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Last Name
Institution

Robert Michael Kacmarek, PH.D.

TitleProfessor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Respiratory Care, Ell 401
55 Fruit St
Boston MA 02114
Phone617/724-4480
Fax617/724-4495

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Villar J, Sulemanji D, Kacmarek RM. The acute respiratory distress syndrome: incidence and mortality, has it changed? Curr Opin Crit Care. 2014 Feb; 20(1):3-9.
    View in: PubMed
  2. Kacmarek RM, Villar J. Management of refractory hypoxemia in ARDS. Minerva Anestesiol. 2013 Oct; 79(10):1173-9.
    View in: PubMed
  3. Kacmarek RM. Mechanical ventilation competencies of the respiratory therapist in 2015 and beyond. Respir Care. 2013 Jun; 58(6):1087-96.
    View in: PubMed
  4. Oto J, Chenelle CT, Marchese AD, Kacmarek RM. A comparison of leak compensation in acute care ventilators during noninvasive and invasive ventilation: a lung model study. Respir Care. 2013 Dec; 58(12):2027-37.
    View in: PubMed
  5. Brusasco C, Corradi F, Vargas M, Bona M, Bruno F, Marsili M, Simonassi F, Santori G, Severgnini P, Kacmarek RM, Pelosi P. In vitro evaluation of heat and moisture exchangers designed for spontaneously breathing tracheostomized patients. Respir Care. 2013 Nov; 58(11):1878-85.
    View in: PubMed
  6. Villar J, Kacmarek RM. What is new in refractory hypoxemia? Intensive Care Med. 2013 Jul; 39(7):1207-10.
    View in: PubMed
  7. Villar J, Pérez-Méndez L, Blanco J, Añón JM, Blanch L, Belda J, Santos-Bouza A, Fernández RL, Kacmarek RM. A universal definition of ARDS: the PaO2/FiO 2 ratio under a standard ventilatory setting-a prospective, multicenter validation study. Intensive Care Med. 2013 Apr; 39(4):583-92.
    View in: PubMed
  8. Villar J, Kacmarek RM. Modern critical care medicine from china: an ancient civilization*. Crit Care Med. 2013 Jan; 41(1):343-5.
    View in: PubMed
  9. López-Fernández Y, Azagra AM, de la Oliva P, Modesto V, Sánchez JI, Parrilla J, Arroyo MJ, Reyes SB, Pons-Ódena M, López-Herce J, Fernández RL, Kacmarek RM, Villar J. Pediatric Acute Lung Injury Epidemiology and Natural History study: Incidence and outcome of the acute respiratory distress syndrome in children. Crit Care Med. 2012 Dec; 40(12):3238-45.
    View in: PubMed
  10. Liu YH, Wang AL, Marchese AD, Kacmarek RM, Jiang Y. Jet or intensive care unit ventilator during simulated percutaneous transtracheal ventilation: a lung model study. Br J Anaesth. 2013 Mar; 110(3):456-62.
    View in: PubMed
  11. Sulemanji DS, Marchese A, Wysocki M, Kacmarek RM. Adaptive support ventilation with and without end-tidal CO2 closed loop control versus conventional ventilation. Intensive Care Med. 2013 Apr; 39(4):703-10.
    View in: PubMed
  12. Villar J, Kacmarek RM. The American-European Consensus Conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure! Med Intensiva. 2012 Nov; 36(8):571-5.
    View in: PubMed
  13. Chacón E, Estruga A, Murias G, Sales B, Montanya J, Lucangelo U, Garcia-Esquirol O, Villagrá A, Villar J, Kacmarek RM, Burgueño MJ, Blanch L, Jam R. Nurses' detection of ineffective inspiratory efforts during mechanical ventilation. Am J Crit Care. 2012 Jul; 21(4):e89-93.
    View in: PubMed
  14. Villar J, Kacmarek RM. Positive end-expiratory pressure after uncomplicated coronary artery bypass grafting: a two-edge sword. Minerva Anestesiol. 2012 Jul; 78(7):743-5.
    View in: PubMed
  15. Kacmarek RM, Villar J. The chest wall: the all too commonly forgotten cause of pulmonary dysfunction*. Crit Care Med. 2012 Jul; 40(7):2258-9.
    View in: PubMed
  16. Kacmarek RM, Villar J. Acute application of noninvasive ventilation outside the ICU: when is it safe? Respir Care. 2012 May; 57(5):815-6.
    View in: PubMed
  17. Blanch L, Sales B, Montanya J, Lucangelo U, Garcia-Esquirol O, Villagra A, Chacon E, Estruga A, Borelli M, Burgueño MJ, Oliva JC, Fernandez R, Villar J, Kacmarek R, Murias G. Validation of the Better Care® system to detect ineffective efforts during expiration in mechanically ventilated patients: a pilot study. Intensive Care Med. 2012 May; 38(5):772-80.
    View in: PubMed
  18. de la Oliva P, Schüffelmann C, Gómez-Zamora A, Villar J, Kacmarek RM. Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial. Intensive Care Med. 2012 May; 38(5):838-46.
    View in: PubMed
  19. Kacmarek RM, Barnes TA, Durbin CG. Survey of directors of respiratory therapy departments regarding the future education and credentialing of respiratory care students and staff. Respir Care. 2012 May; 57(5):710-20.
    View in: PubMed
  20. Correger E, Murias G, Chacon E, Estruga A, Sales B, Lopez-Aguilar J, Montanya J, Lucangelo U, Garcia-Esquirol O, Villagra A, Villar J, Kacmarek RM, Burgueño MJ, Blanch L. [Interpretation of ventilator curves in patients with acute respiratory failure]. Med Intensiva. 2012 May; 36(4):294-306.
    View in: PubMed
  21. Villar J, Blanco J, Añón JM, Santos-Bouza A, Blanch L, Ambrós A, Gandía F, Carriedo D, Mosteiro F, Basaldúa S, Fernández RL, Kacmarek RM. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med. 2011 Dec; 37(12):1932-41.
    View in: PubMed
  22. Villar J, Cabrera NE, Valladares F, Casula M, Flores C, Blanch L, Quilez ME, Santana-Rodríguez N, Kacmarek RM, Slutsky AS. Activation of the Wnt/ß-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. PLoS One. 2011; 6(9):e23914.
    View in: PubMed
  23. Kacmarek RM. The mechanical ventilator: past, present, and future. Respir Care. 2011 Aug; 56(8):1170-80.
    View in: PubMed
  24. Jiang Y, Bao FP, Liang Y, Kimball WR, Liu Y, Zapol WM, Kacmarek RM. Effectiveness of breathing through nasal and oral routes in unconscious apneic adult human subjects: a prospective randomized crossover trial. Anesthesiology. 2011 Jul; 115(1):129-35.
    View in: PubMed
  25. Villar J, Cabrera NE, Casula M, Valladares F, Flores C, López-Aguilar J, Blanch L, Zhang H, Kacmarek RM, Slutsky AS. WNT/ß-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injury. Intensive Care Med. 2011 Jul; 37(7):1201-9.
    View in: PubMed
  26. Barnes TA, Kacmarek RM, Durbin CG. Survey of respiratory therapy education program directors in the United States. Respir Care. 2011 Dec; 56(12):1906-15.
    View in: PubMed
  27. Kacmarek RM, Villar J. When it comes to ventilation, noisy is better than quiet and variability is healthier than constant! Crit Care Med. 2011 Apr; 39(4):898-9.
    View in: PubMed
  28. Marchese AD, Sulemanji D, Chipman D, Villar J, Kacmarek RM. Performance of current intensive care unit ventilators during pressure and volume ventilation. Respir Care. 2011 Jul; 56(7):928-40.
    View in: PubMed
  29. Kacmarek RM. Proportional assist ventilation and neurally adjusted ventilatory assist. Respir Care. 2011 Feb; 56(2):140-8; discussion 149-52.
    View in: PubMed
  30. Villar J, Blanco J, Kacmarek RM. Acute respiratory distress syndrome definition: do we need a change? Curr Opin Crit Care. 2011 Feb; 17(1):13-7.
    View in: PubMed
  31. Barnes TA, Kacmarek RM, Kageler WV, Morris MJ, Durbin CG. Transitioning the respiratory therapy workforce for 2015 and beyond. Respir Care. 2011 May; 56(5):681-90.
    View in: PubMed
  32. Villar J, Pérez-Méndez L, Basaldúa S, Blanco J, Aguilar G, Toral D, Zavala E, Romera MA, González-Díaz G, Nogal FD, Santos-Bouza A, Ramos L, Macías S, Kacmarek RM. A risk tertiles model for predicting mortality in patients with acute respiratory distress syndrome: age, plateau pressure, and P(aO(2))/F(IO(2)) at ARDS onset can predict mortality. Respir Care. 2011 Apr; 56(4):420-8.
    View in: PubMed
  33. Kacmarek RM, Villar J. Lung recruitment maneuvers during acute respiratory distress syndrome: is it useful? Minerva Anestesiol. 2011 Jan; 77(1):85-9.
    View in: PubMed
  34. Ferreira JC, Benseñor FE, Rocha MJ, Salge JM, Harris RS, Malhotra A, Kairalla RA, Kacmarek RM, Carvalho CR. A sigmoidal fit for pressure-volume curves of idiopathic pulmonary fibrosis patients on mechanical ventilation: clinical implications. Clinics (Sao Paulo). 2011; 66(7):1157-63.
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  35. Kacmarek RM, Villar J. Clinical repercussions of high-frequency percussive ventilation: a burning issue. Crit Care Med. 2010 Oct; 38(10):2069-70.
    View in: PubMed
  36. Pitts R, Fisher D, Sulemanji D, Kratohvil J, Jiang Y, Kacmarek R. Variables affecting leakage past endotracheal tube cuffs: a bench study. Intensive Care Med. 2010 Dec; 36(12):2066-73.
    View in: PubMed
  37. Barnes TA, Gale DD, Kacmarek RM, Kageler WV. Competencies needed by graduate respiratory therapists in 2015 and beyond. Respir Care. 2010 May; 55(5):601-16.
    View in: PubMed
  38. Villar J, Cabrera N, Casula M, Flores C, Valladares F, Muros M, Blanch L, Slutsky AS, Kacmarek RM. Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model. Intensive Care Med. 2010 Jun; 36(6):1049-57.
    View in: PubMed
  39. Villar J, Cabrera NE, Casula M, Flores C, Valladares F, Díaz-Flores L, Muros M, Slutsky AS, Kacmarek RM. Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model. Respir Res. 2010; 11:27.
    View in: PubMed
  40. Villar J, Kacmarek RM. Rescue strategies for refractory hypoxemia: a critical appraisal. F1000 Med Rep. 2009; 1.
    View in: PubMed
  41. Sulemanji D, Marchese A, Garbarini P, Wysocki M, Kacmarek RM. Adaptive support ventilation: an appropriate mechanical ventilation strategy for acute respiratory distress syndrome? Anesthesiology. 2009 Oct; 111(4):863-70.
    View in: PubMed
  42. Villar J, Pérez-Méndez L, Espinosa E, Flores C, Blanco J, Muriel A, Basaldúa S, Muros M, Blanch L, Artigas A, Kacmarek RM. Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis. PLoS One. 2009; 4(8):e6818.
    View in: PubMed
  43. Richard JC, Kacmarek RM. ICU mechanical ventilators, technological advances vs. user friendliness: the right picture is worth a thousand numbers. Intensive Care Med. 2009 Oct; 35(10):1662-3.
    View in: PubMed
  44. Villar J, Herrera-Abreu MT, Valladares F, Muros M, Pérez-Méndez L, Flores C, Kacmarek RM. Experimental ventilator-induced lung injury: exacerbation by positive end-expiratory pressure. Anesthesiology. 2009 Jun; 110(6):1341-7.
    View in: PubMed
  45. Ferreira JC, Chipman DW, Hill NS, Kacmarek RM. Bilevel vs ICU ventilators providing noninvasive ventilation: effect of system leaks: a COPD lung model comparison. Chest. 2009 Aug; 136(2):448-56.
    View in: PubMed
  46. Kacmarek RM, Durbin CG, Barnes TA, Kageler WV, Walton JR, O'Neil EH. Creating a vision for respiratory care in 2015 and beyond. Respir Care. 2009 Mar; 54(3):375-89.
    View in: PubMed
  47. Kacmarek RM. Should noninvasive ventilation be used with the do-not-intubate patient? Respir Care. 2009 Feb; 54(2):223-9; discussion 229-31.
    View in: PubMed
  48. Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS. A comparison of methods to identify open-lung PEEP. Intensive Care Med. 2009 Apr; 35(4):740-7.
    View in: PubMed
  49. Epstein SK, Kacmarek RM. Noninvasive ventilation in acute care: controversies and emerging concepts. Foreword. Respir Care. 2009 Jan; 54(1):38-9.
    View in: PubMed
  50. Marchese AD, Chipman D, de la Oliva P, Kacmarek RM. Adult ICU ventilators to provide neonatal ventilation: a lung simulator study. Intensive Care Med. 2009 Apr; 35(4):631-8.
    View in: PubMed
  51. Prodhan P, Dela Rosa RS, Shubina M, Haver KE, Matthews BD, Buck S, Kacmarek RM, Noviski NN. Wheeze detection in the pediatric intensive care unit: comparison among physician, nurses, respiratory therapists, and a computerized respiratory sound monitor. Respir Care. 2008 Oct; 53(10):1304-9.
    View in: PubMed
  52. Jiang Y, Liang Y, Kacmarek RM. The principle of upper airway unidirectional flow facilitates breathing in humans. J Appl Physiol. 2008 Sep; 105(3):854-8.
    View in: PubMed
  53. Liang Y, Kimball WR, Kacmarek RM, Zapol WM, Jiang Y. Nasal ventilation is more effective than combined oral-nasal ventilation during induction of general anesthesia in adult subjects. Anesthesiology. 2008 Jun; 108(6):998-1003.
    View in: PubMed
  54. Soares SM, Oliveira RA, Franca SA, Rezende SM, Dragosavac D, Kacmarek RM, Carvalho CR. Continuous positive airway pressure increases inspiratory capacity of COPD patients. Respirology. 2008 May; 13(3):387-93.
    View in: PubMed
  55. Ferreira JC, Chipman DW, Kacmarek RM. Trigger performance of mid-level ICU mechanical ventilators during assisted ventilation: a bench study. Intensive Care Med. 2008 Sep; 34(9):1669-75.
    View in: PubMed
  56. Kacmarek RM. Last word on point:counterpoint: High-frequency ventilation is/is not the optimal physiological approach to ventilate ARDS patients. J Appl Physiol. 2008 Apr; 104(4):1241.
    View in: PubMed
  57. Kacmarek RM. Counterpoint: High-frequency ventilation is not the optimal physiological approach to ventilate ARDS patients. J Appl Physiol. 2008 Apr; 104(4):1232-3; discussion 1233-5.
    View in: PubMed
  58. Sinuff T, Cook DJ, Keenan SP, Burns KE, Adhikari NK, Rocker GM, Mehta S, Kacmarek R, Eva K, Hill NS. Noninvasive ventilation for acute respiratory failure near the end of life. Crit Care Med. 2008 Mar; 36(3):789-94.
    View in: PubMed
  59. Schettino G, Altobelli N, Kacmarek RM. Noninvasive positive-pressure ventilation in acute respiratory failure outside clinical trials: experience at the Massachusetts General Hospital. Crit Care Med. 2008 Feb; 36(2):441-7.
    View in: PubMed
  60. Caramez MP, Miyoshi E, Harris RS, Kacmarek RM, Malhotra A. Gas exchange impairment induced by open suctioning in acute respiratory distress syndrome: impact of permissive hypercapnia. Crit Care Med. 2008 Feb; 36(2):560-4.
    View in: PubMed
  61. Kaynar AM, Mathew JJ, Hudlin MM, Gingras DJ, Ritz RH, Jackson MR, Kacmarek RM, Kollef MH. Attitudes of respiratory therapists and nurses about measures to prevent ventilator-associated pneumonia: a multicenter, cross-sectional survey study. Respir Care. 2007 Dec; 52(12):1687-94.
    View in: PubMed
  62. Kacmarek RM. Noninvasive positive-pressure ventilation in postoperative hypoxemic respiratory failure--with a helmet? Respir Care. 2007 Nov; 52(11):1451-3.
    View in: PubMed
  63. Villar J, Pérez-Méndez L, Flores C, Maca-Meyer N, Espinosa E, Muriel A, Sangüesa R, Blanco J, Muros M, Kacmarek RM. A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis. Crit Care Med. 2007 Oct; 35(10):2292-7.
    View in: PubMed
  64. Fessler HE, Derdak S, Ferguson ND, Hager DN, Kacmarek RM, Thompson BT, Brower RG. A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion. Crit Care Med. 2007 Jul; 35(7):1649-54.
    View in: PubMed
  65. Villar J, Pérez-Méndez L, López J, Belda J, Blanco J, Saralegui I, Suárez-Sipmann F, López J, Lubillo S, Kacmarek RM. An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2007 Oct 15; 176(8):795-804.
    View in: PubMed
  66. Chipman DW, Caramez MP, Miyoshi E, Kratohvil JP, Kacmarek RM. Performance comparison of 15 transport ventilators. Respir Care. 2007 Jun; 52(6):740-51.
    View in: PubMed
  67. Steinberg KP, Kacmarek RM. Respiratory controversies in the critical care setting. Should tidal volume be 6 mL/kg predicted body weight in virtually all patients with acute respiratory failure? Respir Care. 2007 May; 52(5):556-64; discussion 565-7.
    View in: PubMed
  68. Kacmarek RM, Kallet RH. Respiratory controversies in the critical care setting. Should recruitment maneuvers be used in the management of ALI and ARDS? Respir Care. 2007 May; 52(5):622-31; discussion 631-5.
    View in: PubMed
  69. Curtis JR, Cook DJ, Sinuff T, White DB, Hill N, Keenan SP, Benditt JO, Kacmarek R, Kirchhoff KT, Levy MM. Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapy. Crit Care Med. 2007 Mar; 35(3):932-9.
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  70. Kacmarek RM. NPPV in acute respiratory failure: is it time to reconsider where it may be applied? Respir Care. 2006 Nov; 51(11):1226-7.
    View in: PubMed
  71. Girgis K, Hamed H, Khater Y, Kacmarek RM. A decremental PEEP trial identifies the PEEP level that maintains oxygenation after lung recruitment. Respir Care. 2006 Oct; 51(10):1132-9.
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  72. Kacmarek RM, Villar J. Lung recruitment in patients with ARDS. N Engl J Med. 2006 Jul 20; 355(3):320; author reply 321-2.
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  73. Borges JB, Okamoto VN, Matos GF, Caramez MP, Arantes PR, Barros F, Souza CE, Victorino JA, Kacmarek RM, Barbas CS, Carvalho CR, Amato MB. Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006 Aug 1; 174(3):268-78.
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  74. Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung-protective ventilation in acute respiratory distress syndrome. Respir Care. 2006 May; 51(5):497-502.
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  75. Villar J, Kacmarek RM, Pérez-Méndez L, Aguirre-Jaime A. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med. 2006 May; 34(5):1311-8.
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  76. Kacmarek RM. Ventilatory management of ARDS: high frequency oscillation and lung recruitment! Crit Care. 2006; 10(4):158.
    View in: PubMed
  77. Curtis JR, Cook DJ, Wall RJ, Angus DC, Bion J, Kacmarek R, Kane-Gill SL, Kirchhoff KT, Levy M, Mitchell PH, Moreno R, Pronovost P, Puntillo K. Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med. 2006 Jan; 34(1):211-8.
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  78. Kacmarek RM. Lung protection: the cost in some is increased work of breathing. Is it too high? Respir Care. 2005 Dec; 50(12):1614-6.
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  79. Kacmarek RM, Wiedemann HP, Lavin PT, Wedel MK, Tütüncü AS, Slutsky AS. Partial liquid ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006 Apr 15; 173(8):882-9.
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  80. Schettino G, Altobelli N, Kacmarek RM. Noninvasive positive pressure ventilation reverses acute respiratory failure in select "do-not-intubate" patients. Crit Care Med. 2005 Sep; 33(9):1976-82.
    View in: PubMed
  81. Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB. Paradoxical responses to positive end-expiratory pressure in patients with airway obstruction during controlled ventilation. Crit Care Med. 2005 Jul; 33(7):1519-28.
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  82. El Masry A, Williams PF, Chipman DW, Kratohvil JP, Kacmarek RM. The impact of closed endotracheal suctioning systems on mechanical ventilator performance. Respir Care. 2005 Mar; 50(3):345-53.
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  83. Ferguson ND, Chiche JD, Kacmarek RM, Hallett DC, Mehta S, Findlay GP, Granton JT, Slutsky AS, Stewart TE. Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: the Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study. Crit Care Med. 2005 Mar; 33(3):479-86.
    View in: PubMed
  84. Kacmarek RM, Malhotra A. High-frequency oscillatory ventilation: what large-animal studies have taught us! Crit Care Med. 2005 Mar; 33(3 Suppl):S148-54.
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  85. Villar J, Pérez-Méndez L, Aguirre-Jaime A, Kacmarek RM. Why are physicians so skeptical about positive randomized controlled clinical trials in critical care medicine? Intensive Care Med. 2005 Feb; 31(2):196-204.
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  86. Nishida T, Suchodolski K, Schettino GP, Sedeek K, Takeuch M, Kacmarek RM. Peak volume history and peak pressure-volume curve pressures independently affect the shape of the pressure-volume curve of the respiratory system. Crit Care Med. 2004 Jun; 32(6):1358-64.
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  87. Shaw CI, Kacmarek RM, Hampton RL, Riggi V, El Masry A, Cooper JB, Hurford WE. Cellular phone interference with the operation of mechanical ventilators. Crit Care Med. 2004 Apr; 32(4):928-31.
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  88. Villar J, Kacmarek RM, Hedenstierna G. From ventilator-induced lung injury to physician-induced lung injury: why the reluctance to use small tidal volumes? Acta Anaesthesiol Scand. 2004 Mar; 48(3):267-71.
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  89. Schwartz AR, Kacmarek RM, Hess DR. Factors affecting oxygen delivery with bi-level positive airway pressure. Respir Care. 2004 Mar; 49(3):270-5.
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  90. Ferguson ND, Kacmarek RM, Chiche JD, Singh JM, Hallett DC, Mehta S, Stewart TE. Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial. Intensive Care Med. 2004 Jun; 30(6):1111-6.
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  91. Sedeek KA, Takeuchi M, Suchodolski K, Vargas SO, Shimaoka M, Schnitzer JJ, Kacmarek RM. Open-lung protective ventilation with pressure control ventilation, high-frequency oscillation, and intratracheal pulmonary ventilation results in similar gas exchange, hemodynamics, and lung mechanics. Anesthesiology. 2003 Nov; 99(5):1102-11.
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  92. Kacmarek RM. Noninvasive positive-pressure ventilation:the little things do make the difference! Respir Care. 2003 Oct; 48(10):919-21.
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  93. Kacmarek RM. Is high frequency oscillation the best lung protective ventilatory approach for ARDS? Intensive Care Med. 2003 Oct; 29(10):1629-31.
    View in: PubMed
  94. Schettino GP, Chatmongkolchart S, Hess DR, Kacmarek RM. Position of exhalation port and mask design affect CO2 rebreathing during noninvasive positive pressure ventilation. Crit Care Med. 2003 Aug; 31(8):2178-82.
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  95. Hess DR, Dillman C, Kacmarek RM. In vitro evaluation of aerosol bronchodilator delivery during mechanical ventilation: pressure-control vs. volume control ventilation. Intensive Care Med. 2003 Jul; 29(7):1145-50.
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  96. Sedeek KA, Takeuchi M, Suchodolski K, Kacmarek RM. Determinants of tidal volume during high-frequency oscillation. Crit Care Med. 2003 Jan; 31(1):227-31.
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  97. Chatmongkolchart S, Schettino GP, Dillman C, Kacmarek RM, Hess DR. In vitro evaluation of aerosol bronchodilator delivery during noninvasive positive pressure ventilation: effect of ventilator settings and nebulizer position. Crit Care Med. 2002 Nov; 30(11):2515-9.
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  98. Richards GA, Hopley M, Kacmarek RM, Fujino Y, Amato M. Successful recruitment. Crit Care Med. 2002 Sep; 30(9):2169; author reply 2169-70.
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  99. Takeuchi M, Goddon S, Dolhnikoff M, Shimaoka M, Hess D, Amato MB, Kacmarek RM. Set positive end-expiratory pressure during protective ventilation affects lung injury. Anesthesiology. 2002 Sep; 97(3):682-92.
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  100. Kacmarek RM. A workable alternative to the problems with tracheal gas insufflation? Intensive Care Med. 2002 Aug; 28(8):1009-11.
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  101. Kacmarek RM. Liquid ventilation. Respir Care Clin N Am. 2002 Jun; 8(2):187-209.
    View in: PubMed
  102. Singh JM, Mehta S, Kacmarek RM. Pro/con clinical debate: is high-frequency oscillatory ventilation useful in the management of adult patients with respiratory failure? Crit Care. 2002 Jun; 6(3):183-5.
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  103. Kacmarek RM. Ventilatory adjuncts. Respir Care. 2002 Mar; 47(3):319-30; discussion 330-3.
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  104. Malhotra A, Ayas N, Kacmarek R. Prone positioning of patients in acute respiratory failure. N Engl J Med. 2002 Jan 24; 346(4):295-7.
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  105. Takeuchi M, Williams P, Hess D, Kacmarek RM. Continuous positive airway pressure in new-generation mechanical ventilators: a lung model study. Anesthesiology. 2002 Jan; 96(1):162-72.
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  106. Kacmarek RM. Combination therapy. Respir Care Clin N Am. 2001 Dec; 7(4):663-81.
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  107. Takeuchi M, Sedeek KA, Schettino GP, Suchodolski K, Kacmarek RM. Peak pressure during volume history and pressure-volume curve measurement affects analysis. Am J Respir Crit Care Med. 2001 Oct 1; 164(7):1225-30.
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  108. Fujino Y, Goddon S, Dolhnikoff M, Hess D, Amato MB, Kacmarek RM. Repetitive high-pressure recruitment maneuvers required to maximally recruit lung in a sheep model of acute respiratory distress syndrome. Crit Care Med. 2001 Aug; 29(8):1579-86.
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  109. Chatmongkolchart S, Williams P, Hess DR, Kacmarek RM. Evaluation of inspiratory rise time and inspiration termination criteria in new-generation mechanical ventilators: a lung model study. Respir Care. 2001 Jul; 46(7):666-77.
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  110. Goddon S, Fujino Y, Hromi JM, Kacmarek RM. Optimal mean airway pressure during high-frequency oscillation: predicted by the pressure-volume curve. Anesthesiology. 2001 May; 94(5):862-9.
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  111. Chatmongkolchart S, Kacmarek RM, Hess DR. Heliox delivery with noninvasive positive pressure ventilation: a laboratory study. Respir Care. 2001 Mar; 46(3):248-54.
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  112. Kacmarek RM. Strategies to optimize alveolar recruitment. Curr Opin Crit Care. 2001 Feb; 7(1):15-20.
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  113. Kacmarek RM. Complications of tracheal gas insufflation. Respir Care. 2001 Feb; 46(2):167-76.
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  114. Kacmarek RM. Partial liquid ventilation: is there a niche? Intensive Care Med. 2001 Jan; 27(1):1-2.
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  115. Kapasi M, Fujino Y, Kirmse M, Catlin EA, Kacmarek RM. Effort and work of breathing in neonates during assisted patient-triggered ventilation. Pediatr Crit Care Med. 2001 Jan; 2(1):9-16.
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  116. Cockrill BA, Kacmarek RM, Fifer MA, Bigatello LM, Ginns LC, Zapol WM, Semigran MJ. Comparison of the effects of nitric oxide, nitroprusside, and nifedipine on hemodynamics and right ventricular contractility in patients with chronic pulmonary hypertension. Chest. 2001 Jan; 119(1):128-36.
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  117. Kacmarek RM, Schwartz DR. Lung recruitment. Respir Care Clin N Am. 2000 Dec; 6(4):597-623.
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  118. Williams P, Kratohvil J, Ritz R, Hess DR, Kacmarek RM. Pressure support and pressure assist/control: are there differences? An evaluation of the newest intensive care unit ventilators. Respir Care. 2000 Oct; 45(10):1169-81.
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  119. Fujino Y, Kacmarek RM, Hess DR. Nitric oxide delivery during high-frequency oscillatory ventilation. Respir Care. 2000 Sep; 45(9):1097-104.
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  120. Fujino Y, Goddon S, Chiche JD, Hromi J, Kacmarek RM. Partial liquid ventilation ventilates better than gas ventilation. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):650-7.
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  121. Kacmarek RM. Central oxygen delivery systems: a disaster waiting to happen? Respir Care. 2000 Mar; 45(3):299.
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  122. Kacmarek RM. Delivery systems for long-term oxygen therapy. Respir Care. 2000 Jan; 45(1):84-92; discussion 92-4.
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  123. Ferreyra G, Goddon S, Fujino Y, Kacmarek RM. The relationship between gas delivery patterns and the lower inflection point of the pressure-volume curve during partial liquid ventilation. Chest. 2000 Jan; 117(1):191-8.
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  124. Kirmse M, Fujino Y, Hromi J, Mang H, Hess D, Kacmarek RM. Pressure-release tracheal gas insufflation reduces airway pressures in lung-injured sheep maintaining eucapnia. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1462-7.
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  125. Kacmarek RM. High frequency oscillation versus conventional ventilation: is one superior? Eur Respir J. 1999 Oct; 14(4):733-4.
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  126. Villar J, Pérez-Méndez L, Kacmarek RM. Current definitions of acute lung injury and the acute respiratory distress syndrome do not reflect their true severity and outcome. Intensive Care Med. 1999 Sep; 25(9):930-5.
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  127. Kacmarek RM. NIPPV: patient-ventilator synchrony, the difference between success and failure? Intensive Care Med. 1999 Jul; 25(7):645-7.
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  128. Kacmarek RM. Newer ventilatory strategies. Curr Opin Anaesthesiol. 1999 Apr; 12(2):133-41.
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  129. Fujino Y, Kirmse M, Hess D, Kacmarek RM. The effect of mode, inspiratory time, and positive end-expiratory pressure on partial liquid ventilation. Am J Respir Crit Care Med. 1999 Apr; 159(4 Pt 1):1087-95.
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  130. Imanaka H, Kirmse M, Mang H, Hess D, Kacmarek RM. Expiratory phase tracheal gas insufflation and pressure control in sheep with permissive hypercapnia. Am J Respir Crit Care Med. 1999 Jan; 159(1):49-54.
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  131. Kacmarek RM. Ventilator-associated lung injury. Int Anesthesiol Clin. 1999; 37(3):47-64.
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  132. Hess DR, Acosta FL, Ritz RH, Kacmarek RM, Camargo CA. The effect of heliox on nebulizer function using a beta-agonist bronchodilator. Chest. 1999 Jan; 115(1):184-9.
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  133. Oelberg DA, Kacmarek RM, Pappagianopoulos PP, Ginns LC, Systrom DM. Ventilatory and cardiovascular responses to inspired He-O2 during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998 Dec; 158(6):1876-82.
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  134. Kirmse M, Fujino Y, Hess D, Kacmarek RM. Positive end-expiratory pressure improves gas exchange and pulmonary mechanics during partial liquid ventilation. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 1):1550-6.
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  135. Chiche JD, Brunet F, Lamy M, Kacmarek R. Protective ventilation for the acute respiratory distress syndrome. N Engl J Med. 1998 Jul 16; 339(3):196-7; author reply 198-9.
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  136. Kirmse M, Hess D, Fujino Y, Kacmarek RM, Hurford WE. Delivery of inhaled nitric oxide using the Ohmeda INOvent Delivery System. Chest. 1998 Jun; 113(6):1650-7.
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  137. Imanaka H, Kacmarek RM, Riggi V, Ritz R, Hess D. Expiratory phase and volume-adjusted tracheal gas insufflation: a lung model study. Crit Care Med. 1998 May; 26(5):939-46.
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  138. Make BJ, Hill NS, Goldberg AI, Bach JR, Criner GJ, Dunne PE, Gilmartin ME, Heffner JE, Kacmarek R, Keens TG, McInturff S, O'Donohue WJ, Oppenheimer EA, Robert D. Mechanical ventilation beyond the intensive care unit. Report of a consensus conference of the American College of Chest Physicians. Chest. 1998 May; 113(5 Suppl):289S-344S.
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  139. Kacmarek RM. Use of nitric oxide with airway diseases. Respir Care Clin N Am. 1997 Dec; 3(4):551-68.
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  140. Imanaka H, Kimball WR, Wain JC, Nishimura M, Okubo K, Hess D, Kacmarek RM. Recovery of diaphragmatic function in awake sheep after two approaches to thoracic surgery. J Appl Physiol. 1997 Nov; 83(5):1733-40.
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  141. Head CA, Brugnara C, Martinez-Ruiz R, Kacmarek RM, Bridges KR, Kuter D, Bloch KD, Zapol WM. Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J Clin Invest. 1997 Sep 1; 100(5):1193-8.
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  142. Imanaka H, Hess D, al-Himyary A, Bigatello LM, Ritz R, Kacmarek RM, Hurford WE. Assessment of errors when expiratory condensate PCO2 is used as a proxy for mixed expired PCO2 during mechanical ventilation. J Clin Monit. 1997 Jul; 13(4):215-22.
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  143. Nishimura M, Imanaka H, Uchiyama A, Tashiro C, Hess D, Kacmarek RM. Nitric oxide (NO) measurement accuracy. J Clin Monit. 1997 Jul; 13(4):241-8.
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  144. Goulet R, Hess D, Kacmarek RM. Pressure vs flow triggering during pressure support ventilation. Chest. 1997 Jun; 111(6):1649-53.
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  145. Sheridan RL, Hurford WE, Kacmarek RM, Ritz RH, Yin LM, Ryan CM, Tompkins RG. Inhaled nitric oxide in burn patients with respiratory failure. J Trauma. 1997 Apr; 42(4):629-34.
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  146. Bunburaphong T, Imanaka H, Nishimura M, Hess D, Kacmarek RM. Performance characteristics of bilevel pressure ventilators: a lung model study. Chest. 1997 Apr; 111(4):1050-60.
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  147. Imanaka H, Hess D, Kirmse M, Bigatello LM, Kacmarek RM, Steudel W, Hurford WE. Inaccuracies of nitric oxide delivery systems during adult mechanical ventilation. Anesthesiology. 1997 Mar; 86(3):676-88.
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  148. Bigatello LM, Nishimura M, Imanaka H, Hess D, Kimball WR, Kacmarek RM. Unloadiing of the work of breathing by proportional assist ventilation in a lung model. Crit Care Med. 1997 Feb; 25(2):267-72.
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  149. Purtz EP, Hess D, Kacmarek RM. Evaluation of electrochemical nitric oxide and nitrogen dioxide analyzers suitable for use during mechanical ventilation. J Clin Monit. 1997 Jan; 13(1):25-34.
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  150. Hess D, Fisher D, Williams P, Pooler S, Kacmarek RM. Medication nebulizer performance. Effects of diluent volume, nebulizer flow, and nebulizer brand. Chest. 1996 Aug; 110(2):498-505.
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  151. Drinkwine J, Kacmarek RM. Noninvasive positive pressure ventilation. Equipment and techniques. Respir Care Clin N Am. 1996 Jun; 2(2):183-94.
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  152. Imanaka H, Kacmarek RM, Ritz R, Hess D. Tracheal gas insufflation-pressure control versus volume control ventilation. A lung model study. Am J Respir Crit Care Med. 1996 Mar; 153(3):1019-24.
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  153. Kacmarek RM, Ripple R, Cockrill BA, Bloch KJ, Zapol WM, Johnson DC. Inhaled nitric oxide. A bronchodilator in mild asthmatics with methacholine-induced bronchospasm. Am J Respir Crit Care Med. 1996 Jan; 153(1):128-35.
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  154. Nishimura M, Hess D, Kacmarek RM. The response of flow-triggered infant ventilators. Am J Respir Crit Care Med. 1995 Dec; 152(6 Pt 1):1901-9.
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  155. Hess D, Fisher D, Peterfreund RA, Kacmarek RM. The delivery of aerosolized steroids from MDIs with nozzle extensions: quantitative laboratory evaluation of a method to improve aerosol delivery to intubated patients. Intensive Care Med. 1995 Nov; 21(11):945-51.
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  156. Sheridan RL, Kacmarek RM, McEttrick MM, Weber JM, Ryan CM, Doody DP, Ryan DP, Schnitzer JJ, Tompkins RG. Permissive hypercapnia as a ventilatory strategy in burned children: effect on barotrauma, pneumonia, and mortality. J Trauma. 1995 Nov; 39(5):854-9.
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  157. Kacmarek RM, Kirmse M, Nishimura M, Mang H, Kimball WR. The effects of applied vs auto-PEEP on local lung unit pressure and volume in a four-unit lung model. Chest. 1995 Oct; 108(4):1073-9.
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  158. Kacmarek RM. Introducing new mechanical ventilation technology: the hospital perspective. Respir Care. 1995 Sep; 40(9):947-51.
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  159. Kacmarek RM. Prophylactic bronchial hygiene following cardiac surgery: what is necessary? Intensive Care Med. 1995 Jun; 21(6):467-8.
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  160. Nishimura M, Hess D, Kacmarek RM, Ritz R, Hurford WE. Nitrogen dioxide production during mechanical ventilation with nitric oxide in adults. Effects of ventilator internal volume, air versus nitrogen dilution, minute ventilation, and inspired oxygen fraction. Anesthesiology. 1995 May; 82(5):1246-54.
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  161. Hess D, Burns E, Romagnoli D, Kacmarek RM. Weekly ventilator circuit changes. A strategy to reduce costs without affecting pneumonia rates. Anesthesiology. 1995 Apr; 82(4):903-11.
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  162. Mang H, Kacmarek RM, Ritz R, Wilson RS, Kimball WP. Cardiorespiratory effects of volume- and pressure-controlled ventilation at various I/E ratios in an acute lung injury model. Am J Respir Crit Care Med. 1995 Mar; 151(3 Pt 1):731-6.
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  163. Hess D, Hirsch C, Marquis-D'Amico C, Kacmarek RM. Imposed work and oxygen delivery during spontaneous breathing with adult disposable manual ventilators. Anesthesiology. 1994 Nov; 81(5):1256-63.
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  164. Semigran MJ, Cockrill BA, Kacmarek R, Thompson BT, Zapol WM, Dec GW, Fifer MA. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol. 1994 Oct; 24(4):982-8.
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  165. Kacmarek RM, Mang H, Barker N, Cycyk-Chapman MC. Effects of disposable or interchangeable positive end-expiratory pressure valves on work of breathing during the application of continuous positive airway pressure. Crit Care Med. 1994 Aug; 22(8):1219-26.
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  166. Nishimura M, Imanaka H, Yoshiya I, Kacmarek RM. Comparison of inspiratory work of breathing between flow-triggered and pressure-triggered demand flow systems in rabbits. Crit Care Med. 1994 Jun; 22(6):1002-9.
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  167. Kacmarek RM. Home mechanical ventilatory assistance for infants. Respir Care. 1994 May; 39(5):550-61; discussion 561-5.
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  168. Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD, Zapol WM. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology. 1994 Apr; 80(4):761-70.
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  169. Peterfreund RA, Niven RW, Kacmarek RM. Syringe-actuated metered dose inhalers: a quantitative laboratory evaluation of albuterol delivery through nozzle extensions. Anesth Analg. 1994 Mar; 78(3):554-8.
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  170. Fratacci MD, Kimball WR, Wain JC, Kacmarek RM, Polaner DM, Zapol WM. Diaphragmatic shortening after thoracic surgery in humans. Effects of mechanical ventilation and thoracic epidural anesthesia. Anesthesiology. 1993 Oct; 79(4):654-65.
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  171. Niven RW, Kacmarek RM, Brain JD, Peterfreund RA. Small bore nozzle extensions to improve the delivery efficiency of drugs from metered dose inhalers: laboratory evaluation. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1590-4.
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  172. Torres A, Kacmarek RM, Kimball WR, Qvist J, Stanek K, Whyte R, Zapol WM. Regional diaphragmatic length and EMG activity during inspiratory pressure support and CPAP in awake sheep. J Appl Physiol. 1993 Feb; 74(2):695-703.
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  173. Kacmarek RM. Essential gas delivery features of mechanical ventilators. Respir Care. 1992 Sep; 37(9):1045-55.
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  174. Polaner DM, Kimball WR, Fratacci MD, Wain JC, Torres A, Kacmarek RM, Zapol WM. Effects of aminophylline on regional diaphragmatic shortening after thoracotomy in the awake lamb. Anesthesiology. 1992 Jul; 77(1):93-100.
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  175. Kacmarek RM. The role of the respiratory therapist in emergency care. Respir Care. 1992 Jun; 37(6):523-30; discussion 530-2.
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  176. Kacmarek RM. Respiratory care practitioner: Carpe Diem! Respir Care. 1992 Mar; 37(3):264-9.
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  177. Kacmarek RM, Kratohvil J. Evaluation of a double-enclosure double-vacuum unit scavenging system for ribavirin administration. Respir Care. 1992 Jan; 37(1):37-45.
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  178. Vaz Fragoso CA, Kacmarek RM, Systrom DM. Improvement in exercise capacity after nocturnal positive pressure ventilation and tracheostomy in a postpoliomyelitis patient. Chest. 1992 Jan; 101(1):254-7.
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  179. Kacmarek RM. Care-giver protection from exposure to aerosolized pharmacologic agents. Is it necessary? Chest. 1991 Oct; 100(4):1104-5.
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  180. Mang H, Kacmarek RM. Prevention of pulmonary complications after abdominal surgery. Lancet. 1991 Aug 3; 338(8762):312-3.
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  181. Curran JF, Stanek KS, Kacmarek RM. Portable airway-suction systems: a comparison of performance. Respir Care. 1991 Apr; 36(4):259-66.
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  182. Stoller JK, Kacmarek RM. Ventilatory strategies in the management of the adult respiratory distress syndrome. Clin Chest Med. 1990 Dec; 11(4):755-72.
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  183. Kacmarek RM, Meklaus GJ. The new generation of mechanical ventilators. Crit Care Clin. 1990 Jul; 6(3):551-78.
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  184. Torres A, Kimball WR, Qvist J, Stanek K, Kacmarek RM, Whyte RI, Montalescot G, Zapol WM. Sonomicrometric regional diaphragmatic shortening in awake sheep after thoracic surgery. J Appl Physiol. 1989 Dec; 67(6):2357-68.
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  185. Kacmarek RM. Inspiratory pressure support: does it make a clinical difference? Intensive Care Med. 1989; 15(6):337-9.
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  186. Kacmarek RM, Thompson JE. Respiratory care of the ventilator-assisted infant in the home. Respir Care. 1986 Jul; 31(7):605-14.
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  187. Kacmarek RM. The present and future roles of the perinatal respiratory care practitioner. Respir Care. 1986 Jun; 31(6):516-23.
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  188. Kacmarek RM, Spearman CB. Equipment used for ventilatory support in the home. Respir Care. 1986 Apr; 31(4):311-28.
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  189. Kacmarek RM, Wilson RS. IMV systems. Do they make a difference? Chest. 1985 May; 87(5):557.
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  190. Kacmarek RM, Dimas S, Reynolds J, Shapiro BA. Technical aspects of positive end-expiratory pressure (PEEP): Part I. Physics of PEEP devices. Respir Care. 1982 Dec; 27(12):1478-89.
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  191. Kacmarek RM, Dimas S, Reynolds J, Shapiro BA. Technical aspects of positive end-expiratory pressure (PEEP): Part II. PEEP with positive-pressure ventilation. Respir Care. 1982 Dec; 27(12):1490-504.
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