Title Associate Professor of Surgery Institution Beth Israel Deaconess Medical Center Address Beth Israel Deaconess Medical Center Surgery 110 Francis Street Boston MA 02215
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Research
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5R01CA263324-02
(Lawler, Sean - Cook, Charles H)
Apr 11, 2022 - Mar 31, 2027
Defining the role of cytomegalovirus in glioblastoma therapies
Role Description: Glioblastoma (GBM) is an incurable brain tumor for which improved therapies are badly needed. There are roughly 10,000 cases diagnosed in the US each year, and median survival is ~14 months. Evidence has been accumulating over recent years linking cytomegalovirus (CMV) to GBM and other cancers. However, the role of CMV in GBM remains poorly defined. CMV is a prevalent virus in humans, where it resides lifelong in a latent state but can be reactivated under certain conditions. Several clinical trials targeting CMV using diverse approaches including immunotherapies and the anti-viral drug CMV have shown very promising responses in GBM patients, but the underlying mechanisms are not clear.
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R01CA263324
(LAWLER, SEAN EDWARD)
Apr 11, 2022 - Mar 31, 2027
Defining the role of cytomegalovirus in glioblastoma therapies
Role: Co-Principal Investigator
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5R01CA195532-05
(Chiocca, E.A.)
Mar 1, 2015 - Feb 28, 2021
Investigating the cytomegalovirus link to glioblastoma using a novel mouse model
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R01GM066115
(COOK, CHARLES H)
May 8, 2003 - May 31, 2016
Bacterial Sepsis and Reactivation of Latent Cytomegalovirus
Role: Principal Investigator
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R01AI053094
(COOK, CHARLES H)
Dec 1, 2002 - Nov 30, 2008
THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCE
Role: Principal Investigator
Bibliographic
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