Frank Martin Sacks, M.D.
|Title||Professor of Cardiovascular Disease Prevention|
|Institution||Harvard School of Public Health|
|Address||Harvard School of Public Health|
Building 1, Room 203
665 Huntington Ave
Boston MA 02115
|Title||Professor of Medicine|
|Institution||Brigham and Women's Hospital|
|Division||Channing Division of Network Medicine|
||2011 Research Achievement Award|
Dr. Sacks is involved in research and public policy in lipid disorders, hypertension, nutrition, and cardiovascular disease.
His research program is a combination of laboratory research on human lipoprotein metabolism, and clinical trials in nutrition and cardiovascular disease. The laboratory research concerns the acute and long term effects of dietary and drug treatments on the function of lipoproteins in humans; the function in humans of specific apolipoproteins in VLDL, LDL, and HDL including apoC-III and apoE; metabolic pathways for HDL subtypes involved in reverse cholesterol transport in humans; and epidemiology of the relation between lipoprotein particle types based on apolipoprotein composition and CVD.
Dr. Sacks was Chair of the Design Committee of the DASH study where the DASH diet was designed, and Chair of the Steering Committee for the DASH-Sodium trial. These multi center National Heart Lung and Blood Institute trials found major beneficial additive effects of low salt and a dietary pattern rich in fruits and vegetables on blood pressure. Dr. Sacks was Principal Investigator of an NIH funded trial on dietary approaches for weight loss and maintenance, the PoundsLost trial. In this trial, 4 diets varying in protein, carbohydrate and fat content were tested in 811 overweight people for 2 years. The diets had the same beneficial effects on weight loss, and all favorably affected risk factors for cardiovascular disease.
Dr. Sacks is active in national and international committees and conferences in dietary and drug treatments of dyslipidemia, and nutrition and health guidelines. . Dr. Sacks was a member of the National Cholesterol Education Program Adult Treatment Panel IV, the NIH advisory group that is developing new guidelines for treatment of dyslipidemia; and he was an external peer reviewer for the NIH of the current guidelines, Adult Treatment Panel III. He is a member of the Hypertriglyceridemia Guidelines Committee of the Endocrine Society. He is Chair of the American Heart Association Nutrition Committee that advises the AHA on nutrition policy. He is a member of the Lifestyle Working Group of the National Heart Lung and Blood Institute Clinical Guidelines for Reducing Cardiovascular Disease. Dr. Sacks teaches at Harvard School of Public Health as course director for nutritional biochemistry and for scientific writing, and at Brigham & Women’s Hospital on treatment of lipid disorders.
Dr. Sacks was the 2011 recipient of the American Heart Association’s Research Achievement Award for lifetime research accomplishments.
Dr. Sacks has published over 180 original research articles and 72 reviews, editorials, and letters.
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