David A. Boas, Ph.D.
| Title | Professor of Radiology |
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| Institution | Massachusetts General Hospital |
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| Department | Radiology |
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| Address | Massachusetts General Hospital Radiology - NMR Ctr/2nd FL 149 13th Street Charlestown MA 02129
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| Phone | 617/724-0130 |
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| Fax | 617/643-5136 |
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| Title | Member of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology |
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| Institution | Massachusetts Institute of Technology |
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| Department | Health Sciences and Technology |
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Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Yaseen MA, Sakadžic S, Wu W, Becker W, Kasischke KA, Boas DA. In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH. Biomed Opt Express. 2013 Feb 1; 4(2):307-21.
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Cooper RJ, Selb J, Gagnon L, Phillip D, Schytz HW, Iversen HK, Ashina M, Boas DA. A systematic comparison of motion artifact correction techniques for functional near-infrared spectroscopy. Front Neurosci. 2012; 6:147.
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Lee J, Wu W, Jiang JY, Zhu B, Boas DA. Dynamic light scattering optical coherence tomography. Opt Express. 2012 Sep 24; 20(20):22262-77.
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Phillip D, Schytz HW, Selb J, Payne S, Iversen HK, Skovgaard LT, Boas DA, Ashina M. Low frequency oscillations in cephalic vessels assessed by near infrared spectroscopy. Eur J Clin Invest. 2012 Nov; 42(11):1180-8.
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Lee J, Boas DA. Frequency-domain measurement of neuronal activity using dynamic optical coherence tomography. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:2643-6.
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Wilcox T, Stubbs J, Hirshkowitz A, Boas DA. Functional activation of the infant cortex during object processing. Neuroimage. 2012 Sep; 62(3):1833-40.
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Cooper RJ, Caffini M, Dubb J, Fang Q, Custo A, Tsuzuki D, Fischl B, Wells W, Dan I, Boas DA. Validating atlas-guided DOT: a comparison of diffuse optical tomography informed by atlas and subject-specific anatomies. Neuroimage. 2012 Sep; 62(3):1999-2006.
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Yücel MA, Huppert TJ, Boas DA, Gagnon L. Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data. Neuroimage. 2012 Jul 16; 61(4):1268-76.
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Schytz HW, Hansen JM, Phillip D, Selb J, Boas DA, Ashina M. Nitric oxide modulation of low-frequency oscillations in cortical vessels in FHM--a NIRS study. Headache. 2012 Jul-Aug; 52(7):1146-54.
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Devor A, Boas D. Neurovascular imaging. Front Neuroenergetics. 2012; 4:1.
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Devor A, Sakadžic S, Srinivasan VJ, Yaseen MA, Nizar K, Saisan PA, Tian P, Dale AM, Vinogradov SA, Franceschini MA, Boas DA. Frontiers in optical imaging of cerebral blood flow and metabolism. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1259-76.
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Zimmermann BB, Roche-Labarbe N, Surova A, Boas DA, Wolf M, Grant PE, Franceschini MA. The confounding effect of systemic physiology on the hemodynamic response in newborns. Adv Exp Med Biol. 2012; 737:103-9.
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Boas DA, Franceschini MA. Haemoglobin oxygen saturation as a biomarker: the problem and a solution. Philos Transact A Math Phys Eng Sci. 2011 Nov 28; 369(1955):4407-24.
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Cooper RJ, Gagnon L, Goldenholz DM, Boas DA, Greve DN. The utility of near-infrared spectroscopy in the regression of low-frequency physiological noise from functional magnetic resonance imaging data. Neuroimage. 2012 Feb 15; 59(4):3128-38.
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Lee J, Srinivasan V, Radhakrishnan H, Boas DA. Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex. Opt Express. 2011 Oct 24; 19(22):21258-70.
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Gagnon L, Yücel MA, Dehaes M, Cooper RJ, Perdue KL, Selb J, Huppert TJ, Hoge RD, Boas DA. Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. Neuroimage. 2012 Feb 15; 59(4):3933-40.
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Yuzawa I, Sakadžic S, Srinivasan VJ, Shin HK, Eikermann-Haerter K, Boas DA, Ayata C. Cortical spreading depression impairs oxygen delivery and metabolism in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):376-86.
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Baraghis E, Devor A, Fang Q, Srinivasan VJ, Wu W, Lesage F, Ayata C, Kasischke KA, Boas DA, Sakadzic S. Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. J Biomed Opt. 2011 Oct; 16(10):106003.
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Devor A, Sakadzic S, Saisan PA, Yaseen MA, Roussakis E, Srinivasan VJ, Vinogradov SA, Rosen BR, Buxton RB, Dale AM, Boas DA. "Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci. 2011 Sep 21; 31(38):13676-81.
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Gagnon L, Cooper RJ, Yücel MA, Perdue KL, Greve DN, Boas DA. Short separation channel location impacts the performance of short channel regression in NIRS. Neuroimage. 2012 Feb 1; 59(3):2518-28.
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Carp SA, Roche-Labarbe N, Franceschini MA, Srinivasan VJ, Sakadžic S, Boas DA. Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels. Biomed Opt Express. 2011 Jul 1; 2(7):2047-54.
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Lee J, Boas DA, Kim SJ. Multiphysics neuron model for cellular volume dynamics. IEEE Trans Biomed Eng. 2011 Oct; 58(10):3000-3.
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Mazhar A, Cuccia DJ, Rice TB, Carp SA, Durkin AJ, Boas DA, Choi B, Tromberg BJ. Laser speckle imaging in the spatial frequency domain. Biomed Opt Express. 2011 Jun 1; 2(6):1553-63.
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Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011; (51).
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Gagnon L, Perdue K, Greve DN, Goldenholz D, Kaskhedikar G, Boas DA. Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling. Neuroimage. 2011 Jun 1; 56(3):1362-71.
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Srinivasan VJ, Atochin DN, Radhakrishnan H, Jiang JY, Ruvinskaya S, Wu W, Barry S, Cable AE, Ayata C, Huang PL, Boas DA. Optical coherence tomography for the quantitative study of cerebrovascular physiology. J Cereb Blood Flow Metab. 2011 Jun; 31(6):1339-45.
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Dehaes M, Grant PE, Sliva DD, Roche-Labarbe N, Pienaar R, Boas DA, Franceschini MA, Selb J. Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. Biomed Opt Express. 2011; 2(3):552-67.
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Tian P, Devor A, Sakadzic S, Dale AM, Boas DA. Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain. J Biomed Opt. 2011 Jan-Feb; 16(1):016006.
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Yaseen MA, Srinivasan VJ, Sakadžic S, Radhakrishnan H, Gorczynska I, Wu W, Fujimoto JG, Boas DA. Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation. J Cereb Blood Flow Metab. 2011 Apr; 31(4):1051-63.
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Radhakrishnan H, Wu W, Boas D, Franceschini MA. Study of neurovascular coupling by modulating neuronal activity with GABA. Brain Res. 2011 Feb 4; 1372:1-12.
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Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA. Combined optical and X-ray tomosynthesis breast imaging. Radiology. 2011 Jan; 258(1):89-97.
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Schytz HW, Hansson A, Phillip D, Selb J, Boas DA, Iversen HK, Ashina M. Spontaneous low-frequency oscillations in cerebral vessels: applications in carotid artery disease and ischemic stroke. J Stroke Cerebrovasc Dis. 2010 Nov-Dec; 19(6):465-74.
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Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EM, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJ, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15246-51.
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Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9.
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Chen HC, Vaid J, Boas DA, Bortfeld H. Examining the phonological neighborhood density effect using near infrared spectroscopy. Hum Brain Mapp. 2011 Sep; 32(9):1363-70.
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Wilcox T, Haslup JA, Boas DA. Dissociation of processing of featural and spatiotemporal information in the infant cortex. Neuroimage. 2010 Dec; 53(4):1256-63.
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Raymond SB, Boas DA, Bacskai BJ, Kumar AT. Lifetime-based tomographic multiplexing. J Biomed Opt. 2010 Jul-Aug; 15(4):046011.
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Hyde DC, Boas DA, Blair C, Carey S. Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infants. Neuroimage. 2010 Nov 1; 53(2):647-52.
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Franceschini MA, Radhakrishnan H, Thakur K, Wu W, Ruvinskaya S, Carp S, Boas DA. The effect of different anesthetics on neurovascular coupling. Neuroimage. 2010 Jul 15; 51(4):1367-77.
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Roche-Labarbe N, Carp SA, Surova A, Patel M, Boas DA, Grant PE, Franceschini MA. Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life. Hum Brain Mapp. 2010 Mar; 31(3):341-52.
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Srinivasan VJ, Sakadzic S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA. Quantitative cerebral blood flow with optical coherence tomography. Opt Express. 2010 Feb 1; 18(3):2477-94.
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Sukhotinsky I, Yaseen MA, Sakadzic S, Ruvinskaya S, Sims JR, Boas DA, Moskowitz MA, Ayata C. Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1168-77.
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Boas DA, Dunn AK. Laser speckle contrast imaging in biomedical optics. J Biomed Opt. 2010 Jan-Feb; 15(1):011109.
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Srinivasan VJ, Jiang JY, Yaseen MA, Radhakrishnan H, Wu W, Barry S, Cable AE, Boas DA. Rapid volumetric angiography of cortical microvasculature with optical coherence tomography. Opt Lett. 2010 Jan 1; 35(1):43-5.
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Yaseen MA, Srinivasan VJ, Sakadzic S, Wu W, Ruvinskaya S, Vinogradov SA, Boas DA. Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy. Opt Express. 2009 Dec 7; 17(25):22341-50.
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Becerra L, Harris W, Grant M, George E, Boas D, Borsook D. Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli. PLoS One. 2009; 4(11):e8016.
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Yücel MA, Devor A, Akin A, Boas DA. The Possible Role of CO(2) in Producing A Post-Stimulus CBF and BOLD Undershoot. Front Neuroenergetics. 2009; 1:7.
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Fang Q, Boas DA. Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing units. Opt Express. 2009 Oct 26; 17(22):20178-90.
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Srinivasan VJ, Sakadzic S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA. Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Opt Lett. 2009 Oct 15; 34(20):3086-8.
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Raymond SB, Kumar AT, Boas DA, Bacskai BJ. Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models. Phys Med Biol. 2009 Oct 21; 54(20):6201-16.
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Boas DA, Payne SJ. Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'. Physiol Meas. 2009 Oct; 30(10):L9-L11; author reply L13-L14.
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Muehlschlegel S, Selb J, Patel M, Diamond SG, Franceschini MA, Sorensen AG, Boas DA, Schwamm LH. Feasibility of NIRS in the neurointensive care unit: a pilot study in stroke using physiological oscillations. Neurocrit Care. 2009; 11(2):288-95.
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Custo A, Boas DA, Tsuzuki D, Dan I, Mesquita R, Fischl B, Grimson WE, Wells W. Anatomical atlas-guided diffuse optical tomography of brain activation. Neuroimage. 2010 Jan 1; 49(1):561-7.
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Payne SJ, Selb J, Boas DA. Effects of autoregulation and CO2 reactivity on cerebral oxygen transport. Ann Biomed Eng. 2009 Nov; 37(11):2288-98.
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Grant PE, Roche-Labarbe N, Surova A, Themelis G, Selb J, Warren EK, Krishnamoorthy KS, Boas DA, Franceschini MA. Increased cerebral blood volume and oxygen consumption in neonatal brain injury. J Cereb Blood Flow Metab. 2009 Oct; 29(10):1704-13.
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Huppert TJ, Jones PB, Devor A, Dunn AK, Teng IC, Dale AM, Boas DA. Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia. J Biomed Opt. 2009 Jul-Aug; 14(4):044038.
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Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA. Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Opt Lett. 2009 Jul 1; 34(13):2066-8.
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Lebedev AY, Cheprakov AV, Sakadzic S, Boas DA, Wilson DF, Vinogradov SA. Dendritic phosphorescent probes for oxygen imaging in biological systems. ACS Appl Mater Interfaces. 2009 Jun; 1(6):1292-304.
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Diamond SG, Perdue KL, Boas DA. A cerebrovascular response model for functional neuroimaging including dynamic cerebral autoregulation. Math Biosci. 2009 Aug; 220(2):102-17.
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Huppert TJ, Allen MS, Diamond SG, Boas DA. Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model. Hum Brain Mapp. 2009 May; 30(5):1548-67.
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Huppert TJ, Diamond SG, Franceschini MA, Boas DA. HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain. Appl Opt. 2009 Apr 1; 48(10):D280-98.
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Schytz HW, Wienecke T, Jensen LT, Selb J, Boas DA, Ashina M. Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT. Eur J Neurol. 2009 Apr; 16(4):461-7.
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Sakadzic S, Yuan S, Dilekoz E, Ruvinskaya S, Vinogradov SA, Ayata C, Boas DA. Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression. Appl Opt. 2009 Apr 1; 48(10):D169-77.
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Ou W, Nissilä I, Radhakrishnan H, Boas DA, Hämäläinen MS, Franceschini MA. Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition. Neuroimage. 2009 Jul 1; 46(3):624-32.
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Keller CJ, Cash SS, Narayanan S, Wang C, Kuzniecky R, Carlson C, Devinsky O, Thesen T, Doyle W, Sassaroli A, Boas DA, Ulbert I, Halgren E. Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex. J Neurosci Methods. 2009 May 15; 179(2):208-18.
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Bortfeld H, Fava E, Boas DA. Identifying cortical lateralization of speech processing in infants using near-infrared spectroscopy. Dev Neuropsychol. 2009; 34(1):52-65.
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Fang Q, Carp SA, Selb J, Boverman G, Zhang Q, Kopans DB, Moore RH, Miller EL, Brooks DH, Boas DA. Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans Med Imaging. 2009 Jan; 28(1):30-42.
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Devor A, Hillman EM, Tian P, Waeber C, Teng IC, Ruvinskaya L, Shalinsky MH, Zhu H, Haslinger RH, Narayanan SN, Ulbert I, Dunn AK, Lo EH, Rosen BR, Dale AM, Kleinfeld D, Boas DA. Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci. 2008 Dec 31; 28(53):14347-57.
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Radhakrishnan H, Vanduffel W, Deng HP, Ekstrom L, Boas DA, Franceschini MA. Fast optical signal not detected in awake behaving monkeys. Neuroimage. 2009 Apr 1; 45(2):410-9.
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Mesquita RC, Huppert TJ, Boas DA. Exploring neuro-vascular and neuro-metabolic coupling in rat somatosensory cortex. Phys Med Biol. 2009 Jan 21; 54(2):175-85.
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Chen Y, Aguirre AD, Ruvinskaya L, Devor A, Boas DA, Fujimoto JG. Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation. J Neurosci Methods. 2009 Mar 30; 178(1):162-73.
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Sakadzic S, Demirbas U, Mempel TR, Moore A, Ruvinskaya S, Boas DA, Sennaroglu A, Kaertner FX, Fujimoto JG. Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser. Opt Express. 2008 Dec 8; 16(25):20848-63.
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Wilcox T, Bortfeld H, Woods R, Wruck E, Armstrong J, Boas D. Hemodynamic changes in the infant cortex during the processing of featural and spatiotemporal information. Neuropsychologia. 2009 Feb; 47(3):657-62.
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Fang Q, Sakadzic S, Ruvinskaya L, Devor A, Dale AM, Boas DA. Oxygen advection and diffusion in a three- dimensional vascular anatomical network. Opt Express. 2008 Oct 27; 16(22):17530-41.
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Carp SA, Selb J, Fang Q, Moore R, Kopans DB, Rafferty E, Boas DA. Dynamic functional and mechanical response of breast tissue to compression. Opt Express. 2008 Sep 29; 16(20):16064-78.
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Huppert TJ, Diamond SG, Boas DA. Direct estimation of evoked hemoglobin changes by multimodality fusion imaging. J Biomed Opt. 2008 Sep-Oct; 13(5):054031.
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Gagnon L, Gauthier C, Hoge RD, Lesage F, Selb J, Boas DA. Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system. J Biomed Opt. 2008 Sep-Oct; 13(5):054019.
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Kumar AT, Raymond SB, Dunn AK, Bacskai BJ, Boas DA. A time domain fluorescence tomography system for small animal imaging. IEEE Trans Med Imaging. 2008 Aug; 27(8):1152-63.
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Jones PB, Shin HK, Boas DA, Hyman BT, Moskowitz MA, Ayata C, Dunn AK. Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia. J Biomed Opt. 2008 Jul-Aug; 13(4):044007.
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Tromberg BJ, Pogue BW, Paulsen KD, Yodh AG, Boas DA, Cerussi AE. Assessing the future of diffuse optical imaging technologies for breast cancer management. Med Phys. 2008 Jun; 35(6):2443-51.
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Boverman G, Miller EL, Brooks DH, Isaacson D, Fang Q, Boas DA. Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomography. IEEE Trans Med Imaging. 2008 Jun; 27(6):752-65.
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Wilcox T, Bortfeld H, Woods R, Wruck E, Boas DA. Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration. Dev Sci. 2008 May; 11(3):361-70.
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Franceschini MA, Nissilä I, Wu W, Diamond SG, Bonmassar G, Boas DA. Coupling between somatosensory evoked potentials and hemodynamic response in the rat. Neuroimage. 2008 Jun; 41(2):189-203.
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Shin HK, Nishimura M, Jones PB, Ay H, Boas DA, Moskowitz MA, Ayata C. Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia. Stroke. 2008 May; 39(5):1548-55.
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Kumar AT, Raymond SB, Bacskai BJ, Boas DA. Comparison of frequency-domain and time-domain fluorescence lifetime tomography. Opt Lett. 2008 Mar 1; 33(5):470-2.
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Becerra L, Harris W, Joseph D, Huppert T, Boas DA, Borsook D. Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems. Neuroimage. 2008 Jun; 41(2):252-9.
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Boas DA, Jones SR, Devor A, Huppert TJ, Dale AM. A vascular anatomical network model of the spatio-temporal response to brain activation. Neuroimage. 2008 Apr 15; 40(3):1116-29.
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Selb J, Dale AM, Boas DA. Linear 3D reconstruction of time-domain diffuse optical imaging differential data: improved depth localization and lateral resolution. Opt Express. 2007 Dec 10; 15(25):16400-12.
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Chen HC, Vaid J, Bortfeld H, Boas DA. Optical imaging of phonological processing in two distinct orthographies. Exp Brain Res. 2008 Jan; 184(3):427-33.
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Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA. Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Phys Med Biol. 2007 Jun 21; 52(12):3619-41.
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Schweiger M, Nissilä I, Boas DA, Arridge SR. Image reconstruction in optical tomography in the presence of coupling errors. Appl Opt. 2007 May 10; 46(14):2743-56.
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Franceschini MA, Thaker S, Themelis G, Krishnamoorthy KK, Bortfeld H, Diamond SG, Boas DA, Arvin K, Grant PE. Assessment of infant brain development with frequency-domain near-infrared spectroscopy. Pediatr Res. 2007 May; 61(5 Pt 1):546-51.
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Shin HK, Dunn AK, Jones PB, Boas DA, Lo EH, Moskowitz MA, Ayata C. Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain. 2007 Jun; 130(Pt 6):1631-42.
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Devor A, Tian P, Nishimura N, Teng IC, Hillman EM, Narayanan SN, Ulbert I, Boas DA, Kleinfeld D, Dale AM. Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J Neurosci. 2007 Apr 18; 27(16):4452-9.
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Ma G, Delorme JF, Gallant P, Boas DA. Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties. Appl Opt. 2007 Apr 1; 46(10):1686-92.
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Hillman EM, Devor A, Bouchard MB, Dunn AK, Krauss GW, Skoch J, Bacskai BJ, Dale AM, Boas DA. Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage. 2007 Mar; 35(1):89-104.
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Huppert TJ, Allen MS, Benav H, Jones PB, Boas DA. A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation. J Cereb Blood Flow Metab. 2007 Jun; 27(6):1262-79.
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Themelis G, D'Arceuil H, Diamond SG, Thaker S, Huppert TJ, Boas DA, Franceschini MA. Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations. J Biomed Opt. 2007 Jan-Feb; 12(1):014033.
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Kumar AT, Raymond SB, Boverman G, Boas DA, Bacskai BJ. Time resolved fluorescence tomography of turbid media based on lifetime contrast. Opt Express. 2006 Dec 11; 14(25):12255-70.
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Aguirre AD, Chen Y, Fujimoto JG, Ruvinskaya L, Devor A, Boas DA. Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography. Opt Lett. 2006 Dec 1; 31(23):3459-61.
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Joseph DK, Huppert TJ, Franceschini MA, Boas DA. Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging. Appl Opt. 2006 Nov 1; 45(31):8142-51.
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Huppert TJ, Hoge RD, Dale AM, Franceschini MA, Boas DA. Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging. J Biomed Opt. 2006 Nov-Dec; 11(6):064018.
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Carp SA, Kauffman T, Fang Q, Rafferty E, Moore R, Kopans D, Boas D. Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. J Biomed Opt. 2006 Nov-Dec; 11(6):064016.
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Bortfeld H, Wruck E, Boas DA. Assessing infants' cortical response to speech using near-infrared spectroscopy. Neuroimage. 2007 Jan 1; 34(1):407-15.
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Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, Ayata C. Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab. 2007 May; 27(5):998-1009.
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Franceschini MA, Joseph DK, Huppert TJ, Diamond SG, Boas DA. Diffuse optical imaging of the whole head. J Biomed Opt. 2006 Sep-Oct; 11(5):054007.
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Selb J, Joseph DK, Boas DA. Time-gated optical system for depth-resolved functional brain imaging. J Biomed Opt. 2006 Jul-Aug; 11(4):044008.
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Custo A, Wells WM, Barnett AH, Hillman EM, Boas DA. Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imaging. Appl Opt. 2006 Jul 1; 45(19):4747-55.
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Kumar AT, Skoch J, Bacskai BJ, Boas DA, Dunn AK. Fluorescence-lifetime-based tomography for turbid media. Opt Lett. 2005 Dec 15; 30(24):3347-9.
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Shin HK, Dunn AK, Jones PB, Boas DA, Moskowitz MA, Ayata C. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab. 2006 Aug; 26(8):1018-30.
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Huppert TJ, Hoge RD, Diamond SG, Franceschini MA, Boas DA. A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans. Neuroimage. 2006 Jan 15; 29(2):368-82.
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Diamond SG, Huppert TJ, Kolehmainen V, Franceschini MA, Kaipio JP, Arridge SR, Boas DA. Dynamic physiological modeling for functional diffuse optical tomography. Neuroimage. 2006 Mar; 30(1):88-101.
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Culver JP, Siegel AM, Franceschini MA, Mandeville JB, Boas DA. Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin. Neuroimage. 2005 Oct 1; 27(4):947-59.
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Zhang Y, Brooks DH, Boas DA. A haemodynamic response function model in spatio-temporal diffuse optical tomography. Phys Med Biol. 2005 Oct 7; 50(19):4625-44.
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Dunn AK, Devor A, Dale AM, Boas DA. Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex. Neuroimage. 2005 Aug 15; 27(2):279-90.
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Boverman G, Miller EL, Li A, Zhang Q, Chaves T, Brooks DH, Boas DA. Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information. Phys Med Biol. 2005 Sep 7; 50(17):3941-56.
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Nioka S, Izzetoglu M, Mawn T, Nijland MJ, Boas D, Chance B. Fetal transabdominal pulse oximeter studies using a hypoxic sheep model. J Matern Fetal Neonatal Med. 2005 Jun; 17(6):393-9.
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Hoge RD, Franceschini MA, Covolan RJ, Huppert T, Mandeville JB, Boas DA. Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI. Neuroimage. 2005 Apr 15; 25(3):701-7.
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Yuan S, Devor A, Boas DA, Dunn AK. Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging. Appl Opt. 2005 Apr 1; 44(10):1823-30.
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Li A, Boverman G, Zhang Y, Brooks D, Miller EL, Kilmer ME, Zhang Q, Hillman EM, Boas DA. Optimal linear inverse solution with multiple priors in diffuse optical tomography. Appl Opt. 2005 Apr 1; 44(10):1948-56.
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Boas DA, Dale AM. Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function. Appl Opt. 2005 Apr 1; 44(10):1957-68.
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Zhang Q, Brukilacchio TJ, Li A, Stott JJ, Chaves T, Hillman E, Wu T, Chorlton M, Rafferty E, Moore RH, Kopans DB, Boas DA. Coregistered tomographic x-ray and optical breast imaging: initial results. J Biomed Opt. 2005 Mar-Apr; 10(2):024033.
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Devor A, Ulbert I, Dunn AK, Narayanan SN, Jones SR, Andermann ML, Boas DA, Dale AM. Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. Proc Natl Acad Sci U S A. 2005 Mar 8; 102(10):3822-7.
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Diamond SG, Huppert TJ, Kolehmainen V, Franceschini MA, Kaipio JP, Arridge SR, Boas DA. Physiological system identification with the Kalman filter in diffuse optical tomography. Med Image Comput Comput Assist Interv. 2005; 8(Pt 2):649-56.
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Selb J, Stott JJ, Franceschini MA, Sorensen AG, Boas DA. Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation. J Biomed Opt. 2005 Jan-Feb; 10(1):11013.
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Boas DA, Frostig RD. Optics in Neuroscience (Special Guest Editorial). Journal of Biomedical Optics. 2005; 10(1):01.
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Zhang Y, Brooks DH, Franceschini MA, Boas DA. Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging. J Biomed Opt. 2005 Jan-Feb; 10(1):11014.
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Wilcox T, Bortfeld H, Woods R, Wruck E, Boas DA. Using near-infrared spectroscopy to assess neural activation during object processing in infants. J Biomed Opt. 2005 Jan-Feb; 10(1):11010.
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Ayata C, Shin HK, Salomone S, Ozdemir-Gursoy Y, Boas DA, Dunn AK, Moskowitz MA. Pronounced hypoperfusion during spreading depression in mouse cortex. J Cereb Blood Flow Metab. 2004 Oct; 24(10):1172-82.
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Hillman EM, Boas DA, Dale AM, Dunn AK. Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media. Opt Lett. 2004 Jul 15; 29(14):1650-2.
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Ayata C, Dunn AK, Gursoy-OZdemir Y, Huang Z, Boas DA, Moskowitz MA. Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. J Cereb Blood Flow Metab. 2004 Jul; 24(7):744-55.
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Boas DA, Chen K, Grebert D, Franceschini MA. Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans. Opt Lett. 2004 Jul 1; 29(13):1506-8.
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Milstein AB, Stott JJ, Oh S, Boas DA, Millane RP, Bouman CA, Webb KJ. Fluorescence optical diffusion tomography using multiple-frequency data. J Opt Soc Am A Opt Image Sci Vis. 2004 Jun; 21(6):1035-49.
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Li A, Zhang Q, Culver JP, Miller EL, Boas DA. Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography. Opt Lett. 2004 Feb 1; 29(3):256-8.
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Boas DA, Dale AM, Franceschini MA. Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy. Neuroimage. 2004; 23 Suppl 1:S275-88.
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Franceschini MA, Boas DA. Noninvasive measurement of neuronal activity with near-infrared optical imaging. Neuroimage. 2004 Jan; 21(1):372-86.
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Culver JP, Siegel AM, Stott JJ, Boas DA. Volumetric diffuse optical tomography of brain activity. Opt Lett. 2003 Nov 1; 28(21):2061-3.
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Li A, Miller EL, Kilmer ME, Brukilacchio TJ, Chaves T, Stott J, Zhang Q, Wu T, Chorlton M, Moore RH, Kopans DB, Boas DA. Tomographic optical breast imaging guided by three-dimensional mammography. Appl Opt. 2003 Sep 1; 42(25):5181-90.
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Jasdzewski G, Strangman G, Wagner J, Kwong KK, Poldrack RA, Boas DA. Differences in the hemodynamic response to event-related motor and visual paradigms as measured by near-infrared spectroscopy. Neuroimage. 2003 Sep; 20(1):479-88.
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Boas DA, Strangman G, Culver JP, Hoge RD, Jasdzewski G, Poldrack RA, Rosen BR, Mandeville JB. Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? Phys Med Biol. 2003 Aug 7; 48(15):2405-18.
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Devor A, Dunn AK, Andermann ML, Ulbert I, Boas DA, Dale AM. Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex. Neuron. 2003 Jul 17; 39(2):353-9.
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Franceschini MA, Fantini S, Thompson JH, Culver JP, Boas DA. Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging. Psychophysiology. 2003 Jul; 40(4):548-60.
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Prince S, Kolehmainen V, Kaipio JP, Franceschini MA, Boas D, Arridge SR. Time-series estimation of biological factors in optical diffusion tomography. Phys Med Biol. 2003 Jun 7; 48(11):1491-504.
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Bamett AH, Culver JP, Sorensen AG, Dale A, Boas DA. Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging. Appl Opt. 2003 Jun 1; 42(16):3095-108.
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Milstein AB, Oh S, Webb KJ, Bouman CA, Zhang Q, Boas DA, Millane RP. Fluorescence optical diffusion tomography. Appl Opt. 2003 Jun 1; 42(16):3081-94.
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Kilmer ME, Miller EL, Barbaro A, Boas D. Three-dimensional shape-based imaging of absorption perturbation for diffuse optical tomography. Appl Opt. 2003 Jun 1; 42(16):3129-44.
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Stott JJ, Culver JP, Arridge SR, Boas DA. Optode positional calibration in diffuse optical tomography. Appl Opt. 2003 Jun 1; 42(16):3154-62.
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Siegel AM, Culver JP, Mandeville JB, Boas DA. Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation. Phys Med Biol. 2003 May 21; 48(10):1391-403.
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Strangman G, Franceschini MA, Boas DA. Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters. Neuroimage. 2003 Apr; 18(4):865-79.
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Yodh AG, Boas DA. Functional Imaging with Diffuse Light. In: Biomedical Photonics. Ed. Vo-Dinh T. CRC Press, Boca Raton. 2003; 21-45.
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Dunn AK, Devor A, Bolay H, Andermann ML, Moskowitz MA, Dale AM, Boas DA. Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation. Opt Lett. 2003 Jan 1; 28(1):28-30.
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Hebden JC, Boas DA, George JS, Durkin AJ. Topics in Biomedical Optics: Introduction. Appl Opt. 2003; 42(16):2869-2870.
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Strangman G, Boas DA, Sutton JP. Non-invasive neuroimaging using near-infrared light. Biol Psychiatry. 2002 Oct 1; 52(7):679-93.
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Strangman G, Culver JP, Thompson JH, Boas DA. A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation. Neuroimage. 2002 Oct; 17(2):719-31.
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Baird AA, Kagan J, Gaudette T, Walz KA, Hershlag N, Boas DA. Frontal lobe activation during object permanence: data from near-infrared spectroscopy. Neuroimage. 2002 Aug; 16(4):1120-5.
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Boas D, Culver J, Stott J, Dunn A. Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head. Opt Express. 2002 Feb 11; 10(3):159-70.
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Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med. 2002 Feb; 8(2):136-42.
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Franceschini MA, Boas DA, Zourabian A, Diamond SG, Nadgir S, Lin DW, Moore JB, Fantini S. Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects. J Appl Physiol. 2002 Jan; 92(1):372-84.
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Boas DA, Culver JP, Stott JJ, Dunn AK. Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head. Opt Express. 2002; 10:159-170.
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Boas DA, Franceschini MA, Dunn AK, Strangman G. Noninvasive imaging of cerebral activation with diffuse optical tomorgraphy. In: InVivo Optical Imaging of Brain Function. CRC Press, Boca Raton. 2002; 193-221.
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Dunn AK, Bolay H, Moskowitz MA, Boas DA. Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab. 2001 Mar; 21(3):195-201.
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Boas D, Gaudette T, Arridge S. Simultaneous imaging and optode calibration with diffuse optical tomography. Opt Express. 2001 Feb 26; 8(5):263-70.
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Boas DA, Brooks DH, Miller EL, DiMarzio CA, Kilmer M, Gaudette RJ, Zhang Q. Imaging the body with diffuse optical tomography. IEEE Signal Processing Magazine. 2001; 18(6):57-75.
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Hintz SR, Benaron DA, Siegel AM, Zourabian A, Stevenson DK, Boas DA. Bedside functional imaging of the premature infant brain during passive motor activation. J Perinat Med. 2001; 29(4):335-43.
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Boas DA, Gaudette T, Strangman G, Cheng X, Marota JJ, Mandeville JB. The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics. Neuroimage. 2001 Jan; 13(1):76-90.
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Kilmer M, Miller E, Boas D, Brooks D. A shape-based reconstruction technique for DPDW data. Opt Express. 2000 Dec 18; 7(13):481-91.
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Dunn A, Boas D. Transport-based image reconstruction in turbid media with small source-detector separations. Opt Lett. 2000 Dec 15; 25(24):1777-9.
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Zourabian A, Siegel A, Chance B, Ramanujan N, Rode M, Boas DA. Trans-abdominal monitoring of fetal arterial blood oxygenation using pulse oximetry. J Biomed Opt. 2000 Oct; 5(4):391-405.
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Gaudette RJ, Brooks DH, DiMarzio CA, Kilmer ME, Miller EL, Gaudette T, Boas DA. A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient. Phys Med Biol. 2000 Apr; 45(4):1051-70.
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Benaron DA, Hintz SR, Villringer A, Boas D, Kleinschmidt A, Frahm J, Hirth C, Obrig H, van Houten JC, Kermit EL, Cheong WF, Stevenson DK. Noninvasive functional imaging of human brain using light. J Cereb Blood Flow Metab. 2000 Mar; 20(3):469-77.
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Dunn AK, Boas DA. Transport-based image reconstruction in turbid media with small source-detector separations. Optics Letters. 2000; 25:1777-1779.
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Benaron DA, Hintz SR, Villringer A, Boas DA, Kleinschmidt A, Frahm J, Hirth C, Obrig H, van Houten JC, Kermit EL, Cheong WF, Stevenson DK. Noninvasive functional imaging of the human brain using light. J. Cerebral Blood Flow and Metabolism. 2000; 20:469-477.
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Cheng X, Boas D. Systematic diffuse optical image errors resulting from uncertainty in the background optical properties. Opt Express. 1999 Apr 12; 4(8):299-307.
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Siegel A, Marota JJ, Boas D. Design and evaluation of a continuous-wave diffuse optical tomography system. Opt Express. 1999 Apr 12; 4(8):287-98.
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Bizheva KK, Siegel AM, Dunn AK, Boas DA. Detection of multiply scattered light in optical coherence tomography. Waves and imaging through complex media, Ed. Sebbah. 1999; 277-298.
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Cheng X, Boas D. Diffuse optical reflection tomography using continuous wave illumination. Opt Express. 1998 Aug 3; 3(3):118-23.
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Walker SA, Boas DA, Gratton E. Photon density waves scattered from cylindrical inhomogeneities: theory and experiments. Appl Opt. 1998 Apr 1; 37(10):1935-44.
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Boas DA, Bizheva KK, Siegel AM. Using dynamic low-coherence interferometry to image Brownian motion within highly scattering media. Opt Lett. 1998 Mar 1; 23(5):319-21.
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Bizheva KK, Siegel AM, Boas DA. Path-length resolved dynamic light scattering in highly scattering random media: the transition to diffusing wave spectroscopy. Phys. Rev. E. 1998; 58:7664-7667.
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Ramanujam N, Boas DA, Li Y. Laser Spectroscopy and Imaging for Characterization of Human Tissue. In: Dahotre NB, Ed. Lasers in Surface Engineering. American Society for Materials, Ohio. 1998.
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Cheng X, Boas DA. Diffuse optical reflectance tomography with continuous-wave illumination. Optics Express. 1998; 3:118-123.
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Boas D. A fundamental limitation of linearized algorithms for diffuse optical tomography. Opt Express. 1997 Dec 22; 1(13):404-13.
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Kelley P, Boas D. Introduction. Opt Express. 1997 Dec 22; 1(13):390.
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Durduran T, Yodh AG, Chance B, Boas DA. Does the photon-diffusion coefficient depend on absorption? J Opt Soc Am A Opt Image Sci Vis. 1997 Dec; 14(12):3358-65.
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Boas DA, Yodh AG. Spatially Varying Dynamic Properties of Turbid Media Probed with Diffusing Temporal Light Correlation. J. Opt. Soc. Am. A. 1997; 14:192-215.
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Boas DA, O'Leary MA, Chance B, Yodh AG. Detection and characterization of optical inhomogeneities with diffuse photon density waves: a signal-to-noise analysis. Appl Opt. 1997 Jan 1; 36(1):75-92.
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Li XD, O'Leary MA, Boas DA, Chance B, Yodh AG. Fluorescent diffuse photon density waves in homogeneous and heterogeneous turbid media: analytic solutions and applications. Appl Opt. 1996 Jul 1; 35(19):3746-58.
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O'Leary MA, Boas DA, Li XD, Chance B, Yodh AG. Fluorescence lifetime imaging in turbid media. Opt Lett. 1996 Jan 15; 21(2):158-60.
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Li XD, O'Leary MA, Boas DA, Chance B, Yodh AG. Flourescent diffuse photon density waves in homogeneous and heterogeneous turbid media: analytic solutions and applications. Applied Optics. 1996; 35(19):3746-3758.
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Boas DA, Meglinsky IV, Zemany L, Campbell LE, Chance B, Yodh AG. Diffusion of temporal field correlation with selected applications. In: Tuchin V, Ed. SPIE Coherence-Domain Methods in Biomedical Optics. 1996; 2732:34-46.
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Liu H, Boas DA, Zhang Y, Yodh AG, Chance B. Determination of optical properties and blood oxygenation in tissue using continuous NIR light. Phys Med Biol. 1995 Nov; 40(11):1983-93.
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Boas DA, Campbell LE, Yodh AG. Scattering and Imaging with Diffusing Temporal Field Correlations. Phys Rev Lett. 1995 Aug 28; 75(9):1855-1858.
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O'Leary MA, Boas DA, Chance B, Yodh AG. Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography. Opt Lett. 1995 Mar 1; 20(5):426-8.
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Boas DA, O'Leary MA, Chance B, Yodh AG. Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media: analytic solution and applications. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4887-91.
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Boas DA, O'Leary MA, Chance B, Yodh AG. Scattering and wavelength transduction of diffuse photon density waves. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 May; 47(5):R2999-R3002.
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O'Leary MA, Boas DA, Chance B, Yodh AG. Refraction of diffuse photon density waves. Phys Rev Lett. 1992 Nov 2; 69(18):2658-2661.
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