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Sara Whitney Lazar, PH.D.

TitleInstructor in Psychology in the Department of Psychiatry
InstitutionMassachusetts General Hospital
DepartmentPsychiatry
AddressMassachusetts General Hospital
Psychiatry - 2nd floor
149 13th Street
Charlestown MA 02129
Phone617/724-9602

 Mentoring 
 current student opportunities
Available: 09/01/12, Expires: 08/30/14

We use neuroimaging to understand how brain activity and structure change as a result of meditation and yoga training. Healthy but stressed individuals are randomized to either a meditation-based stress reduction intervention or health education control intervention. MRI measures of brain function and structure are acquired before and after each intervention, as well as measures of emotion regulation, attention, and well-being. We are also interested in brain-body interaction and the effect of meditation on stress reactivity. The student would be involved in data collection and the analysis of behavioral and questionnaire data. Students really committed to learning MRI data analysis and who can devote sufficient amounts of time can be trained to do so. We also need clinicians to administer the SCID to potential study participants.

 completed student projects
Defining and Measuring Mindfulness
Summer, 06/06/12 - 08/01/12

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kerr CE, Sacchet MD, Lazar SW, Moore CI, Jones SR. Mindfulness starts with the body: somatosensory attention and top-down modulation of cortical alpha rhythms in mindfulness meditation. Front Hum Neurosci. 2013; 7:12.
    View in: PubMed
  2. Kodituwakku S, Lazar SW, Indic P, Chen Z, Brown EN, Barbieri R. Point process time-frequency analysis of dynamic respiratory patterns during meditation practice. Med Biol Eng Comput. 2012 Mar; 50(3):261-75.
    View in: PubMed
  3. Gard T, Hölzel BK, Sack AT, Hempel H, Lazar SW, Vaitl D, Ott U. Pain attenuation through mindfulness is associated with decreased cognitive control and increased sensory processing in the brain. Cereb Cortex. 2012 Nov; 22(11):2692-702.
    View in: PubMed
  4. Stange JP, Eisner LR, Hölzel BK, Peckham AD, Dougherty DD, Rauch SL, Nierenberg AA, Lazar S, Deckersbach T. Mindfulness-based cognitive therapy for bipolar disorder: effects on cognitive functioning. J Psychiatr Pract. 2011 Nov; 17(6):410-9.
    View in: PubMed
  5. Kerr CE, Jones SR, Wan Q, Pritchett DL, Wasserman RH, Wexler A, Villanueva JJ, Shaw JR, Lazar SW, Kaptchuk TJ, Littenberg R, Hämäläinen MS, Moore CI. Effects of mindfulness meditation training on anticipatory alpha modulation in primary somatosensory cortex. Brain Res Bull. 2011 May 30; 85(3-4):96-103.
    View in: PubMed
  6. Deckersbach T, Hölzel BK, Eisner LR, Stange JP, Peckham AD, Dougherty DD, Rauch SL, Lazar S, Nierenberg AA. Mindfulness-based cognitive therapy for nonremitted patients with bipolar disorder. CNS Neurosci Ther. 2012 Feb; 18(2):133-41.
    View in: PubMed
  7. Hölzel BK, Carmody J, Vangel M, Congleton C, Yerramsetti SM, Gard T, Lazar SW. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res. 2011 Jan 30; 191(1):36-43.
    View in: PubMed
  8. Van Dijk KR, Hedden T, Venkataraman A, Evans KC, Lazar SW, Buckner RL. Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. J Neurophysiol. 2010 Jan; 103(1):297-321.
    View in: PubMed
  9. Hölzel BK, Carmody J, Evans KC, Hoge EA, Dusek JA, Morgan L, Pitman RK, Lazar SW. Stress reduction correlates with structural changes in the amygdala. Soc Cogn Affect Neurosci. 2010 Mar; 5(1):11-7.
    View in: PubMed
  10. Evans KC, Dougherty DD, Schmid AM, Scannell E, McCallister A, Benson H, Dusek JA, Lazar SW. Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI study. Neuroimage. 2009 Sep; 47(3):961-71.
    View in: PubMed
  11. Dusek JA, Chang BH, Zaki J, Lazar S, Deykin A, Stefano GB, Wohlhueter AL, Hibberd PL, Benson H. Association between oxygen consumption and nitric oxide production during the relaxation response. Med Sci Monit. 2006 Jan; 12(1):CR1-10.
    View in: PubMed
  12. Lazar SW, Kerr CE, Wasserman RH, Gray JR, Greve DN, Treadway MT, McGarvey M, Quinn BT, Dusek JA, Benson H, Rauch SL, Moore CI, Fischl B. Meditation experience is associated with increased cortical thickness. Neuroreport. 2005 Nov 28; 16(17):1893-7.
    View in: PubMed
  13. Lazar SW, Bush G, Gollub RL, Fricchione GL, Khalsa G, Benson H. Functional brain mapping of the relaxation response and meditation. Neuroreport. 2000 May 15; 11(7):1581-5.
    View in: PubMed
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