA binding reveals the permissive nature of the Escherichia coli genome and identifies unconventional target sites. Genes Dev. 2005 Nov 1; 19(21):2619-30.
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  63. Gibbons FD, Proft M, Struhl K, Roth FP. Chipper: discovering transcription-factor targets from chromatin immunoprecipitation microarrays using variance stabilization. Genome Biol. 2005; 6(11):R96.
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  64. Proft M, Gibbons FD, Copeland M, Roth FP, Struhl K. Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Aug; 4(8):1343-52.
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  65. Sekinger EA, Moqtaderi Z, Struhl K. Intrinsic histone-DNA interactions and low nucleosome density are important for preferential accessibility of promoter regions in yeast. Mol Cell. 2005 Jun 10; 18(6):735-48.
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  66. Katan-Khaykovich Y, Struhl K. Heterochromatin formation involves changes in histone modifications over multiple cell generations. EMBO J. 2005 Jun 15; 24(12):2138-49.
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  67. Geisberg JV, Struhl K. Analysis of protein co-occupancy by quantitative sequential chromatin immunoprecipitation. Curr Protoc Mol Biol. 2005 May; Chapter 21:Unit 21.8.
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  68. Struhl K. Transcriptional activation: mediator can act after preinitiation complex formation. Mol Cell. 2005 Mar 18; 17(6):752-4.
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  69. Mason PB, Struhl K. Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo. Mol Cell. 2005 Mar 18; 17(6):831-40.
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  70. Aparicio O, Geisberg JV, Sekinger E, Yang A, Moqtaderi Z, Struhl K. Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo. Curr Protoc Mol Biol. 2005 Feb; Chapter 21:Unit 21.3.
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  71. Wade JT, Hall DB, Struhl K. The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes. Nature. 2004 Dec 23; 432(7020):1054-8.
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  72. Wade JT, Struhl K. Association of RNA polymerase with transcribed regions in Escherichia coli. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17777-82.
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  73. Schwabish MA, Struhl K. Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II. Mol Cell Biol. 2004 Dec; 24(23):10111-7.
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  74. Geisberg JV, Struhl K. Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo. Nucleic Acids Res. 2004; 32(19):e151.
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  75. Moqtaderi Z, Struhl K. Defining in vivo targets of nuclear proteins by chromatin immunoprecipitation and microarray analysis. Curr Protoc Mol Biol. 2004 Nov; Chapter 21:Unit 21.9.
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  76. Grainger DC, Overton TW, Reppas N, Wade JT, Tamai E, Hobman JL, Constantinidou C, Struhl K, Church G, Busby SJ. Genomic studies with Escherichia coli MelR protein: applications of chromatin immunoprecipitation and microarrays. J Bacteriol. 2004 Oct; 186(20):6938-43.
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  77. Aparicio O, Geisberg JV, Struhl K. Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo. Curr Protoc Cell Biol. 2004 Sep; Chapter 17:Unit 17.7.
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  78. Proft M, Struhl K. MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction. Cell. 2004 Aug 6; 118(3):351-61.
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  79. Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell. 2004 Jun 4; 14(5):553-7.
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  80. Geisberg JV, Struhl K. Cellular stress alters the transcriptional properties of promoter-bound Mot1-TBP complexes. Mol Cell. 2004 May 21; 14(4):479-89.
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  81. Moqtaderi Z, Struhl K. Genome-wide occupancy profile of the RNA polymerase III machinery in Saccharomyces cerevisiae reveals loci with incomplete transcription complexes. Mol Cell Biol. 2004 May; 24(10):4118-27.
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  82. Cawley S, Bekiranov S, Ng HH, Kapranov P, Sekinger EA, Kampa D, Piccolboni A, Sementchenko V, Cheng J, Williams AJ, Wheeler R, Wong B, Drenkow J, Yamanaka M, Patel S, Brubaker S, Tammana H, Helt G, Struhl K, Gingeras TR. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell. 2004 Feb 20; 116(4):499-509.
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  83. Reid JL, Moqtaderi Z, Struhl K. Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae. Mol Cell Biol. 2004 Jan; 24(2):757-64.
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  84. Mason PB, Struhl K. The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo. Mol Cell Biol. 2003 Nov; 23(22):8323-33.
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  85. Ng HH, Dole S, Struhl K. The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem. 2003 Sep 5; 278(36):33625-8.
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  86. Ng HH, Robert F, Young RA, Struhl K. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell. 2003 Mar; 11(3):709-19.
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  87. Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1820-5.
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  88. Geisberg JV, Moqtaderi Z, Kuras L, Struhl K. Mot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae. Mol Cell Biol. 2002 Dec; 22(23):8122-34.
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  89. Hall DB, Struhl K. The VP16 activation domain interacts with multiple transcriptional components as determined by protein-protein cross-linking in vivo. J Biol Chem. 2002 Nov 29; 277(48):46043-50.
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  90. Deckert J, Struhl K. Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein. Mol Cell Biol. 2002 Sep; 22(18):6458-70.
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  91. Ng HH, Xu RM, Zhang Y, Struhl K. Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J Biol Chem. 2002 Sep 20; 277(38):34655-7.
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  92. Feng Q, Wang H, Ng HH, Erdjument-Bromage H, Tempst P, Struhl K, Zhang Y. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol. 2002 Jun 25; 12(12):1052-8.
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  93. Ng HH, Feng Q, Wang H, Erdjument-Bromage H, Tempst P, Zhang Y, Struhl K. Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev. 2002 Jun 15; 16(12):1518-27.
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  94. Proft M, Struhl K. Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell. 2002 Jun; 9(6):1307-17.
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  95. Strässer K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondón AG, Aguilera A, Struhl K, Reed R, Hurt E. TREX is a conserved complex coupling transcription with messenger RNA export. Nature. 2002 May 16; 417(6886):304-8.
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  96. Mencía M, Moqtaderi Z, Geisberg JV, Kuras L, Struhl K. Activator-specific recruitment of TFIID and regulation of ribosomal protein genes in yeast. Mol Cell. 2002 Apr; 9(4):823-33.
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  97. Ng HH, Robert F, Young RA, Struhl K. Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Genes Dev. 2002 Apr 1; 16(7):806-19.
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  98. Katan-Khaykovich Y, Struhl K. Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors. Genes Dev. 2002 Mar 15; 16(6):743-52.
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  99. Struhl K. Gene regulation. A paradigm for precision. Science. 2001 Aug 10; 293(5532):1054-5.
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  100. Kulish D, Struhl K. TFIIS enhances transcriptional elongation through an artificial arrest site in vivo. Mol Cell Biol. 2001 Jul; 21(13):4162-8.
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  101. Tabor S, Struhl K. Enzymatic labeling of DNA. Curr Protoc Hum Genet. 2001 May; Appendix 3:Appendix 3E.
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  102. Tabor S, Struhl K. Endonucleases. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.12.
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  103. Lee M, Struhl K. Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein. Genetics. 2001 May; 158(1):87-93.
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  104. Struhl K. Subcloning of DNA fragments. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.16.
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  105. Baldwin AS, Oettinger M, Struhl K. Methylation and uracil interference assays for analysis of protein-DNA interactions. Curr Protoc Mol Biol. 2001 May; Chapter 12:Unit 12.3.
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  106. Struhl K. Reagents and radioisotopes used to manipulate nucleic acids. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.4.
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  107. Brown T, Struhl K. Hybridization analysis of DNA blots. Curr Protoc Protein Sci. 2001 May; Appendix 4:Appendix 4H.
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  108. Seidman CE, Struhl K. Introduction of plasmid DNA into cells. Curr Protoc Neurosci. 2001 May; Appendix 1:Appendix 1L.
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  109. Struhl K. Ribonucleases. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.13.
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  110. Struhl K. Analysis of DNA-protein interactions using proteins synthesized in vitro from cloned genes. Curr Protoc Mol Biol. 2001 May; Chapter 12:Unit 12.9.
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  111. Tabor S, Struhl K, Scharf SJ, Gelfand DH. DNA-dependent DNA polymerases. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.5.
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  112. Greene JM, Struhl K. S1 analysis of messenger RNA using single-stranded DNA probes. Curr Protoc Mol Biol. 2001 May; Chapter 4:Unit4.6.
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  113. Struhl K. Reagents and radioisotopes used to manipulate nucleic acids. Curr Protoc Immunol. 2001 May; Chapter 10:Unit 10.9.
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  114. Seidman CE, Struhl K. Introduction of plasmid DNA into cells. Curr Protoc Protein Sci. 2001 May; Appendix 4:4D.
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  115. Seidman CE, Struhl K, Sheen J, Jessen T. Introduction of plasmid DNA into cells. Curr Protoc Mol Biol. 2001 May; Chapter 1:Unit1.8.
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  116. Struhl K. Synthesizing proteins in vitro by transcription and translation of cloned genes. Curr Protoc Mol Biol. 2001 May; Chapter 10:Unit 10.17.
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  117. Geisberg JV, Holstege FC, Young RA, Struhl K. Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Mol Cell Biol. 2001 Apr; 21(8):2736-42.
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  118. Deckert J, Struhl K. Histone acetylation at promoters is differentially affected by specific activators and repressors. Mol Cell Biol. 2001 Apr; 21(8):2726-35.
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  119. Mencía M, Struhl K. Region of yeast TAF 130 required for TFIID to associate with promoters. Mol Cell Biol. 2001 Feb; 21(4):1145-54.
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  120. Kuo MH, vom Baur E, Struhl K, Allis CD. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. Mol Cell. 2000 Dec; 6(6):1309-20.
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  121. Reid JL, Iyer VR, Brown PO, Struhl K. Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell. 2000 Dec; 6(6):1297-307.
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  122. Mai X, Chou S, Struhl K. Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements. Mol Cell Biol. 2000 Sep; 20(18):6668-76.
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  123. Lee M, Chatterjee S, Struhl K. Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast. Genetics. 2000 Aug; 155(4):1535-42.
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  124. Dorris DR, Struhl K. Artificial recruitment of TFIID, but not RNA polymerase II holoenzyme, activates transcription in mammalian cells. Mol Cell Biol. 2000 Jun; 20(12):4350-8.
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  125. Garcia-Gimeno MA, Struhl K. Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol. 2000 Jun; 20(12):4340-9.
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  126. Kuras L, Kosa P, Mencia M, Struhl K. TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo. Science. 2000 May 19; 288(5469):1244-8.
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  127. Stargell LA, Moqtaderi Z, Dorris DR, Ogg RC, Struhl K. TFIIA has activator-dependent and core promoter functions in vivo. J Biol Chem. 2000 Apr 28; 275(17):12374-80.
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  128. Geisberg JV, Struhl K. TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo. Mol Cell Biol. 2000 Mar; 20(5):1478-88.
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  129. Chou S, Chatterjee S, Lee M, Struhl K. Transcriptional activation in yeast cells lacking transcription factor IIA. Genetics. 1999 Dec; 153(4):1573-81.
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  130. Struhl K. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell. 1999 Jul 9; 98(1):1-4.
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  131. Kuras L, Struhl K. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature. 1999 Jun 10; 399(6736):609-13.
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  132. Ranallo RT, Struhl K, Stargell LA. A TATA-binding protein mutant defective for TFIID complex formation in vivo. Mol Cell Biol. 1999 Jun; 19(6):3951-7.
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  133. Keaveney M, Struhl K. Incorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo. Genes Cells. 1999 Apr; 4(4):197-203.
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  134. Gaudreau L, Keaveney M, Nevado J, Zaman Z, Bryant GO, Struhl K, Ptashne M. Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2668-73.
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  135. Van Heeckeren WJ, Dorris DR, Struhl K. The mating-type proteins of fission yeast induce meiosis by directly activating mei3 transcription. Mol Cell Biol. 1998 Dec; 18(12):7317-26.
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  136. Benson JD, Benson M, Howley PM, Struhl K. Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes. EMBO J. 1998 Nov 16; 17(22):6714-22.
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  137. Moqtaderi Z, Keaveney M, Struhl K. The histone H3-like TAF is broadly required for transcription in yeast. Mol Cell. 1998 Nov; 2(5):675-82.
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  138. Kadosh D, Struhl K. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol. 1998 Sep; 18(9):5121-7.
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  139. Struhl K, Moqtaderi Z. The TAFs in the HAT. Cell. 1998 Jul 10; 94(1):1-4.
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  140. Keaveney M, Struhl K. Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast. Mol Cell. 1998 May; 1(6):917-24.
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  141. Kadosh D, Struhl K. Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev. 1998 Mar 15; 12(6):797-805.
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  142. Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 1998 Mar 1; 12(5):599-606.
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  143. Struhl K, Kadosh D, Keaveney M, Kuras L, Moqtaderi Z. Activation and repression mechanisms in yeast. Cold Spring Harb Symp Quant Biol. 1998; 63:413-21.
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  144. Chou S, Struhl K. Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains. Mol Cell Biol. 1997 Dec; 17(12):6794-802.
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  145. Fernandes L, Rodrigues-Pousada C, Struhl K. Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol. 1997 Dec; 17(12):6982-93.
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  146. Kadosh D, Struhl K. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell. 1997 May 2; 89(3):365-71.
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  147. Mahadevan S, Raghunand TR, Panicker S, Struhl K. Characterisation of 3' end formation of the yeast HIS3 mRNA. Gene. 1997 Apr 29; 190(1):69-76.
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  148. Lee M, Struhl K. A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo. Mol Cell Biol. 1997 Mar; 17(3):1336-45.
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  149. Struhl K. Selective roles for TATA-binding-protein-associated factors in vivo. Genes Funct. 1997 Feb; 1(1):5-9.
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  150. De Rubertis F, Kadosh D, Henchoz S, Pauli D, Reuter G, Struhl K, Spierer P. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature. 1996 Dec 12; 384(6609):589-91.
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  151. Moqtaderi Z, Yale JD, Struhl K, Buratowski S. Yeast homologues of higher eukaryotic TFIID subunits. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14654-8.
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  152. Struhl K. Transcriptional enhancement by acidic activators. Biochim Biophys Acta. 1996 Dec 9; 1288(3):O15-7.
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  153. Moqtaderi Z, Bai Y, Poon D, Weil PA, Struhl K. TBP-associated factors are not generally required for transcriptional activation in yeast. Nature. 1996 Sep 12; 383(6596):188-91.
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  154. Stargell LA, Struhl K. A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo. Mol Cell Biol. 1996 Aug; 16(8):4456-64.
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  155. Stargell LA, Struhl K. Mechanisms of transcriptional activation in vivo: two steps forward. Trends Genet. 1996 Aug; 12(8):311-5.
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  156. Iyer V, Struhl K. Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5208-12.
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  157. Struhl K. Chromatin structure and RNA polymerase II connection: implications for transcription. Cell. 1996 Jan 26; 84(2):179-82.
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  158. Iyer V, Struhl K. Mechanism of differential utilization of the his3 TR and TC TATA elements. Mol Cell Biol. 1995 Dec; 15(12):7059-66.
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  159. Lee M, Struhl K. Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo. Mol Cell Biol. 1995 Oct; 15(10):5461-9.
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  160. Kim J, Struhl K. Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains. Nucleic Acids Res. 1995 Jul 11; 23(13):2531-7.
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  161. Stargell LA, Struhl K. The TBP-TFIIA interaction in the response to acidic activators in vivo. Science. 1995 Jul 7; 269(5220):75-8.
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  162. Iyer V, Struhl K. Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure. EMBO J. 1995 Jun 1; 14(11):2570-9.
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  163. Chatterjee S, Struhl K. Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain. Nature. 1995 Apr 27; 374(6525):820-2.
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  164. Tzamarias D, Struhl K. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev. 1995 Apr 1; 9(7):821-31.
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  165. Ponticelli AS, Pardee TS, Struhl K. The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1995 Feb; 15(2):983-8.
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  166. Struhl K. Yeast transcriptional regulatory mechanisms. Annu Rev Genet. 1995; 29:651-74.
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  167. Klein C, Struhl K. Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo. Science. 1994 Oct 14; 266(5183):280-2.
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  168. Tzamarias D, Struhl K. Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex. Nature. 1994 Jun 30; 369(6483):758-61.
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  169. Cormack BP, Strubin M, Stargell LA, Struhl K. Conserved and nonconserved functions of the yeast and human TATA-binding proteins. Genes Dev. 1994 Jun 1; 8(11):1335-43.
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  170. Arndt KM, Wobbe CR, Ricupero-Hovasse S, Struhl K, Winston F. Equivalent mutations in the two repeats of yeast TATA-binding protein confer distinct TATA recognition specificities. Mol Cell Biol. 1994 Jun; 14(6):3719-28.
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  171. Engelberg D, Klein C, Martinetto H, Struhl K, Karin M. The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell. 1994 May 6; 77(3):381-90.
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  172. Collart MA, Struhl K. NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev. 1994 Mar 1; 8(5):525-37.
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  173. Klein C, Struhl K. Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity. Mol Cell Biol. 1994 Mar; 14(3):1920-8.
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  174. Struhl K. Duality of TBP, the universal transcription factor. Science. 1994 Feb 25; 263(5150):1103-4.
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  175. Cormack BP, Struhl K. Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription. Science. 1993 Oct 8; 262(5131):244-8.
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  176. Pu WT, Struhl K. Dimerization of leucine zippers analyzed by random selection. Nucleic Acids Res. 1993 Sep 11; 21(18):4348-55.
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  177. Struhl K. Yeast transcription factors. Curr Opin Cell Biol. 1993 Jun; 5(3):513-20.
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  178. Kim J, Tzamarias D, Ellenberger T, Harrison SC, Struhl K. Adaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4513-7.
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  179. Struhl K. Gene expression: chromatin and transcription factors: who's on first? Curr Biol. 1993 Apr 1; 3(4):220-2.
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  180. Collart MA, Struhl K. CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. EMBO J. 1993 Jan; 12(1):177-86.
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  181. Ellenberger TE, Brandl CJ, Struhl K, Harrison SC. The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell. 1992 Dec 24; 71(7):1223-37.
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  182. Vincent AC, Struhl K. ACR1, a yeast ATF/CREB repressor. Mol Cell Biol. 1992 Dec; 12(12):5394-405.
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  183. Oliviero S, Robinson GS, Struhl K, Spiegelman BM. Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation. Genes Dev. 1992 Sep; 6(9):1799-809.
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  184. van Heeckeren WJ, Sellers JW, Struhl K. Role of the conserved leucines in the leucine zipper dimerization motif of yeast GCN4. Nucleic Acids Res. 1992 Jul 25; 20(14):3721-4.
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  185. Cormack BP, Struhl K. The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells. Cell. 1992 May 15; 69(4):685-96.
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  186. Tzamarias D, Pu WT, Struhl K. Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2007-11.
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  187. Pu WT, Struhl K. Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res. 1992 Feb 25; 20(4):771-5.
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  188. Strubin M, Struhl K. Yeast and human TFIID with altered DNA-binding specificity for TATA elements. Cell. 1992 Feb 21; 68(4):721-30.
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  189. Kelleher RJ, Flanagan PM, Chasman DI, Ponticelli AS, Struhl K, Kornberg RD. Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro. Genes Dev. 1992 Feb; 6(2):296-303.
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  190. Struhl K, Cameron JR, Davis RW. Functional genetic expression of eukaryotic DNA in Escherichia coli. 1976. Biotechnology. 1992; 24:353-7.
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  191. Pu WT, Struhl K. Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol. 1991 Oct; 11(10):4918-26.
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  192. Pu WT, Struhl K. The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):6901-5.
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  193. Struhl K. Mechanisms for diversity in gene expression patterns. Neuron. 1991 Aug; 7(2):177-81.
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  194. Cormack BP, Strubin M, Ponticelli AS, Struhl K. Functional differences between yeast and human TFIID are localized to the highly conserved region. Cell. 1991 Apr 19; 65(2):341-8.
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  195. Oliviero S, Struhl K. Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter. Proc Natl Acad Sci U S A. 1991 Jan 1; 88(1):224-8.
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  196. Struhl K. Reverse biochemistry: methods and applications for synthesizing yeast proteins in vitro. Methods Enzymol. 1991; 194:520-35.
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  197. Weiss MA, Ellenberger T, Wobbe CR, Lee JP, Harrison SC, Struhl K. Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA. Nature. 1990 Oct 11; 347(6293):575-8.
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  198. Sellers JW, Vincent AC, Struhl K. Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites. Mol Cell Biol. 1990 Oct; 10(10):5077-86.
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  199. Mahadevan S, Struhl K. Tc, an unusual promoter element required for constitutive transcription of the yeast HIS3 gene. Mol Cell Biol. 1990 Sep; 10(9):4447-55.
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  200. Brandl CJ, Struhl K. A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element. Mol Cell Biol. 1990 Aug; 10(8):4256-65.
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  201. Wobbe CR, Struhl K. Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro. Mol Cell Biol. 1990 Aug; 10(8):3859-67.
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  202. Ponticelli AS, Struhl K. Analysis of Saccharomyces cerevisiae his3 transcription in vitro: biochemical support for multiple mechanisms of transcription. Mol Cell Biol. 1990 Jun; 10(6):2832-9.
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  203. Singer VL, Wobbe CR, Struhl K. A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation. Genes Dev. 1990 Apr; 4(4):636-45.
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  204. Harbury PA, Struhl K. Functional distinctions between yeast TATA elements. Mol Cell Biol. 1989 Dec; 9(12):5298-304.
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  205. Oliphant AR, Struhl K. An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9094-8.
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  206. Sellers JW, Struhl K. Changing fos oncoprotein to a jun-independent DNA binding protein with GCN4 dimerization specificity by swapping "leucine zippers". Nature. 1989 Sep 7; 341(6237):74-6.
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  207. Oliphant AR, Brandl CJ, Struhl K. Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein. Mol Cell Biol. 1989 Jul; 9(7):2944-9.
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  208. Struhl G, Struhl K, Macdonald PM. The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell. 1989 Jun 30; 57(7):1259-73.
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  209. Struhl K. Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins. Trends Biochem Sci. 1989 Apr; 14(4):137-40.
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  210. Brandl CJ, Struhl K. Yeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2652-6.
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  211. Chen W, Struhl K. Yeast upstream activator protein GCN4 can stimulate transcription when its binding site replaces the TATA element. EMBO J. 1989 Jan; 8(1):261-8.
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  212. Struhl K. Molecular mechanisms of transcriptional regulation in yeast. Annu Rev Biochem. 1989; 58:1051-77.
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  213. Hill DE, Struhl K. Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation. Nucleic Acids Res. 1988 Oct 11; 16(19):9253-65.
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  214. Oliphant AR, Struhl K. Defining the consensus sequences of E.coli promoter elements by random selection. Nucleic Acids Res. 1988 Aug 11; 16(15):7673-83.
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  215. Hope IA, Mahadevan S, Struhl K. Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein. Nature. 1988 Jun 16; 333(6174):635-40.
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  216. Struhl K. The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast. Nature. 1988 Apr 14; 332(6165):649-50.
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  217. Chen W, Struhl K. Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2691-5.
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  218. Kanazawa S, Driscoll M, Struhl K. ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol Cell Biol. 1988 Feb; 8(2):664-73.
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  219. Struhl K, Brandl CJ, Chen W, Harbury PA, Hope IA, Mahadevan S. Transcriptional activation by yeast GCN4, a functional homolog to the jun oncoprotein. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:701-9.
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  220. Chen W, Tabor S, Struhl K. Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell. 1987 Sep 25; 50(7):1047-55.
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  221. Struhl K. The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Cell. 1987 Sep 11; 50(6):841-6.
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  222. Hope IA, Struhl K. GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J. 1987 Sep; 6(9):2781-4.
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  223. Struhl K. Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast. Cell. 1987 May 8; 49(3):295-7.
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  224. Struhl K. Effect of deletion and insertion on double-strand-break repair in Saccharomyces cerevisiae. Mol Cell Biol. 1987 Mar; 7(3):1300-3.
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  225. Hill DE, Oliphant AR, Struhl K. Mutagenesis with degenerate oligonucleotides: an efficient method for saturating a defined DNA region with base pair substitutions. Methods Enzymol. 1987; 155:558-68.
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  226. Oliphant AR, Struhl K. The use of random-sequence oligonucleotides for determining consensus sequences. Methods Enzymol. 1987; 155:568-82.
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  227. Struhl K, Hill DE. Two related regulatory sequences are required for maximal induction of Saccharomyces cerevisiae his3 transcription. Mol Cell Biol. 1987 Jan; 7(1):104-10.
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  228. Hill DE, Struhl K. A rapid method for determining tRNA charging levels in vivo: analysis of yeast mutants defective in the general control of amino acid biosynthesis. Nucleic Acids Res. 1986 Dec 22; 14(24):10045-51.
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  229. Struhl K. Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms. Mol Cell Biol. 1986 Nov; 6(11):3847-53.
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  230. Hill DE, Hope IA, Macke JP, Struhl K. Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activator protein. Science. 1986 Oct 24; 234(4775):451-7.
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  231. Struhl K. Yeast HIS3 expression in Escherichia coli depends upon fortuitous homology between eukaryotic and prokaryotic promoter elements. J Mol Biol. 1986 Sep 20; 191(2):221-9.
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  232. Hope IA, Struhl K. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell. 1986 Sep 12; 46(6):885-94.
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  233. Oliphant AR, Nussbaum AL, Struhl K. Cloning of random-sequence oligodeoxynucleotides. Gene. 1986; 44(2-3):177-83.
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  234. Struhl K. Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene region. Nucleic Acids Res. 1985 Dec 9; 13(23):8587-601.
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  235. Struhl K. Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8419-23.
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  236. Chen W, Struhl K. Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J. 1985 Dec 1; 4(12):3273-80.
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  237. Hope IA, Struhl K. GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell. 1985 Nov; 43(1):177-88.
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  238. Struhl K. Negative control at a distance mediates catabolite repression in yeast. Nature. 1985 Oct 31-Nov 6; 317(6040):822-4.
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  239. Oettinger MA, Struhl K. Suppressors of Saccharomyces cerevisiae his3 promoter mutations lacking the upstream element. Mol Cell Biol. 1985 Aug; 5(8):1901-9.
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  240. Struhl K, Chen W, Hill DE, Hope IA, Oettinger MA. Constitutive and coordinately regulated transcription of yeast genes: promoter elements, positive and negative regulatory sites, and DNA binding proteins. Cold Spring Harb Symp Quant Biol. 1985; 50:489-503.
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  241. Struhl K. Genetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7865-9.
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  242. Struhl K. Direct selection for gene replacement events in yeast. Gene. 1983 Dec; 26(2-3):231-41.
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  243. Struhl K. The new yeast genetics. Nature. 1983 Sep 29-Oct 5; 305(5933):391-7.
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  244. Struhl K. Promoter elements, regulatory elements, and chromatin structure of the yeast his3 gene. Cold Spring Harb Symp Quant Biol. 1983; 47 Pt 2:901-10.
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  245. Struhl K. The yeast his3 promoter contains at least two distinct elements. Proc Natl Acad Sci U S A. 1982 Dec; 79(23):7385-9.
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  246. Struhl K. Regulatory sites for his3 gene expression in yeast. Nature. 1982 Nov 18; 300(5889):285-6.
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  247. Struhl K, Davis RW. Promotor mutants of the yeast his3 gene. J Mol Biol. 1981 Nov 5; 152(3):553-68.
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  248. Struhl K, Davis RW. Position effects in Saccharomyces cerevisiae. J Mol Biol. 1981 Nov 5; 152(3):569-75.
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  249. Struhl K, Davis RW. Transcription of the his3 gene region in Saccharomyces cerevisiae. J Mol Biol. 1981 Nov 5; 152(3):535-52.
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  250. Struhl K. Deletion, recombination and gene expression involving the bacteriophage lambda attachment site. J Mol Biol. 1981 Nov 5; 152(3):517-33.
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  251. Struhl K. Deletion mapping a eukaryotic promoter. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4461-5.
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  252. Struhl K, Davis RW. Conservation and DNA sequence arrangement of the DNA polymerase I gene region from Klebsiella aerogenes, Klebsiella pneumoniae and Escherichia coli. J Mol Biol. 1980 Aug 25; 141(4):343-68.
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  253. Struhl K, Davis RW. A physical, genetic and transcriptional map of the cloned his3 gene region of Saccharomyces cerevisiae. J Mol Biol. 1980 Jan 25; 136(3):309-32.
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  254. Struhl K, Stinchcomb DT, Davis RW. A physiological study of functional expression in Escherichia coli of the cloned yeast imidazoleglycerolphosphate dehydratase gene. J Mol Biol. 1980 Jan 25; 136(3):291-307.
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  255. Brennan MB, Struhl K. Mechanisms of increasing expression of a yeast gene in Escherichia coli. J Mol Biol. 1980 Jan 25; 136(3):333-8.
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  256. Botstein D, Falco SC, Stewart SE, Brennan M, Scherer S, Stinchcomb DT, Struhl K, Davis RW. Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene. 1979 Dec; 8(1):17-24.
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  257. Stinchcomb DT, Struhl K, Davis RW. Isolation and characterisation of a yeast chromosomal replicator. Nature. 1979 Nov 1; 282(5734):39-43.
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  258. Struhl K, Davis RW, Fink GR. Suppression of a yeast amber mutation in Escherichia coli. Nature. 1979 May 3; 279(5708):78-9.
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  259. Struhl K, Stinchcomb DT, Scherer S, Davis RW. High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1035-9.
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  260. Struhl K, Davis RW. Production of a functional eukaryotic enzyme in Escherichia coli: cloning and expression of the yeast structural gene for imidazole-glycerolphosphate dehydratase (his3). Proc Natl Acad Sci U S A. 1977 Dec; 74(12):5255-9.
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  261. Struhl K, Magasanik B. Ammonia-sensitive mutant of Klebsiella aerogenes. J Bacteriol. 1976 May; 126(2):739-42.
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  262. Struhl K, Cameron JR, Davis RW. Functional genetic expression of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A. 1976 May; 73(5):1471-5.
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