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Shader RI. The liver: a vulnerable helper. Clin Ther. 2013 Mar; 35(3):199-200.
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Shader RI. Influenza vaccines-thoughts and current status. Clin Ther. 2013 Feb; 35(2):101-2.
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Shader RI. A new year, a new look. Clin Ther. 2013 Jan; 35(1):1.
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Shader RI. Too good to be true? Aspirin and schizophrenia. J Clin Psychopharmacol. 2012 Oct; 32(5):583-4.
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Umberg EN, Shader RI, Hsu LK, Greenblatt DJ. From disordered eating to addiction: the "food drug" in bulimia nervosa. J Clin Psychopharmacol. 2012 Jun; 32(3):376-89.
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Klein DF, Glick ID, Shader RI. Central nervous system drug development, basic, and clinical research: thinking outside the box. J Clin Psychopharmacol. 2011 Oct; 31(5):553-4.
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Greenblatt DJ, Harmatz JS, Shader RI. Psychotropic drug prescribing in the United States: extent, costs, and expenditures. J Clin Psychopharmacol. 2011 Feb; 31(1):1-3.
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Shader RI. Good news and disappointing news: a new era in health care delivery. J Clin Psychopharmacol. 2010 Jun; 30(3):223-4.
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Shader RI. Water safety, medication disposal, and more: an update. J Clin Psychopharmacol. 2010 Feb; 30(1):1-2.
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Shader RI. The cart before the horse? Health insurance reform before health care reform. J Clin Psychopharmacol. 2009 Oct; 29(5):413-4.
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Shader RI. Antidepressants as hydrobromide salts: are they a cause for concern? J Clin Psychopharmacol. 2009 Aug; 29(4):317-8.
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Shader RI. Some personal reflections on health care reform. J Clin Psychopharmacol. 2008 Dec; 28(6):599-600.
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Shader RI. Water, water everywhere: but is it safe to drink? Return to a muddy topic. J Clin Psychopharmacol. 2008 Jun; 28(3):261-3.
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Shader RI. Dose dumping and the dumping of doses. J Clin Psychopharmacol. 2007 Aug; 27(4):327-8.
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Fahey JM, Pritchard GA, Reddi JM, Pratt JS, Grassi JM, Shader RI, Greenblatt DJ. The effect of chronic lorazepam administration in aging mice. Brain Res. 2006 Nov 6; 1118(1):13-24.
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Shader RI. Kynurenine--an old pathway retraced. J Clin Psychopharmacol. 2006 Aug; 26(4):351-2.
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Shader RI, Oesterheld JR. Facts and public policy: should I keep my child on ADHD drugs? J Clin Psychopharmacol. 2006 Jun; 26(3):223-4.
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Greenblatt DJ, Gan L, Harmatz JS, Shader RI. Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the Digit-Symbol Substitution Test. Br J Clin Pharmacol. 2005 Sep; 60(3):244-8.
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Shader RI. Demoralization revisited. J Clin Psychopharmacol. 2005 Aug; 25(4):291-2.
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Glick ID, Zisook S, Shader RI. The challenge of teaching psychopharmacology and improving clinical practice. J Clin Psychopharmacol. 2005 Jun; 25(3):203-5.
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Vitiello B, Shader RI, Parker CB, Ritz L, Harlan W, Greenblatt DJ, Gadde KM, Krishnan KR, Davidson JR. Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial. J Clin Psychopharmacol. 2005 Jun; 25(3):243-9.
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Greenblatt DJ, Harmatz JS, von Moltke LL, Wright CE, Shader RI. Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate. Clin Pharmacol Ther. 2004 Nov; 76(5):467-79.
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Greenblatt DJ, Ehrenberg BL, Culm KE, Scavone JM, Corbett KE, Friedman HL, Harmatz JS, Shader RI. Kinetics and EEG effects of midazolam during and after 1-minute, 1-hour, and 3-hour intravenous infusions. J Clin Pharmacol. 2004 Jun; 44(6):605-11.
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Greenblatt DJ, Shader RI. In memoriam: Louis Lasagna, MD 1923-2003. J Clin Psychopharmacol. 2004 Jun; 24(3):243-4.
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Ross-Degnan D, Simoni-Wastila L, Brown JS, Gao X, Mah C, Cosler LE, Fanning T, Gallagher P, Salzman C, Shader RI, Inui TS, Soumerai SB. A controlled study of the effects of state surveillance on indicators of problematic and non-problematic benzodiazepine use in a Medicaid population. Int J Psychiatry Med. 2004; 34(2):103-23.
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Shader RI. Drug-attributed hepatic failure: causality, risk assessment, consent, and confusion. J Clin Psychopharmacol. 2003 Dec; 23(6):533-4.
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Warrington JS, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ. The effect of age on sildenafil biotransformation in rat and mouse liver microsomes. Drug Metab Dispos. 2003 Nov; 31(11):1306-9.
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Olubodun JO, Ochs HR, von Moltke LL, Roubenoff R, Hesse LM, Harmatz JS, Shader RI, Greenblatt DJ. Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men. Br J Clin Pharmacol. 2003 Sep; 56(3):297-304.
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Shader RI. Antagonists, inverse agonists, and protagonists. J Clin Psychopharmacol. 2003 Aug; 23(4):321-2.
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Shader RI. Foods, genetics, and drug interactions. J Clin Psychopharmacol. 2003 Jun; 23(3):221-2.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Fogelman SM, Chen G, Graf JA, Mertzanis P, Byron S, Culm KE, Granda BW, Daily JP, Shader RI. Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone. J Clin Pharmacol. 2003 Apr; 43(4):414-22.
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Shader RI, Greenblatt DJ. The safety of over-the-counter drugs: some reflections and unanswered questions. J Clin Psychopharmacol. 2003 Apr; 23(2):111-2.
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Olubodun JO, Ochs HR, Trüten V, Klein A, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ. Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use. J Clin Pharmacol. 2002 Oct; 42(10):1142-6.
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Warrington JS, Von Moltke LL, Shader RI, Greenblatt DJ. In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11. Drug Metab Dispos. 2002 Jun; 30(6):655-7.
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Shader RI. Discontinue after last dose--an editorial and information about prescription writing. J Clin Psychopharmacol. 2002 Jun; 22(3):235.
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Perloff MD, von Moltke LL, Störmer E, Shader RI, Greenblatt DJ. Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. Br J Pharmacol. 2001 Dec; 134(8):1601-8.
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Venkatakrishnan K, Schmider J, Harmatz JS, Ehrenberg BL, von Moltke LL, Graf JA, Mertzanis P, Corbett KE, Rodriguez MC, Shader RI, Greenblatt DJ. Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies. J Clin Pharmacol. 2001 Oct; 41(10):1043-54.
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Shader RI, Greenblatt DJ. Selective serotonin reuptake inhibitor antidepressants: cardiovascular complications--sorting through findings. J Clin Psychopharmacol. 2001 Oct; 21(5):467-8.
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Greenblatt DJ, Patki KC, von Moltke LL, Shader RI. Drug interactions with grapefruit juice: an update. J Clin Psychopharmacol. 2001 Aug; 21(4):357-9.
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von Moltke LL, Greenblatt DJ, Giancarlo GM, Granda BW, Harmatz JS, Shader RI. Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram. Drug Metab Dispos. 2001 Aug; 29(8):1102-9.
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Fogas BS, Oesterheld JR, Shader RI. A retrospective study of children's perceptions of participation as clinical research subjects in a minimal risk study. J Dev Behav Pediatr. 2001 Aug; 22(4):211-6.
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Ciraulo DA, Knapp CM, LoCastro J, Greenblatt DJ, Shader RI. A benzodiazepine mood effect scale: reliability and validity determined for alcohol-dependent subjects and adults with a parental history of alcoholism. Am J Drug Alcohol Abuse. 2001 May; 27(2):339-47.
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Fahey JM, Pritchard GA, Grassi JM, Pratt JS, Shader RI, Greenblatt DJ. Pharmacodynamic and receptor binding changes during chronic lorazepam administration. Pharmacol Biochem Behav. 2001 May-Jun; 69(1-2):1-8.
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Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ. Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion. Drug Metab Dispos. 2001 Feb; 29(2):100-2.
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Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ. CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb; 29(2):133-40.
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von Moltke LL, Greenblatt DJ, Granda BW, Giancarlo GM, Duan SX, Daily JP, Harmatz JS, Shader RI. Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors. J Clin Pharmacol. 2001 Jan; 41(1):85-91.
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Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ. CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. Drug Metab Dispos. 2000 Oct; 28(10):1176-83.
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Störmer E, von Moltke LL, Shader RI, Greenblatt DJ. Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4. Drug Metab Dispos. 2000 Oct; 28(10):1168-75.
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Shader RI, Greenblatt DJ. More on oral contraceptives, drug interactions, herbal medicines, and hormone replacement therapy. J Clin Psychopharmacol. 2000 Aug; 20(4):397-8.
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Greenblatt DJ, von Moltke LL, Ehrenberg BL, Harmatz JS, Corbett KE, Wallace DW, Shader RI. Kinetics and dynamics of lorazepam during and after continuous intravenous infusion. Crit Care Med. 2000 Aug; 28(8):2750-7.
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Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Harmatz JS, Shader RI. Differences in pharmacodynamics but not pharmacokinetics between subjects with panic disorder and healthy subjects after treatment with a single dose of alprazolam. J Clin Psychopharmacol. 2000 Jun; 20(3):338-46.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Durol AL, Daily JP, Graf JA, Mertzanis P, Hoffman JL, Shader RI. Differential impairment of triazolam and zolpidem clearance by ritonavir. J Acquir Immune Defic Syndr. 2000 Jun 1; 24(2):129-36.
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Greenblatt DJ, Harmatz JS, von Moltke LL, Wright CE, Durol AL, Harrel-Joseph LM, Shader RI. Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences. J Pharmacol Exp Ther. 2000 May; 293(2):435-43.
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Shader RI, Oesterheld JR. Contraceptive effectiveness: cytochromes and induction. J Clin Psychopharmacol. 2000 Apr; 20(2):119-21.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Durol AL, Daily JP, Graf JA, Mertzanis P, Hoffman JL, Shader RI. Alprazolam-ritonavir interaction: implications for product labeling. Clin Pharmacol Ther. 2000 Apr; 67(4):335-41.
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Warrington JS, Shader RI, von Moltke LL, Greenblatt DJ. In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions. Drug Metab Dispos. 2000 Apr; 28(4):392-7.
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Zalma A, von Moltke LL, Granda BW, Harmatz JS, Shader RI, Greenblatt DJ. In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors. Biol Psychiatry. 2000 Apr 1; 47(7):655-61.
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Warrington JS, Poku JW, von Moltke LL, Shader RI, Harmatz JS, Greenblatt DJ. Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes. J Pharmacol Exp Ther. 2000 Mar; 292(3):1024-31.
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Perloff MD, von Moltke LL, Court MH, Kotegawa T, Shader RI, Greenblatt DJ. Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. J Pharmacol Exp Ther. 2000 Feb; 292(2):618-28.
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Sarid-Segal O, Knapp CM, Ciraulo AM, Greenblatt DJ, Shader RI, Ciraulo DA. Decreased EEG sensitivity to alprazolam in subjects with a parental history of alcoholism. J Clin Pharmacol. 2000 Jan; 40(1):84-90.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Shader RI. Human cytochromes mediating sertraline biotransformation: seeking attribution. J Clin Psychopharmacol. 1999 Dec; 19(6):489-93.
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Shader RI, Granda BW, von Moltke LL, Giancarlo GM, Greenblatt DJ. Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast. Biopharm Drug Dispos. 1999 Nov; 20(8):385-8.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Shader RI. Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions. J Clin Psychopharmacol. 1999 Oct; 19(5 Suppl 1):23S-35S.
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von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Duan SX, Fogelman SM, Harmatz JS, Shader RI. Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects. Biol Psychiatry. 1999 Sep 15; 46(6):839-49.
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Shader RI, Harmatz JS, Oesterheld JR, Parmelee DX, Sallee FR, Greenblatt DJ. Population pharmacokinetics of methylphenidate in children with attention-deficit hyperactivity disorder. J Clin Pharmacol. 1999 Aug; 39(8):775-85.
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Greenblatt DJ, von Moltke LL, Daily JP, Harmatz JS, Shader RI. Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction. J Clin Psychopharmacol. 1999 Aug; 19(4):293-6.
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von Moltke LL, Greenblatt DJ, Granda BW, Grassi JM, Schmider J, Harmatz JS, Shader RI. Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology (Berl). 1999 Jul; 145(1):113-22.
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Von Moltke LL, Greenblatt DJ, Granda BW, Duan SX, Grassi JM, Venkatakrishnan K, Harmatz JS, Shader RI. Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations. Br J Clin Pharmacol. 1999 Jul; 48(1):89-97.
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Shader RI, Greenblatt DJ. More on potassium, the heart, and antipsychotic agents. J Clin Psychopharmacol. 1999 Jun; 19(3):201-2.
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Schmider J, von Moltke LL, Shader RI, Harmatz JS, Greenblatt DJ. Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine. Drug Metab Rev. 1999 May; 31(2):545-60.
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Fogelman SM, Schmider J, Venkatakrishnan K, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ. O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May; 20(5):480-90.
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Shader RI, Greenblatt DJ. The reappearance of a monamine oxidase inhibitor (isocarboxazid) J Clin Psychopharmacol. 1999 Apr; 19(2):105-6.
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Greenblatt DJ, Shader RI. Mass units or molar units for drug concentration? J Clin Psychopharmacol. 1999 Feb; 19(1):1-2.
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Fahey JM, Pritchard GA, Pratt JS, Shader RI, Greenblatt DJ. Lorazepam attenuates the behavioral effects of dizocilpine. Pharmacol Biochem Behav. 1999 Jan; 62(1):103-10.
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Fahey JM, Pritchard GA, Grassi JM, Pratt JS, Shader RI, Greenblatt DJ. In situ hybridization histochemistry as a method to assess GABA(A) receptor subunit mRNA expression following chronic alprazolam administration. J Psychopharmacol. 1999; 13(3):211-8.
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von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Fogelman SM, Harmatz JS, Kramer SJ, Fabre LF, Shader RI. Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects. Psychopharmacology (Berl). 1998 Dec; 140(3):293-9.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Mertzanis P, Graf JA, Durol AL, Counihan M, Roth-Schechter B, Shader RI. Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole. Clin Pharmacol Ther. 1998 Dec; 64(6):661-71.
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Shader RI, Greenblatt DJ. Potassium, antipsychotic agents, arrhythmias, and sudden death. J Clin Psychopharmacol. 1998 Dec; 18(6):427-8.
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Greenblatt DJ, Harmatz JS, von Moltke LL, Ehrenberg BL, Harrel L, Corbett K, Counihan M, Graf JA, Darwish M, Mertzanis P, Martin PT, Cevallos WH, Shader RI. Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo. Clin Pharmacol Ther. 1998 Nov; 64(5):553-61.
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von Moltke LL, Greenblatt DJ, Duan SX, Daily JP, Harmatz JS, Shader RI. Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo. J Pharm Sci. 1998 Oct; 87(10):1184-9.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Counihan M, Graf JA, Durol AL, Mertzanis P, Duan SX, Wright CE, Shader RI. Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. Clin Pharmacol Ther. 1998 Sep; 64(3):278-85.
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von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Schmider J, Harmatz JS, Shader RI. Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. J Pharm Pharmacol. 1998 Sep; 50(9):997-1004.
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Greenblatt DJ, Wright CE, von Moltke LL, Harmatz JS, Ehrenberg BL, Harrel LM, Corbett K, Counihan M, Tobias S, Shader RI. Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences. Clin Pharmacol Ther. 1998 Sep; 64(3):237-47.
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von Moltke LL, Greenblatt DJ, Ciraulo DA, Grassi JM, Granda BW, Duan SX, Harmatz JS, Shader RI. Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine. J Clin Psychopharmacol. 1998 Aug; 18(4):338-41.
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Shader RI, Fogelman SM, Greenblatt DJ. Epiphenomenal, causal, or correlational--more on the mechanism(s) of action of antidepressants. J Clin Psychopharmacol. 1998 Aug; 18(4):265-7.
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Scavone JM, Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI. Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers. J Clin Pharmacol. 1998 Jul; 38(7):603-9.
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Greenblatt DJ, Shader RI. Conflicts of interest, redundant publication, and identification of authorship: a plea for trust instead of suspicion. J Clin Psychopharmacol. 1998 Jun; 18(3):183-4.
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Venkatakrishnan K, Greenblatt DJ, von Moltke LL, Shader RI. Alprazolam is another substrate for human cytochrome P450-3A isoforms. J Clin Psychopharmacol. 1998 Jun; 18(3):256.
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Fahey JM, Pritchard GA, Moltke LL, Pratt JS, Grassi JM, Shader RI, Greenblatt DJ. Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice. J Pharmacol Exp Ther. 1998 Apr; 285(1):271-6.
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Shader RI, Greenblatt DJ. Clozapine and fluvoxamine, a curious complexity. J Clin Psychopharmacol. 1998 Apr; 18(2):101-2.
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Oesterheld JR, Shader RI. Cytochromes: a primer for child and adolescent psychiatrists. J Am Acad Child Adolesc Psychiatry. 1998 Apr; 37(4):447-50.
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Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ. Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998 Mar; 50(3):265-74.
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Venkatakrishnan K, Greenblatt DJ, von Moltke LL, Schmider J, Harmatz JS, Shader RI. Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. J Clin Pharmacol. 1998 Feb; 38(2):112-21.
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von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Duan SX, Fogelman SM, Daily JP, Harmatz JS, Shader RI. Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir. J Clin Pharmacol. 1998 Feb; 38(2):106-11.
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von Moltke LL, Greenblatt DJ, Schmider J, Wright CE, Harmatz JS, Shader RI. In vitro approaches to predicting drug interactions in vivo. Biochem Pharmacol. 1998 Jan 15; 55(2):113-22.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Shader RI. Drug interactions with newer antidepressants: role of human cytochromes P450. J Clin Psychiatry. 1998; 59 Suppl 15:19-27.
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Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Harmatz JS, Shader RI. Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects. J Clin Pharmacol. 1998 Jan; 38(1):14-21.
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Schmider J, Greenblatt DJ, von Moltke LL, Karsov D, Shader RI. Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation. Br J Clin Pharmacol. 1997 Nov; 44(5):495-8.
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Shader RI, Greenblatt DJ. It's in the bag: drug absorption by drug-delivery systems. J Clin Psychopharmacol. 1997 Oct; 17(5):339-40.
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Shader RI, Greenblatt DJ. Can you provide a table of equivalences for benzodiazepines and other marketed benzodiazepine receptor agonists? J Clin Psychopharmacol. 1997 Aug; 17(4):331.
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Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MM, Harmatz JS, Shader RI. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997 Aug; 37(8):693-703.
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Shader RI, Greenblatt DJ. Fruit juices and pharmacology. J Clin Psychopharmacol. 1997 Aug; 17(4):245-6.
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von Moltke LL, Greenblatt DJ, Duan SX, Schmider J, Wright CE, Harmatz JS, Shader RI. Human cytochromes mediating N-demethylation of fluoxetine in vitro. Psychopharmacology (Berl). 1997 Aug; 132(4):402-7.
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Scavone JM, Greenblatt DJ, Abernethy DR, Luna BG, Harmatz JS, Shader RI. Influence of oral contraceptive use and cigarette smoking, alone and together, on antipyrine pharmacokinetics. J Clin Pharmacol. 1997 May; 37(5):437-41.
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Shader RI, Fogelman SM, Greenblatt DJ. Newer antidepressants: further reflections. J Clin Psychopharmacol. 1997 Apr; 17(2):75-7.
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Court MH, Von Moltke LL, Shader RI, Greenblatt DJ. Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharm Drug Dispos. 1997 Apr; 18(3):213-26.
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Schmider J, Greenblatt DJ, Fogelman SM, von Moltke LL, Shader RI. Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1. Biopharm Drug Dispos. 1997 Apr; 18(3):227-40.
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Charpentier KP, von Moltke LL, Poku JW, Harmatz JS, Shader RI, Greenblatt DJ. Alprazolam hydroxylation by mouse liver microsomes in vitro: the effect of age and phenobarbital induction. Biopharm Drug Dispos. 1997 Mar; 18(2):139-49.
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Schmider J, Greenblatt DJ, von Moltke LL, Karsov D, Vena R, Friedman HL, Shader RI. Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. J Clin Pharmacol. 1997 Mar; 37(3):193-200.
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von Moltke LL, Duan SX, Greenblatt DJ, Fogelman SM, Schmider J, Harmatz JS, Shader RI. Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms. Biol Psychiatry. 1997 Feb 1; 41(3):377-80.
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Shader RI, Fogelman SM, Greenblatt DJ. Newer antidepressants: hypotheses and evidence. J Clin Psychopharmacol. 1997 Feb; 17(1):1-3.
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Ciraulo DA, Barnhill JG, Ciraulo AM, Sarid-Segal O, Knapp C, Greenblatt DJ, Shader RI. Alterations in pharmacodynamics of anxiolytics in abstinent alcoholic men: subjective responses, abuse liability, and electroencephalographic effects of alprazolam, diazepam, and buspirone. J Clin Pharmacol. 1997 Jan; 37(1):64-73.
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Greenblatt DJ, von Moltke LL, Shader RI. The importance of presystemic extraction in clinical psychopharmacology. J Clin Psychopharmacol. 1996 Dec; 16(6):417-9.
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von Moltke LL, Greenblatt DJ, Duan SX, Schmider J, Kudchadker L, Fogelman SM, Harmatz JS, Shader RI. Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine. Psychopharmacology (Berl). 1996 Dec; 128(4):398-407.
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Shader RI, Greenblatt DJ. Protease inhibitors and drug interactions--an alert. J Clin Psychopharmacol. 1996 Oct; 16(5):343-4.
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Greenblatt DJ, von Moltke LL, Schmider J, Harmatz JS, Shader RI. Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies. J Clin Pharmacol. 1996 Sep; 36(9):792-8.
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von Moltke LL, Greenblatt DJ, Schmider J, Duan SX, Wright CE, Harmatz JS, Shader RI. Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents. J Clin Pharmacol. 1996 Sep; 36(9):783-91.
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Schmider J, Greenblatt DJ, von Moltke LL, Shader RI. Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans. J Clin Psychopharmacol. 1996 Aug; 16(4):267-72.
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Ciraulo DA, Sarid-Segal O, Knapp C, Ciraulo AM, Greenblatt DJ, Shader RI. Liability to alprazolam abuse in daughters of alcoholics. Am J Psychiatry. 1996 Jul; 153(7):956-8.
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Schmider J, Greenblatt DJ, Harmatz JS, Shader RI. Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation. Br J Clin Pharmacol. 1996 Jun; 41(6):593-604.
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Shader RI, von Moltke LL, Schmider J, Harmatz JS, Greenblatt DJ. The clinician and drug interactions--an update. J Clin Psychopharmacol. 1996 Jun; 16(3):197-201.
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Schmider J, Greenblatt DJ, von Moltke LL, Harmatz JS, Shader RI. Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation. Br J Clin Pharmacol. 1996 Apr; 41(4):339-43.
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Shader RI. I have heard that buspirone regularly affects various blood tests. Is this so? J Clin Psychopharmacol. 1996 Apr; 16(2):194.
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von Moltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Wright CE, Shader RI. Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo. J Clin Psychopharmacol. 1996 Apr; 16(2):104-12.
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Shader RI, Greenblatt DJ. Twice may be too many: redundant publications. J Clin Psychopharmacol. 1996 Feb; 16(1):1-2.
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von Moltke LL, Greenblatt DJ, Harmatz JS, Duan SX, Harrel LM, Cotreau-Bibbo MM, Pritchard GA, Wright CE, Shader RI. Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole. J Pharmacol Exp Ther. 1996 Feb; 276(2):370-9.
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Schmider J, Greenblatt DJ, von Moltke LL, Harmatz JS, Duan SX, Karsov D, Shader RI. Characterization of six in vitro reactions mediated by human cytochrome P450: application to the testing of cytochrome P450-directed antibodies. Pharmacology. 1996 Feb; 52(2):125-34.
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Oesterheld JR, Shader RI. Case 8: the wambly sophomaniac. J Clin Psychopharmacol. 1995 Dec; 15(6):449.
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Schmider J, Greenblatt DJ, von Moltke LL, Harmatz JS, Shader RI. N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors. J Pharmacol Exp Ther. 1995 Nov; 275(2):592-7.
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Shader RI, Oesterheld JR. Case 7: the addled nonagenarian. J Clin Psychopharmacol. 1995 Oct; 15(5):378.
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Shader RI, Oesterheld JR. Case 6: a free solution. J Clin Psychopharmacol. 1995 Aug; 15(4):297.
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Shader RI, Oesterheld JR. Canny cases. Case 5: the dextral dodder. J Clin Psychopharmacol. 1995 Jun; 15(3):232.
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Shader RI. I read a recent report suggesting a causal relationship between a dystonic reaction in a patient and her use of sumatriptan. Is this likely? J Clin Psychopharmacol. 1995 Jun; 15(3):231.
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von Moltke LL, Greenblatt DJ, Court MH, Duan SX, Harmatz JS, Shader RI. Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. J Clin Psychopharmacol. 1995 Apr; 15(2):125-31.
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Oesterheld JR, Shader RI. Canny cases. Case 4: A precipitate poisoning. J Clin Psychopharmacol. 1995 Apr; 15(2):147.
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Shader RI, Greenblatt DJ. More on drugs and pregnancy. J Clin Psychopharmacol. 1995 Feb; 15(1):1-2.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Harrel LM, Tobias S, Shader RI, Wright CE. Interaction of triazolam and ketoconazole. Lancet. 1995 Jan 21; 345(8943):191.
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von Moltke LL, Greenblatt DJ, Schmider J, Harmatz JS, Shader RI. Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology. Clin Pharmacokinet. 1995; 29 Suppl 1:33-43; discussion 43-4.
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Shader RI, Greenblatt DJ, von Moltke LL. Fluoxetine inhibition of phenytoin metabolism. J Clin Psychopharmacol. 1994 Dec; 14(6):375-6.
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Shader RI, Oesterheld JR. Case 2: Dizzy Giuseppi or the vertiginous virtuoso. J Clin Psychopharmacol. 1994 Dec; 14(6):437.
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Shader RI. Is there anything new on the use of psychotropic drugs during pregnancy? J Clin Psychopharmacol. 1994 Dec; 14(6):438.
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von Moltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Shader RI. In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction. J Clin Pharmacol. 1994 Dec; 34(12):1222-7.
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Oesterheld JR, Shader RI. The verdant octogenarian. J Clin Psychopharmacol. 1994 Oct; 14(5):366.
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Shader RI, Harmatz JS, Greenblatt DJ. Thinking while balancing: what to do about replacing dropouts. J Clin Psychopharmacol. 1994 Aug; 14(4):229.
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Lasagna L, Shader RI. A white paper on the appropriateness of proposals by the FDA to modify labeling of benzodiazepine sedative-hypnotics. J Clin Pharmacol. 1994 Aug; 34(8):812-5.
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Greenblatt DJ, Harmatz JS, Gouthro TA, Locke J, Shader RI. Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: kinetic-dynamic studies. Clin Pharmacol Ther. 1994 Jul; 56(1):100-11.
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von Moltke LL, Greenblatt DJ, Cotreau-Bibbo MM, Harmatz JS, Shader RI. Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine. Br J Clin Pharmacol. 1994 Jul; 38(1):23-31.
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Tsang MW, Shader RI, Greenblatt DJ. Metabolism of haloperidol: clinical implications and unanswered questions. J Clin Psychopharmacol. 1994 Jun; 14(3):159-62.
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von Moltke LL, Greenblatt DJ, Cotreau-Bibbo MM, Duan SX, Harmatz JS, Shader RI. Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo. J Pharmacol Exp Ther. 1994 Mar; 268(3):1278-83.
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von Moltke LL, Greenblatt DJ, Harmatz JS, Shader RI. Cytochromes in psychopharmacology. J Clin Psychopharmacol. 1994 Feb; 14(1):1-4.
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Hollister LE, Müller-Oerlinghausen B, Rickels K, Shader RI. Clinical uses of benzodiazepines. J Clin Psychopharmacol. 1993 Dec; 13(6 Suppl 1):1S-169S.
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Shader RI, Greenblatt DJ. MedWatch, the new FDA adverse effects reporting system. J Clin Psychopharmacol. 1993 Oct; 13(5):303-4.
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Greenblatt DJ, von Moltke LL, Harmatz JS, Ciraulo DA, Shader RI. Alprazolam pharmacokinetics, metabolism, and plasma levels: clinical implications. J Clin Psychiatry. 1993 Oct; 54 Suppl:4-11; discussion 12-4.
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von Moltke LL, Greenblatt DJ, Harmatz JS, Shader RI. Alprazolam metabolism in vitro: studies of human, monkey, mouse, and rat liver microsomes. Pharmacology. 1993 Oct; 47(4):268-76.
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Greenblatt DJ, Harmatz JS, Shader RI. Plasma alprazolam concentrations. Relation to efficacy and side effects in the treatment of panic disorder. Arch Gen Psychiatry. 1993 Sep; 50(9):715-22.
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Shader RI, Greenblatt DJ. Use of benzodiazepines in anxiety disorders. N Engl J Med. 1993 May 13; 328(19):1398-405.
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Greenblatt DJ, Scavone JM, Harmatz JS, Engelhardt N, Shader RI. Cognitive effects of beta-adrenergic antagonists after single doses: pharmacokinetics and pharmacodynamics of propranolol, atenolol, lorazepam, and placebo. Clin Pharmacol Ther. 1993 May; 53(5):577-84.
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Byrnes JJ, Miller LG, Perkins K, Greenblatt DJ, Shader RI. Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects. Neuropsychopharmacology. 1993 May; 8(3):267-73.
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Ahmed I, Dagincourt PG, Miller LG, Shader RI. Possible interaction between fluoxetine and pimozide causing sinus bradycardia. Can J Psychiatry. 1993 Feb; 38(1):62-3.
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von Moltke LL, Greenblatt DJ, Shader RI. Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications. Clin Pharmacokinet. 1993 Feb; 24(2):141-60.
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Byrnes JJ, Miller LG, Greenblatt DJ, Shader RI. Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam. Psychopharmacology (Berl). 1993; 111(1):91-5.
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Glick ID, Janowsky DS, Salzman C, Shader RI. A proposal for a model psychopharmacology curriculum for psychiatric residents. Neuropsychopharmacology. 1993 Jan; 8(1):1-5.
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Shader RI. Does continuous use of fluoxetine during the first trimester of pregnancy present a high risk for malformation or abnormal development to the exposed fetus? J Clin Psychopharmacol. 1992 Dec; 12(6):441.
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Greenblatt DJ, Shader RI. Mental illness, pharmacotherapy, and automobile operation: what is the risk? J Clin Psychopharmacol. 1992 Dec; 12(6):382-3.
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Shader RI. Does lithium both cause and treat pseudobulbar affect? J Clin Psychopharmacol. 1992 Oct; 12(5):360.
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Shader RI. A patient of mine missed a period while taking fluoxetine; it turned out that she was not pregnant. However, the question arose about the safety of fluoxetine during pregnancy. What is known? J Clin Psychopharmacol. 1992 Jun; 12(3):213.
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Shader RI, Greenblatt DJ. A possible new approach to the treatment of neuroleptic malignant syndrome. J Clin Psychopharmacol. 1992 Jun; 12(3):155.
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Kaplan GB, Greenblatt DJ, Kent MA, Cotreau MM, Arcelin G, Shader RI. Caffeine-induced behavioral stimulation is dose-dependent and associated with A1 adenosine receptor occupancy. Neuropsychopharmacology. 1992 May; 6(3):145-53.
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Miller LG, Galpern WR, Byrnes JJ, Greenblatt DJ, Shader RI. Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam. J Pharmacol Exp Ther. 1992 Apr; 261(1):285-9.
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Shader RI. Are any antianxiety agents safer for patients who spend a great deal of time in direct sunlight? J Clin Psychopharmacol. 1992 Apr; 12(2):146.
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Lopez F, Miller LG, Greenblatt DJ, Schatzki A, Lumpkin M, Shader RI. Chronic low-dose alprazolam augments gamma-aminobutyric acid(A) receptor function. J Clin Psychopharmacol. 1992 Apr; 12(2):119-23.
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Shader RI, Greenblatt DJ. MAOIs and hypertension. J Clin Psychopharmacol. 1992 Feb; 12(1):1-2.
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Scavone JM, Greenblatt DJ, Goddard JE, Friedman H, Harmatz JS, Shader RI. The pharmacokinetics and pharmacodynamics of sublingual and oral alprazolam in the post-prandial state. Eur J Clin Pharmacol. 1992; 42(4):439-43.
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Galpern WR, Miller LG, Greenblatt DJ, Szabo GK, Browne TR, Shader RI. Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine. Biochem Pharmacol. 1991 Dec 11; 42 Suppl:S99-104.
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Greenblatt DJ, Harmatz JS, Shader RI. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II). Clin Pharmacokinet. 1991 Oct; 21(4):262-73.
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Shader RI, Greenblatt DJ. Outliers--noise, nuisance, or opportunity? J Clin Psychopharmacol. 1991 Oct; 11(5):283.
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Miller LG, Chesley S, Galpern WR, Greenblatt DJ, Shader RI. Prenatal benzodiazepine administration. II. Lorazepam exposure is associated with decreases in [35S]TBPS binding but not benzodiazepine binding. Pharmacol Biochem Behav. 1991 Oct; 40(2):429-32.
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Shader RI, Greenblatt DJ, Balter MB. Appropriate use and regulatory control of benzodiazepines. J Clin Pharmacol. 1991 Sep; 31(9):781-4.
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Greenblatt DJ, Harmatz JS, Shader RI. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part I). Clin Pharmacokinet. 1991 Sep; 21(3):165-77.
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Greenblatt DJ, Harmatz JS, Shapiro L, Engelhardt N, Gouthro TA, Shader RI. Sensitivity to triazolam in the elderly. N Engl J Med. 1991 Jun 13; 324(24):1691-8.
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Shader RI, Greenblatt DJ, Harmatz JS, Scavone JM. Alprazolam, panic disorder, and the new 2 mg tablet. J Clin Psychopharmacol. 1991 Jun; 11(3):153-4.
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Goff DC, Arana GW, Greenblatt DJ, Dupont R, Ornsteen M, Harmatz JS, Shader RI. The effect of benztropine on haloperidol-induced dystonia, clinical efficacy and pharmacokinetics: a prospective, double-blind trial. J Clin Psychopharmacol. 1991 Apr; 11(2):106-12.
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Miller LG, Lumpkin M, Galpern WR, Greenblatt DJ, Shader RI. Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging. J Neurochem. 1991 Apr; 56(4):1241-7.
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Shader RI. Clozapine--a perspective. Accepted as a consensus statement by the ACNP Council, August 13, 1990. Neuropsychopharmacology. 1991 Feb; 4(2):151-2.
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Miller LG, Lumpkin M, Greenblatt DJ, Shader RI. Accelerated benzodiazepine receptor recovery after lorazepam discontinuation. FASEB J. 1991 Jan; 5(1):93-7.
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Metz A, Shader RI. Combination of fluoxetine with pemoline in the treatment of major depressive disorder. Int Clin Psychopharmacol. 1991; 6(2):93-6.
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Galpern WR, Lumpkin M, Greenblatt DJ, Shader RI, Miller LG. Chronic benzodiazepine administration. VII. Behavioral tolerance and withdrawal and receptor alterations associated with clonazepam administration. Psychopharmacology (Berl). 1991; 104(2):225-30.
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Chesley S, Lumpkin M, Schatzki A, Galpern WR, Greenblatt DJ, Shader RI, Miller LG. Prenatal exposure to benzodiazepine--I. Prenatal exposure to lorazepam in mice alters open-field activity and GABAA receptor function. Neuropharmacology. 1991 Jan; 30(1):53-8.
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Barnhill JG, Miller LG, Greenblatt DJ, Thompson ML, Ciraulo DA, Shader RI. Benzodiazepine receptor binding response to acute and chronic stress is increased in aging animals. Pharmacology. 1991; 42(4):181-7.
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Greenblatt DJ, Javaid JI, Locniskar A, Harmatz JS, Shader RI. Gas chromatographic analysis of alprazolam in plasma: replicability, stability and specificity. J Chromatogr. 1990 Dec 14; 534:202-7.
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Shader RI, Greenblatt DJ. Draft legislation: the Science Research Protection Act of 1990. J Clin Psychopharmacol. 1990 Dec; 10(6):387-8.
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Galpern WR, Miller LG, Greenblatt DJ, Shader RI. Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABAA-receptor function. Br J Pharmacol. 1990 Dec; 101(4):839-42.
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Shader RI, Greenblatt DJ. Lithium and the newborn heart. J Clin Psychopharmacol. 1990 Oct; 10(5):311.
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Chesley SF, Schatzki AD, DeUrrutia J, Greenblatt DJ, Shader RI, Miller LG. Cocaine augments peripheral benzodiazepine binding in humans. J Clin Psychiatry. 1990 Oct; 51(10):404-6.
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Miller LG, Heller J, Lumpkin M, Weill CL, Greenblatt DJ, Shader RI. Augmentation of GABAA receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neurons. Biochem Pharmacol. 1990 Sep 15; 40(6):1337-44.
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Greenblatt DJ, Shader RI. Benzodiazepine hypnotics. J Clin Psychopharmacol. 1990 Aug; 10(4 Suppl):1S-2S.
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Kaplan GB, Tai NT, Greenblatt DJ, Shader RI. Caffeine-induced behavioural stimulation is dose- and concentration-dependent. Br J Pharmacol. 1990 Jul; 100(3):435-40.
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Miller LG, Galpern WR, Greenblatt DJ, Lumpkin M, Shader RI. Chronic benzodiazepine administration. VI. A partial agonist produces behavioral effects without tolerance or receptor alterations. J Pharmacol Exp Ther. 1990 Jul; 254(1):33-8.
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Metz A, Shader RI. Adverse interactions encountered when using trazodone to treat insomnia associated with fluoxetine. Int Clin Psychopharmacol. 1990 Jul; 5(3):191-4.
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Ciraulo DA, Shader RI. Fluoxetine drug-drug interactions. II. J Clin Psychopharmacol. 1990 Jun; 10(3):213-7.
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Barnhill JG, Greenblatt DJ, Miller LG, Gaver A, Harmatz JS, Shader RI. Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals. J Pharmacol Exp Ther. 1990 Jun; 253(3):1153-61.
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Greenblatt DJ, Shader RI. Say "no" to drug testing. J Clin Psychopharmacol. 1990 Jun; 10(3):157-9.
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Roy-Byrne PP, Cowley DS, Greenblatt DJ, Shader RI, Hommer D. Reduced benzodiazepine sensitivity in panic disorder. Arch Gen Psychiatry. 1990 Jun; 47(6):534-8.
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Lapierre KA, Greenblatt DJ, Goddard JE, Harmatz JS, Shader RI. The neuropsychiatric effects of aspartame in normal volunteers. J Clin Pharmacol. 1990 May; 30(5):454-60.
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Shader RI, Greenblatt DJ. Newly marketed medications: ABCs and mind your Qs. J Clin Psychopharmacol. 1990 Apr; 10(2):81-2.
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Greenblatt DJ, Miller LG, Shader RI. Neurochemical and pharmacokinetic correlates of the clinical action of benzodiazepine hypnotic drugs. Am J Med. 1990 Mar 2; 88(3A):18S-24S.
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Lopez F, Miller LG, Greenblatt DJ, Chesley S, Schatzki A, Shader RI. Chronic administration of benzodiazepines--V. Rapid onset of behavioral and neurochemical alterations after discontinuation of alprazolam. Neuropharmacology. 1990 Mar; 29(3):237-41.
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Ciraulo DA, Antal EJ, Smith RB, Olson DR, Goldberg DA, Rand EH, Raskin RB, Phillips JP, Shader RI, Greenblatt DJ. The relationship of alprazolam dose to steady-state plasma concentrations. J Clin Psychopharmacol. 1990 Feb; 10(1):27-32.
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Ciraulo DA, Shader RI. Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics. J Clin Psychopharmacol. 1990 Feb; 10(1):48-50.
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Jarvik LF, Berg L, Bartus R, Heston L, Leith N, Phelps C, Shader R, Whitehouse P. Clinical drug trials in Alzheimer disease. What are some of the issues? Alzheimer Dis Assoc Disord. 1990; 4(4):193-202.
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Miller LG, Greenblatt DJ, Lopez F, Schatzki A, Heller J, Lumpkin M, Shader RI. Chronic benzodiazepine administration: effects in vivo and in vitro. Adv Biochem Psychopharmacol. 1990; 46:167-75.
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Lopez F, Miller LG, Thompson ML, Schatzki A, Chesley S, Greenblatt DJ, Shader RI. Chronic morphine administration augments benzodiazepine binding and GABAA receptor function. Psychopharmacology (Berl). 1990; 101(4):545-9.
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Greenblatt DJ, Miller LG, Shader RI. Benzodiazepine discontinuation syndromes. J Psychiatr Res. 1990; 24 Suppl 2:73-9.
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Kaplan GB, Tai NT, Greenblatt DJ, Shader RI. Separate and combined effects of caffeine and alprazolam on motor activity and benzodiazepine receptor binding in vivo. Psychopharmacology (Berl). 1990; 101(4):539-44.
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Baron DH, Sands BF, Ciraulo DA, Shader RI. The diagnosis and treatment of panic disorder in alcoholics: three cases. Am J Drug Alcohol Abuse. 1990; 16(3-4):287-95.
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Lopez F, Miller LG, Greenblatt DJ, Kaplan GB, Shader RI. Interaction of caffeine with the GABAA receptor complex: alterations in receptor function but not ligand binding. Eur J Pharmacol. 1989 Dec 5; 172(6):453-9.
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Shader RI, Greenblatt DJ. "Dingelling". J Clin Psychopharmacol. 1989 Dec; 9(6):395.
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Miller LG, Woolverton S, Greenblatt DJ, Lopez F, Roy RB, Shader RI. Chronic benzodiazepine administration. IV. Rapid development of tolerance and receptor downregulation associated with alprazolam administration. Biochem Pharmacol. 1989 Nov 1; 38(21):3773-7.
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Roy-Byrne PP, Lewis N, Villacres E, Diem H, Greenblatt DJ, Shader RI, Veith R. Preliminary evidence of benzodiazepine subsensitivity in panic disorder. Biol Psychiatry. 1989 Nov; 26(7):744-8.
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Greenblatt DJ, Harmatz JS, Friedman H, Locniskar A, Shader RI. A large-sample study of diazepam pharmacokinetics. Ther Drug Monit. 1989 Nov; 11(6):652-7.
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Locniskar A, Greenblatt DJ, Harmatz JS, Shader RI. Bioinequivalence of a generic brand of diazepam. Biopharm Drug Dispos. 1989 Nov-Dec; 10(6):597-605.
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Ciraulo DA, Barnhill JG, Ciraulo AM, Greenblatt DJ, Shader RI. Parental alcoholism as a risk factor in benzodiazepine abuse: a pilot study. Am J Psychiatry. 1989 Oct; 146(10):1333-5.
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Schatzki A, Lopez F, Greenblatt DJ, Shader RI, Miller LG. Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines. Br J Pharmacol. 1989 Oct; 98(2):451-4.
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Shader RI, Greenblatt DJ. Lithium nephropathy and antipyretic analgesics--an uncontrolled variable. J Clin Psychopharmacol. 1989 Oct; 9(5):319.
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Greenblatt DJ, Shader RI, Harmatz JS. Implications of altered drug disposition in the elderly: studies of benzodiazepines. J Clin Pharmacol. 1989 Oct; 29(10):866-72.
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Shader RI, Greenblatt DJ. Benzodiazepines and pregnancy--more to say and more to learn. J Clin Psychopharmacol. 1989 Aug; 9(4):237.
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Greenblatt DJ, Ehrenberg BL, Gunderman J, Scavone JM, Tai NT, Harmatz JS, Shader RI. Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam. J Pharmacol Exp Ther. 1989 Jul; 250(1):134-40.
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Shader RI, Greenblatt DJ. Misconduct in science and misconduct against scientists. J Clin Psychopharmacol. 1989 Jun; 9(3):159.
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Shader RI. Concomitant estrogen use has been alleged to increase the side effects of certain oxidatively-metabolized psychiatric drugs. Are there any estrogen-free oral contraceptives (OCs)? J Clin Psychopharmacol. 1989 Jun; 9(3):233.
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Friedman H, Greenblatt DJ, Scavone JM, Burstein ES, Ochs HR, Harmatz JS, Shader RI. Clearance of the antihistamine doxylamine. Reduced in elderly men but not in elderly women. Clin Pharmacokinet. 1989 May; 16(5):312-6.
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Shader RI, Greenblatt DJ. Errors in science versus scientific fraud. J Clin Psychopharmacol. 1989 Apr; 9(2):77.
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Greenblatt DJ, Ehrenberg BL, Gunderman J, Locniskar A, Scavone JM, Harmatz JS, Shader RI. Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo. Clin Pharmacol Ther. 1989 Apr; 45(4):356-65.
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Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI. Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam. Arch Gen Psychiatry. 1989 Apr; 46(4):326-32.
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Kaplan GB, Greenblatt DJ, Leduc BW, Thompson ML, Shader RI. Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity. J Pharmacol Exp Ther. 1989 Mar; 248(3):1078-83.
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Miller LG, Greenblatt DJ, Roy RB, Gaver A, Lopez F, Shader RI. Chronic benzodiazepine administration. III. Upregulation of gamma-aminobutyric acidA receptor binding and function associated with chronic benzodiazepine antagonist administration. J Pharmacol Exp Ther. 1989 Mar; 248(3):1096-101.
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Greenblatt DJ, Divoll MK, Abernethy DR, Ochs HR, Harmatz JS, Shader RI. Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition. Pharmacology. 1989; 38(5):327-34.
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Ciraulo DA, Sands BF, Shader RI. Critical review of liability for benzodiazepine abuse among alcoholics. Am J Psychiatry. 1988 Dec; 145(12):1501-6.
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Greenblatt DJ, Divoll MK, Soong MH, Boxenbaum HG, Harmatz JS, Shader RI. Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam. J Clin Pharmacol. 1988 Sep; 28(9):853-9.
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Ciraulo DA, Barnhill JG, Greenblatt DJ, Shader RI, Ciraulo AM, Tarmey MF, Molloy MA, Foti ME. Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men. J Clin Psychiatry. 1988 Sep; 49(9):333-7.
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Greenblatt DJ, Harmatz JS, Dorsey C, Shader RI. Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo. Clin Pharmacol Ther. 1988 Sep; 44(3):326-34.
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Shader RI, Greenblatt DJ. Bees, ginseng and MAOIs revisited. J Clin Psychopharmacol. 1988 Aug; 8(4):235.
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Miller LG, Greenblatt DJ, Roy RB, Summer WR, Shader RI. Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function. J Pharmacol Exp Ther. 1988 Jul; 246(1):177-82.
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Miller LG, Greenblatt DJ, Barnhill JG, Shader RI. Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased gamma-aminobutyric acidA receptor function. J Pharmacol Exp Ther. 1988 Jul; 246(1):170-6.
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Lopez F, Miller LG, Greenblatt DJ, Paul SM, Shader RI. Low-dose alprazolam augments motor activity in mice. Pharmacol Biochem Behav. 1988 Jun; 30(2):511-3.
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Arana GW, Reichlin S, Workman R, Haaser R, Shader RI. The dexamethasone suppression index: enhancement of DST diagnostic utility for depression by expressing serum cortisol as a function of serum dexamethasone. Am J Psychiatry. 1988 Jun; 145(6):707-11.
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Scavone JM, Greenblatt DJ, Locniskar A, Shader RI. Alprazolam pharmacokinetics in women on low-dose oral contraceptives. J Clin Pharmacol. 1988 May; 28(5):454-7.
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Shader RI, Greenblatt DJ. Thyroid function monitoring for lithium-treated patients. J Clin Psychopharmacol. 1988 Apr; 8(2):81.
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Miller LG, Greenblatt DJ, Barnhill JG, Summer WR, Shader RI. 'GABA shift' in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA. Eur J Pharmacol. 1988 Mar 22; 148(1):123-30.
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Friedman H, Greenblatt DJ, Burstein ES, Scavone JM, Harmatz JS, Shader RI. Triazolam kinetics: interaction with cimetidine, propranolol, and the combination. J Clin Pharmacol. 1988 Mar; 28(3):228-33.
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Miller LG, Greenblatt DJ, Barnhill JG, Shader RI. Differential modulation of benzodiazepine receptor binding by ethanol in LS and SS mice. Pharmacol Biochem Behav. 1988 Mar; 29(3):471-7.
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Shader RI, Harmatz JS, Salzman C. Sandoz Clinical Assessment-Geriatric (SCAG). Psychopharmacol Bull. 1988; 24(4):765-9.
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Miller LG, Deutsch SI, Greenblatt DJ, Paul SM, Shader RI. Acute barbiturate administration increases benzodiazepine receptor binding in vivo. Psychopharmacology (Berl). 1988; 96(3):385-90.
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Miller LG, Greenblatt DJ, Abernethy DR, Friedman H, Luu MD, Paul SM, Shader RI. Kinetics, brain uptake, and receptor binding characteristics of flurazepam and its metabolites. Psychopharmacology (Berl). 1988; 94(3):386-91.
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Greenblatt DJ, Divoll MK, Harmatz JS, Shader RI. Antipyrine absorption and disposition in the elderly. Pharmacology. 1988; 36(2):125-33.
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Roy-Byrne PP, Lewis N, Villacres E, Greenblatt DJ, Shader RI, Veith RC. Suppression of norepinephrine appearance rate in plasma by diazepam in humans. Life Sci. 1988; 43(20):1615-23.
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Kennedy JS, Friedman H, Scavone JM, Harmatz JS, Shader RI, Greenblatt DJ. Effect of blood collection tubes on antidepressant concentrations. J Chromatogr. 1987 Dec 25; 423:373-5.
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Shader RI, Greenblatt DJ. Back to basics--diagnosis before treatment: homelessness, hypothyroidism, aging, and lithium. J Clin Psychopharmacol. 1987 Dec; 7(6):375-6.
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Kennedy JS, Leduc BW, Scavone JM, Harmatz JS, Shader RI, Greenblatt DJ. Pharmacokinetics of intravenous caffeine: comparison of high-performance liquid chromatographic and gas chromatographic methods. J Chromatogr. 1987 Nov 27; 422:274-80.
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Miller LG, Greenblatt DJ, Barnhill JG, Deutsch SI, Shader RI, Paul SM. Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam. J Neurochem. 1987 Nov; 49(5):1595-601.
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Greenblatt DJ, Miller LG, Shader RI. Clonazepam pharmacokinetics, brain uptake, and receptor interactions. J Clin Psychiatry. 1987 Oct; 48 Suppl:4-11.
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Scavone JM, Greenblatt DJ, Shader RI. Alprazolam kinetics following sublingual and oral administration. J Clin Psychopharmacol. 1987 Oct; 7(5):332-4.
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Greenblatt DJ, Harmatz JS, Zinny MA, Shader RI. Effect of gradual withdrawal on the rebound sleep disorder after discontinuation of triazolam. N Engl J Med. 1987 Sep 17; 317(12):722-8.
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Greenblatt DJ, Friedman H, Burstein ES, Scavone JM, Blyden GT, Ochs HR, Miller LG, Harmatz JS, Shader RI. Trazodone kinetics: effect of age, gender, and obesity. Clin Pharmacol Ther. 1987 Aug; 42(2):193-200.
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Miller LG, Thompson ML, Greenblatt DJ, Deutsch SI, Shader RI, Paul SM. Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice. Brain Res. 1987 Jun 30; 414(2):395-400.
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Dreyfuss D, Shader RI, Harmatz JS, Greenblatt DJ. Bioequivalence studies in the elderly: a pilot study of two oxazepam dosage forms. J Clin Psychopharmacol. 1987 Jun; 7(3):200.
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Ochs HR, Greenblatt DJ, Friedman H, Burstein ES, Locniskar A, Harmatz JS, Shader RI. Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol. Clin Pharmacol Ther. 1987 May; 41(5):562-70.
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Shader RI, Greenblatt DJ. Herpes and clinical psychopharmacology. J Clin Psychopharmacol. 1987 Apr; 7(2):65.
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Miller LG, Greenblatt DJ, Shader RI. Benzodiazepine receptor binding: influence of physiologic and pharmacologic factors. Biopharm Drug Dispos. 1987 Mar-Apr; 8(2):103-14.
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Greenblatt DJ, Shader RI. Bioequivalence of generic drugs in clinical psychopharmacology. J Clin Psychopharmacol. 1987 Feb; 7(1):A21-3.
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Miller LG, Greenblatt DJ, Paul SM, Shader RI. Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions. J Pharmacol Exp Ther. 1987 Feb; 240(2):516-22.
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Greenblatt DJ, Shader RI. Drug absorption rate: a critical component of bioequivalence assessment in psychopharmacology. J Clin Pharmacol. 1987 Feb; 27(2):85-6.
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Scavone JM, Friedman H, Greenblatt DJ, Shader RI. Effect of age, body composition, and lipid solubility on benzodiazepine tissue distribution in rats. Arzneimittelforschung. 1987 Jan; 37(1):2-6.
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Greenblatt DJ, Friedman HL, Shader RI. Correlating pharmacokinetics and pharmacodynamics of benzodiazepines: problems and assumptions. Psychopharmacol Ser. 1987; 3:62-71.
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Ochs HR, Miller LG, Greenblatt DJ, Shader RI. Actual versus reported benzodiazepine usage by medical outpatients. Eur J Clin Pharmacol. 1987; 32(4):383-8.
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Friedman H, Greenblatt DJ, Burstein ES, Harmatz JS, Shader RI. Population study of triazolam pharmacokinetics. Br J Clin Pharmacol. 1986 Dec; 22(6):639-42.
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Abernethy DR, Greenblatt DJ, Locniskar A, Ochs HR, Harmatz JS, Shader RI. Obesity effects on nitrazepam disposition. Br J Clin Pharmacol. 1986 Nov; 22(5):551-7.
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Dreyfuss D, Shader RI, Harmatz JS, Greenblatt DJ. Kinetics and dynamics of single doses of oxazepam in the elderly: implications of absorption rate. J Clin Psychiatry. 1986 Oct; 47(10):511-4.
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Shader RI. Is activated charcoal helpful in the treatment of overdosages (ODs) with tricyclic antidepressants (TCAs)? J Clin Psychopharmacol. 1986 Oct; 6(5):327-8.
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Blyden GT, Greenblatt DJ, Scavone JM, Shader RI. Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration. J Clin Pharmacol. 1986 Sep-Oct; 26(7):529-33.
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Greenblatt DJ, Abernethy DR, Boxenbaum HG, Matlis R, Ochs HR, Harmatz JS, Shader RI. Influence of age, gender, and obesity on salicylate kinetics following single doses of aspirin. Arthritis Rheum. 1986 Aug; 29(8):971-80.
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Shader RI, Greenblatt DJ. Nomifensine--a farewell and future concerns. J Clin Psychopharmacol. 1986 Jun; 6(3):A21.
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Shader RI, Dreyfuss D, Gerrein JR, Harmatz JS, Allison SJ, Greenblatt DJ. Sedative effects and impaired learning and recall after single oral doses of lorazepam. Clin Pharmacol Ther. 1986 May; 39(5):526-9.
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Arana GW, Goff DC, Friedman H, Ornsteen M, Greenblatt DJ, Black B, Shader RI. Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms? Am J Psychiatry. 1986 May; 143(5):650-1.
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Locniskar A, Greenblatt DJ, Harmatz JS, Zinny MA, Shader RI. Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists. J Clin Pharmacol. 1986 Apr; 26(4):299-303.
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Shader RI, Greenblatt DJ. "Look-alikes" and generics. J Clin Psychopharmacol. 1986 Apr; 6(2):A17-8.
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Scavone JM, Greenblatt DJ, Friedman H, Shader RI. Enhanced bioavailability of triazolam following sublingual versus oral administration. J Clin Pharmacol. 1986 Mar; 26(3):208-10.
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Scavone JM, Greenblatt DJ, Harmatz JS, Shader RI. Kinetic and dynamic interaction of brotizolam and ethanol. Br J Clin Pharmacol. 1986 Feb; 21(2):197-204.
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Greenblatt DJ, Locniskar A, Scavone JM, Blyden GT, Ochs HR, Harmatz JS, Shader RI. Absence of interaction of cimetidine and ranitidine with intravenous and oral midazolam. Anesth Analg. 1986 Feb; 65(2):176-80.
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Arana GW, Ornsteen ML, Kanter F, Friedman HL, Greenblatt DJ, Shader RI. The use of benzodiazepines for psychotic disorders: a literature review and preliminary clinical findings. Psychopharmacol Bull. 1986; 22(1):77-87.
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Greenblatt DJ, Abernethy DR, Shader RI. Pharmacokinetic aspects of drug therapy in the elderly. Ther Drug Monit. 1986; 8(3):249-55.
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Friedman H, Abernethy DR, Greenblatt DJ, Shader RI. The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma. Psychopharmacology (Berl). 1986; 88(3):267-70.
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Greenblatt DJ, Shader RI. Long-term administration of benzodiazepines: pharmacokinetic versus pharmacodynamic tolerance. Psychopharmacol Bull. 1986; 22(2):416-23.
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Abernethy DR, Greenblatt DJ, Shader RI. Benzodiazepine hypnotic metabolism: drug interactions and clinical implications. Acta Psychiatr Scand Suppl. 1986; 332:32-8.
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Greenblatt DJ, Abernethy DR, Locniskar A, Ochs HR, Harmatz JS, Shader RI. Age, sex, and nitrazepam kinetics: relation to antipyrine disposition. Clin Pharmacol Ther. 1985 Dec; 38(6):697-703.
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Friedman H, Ochs HR, Greenblatt DJ, Shader RI. Tissue distribution of diazepam and its metabolite desmethyldiazepam: a human autopsy study. J Clin Pharmacol. 1985 Nov-Dec; 25(8):613-5.
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Shader RI, Greenblatt DJ. User unfriendly drugs--fillers, additives, excipients. J Clin Psychopharmacol. 1985 Aug; 5(4):A15-6.
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Abernethy DR, Greenblatt DJ, Ameer B, Shader RI. Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation. J Pharmacol Exp Ther. 1985 Aug; 234(2):345-9.
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Shader RI, Greenblatt DJ. MAOIs and drug interactions--a proposal for a clearinghouse. J Clin Psychopharmacol. 1985 Jun; 5(3):A17.
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Shader RI, Greenblatt DJ. The chronic patient: issues and concerns. J Clin Psychopharmacol. 1985 Jun; 5(3 Suppl):1S-2S.
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Shader RI, Greenblatt DJ. Phenelzine and the dream machine--ramblings and reflections. J Clin Psychopharmacol. 1985 Apr; 5(2):65.
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Greenblatt DJ, Matlis R, Scavone JM, Blyden GT, Harmatz JS, Shader RI. Oxaprozin pharmacokinetics in the elderly. Br J Clin Pharmacol. 1985 Mar; 19(3):373-8.
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Arana GW, Pearlman C, Shader RI. Alprazolam-induced mania: two clinical cases. Am J Psychiatry. 1985 Mar; 142(3):368-9.
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Abernethy DR, Greenblatt DJ, Morse DS, Shader RI. Interaction of propoxyphene with diazepam, alprazolam and lorazepam. Br J Clin Pharmacol. 1985 Jan; 19(1):51-7.
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Abernethy DR, Greenblatt DJ, Shader RI. Imipramine and desipramine disposition in the elderly. J Pharmacol Exp Ther. 1985 Jan; 232(1):183-8.
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Shader RI. Panic disorders: clinical update 1984. Epidemiologic and family studies. Psychosomatics. 1984 Oct; 25(10 Suppl):10-5.
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Shader RI, Pary RJ, Harmatz JS, Allison S, Locniskar A, Greenblatt DJ. Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam. J Clin Psychiatry. 1984 Oct; 45(10):411-3.
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Greenblatt DJ, Abernethy DR, Matlis R, Harmatz JS, Shader RI. Absorption and disposition of ibuprofen in the elderly. Arthritis Rheum. 1984 Sep; 27(9):1066-9.
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Shader RI, Greenblatt DJ. An interactive model for panic disorders. J Clin Psychopharmacol. 1984 Aug; 4(4):177.
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Greenblatt DJ, Abernethy DR, Locniskar A, Harmatz JS, Limjuco RA, Shader RI. Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology. 1984 Jul; 61(1):27-35.
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Greenblatt DJ, Abernethy DR, Morse DS, Harmatz JS, Shader RI. Clinical importance of the interaction of diazepam and cimetidine. N Engl J Med. 1984 Jun 21; 310(25):1639-43.
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Abernethy DR, Greenblatt DJ, Shader RI. Imipramine disposition in users of oral contraceptive steroids. Clin Pharmacol Ther. 1984 Jun; 35(6):792-7.
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Shader RI, Greenblatt DJ. Benzodiazepine overuse-misuse. J Clin Psychopharmacol. 1984 Jun; 4(3):123-4.
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Abernethy DR, Greenblatt DJ, Shader RI. Imipramine-cimetidine interaction: impairment of clearance and enhanced absolute bioavailability. J Pharmacol Exp Ther. 1984 Jun; 229(3):702-5.
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Locniskar A, Greenblatt DJ, Zinny MA, Harmatz JS, Shader RI. Absolute bioavailability and effect of food and antacid on diazepam absorption from a slow-release preparation. J Clin Pharmacol. 1984 May-Jun; 24(5-6):255-63.
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Greenblatt DJ, Shader RI, Divoll M, Harmatz JS. Adverse reactions to triazolam, flurazepam, and placebo in controlled clinical trials. J Clin Psychiatry. 1984 May; 45(5):192-5.
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Abernethy DR, Greenblatt DJ, Ochs HR, Willis CR, Miller DD, Shader RI. Haloperidol determination in serum and cerebrospinal fluid using gas--liquid chromatography with nitrogen--phosphorus detection: application to pharmacokinetic studies. J Chromatogr. 1984 Apr 13; 307(1):194-9.
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Greenblatt DJ, Abernethy DR, Koepke HH, Shader RI. Interaction of cimetidine with oxazepam, lorazepam, and flurazepam. J Clin Pharmacol. 1984 Apr; 24(4):187-93.
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Ochs HR, Greenblatt DJ, Arendt RM, Hübbel W, Shader RI. Pharmacokinetic noninteraction of triazolam and ethanol. J Clin Psychopharmacol. 1984 Apr; 4(2):106-7.
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Greenblatt DJ, Shader RI. Short half-life benzodiazepines. Ration Drug Ther. 1984 Apr; 18(4):1-5.
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Shader RI. Can elderly nursing home patients with involuntary grimacing and vocalization be helped with psychopharmacological agents? J Clin Psychopharmacol. 1984 Apr; 4(2):121.
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Shader RI, Greenblatt DJ. Benzodiazepines during early pregnancy. J Clin Psychopharmacol. 1984 Apr; 4(2):65.
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Abernethy DR, Greenblatt DJ, Shader RI. Trimipramine kinetics and absolute bioavailability: use of gas-liquid chromatography with nitrogen-phosphorus detection. Clin Pharmacol Ther. 1984 Mar; 35(3):348-53.
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Greenblatt DJ, Abernethy DR, Divoll M, Locniskar A, Harmatz JS, Shader RI. Noninteraction of temazepam and cimetidine. J Pharm Sci. 1984 Mar; 73(3):399-401.
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Abernethy DR, Greenblatt DJ, Divoll M, Smith RB, Shader RI. The influence of obesity on the pharmacokinetics of oral alprazolam and triazolam. Clin Pharmacokinet. 1984 Mar-Apr; 9(2):177-83.
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Abernethy DR, Greenblatt DJ, Eshelman FN, Shader RI. Ranitidine does not impair oxidative or conjugative metabolism: noninteraction with antipyrine, diazepam, and lorazepam. Clin Pharmacol Ther. 1984 Feb; 35(2):188-92.
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Greenblatt DJ, Arendt RM, Shader RI. Pharmacodynamics of benzodiazepines after single oral doses: kinetic and physiochemical correlates. Psychopharmacology Suppl. 1984; 1:92-7.
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Greenblatt DJ, Shader RI, Abernethy DR. Anxiolytic drug therapy in patients with medical disease: clinical importance of pharmacokinetic drug interactions. Psychopharmacol Bull. 1984; 20(4):645-8.
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Abernethy DR, Greenblatt DJ, Shader RI. Plasma levels of trazodone: methodology and applications. Pharmacology. 1984; 28(1):42-6.
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Abernethy DR, Greenblatt DJ, Ochs HR, Shader RI. Benzodiazepine drug-drug interactions commonly occurring in clinical practice. Curr Med Res Opin. 1984; 8 Suppl 4:80-93.
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Abernethyl DR, Divoll M, Greenblatt DJ, Harmatz JS, Shader RI. Absolute bioavailability of imipramine: influence of food. Psychopharmacology (Berl). 1984; 83(1):104-6.
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Greenblatt DJ, Divoll M, Shader RI. Automated gas chromatographic determination of plasma alprazolam concentrations. J Clin Psychopharmacol. 1983 Dec; 3(6):366-8.
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Greenblatt DJ, Abernethy DR, Divoll M, Ochs HR, Shader RI. Antipyretic analgesic drugs as models for studies of drug disposition in old age. Am J Med. 1983 Nov 14; 75(5A):127-32.
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Shader RI, Greenblatt DJ. Some current treatment options for symptoms of anxiety. J Clin Psychiatry. 1983 Nov; 44(11 Pt 2):21-30.
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Arendt RM, Greenblatt DJ, deJong RH, Bonin JD, Abernethy DR, Ehrenberg BL, Giles HG, Sellers EM, Shader RI. In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution. J Pharmacol Exp Ther. 1983 Oct; 227(1):98-106.
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Greenblatt DJ, Arendt RM, Abernethy DR, Giles HG, Sellers EM, Shader RI. In vitro quantitation of benzodiazepine lipophilicity: relation to in vivo distribution. Br J Anaesth. 1983 Oct; 55(10):985-9.
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Shader RI, Greenblatt DJ. Triazolam and anterograde amnesia: all is not well in the Z-zone. J Clin Psychopharmacol. 1983 Oct; 3(5):273.
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Greenblatt DJ, Shader RI, Abernethy DR. Drug therapy. Current status of benzodiazepines. N Engl J Med. 1983 Aug 18; 309(7):410-6.
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Greenblatt DJ, Shader RI, Abernethy DR. Drug therapy. Current status of benzodiazepines. N Engl J Med. 1983 Aug 11; 309(6):354-8.
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Abernethy DR, Greenblatt DJ, Divoll M, Shader RI. Prolonged accumulation of diazepam in obesity. J Clin Pharmacol. 1983 Aug-Sep; 23(8-9):369-76.
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Shader RI, Greenblatt DJ. Shades of the patent medicine man. J Clin Psychopharmacol. 1983 Aug; 3(4):211.
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Abernethy DR, Greenblatt DJ, Divoll M, Shader RI. Pharmacokinetics of alprazolam. J Clin Psychiatry. 1983 Aug; 44(8 Pt 2):45-7.
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Coffey B, Shader RI, Greenblatt DJ. Pharmacokinetics of benzodiazepines and psychostimulants in children. J Clin Psychopharmacol. 1983 Aug; 3(4):217-25.
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Abernethy DR, Greenblatt DJ, Divoll M, Shader RI. Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen. J Lab Clin Med. 1983 Jun; 101(6):873-80.
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Abernethy DR, Greenblatt DJ, Ochs HR, Weyers D, Divoll M, Harmatz JS, Shader RI. Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives. Clin Pharmacol Ther. 1983 May; 33(5):628-32.
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Greenblatt DJ, Divoll M, Abernethy DR, Ochs HR, Shader RI. Clinical pharmacokinetics of the newer benzodiazepines. Clin Pharmacokinet. 1983 May-Jun; 8(3):233-52.
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Shader RI. Can lithium cause hair loss? J Clin Psychopharmacol. 1983 Apr; 3(2):122-3.
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Greenblatt DJ, Abernethy DR, Divoll M, Harmatz JS, Shader RI. Pharmacokinetic properties of benzodiazepine hypnotics. J Clin Psychopharmacol. 1983 Apr; 3(2):129-32.
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Ochs HR, Greenblatt DJ, Eckardt B, Harmatz JS, Shader RI. Repeated diazepam dosing in cirrhotic patients: cumulation and sedation. Clin Pharmacol Ther. 1983 Apr; 33(4):471-6.
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Shader RI, Greenblatt DJ. Propranolol's psychiatric side effects. J Clin Psychopharmacol. 1983 Apr; 3(2):65.
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Salzman C, Shader RI, Greenblatt DJ, Harmatz JS. Long v short half-life benzodiazepines in the elderly. Kinetics and clinical effects of diazepam and oxazepam. Arch Gen Psychiatry. 1983 Mar; 40(3):293-7.
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Greenblatt DJ, Divoll M, Abernethy DR, Moschitto LJ, Smith RB, Shader RI. Alprazolam kinetics in the elderly. Relation to antipyrine disposition. Arch Gen Psychiatry. 1983 Mar; 40(3):287-90.
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Abernethy DR, Greenblatt DJ, Divoll M, Ameer B, Shader RI. Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine. J Pharmacol Exp Ther. 1983 Mar; 224(3):508-13.
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Greenblatt DJ, Divoll M, Abernethy DR, Moschitto LJ, Smith RB, Shader RI. Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity. Br J Clin Pharmacol. 1983 Mar; 15(3):303-9.
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Appelbaum PS, Jackson AH, Shader RI. Psychiatrists' responses to violence: pharmacologic management of psychiatric inpatients. Am J Psychiatry. 1983 Mar; 140(3):301-4.
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Greenblatt DJ, Locniskar A, Shader RI. Pilot pharmacokinetic study of brotizolam, a thienodiazepine hypnotic, using electron-capture gas-liquid chromatography. Sleep. 1983; 6(1):72-6.
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Greenblatt DJ, Locniskar A, Shader RI. Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography. Psychopharmacology (Berl). 1983; 80(2):178-80.
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Greenblatt DJ, Divoll M, Puri SK, Ho I, Zinny MA, Shader RI. Reduced single-dose clearance of clobazam in elderly men predicts increased multiple-dose accumulation. Clin Pharmacokinet. 1983 Jan-Feb; 8(1):83-94.
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Divoll M, Greenblatt DJ, Ochs HR, Shader RI. Absolute bioavailability of oral and intramuscular diazepam: effects of age and sex. Anesth Analg. 1983 Jan; 62(1):1-8.
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Abernethy DR, Greenblatt DJ, Divoll M, Moschitto LJ, Harmatz JS, Shader RI. Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. Psychopharmacology (Berl). 1983; 80(3):275-8.
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Greenblatt DJ, Abernethy DR, Divoll M, Shader RI. Close correlation of acetaminophen clearance with that of conjugated benzodiazepines but not oxidized benzodiazepines. Eur J Clin Pharmacol. 1983; 25(1):113-5.
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Greenblatt DJ, Divoll M, Abernethy DR, Locniskar A, Shader RI. Pharmacokinetics of benzodiazepine hypnotics. Pharmacology. 1983; 27 Suppl 2:70-5.
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Greenblatt DJ, Divoll M, Abernethy DR, Ochs HR, Shader RI. Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics. Drug Metab Rev. 1983; 14(2):251-92.
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Shader RI, Goodman M, Gever J. Panic disorders: current perspectives. J Clin Psychopharmacol. 1982 Dec; 2(6 Suppl):2S-10S.
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Greenblatt DJ, Divoll M, Abernethy DR, Shader RI. Physiologic changes in old age: relation to altered drug disposition. J Am Geriatr Soc. 1982 Nov; 30(11 Suppl):S6-10.
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Divoll M, Greenblatt DJ, Abernethy DR, Shader RI. Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly. J Am Geriatr Soc. 1982 Nov; 30(11):684-9.
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Greenblatt DJ, Shader RI. New anxiolytics: are they really new? Psychopharmacol Bull. 1982 Oct; 18(4):58-61.
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Shader RI, Greenblatt DJ. Management of anxiety in the elderly: the balance between therapeutic and adverse effects. J Clin Psychiatry. 1982 Sep; 43(9 Pt 2):8-18.
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Abernethy DR, Greenblatt DJ, Divoll M, Shader RI. Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate). J Pharm Sci. 1982 Aug; 71(8):942-4.
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Abernethy DR, Greenblatt DJ, Steel K, Shader RI. Impairment of hepatic drug oxidation by propoxyphene. Ann Intern Med. 1982 Aug; 97(2):223-4.
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Shader RI, Greenblatt DJ. The psychiatrist as mind sweeper. J Clin Psychopharmacol. 1982 Aug; 2(4):233-4.
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Greenblatt DJ, Locniskar A, Shader RI. Halazepam, another precursor of desmethyldiazepam. Lancet. 1982 Jun 12; 1(8285):1358-9.
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Greenblatt DJ, Sellers EM, Shader RI. Drug therapy: drug disposition in old age. N Engl J Med. 1982 May 6; 306(18):1081-8.
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Abernethy DR, Greenblatt DJ, Divoll M, Arendt R, Ochs HR, Shader RI. Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids. N Engl J Med. 1982 Apr 1; 306(13):791-2.
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Good MI, Shader RI. Lethality and behavioral side effects of chloroquine. J Clin Psychopharmacol. 1982 Feb; 2(1):40-7.
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Shader RI, Ciraulo DA, Greenblatt DJ, Harmatz JS. Steady-state plasma desmethyldiazepam during long-term clorazepate use: effects of antacids. Clin Pharmacol Ther. 1982 Feb; 31(2):180-3.
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Greenblatt DJ, Divoll M, Harmatz JS, Shader RI. Pharmacokinetic comparison of sublingual lorazepam with intravenous, intramuscular, and oral lorazepam. J Pharm Sci. 1982 Feb; 71(2):248-52.
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Divoll M, Greenblatt DJ, Shader RI. Liquid chromatographic determination of chlordiazepoxide and metabolites in plasma. Pharmacology. 1982; 24(5):261-6.
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Divoll M, Greenblatt DJ, Ciraulo DA, Puri SK, Ho I, Shader RI. Clobazam kinetics: intrasubject variability and effect of food on adsorption. J Clin Pharmacol. 1982 Jan; 22(1):69-73.
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Greenblatt DJ, Divoll M, Abernethy DR, Harmatz JS, Shader RI. Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. J Pharmacol Exp Ther. 1982 Jan; 220(1):120-6.
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Greenblatt DJ, Divoll M, Abernethy DR, Locniskar A, Shader RI. Pharmacokinetics of benzodiazepine hypnotics. Int Pharmacopsychiatry. 1982; 17 Suppl 2:70-5.
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Greenblatt DJ, Divoll M, Abernethy DR, Shader RI. Benzodiazepine hypnotics: kinetic and therapeutic options. Sleep. 1982; 5 Suppl 1:S18-27.
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Shader RI, Divoll M, Greenblatt DJ. Kinetics of oxazepam and lorazepam in two subjects with Gilbert syndrome. J Clin Psychopharmacol. 1981 Nov; 1(6):400-2.
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Greenblatt DJ, Divoll M, Puri SK, Ho I, Zinny MA, Shader RI. Clobazam kinetics in the elderly. Br J Clin Pharmacol. 1981 Nov; 12(5):631-6.
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Divoll M, Greenblatt DJ, Harmatz JS, Shader RI. Effect of age and gender on disposition of temazepam. J Pharm Sci. 1981 Oct; 70(10):1104-7.
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Greenblatt DJ, Divoll M, Harmatz JS, MacLaughlin DS, Shader RI. Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs. Clin Pharmacol Ther. 1981 Oct; 30(4):475-86.
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Greenblatt DJ, Shader RI. Clinical use of the benzodiazepines. Ration Drug Ther. 1981 Oct; 15(10):1-6.
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Greenblatt DJ, Divoll M, Moschitto LJ, Shader RI. Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam. J Chromatogr. 1981 Sep 11; 225(1):202-7.
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Shader RI. How important is it to assess thyroid function in patients with depressive symptomatology? J Clin Psychopharmacol. 1981 Sep; 1(5):322.
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Shader RI, Greenblatt DJ. Amoxapine, an observation, and a perspective on MAOIs and their safety. J Clin Psychopharmacol. 1981 Sep; 1(5):263.
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Abernethy DR, Greenblatt DJ, Divoll M, Harmatz JS, Shader RI. Alterations in drug distribution and clearance due to obesity. J Pharmacol Exp Ther. 1981 Jun; 217(3):681-5.
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Shader RI, Greenblatt DJ. Some thoughts on a new antidepressant and a marking of the death of John Cade, MD. J Clin Psychopharmacol. 1981 May; 1(3):117-8.
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Abernethy DR, Greenblatt DJ, Shader RI. Treatment of diazepam withdrawal syndrome with propranolol. Ann Intern Med. 1981 Mar; 94(3):354-5.
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Shader RI, Greenblatt DJ. Antidepressants: the second harvest and DSM-III. J Clin Psychopharmacol. 1981 Mar; 1(2):51-2.
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Shader RI. What can be done for depression following acute schizophreniform psychosis? J Clin Psychopharmacol. 1981 Mar; 1(2):97.
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Shader RI. Benzodiazepines in clinical medicine: discussion. Br J Clin Pharmacol. 1981; 11 Suppl 1:55S-59S.
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Greenblatt DJ, Shader RI, Divoll M, Harmatz JS. Benzodiazepines: a summary of pharmacokinetic properties. Br J Clin Pharmacol. 1981; 11 Suppl 1:11S-16S.
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Abernethy DR, Greenblatt DJ, Shader RI. Tricyclic antidepressant determination in human plasma by gas-liquid chromatography using nitrogen-phosphorous detection: application to single-dose pharmacokinetic studies. Pharmacology. 1981; 23(2):57-63.
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Shader RI, Greenblatt DJ. The use of benzodiazepines in clinical practice. Br J Clin Pharmacol. 1981; 11 Suppl 1:5S-9S.
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Greenblatt DJ, Laughren TP, Allen MD, Harmatz JS, Shader RI. Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy. Br J Clin Pharmacol. 1981 Jan; 11(1):35-40.
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Divoll M, Greenblatt DJ, Lacasse Y, Shader RI. Benzodiazepine overdosage: plasma concentrations and clinical outcome. Psychopharmacology (Berl). 1981; 73(4):381-3.
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Ratey JJ, Ciraulo DA, Shader RI. Lithium and marijuana. J Clin Psychopharmacol. 1981 Jan; 1(1):32-3.
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Shader RI, Greenblatt DJ, Ciraulo DA, Divoll M, Harmatz JS, Georgotas A. Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate. Psychopharmacology (Berl). 1981; 75(2):193-7.
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Allen MD, Greenblatt DJ, LaCasse Y, Shader RI. Pharmacokinetic study of lorazepam overdosage. Am J Psychiatry. 1980 Nov; 137(11):1414-5.
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Greenblatt DJ, Divoll M, Harmatz JS, Shader RI. Oxazepam kinetics: effects of age and sex. J Pharmacol Exp Ther. 1980 Oct; 215(1):86-91.
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Shader RI. A brief commentary on the Boston State Hospital case. Psychopharmacol Bull. 1980 Oct; 16(4):20-2.
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Allen MD, Greenblatt DJ, Harmatz JS, Shader RI. Desmethyldiazepam kinetics in the elderly after oral prazepam. Clin Pharmacol Ther. 1980 Aug; 28(2):196-202.
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Greenblatt DJ, Shader RI. Pharmacokinetic aspects of anxiolytic drug therapy. Can J Neurol Sci. 1980 Aug; 7(3):269-70.
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Weiss KJ, Ciraulo DA, Shader RI. Physostigmine test in the rabbit syndrome and tardive dyskinesia. Am J Psychiatry. 1980 May; 137(5):627-8.
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Greenblatt DJ, Allen MD, Harmatz JS, Shader RI. Diazepam disposition determinants. Clin Pharmacol Ther. 1980 Mar; 27(3):301-12.
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Geschwind N, Shader RI, Bear D, North B, Levin K, Chetham D. Case 2: Behavioral changes with temporal lobe epilepsy: assessment and treatment. J Clin Psychiatry. 1980 Mar; 41(3):89-95.
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Shader RI, Elkins R. The effects of antianxiety and antipsychotic drugs and sexual behavior. Mod Probl Pharmacopsychiatry. 1980; 15:91-110.
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Greenblatt DJ, Shader RI. Effects of age and other drugs on benzodiazepine kinetics. Arzneimittelforschung. 1980; 30(5a):886-90.
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Shader RI, Greenblatt DJ. Clinical indications for plasma level monitoring of psychotropic drugs. Am J Psychiatry. 1979 Dec; 136(12):1590-1.
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Barclay WR, Ayd FJ, Callan JP, Curran WJ, Gardner EA, Greenblatt DJ, Ladimer I, Lapierre Y, Lehmann HE, O'Donnell TJ, van Praag HM, Shader RI. Behavioural reactions to triazolam. Lancet. 1979 Nov 10; 2(8150):1018.
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Greenblatt DJ, Allen MD, Harmatz JS, Noel BJ, Shader RI. Overdosage with pentobarbital and secobarbital: assessment of factors related to outcome. J Clin Pharmacol. 1979 Nov-Dec; 19(11-12):758-68.
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Ochs HR, Greenblatt DJ, Allen MD, Harmatz JS, Shader RI, Bodem G. Effect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate. Clin Pharmacol Ther. 1979 Oct; 26(4):449-56.
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Appelbaum PS, Shader RI, Funkenstein HH, Hanson MA. Difficulties in the clinical diagnosis of lithium toxicity. Am J Psychiatry. 1979 Sep; 136(9):1212-3.
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Allen MD, Greenblatt DJ, Harmatz JS, Shader RI. Single-dose kinetics of prazepam, a precursor of desmethyldiazepam. J Clin Pharmacol. 1979 Aug-Sep; 19(8-9 Pt 1):445-50.
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Greenblatt DJ, Allen MD, Locniskar A, Harmatz JS, Shader RI. Lorazepam kinetics in the elderly. Clin Pharmacol Ther. 1979 Jul; 26(1):103-13.
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Shader RI, Greenblatt DJ. Pharmacokinetics and clinical drug effects in the elderly [proceedings]. Psychopharmacol Bull. 1979 Apr; 15(2):8-14.
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Greenblatt DJ, Allen MD, MacLaughlin DS, Huffman DH, Harmatz JS, Shader RI. Single- and multiple-dose kinetics of oral lorazepam in humans: the predictability of accumulation. J Pharmacokinet Biopharm. 1979 Apr; 7(2):159-79.
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Greenblatt DJ, Shader RI, Harmatz JS, Georgotas A. Self-rated sedation and plasma concentrations of desmethyldiazepam following single doses of clorazepate. Psychopharmacology (Berl). 1979; 66(3):289-90.
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Shader RI, Greenblatt DJ. Benzodiazepines: some aspects of their clinical pharmacology. Ciba Found Symp. 1979; (74):141-55.
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Greenblatt DJ, Allen MD, Harmatz JS, Noel BJ, Shader RI. Correlates of outcome following acute glutethimide overdosage. J Forensic Sci. 1979 Jan; 24(1):76-86.
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Greenblatt DJ, Shader RI, Franke K, MacLaughlin DS, Harmatz JS, Allen MD, Werner A, Woo E. Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans. J Pharm Sci. 1979 Jan; 68(1):57-63.
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Greenblatt DJ, Shader RI. Prazepam and lorazepam, two new benzodiazepines. N Engl J Med. 1978 Dec 14; 299(24):1342-4.
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Greenblatt DJ, Allen MD, MacLaughlin DS, Harmatz JS, Shader RI. Diazepam absorption: effect of antacids and food. Clin Pharmacol Ther. 1978 Nov; 24(5):600-9.
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Shader RI, Ciraulo DA, Greenblatt DJ. Drug interactions involving psychotropic drugs. Psychosomatics. 1978 Nov; 19(11):671-3, 677-81.
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Greenblatt DJ, Woo E, Allen MD, Orsulak PJ, Shader RI. Rapid recovery from massive diazepam overdose. JAMA. 1978 Oct 20; 240(17):1872-4.
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Kyriakopoulos AA, Greenblatt DJ, Shader RI. Clinical pharmacokinetics of lorazepam: a review. J Clin Psychiatry. 1978 Oct; 39(10 Pt 2):16-23.
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Greenblatt DJ, Shader RI, Franke K, Harmatz JS. Pharmacokinetics of chlordiazepoxide and metabolites following single and multiple oral doses. Int J Clin Pharmacol Biopharm. 1978 Oct; 16(10):486-93.
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Greenblatt DJ, Franke K, Shader RI. Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam. J Chromatogr. 1978 Sep 1; 146(2):311-20.
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Greenblatt DJ, Shader RI, MacLeod SM, Sellers EM. Clinical pharmacokinetics of chlordiazepoxide. Clin Pharmacokinet. 1978 Sep-Oct; 3(5):381-94.
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Shader RI, Georgotas A, Greenblatt DJ, Harmatz JS, Allen MD. Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide. Clin Pharmacol Ther. 1978 Sep; 24(3):308-15.
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Sokol GH, Greenblatt DJ, Lloyd BL, Georgotas A, Allen MD, Harmatz JS, Smith TW, Shader RI. Effect of abdominal radiation therapy on drug absorption in humans. J Clin Pharmacol. 1978 Aug-Sep; 18(8-9):388-96.
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Greenblatt DJ, Shader RI. Pharmacokinetic understanding of antianxiety drug therapy. South Med J. 1978 Aug; 71 Suppl 2:2-9.
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Greenblatt DJ, Gross PL, Harris J, Shader RI, Ciraulo DA. Fatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal. J Clin Psychiatry. 1978 Aug; 39(8):673-5.
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Salzman C, Shader RI. Depression in the elderly. II. Possible drug etiologies; differential diagnostic criteria. J Am Geriatr Soc. 1978 Jul; 26(7):303-8.
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Greenblatt DJ, Shader RI, MacLeod SM, Sellers EM, Franke K, Giles HG. Absorption of oral and intramuscular chlordiazepoxide. Eur J Clin Pharmacol. 1978 Jun 19; 13(4):267-74.
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Salzman C, Shader RI. Depression in the elderly. I. Relationship between depression, psychologic defense mechanisms and physical illness. J Am Geriatr Soc. 1978 Jun; 26(6):253-60.
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Shader RI, Elkins R, Ciraulo D, Salzman C. On guidelines for maximum dosages. Am J Psychiatry. 1978 Apr; 135(4):499-500.
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Greenblatt DJ, Shader RI. Prazepam, a precursor of desmethyldiazepam. Lancet. 1978 Apr 1; 1(8066):720.
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Greenblatt DJ, Harmatz JS, Shader RI. Factors influencing diazepam pharmacokinetics: age, sex, and liver disease. Int J Clin Pharmacol Biopharm. 1978 Apr; 16(4):177-9.
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Greenblatt DJ, Harmatz JS, Shader RI. Sex differences in diazepam protein binding in patients with renal insufficiency. Pharmacology. 1978; 16(1):26-9.
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Greenblatt DJ, Shader RI. Dependence, tolerance, and addiction to benzodiazepines: clinical and pharmacokinetic considerations. Drug Metab Rev. 1978; 8(1):13-28.
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Greenblatt DJ, Shader RI, Franke K, MacLaughlin DS, Ransil BJ, Koch-Weser J. Kinetics of intravenous chlordiazepoxide: sex differences in drug distribution. Clin Pharmacol Ther. 1977 Dec; 22(6):893-903.
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Kochansky GE, Salzman C, Shader RI, Harmatz JS, Ogletree AM. Effects of chlordiazepoxide and oxazepam administration on verbal hostility. Arch Gen Psychiatry. 1977 Dec; 34(12):1457-9.
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Greenblatt DJ, Harmatz JS, Stanski DR, Shader RI, Franke K, Koch-Weser J. Factors influencing blood concentrations of chlordiazepoxide: a use of multiple regression analysis. Psychopharmacology (Berl). 1977 Nov 15; 54(3):277-82.
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Shader RI, Greenblatt DJ, Harmatz JS, Franke K, Koch-Weser J. Absorption and disposition of chlordiazepoxide in young and elderly male volunteers. J Clin Pharmacol. 1977 Nov-Dec; 17(11-12):709-18.
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Greenblatt DJ, Comer WH, Elliott HW, Shader RI, Knowles JA, Ruelius HW. Clinical pharmacokinetics of lorazepam. III. Intravenous injection. Preliminary results. J Clin Pharmacol. 1977 Aug-Sep; 17(8-9):490-4.
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Greenblatt DJ, Knowles JA, Comer WH, Shader RI, Harmatz JS, Ruelius HW. Clinical pharmacokinetics of lorazepam. IV. Long-term oral administration. J Clin Pharmacol. 1977 Aug-Sep; 17(8-9):495-500.
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Good MI, Shader RI. Behavioral toxicity and equivocal suicide associated with chloroquine and its derivatives. Am J Psychiatry. 1977 Jul; 134(7):798-601.
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Shader RI, Greenblatt DJ. Clinical implications of benzodiazepine pharmacokinetics. Am J Psychiatry. 1977 Jun; 134(6):652-6.
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Greenblatt DJ, Shader RI, Harmatz JS, Franke K, Koch-Weser J. Absorption rate, blood concentrations, and early response to oral chlordiazepoxide. Am J Psychiatry. 1977 May; 134(5):559-62.
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Greenblatt DJ, Allen MD, Noel BJ, Shader RI. Acute overdosage with benzodiazepine derivatives. Clin Pharmacol Ther. 1977 Apr; 21(4):497-514.
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Greenblatt DJ, Allen MD, Shader RI. Toxicity of high-dose flurazepam in the elderly. Clin Pharmacol Ther. 1977 Mar; 21(3):355-61.
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Swett CP, Shader RI. Cardiac side effects and sudden death in hospitalized psychiatric patients. Dis Nerv Syst. 1977 Feb; 38(2):69-72.
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Greenblatt DJ, Joyce TH, Comer WH, Knowles JA, Shader RI, Kyriakopoulos AA, MacLaughlin DS, Ruelius HW. Clinical pharmacokinetics of lorazepam. II. Intramuscular injection. Clin Pharmacol Ther. 1977 Feb; 21(2):222-30.
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Shader RI, Jackson AH, Harmatz JS, Appelbaum PS. Patterns of violent behavior among schizophrenic inpatients. Dis Nerv Syst. 1977 Jan; 38(1):13-6.
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Salzman C, Kochansky GE, Van Der Kolk BA, Shader RI. The effect of marijuana on small group process. Am J Drug Alcohol Abuse. 1977; 4(2):251-5.
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Stanski DR, Greenblatt DJ, Selwyn A, Shader RI, Franke K, Koch-Weser J. Plasma and cerebrospinal fluid concentrations of chlordiazepoxide and its metabolites in surgical patients. Clin Pharmacol Ther. 1976 Nov; 20(5):571-8.
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Salzman C, Van Der Kolk BA, Shader RI. Marijuana and hostility in a small-group setting. Am J Psychiatry. 1976 Sep; 133(9):1029-33.
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Greenblatt DJ, Schillings RT, Kyriakopoulos AA, Shader RI, Sisenwine SF, Knowles JA, Ruelius HW. Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam. Clin Pharmacol Ther. 1976 Sep; 20(3):329-41.
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Greenblatt DJ, Allen MD, Koch-Weser J, Shader RI. Accidental poisoning with psychotropic drugs in children. Am J Dis Child. 1976 May; 130(5):507-11.
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Salzman C, Hoffer A, Shader RI. Alumni of the Massachusetts mental health center residency training. Arch Gen Psychiatry. 1976 Apr; 33(4):421-3.
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Shader RI. Problems of polypharmacy in depression. Dis Nerv Syst. 1976 Mar; 37(3 PT 2):30-4.
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Greenblatt DJ, Shader RI, Harmatz JS, Franke K, Koch-Weser J. Influence of magnesium and aluminum hydroxide mixture on chlordiazepoxide absorption. Clin Pharmacol Ther. 1976 Feb; 19(2):234-9.
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Greenblatt DJ, Shader RI, Koch-Weser J. Serum creatine phosphokinase concentrations after intramuscular chlordiazepoxide and its solvent. J Clin Pharmacol. 1976 Feb-Mar; 16(2-3):118-21.
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Greenblatt DJ, Shader RI, Lofgren S. Rational psycho-pharmacology for patients with medical diseases. Annu Rev Med. 1976; 27:407-20.
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Shader RI. Discussion: sources of variance in studies of drugs and other therapies. Proc Annu Meet Am Psychopathol Assoc. 1976; (64):294-312.
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Salzman C, Shader RI, Van der Kolk BA. Clinical psychopharmacology and the elderly patient. N Y State J Med. 1976 Jan; 76(1):71-7.
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Salzman C, Shader RI, Harmatz JS. Response of the elderly to psychotrophic drugs: predictable or idiosyncratic? Psychopharmacol Bull. 1975 Oct; 11(4):48-50.
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Greenblatt DJ, Shader RI, Koch-Weser J, Franke K. Clinical pharmacokinetics of chlordiazepoxide. Psychopharmacol Bull. 1975 Oct; 11(4):34-5.
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Salzman C, Shader RI, Harmatz J, Robertson L. Psychopharmacologic investigations in elderly volunteers: Effect of diazepam in males. J Am Geriatr Soc. 1975 Oct; 23(10):451-7.
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Kochansky GE, salzman C, Shader RI, Harmatz JS, Ogeltree AM. The differential effects of chlordiazepoxide and oxazepam on hostility in a small group setting. Am J Psychiatry. 1975 Aug; 132(8):861-3.
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Greenblatt DJ, Shader RI, Koch-Weser J. Flurazepam hydrochloride, a benzodiazepine hypnotic. Ann Intern Med. 1975 Aug; 83(2):237-41.
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Harmatz JS, Shader RI. Psychopharmacologic investigations in healthy elderly volunteers: MMPI depression scale. J Am Geriatr Soc. 1975 Aug; 23(8):350-4.
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Kochansky GE, Hemenway TS, Salzman C, Shader RI. Methaqualone abusers: a preliminary survey of college students. Dis Nerv Syst. 1975 Jul; 36(7):348-51.
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Shader RI, Harmatz JS, Kochansky GE, Cole JO. Psychopharmacologic investigations in healthy elderly volunteers: effects of pipradrol-vitamin (Alertonic) elixir and placebo in relation to research design. J Am Geriatr Soc. 1975 Jun; 23(6):277-9.
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Greenblatt DJ, Shader RI, Koch-Weser J. Pharmacokinetics in clinical medicine: oxazepam versus other benzodiazepines. Dis Nerv Syst. 1975 May; 36(5 Pt. 2):6-13.
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Salzman C, Kochansky GE, Shader RI, Harmatz JS, Ogletree AM. Is oxazepam associated with hostility? Dis Nerv Syst. 1975 May; 36(5 Pt. 2):30-2.
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Greenblatt DJ, Shader RI. Treating the drug abuser in the ED. RN. 1975 May; 38(5):OR1, OR5, OR8 passim.
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Shader RI, Greenblatt DJ, Salzman C, Kochansky GE, Harmatz JS. Benzodiazepines: Safety and toxicity. Dis Nerv Syst. 1975 May; 36(5 Pt. 2):23-6.
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Harmatz J, Shader RI. Letter: Correlation of human menstruation and lunar phase. Am J Obstet Gynecol. 1975 Apr 15; 121(8):1124.
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Greenblatt DJ, Shader RI, Koch-Weser J. Psychotropic drug use in the Boston area. A report from the Boston Collaborative Drug Surveillance Program. Arch Gen Psychiatry. 1975 Apr; 32(4):518-21.
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Shader RI, Harmatz JS. Molindone: a pilot evaluation during the premenstruum. Curr Ther Res Clin Exp. 1975 Apr; 17(4):403-6.
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Greenblatt DJ, Shader RI. Urgent pharmacotherapy for drug abuse. Curr Psychiatr Ther. 1975; 15:171-9.
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Shader RI. Cardiac effects of imipramine hydrochloride in the elderly. Psychopharmacol Bull. 1975 Jan; 11(1):15-6.
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Greenblatt DJ, Shader RI, Koch-Weser J. Flurazepam hydrochloride. Clin Pharmacol Ther. 1975 Jan; 17(1):1-14.
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Greenblatt DJ, Shader RI. Rational use of psychotropic drugs. IV. Antidepressants. Am J Hosp Pharm. 1975 Jan; 32(1):59-64.
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Greenblatt DJ, Shader RI. Drug therapy. Benzodiazepines (second of two parts). N Engl J Med. 1974 Dec 5; 291(23):1239-43.
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Greenblatt DJ, Shader RI. Rational use of psychotropic drugs. III. Major tranquilizers. Am J Hosp Pharm. 1974 Dec; 31(12):1226-31.
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Greenblatt DJ, Shader RI, Koch-Weser J. Pharmacokinetic determinants of the response to single doses of chlordiazepoxide. Am J Psychiatry. 1974 Dec; 131(12):1395-7.
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Greenblatt DJ, Shader RI, Koch-Weser J. Slow absorption of intramuscular chlordiazepoxide. N Engl J Med. 1974 Nov 21; 291(21):1116-8.
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Greenblatt DJ, Shader RI. Drug therapy. Benzodiazepines (first of two parts). N Engl J Med. 1974 Nov 7; 291(19):1011-5.
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Greenblatt DJ, Shader RI. Rational use of psychotropic drugs. IV. Antidepressants. J Maine Med Assoc. 1974 Nov; 65(11):283-8.
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Greenblatt DJ, Shader RI. Rational use of psychotropic drugs II. Antianxiety agents. Am J Hosp Pharm. 1974 Nov; 31(11):1077-80.
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Greenblatt DJ, Shader RI. Drug therapy reviews: rational use of psychotropic drugs. III. Major tranquilizers. J Maine Med Assoc. 1974 Oct; 65(10):251-6.
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Salzman C, Kochansky GE, Shader RI, Porrino LJ, Harmatz JS, Swett CP. Chlordiazepoxide-induced hostility in a small group setting. Arch Gen Psychiatry. 1974 Sep; 31(3):401-5.
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Shader RI, Greenblatt DJ. Suggestions for treating drug abusers in a family practice. Med Times. 1974 Sep; 102(9):91-2 passim.
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Greenblatt DJ, Shader RI. Rational use of psychotropic drugs. II. Antianxiety agents. J Maine Med Assoc. 1974 Sep; 65(9):225-9.
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Cohler BJ, Grunebaum HU, Weiss JL, Robbins DM, Shader RI, Gallant D, Hartman CR. Social role performance and psychopathology among recently hospitalized and nonhospitalized mothers. II. Correlates with life stress and self-reported psychopathology. J Nerv Ment Dis. 1974 Aug; 159(2):81-90.
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Greenblatt DJ, Koch-Weser J, Shader RI. Multiple complications and death following protriptyline overdose. JAMA. 1974 Jul 29; 229(5):556-7.
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Shader RI, Harmatz JS, Tammerk HA. Menarcheal age and personality: the choice of a statistical test of relationship. Psychosom Med. 1974 Jul-Aug; 36(4):321-6.
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Shader RI, Harmatz J, La Brie R. Vitamin C prophylaxis and some problems of statistical inference. Curr Ther Res Clin Exp. 1974 Jun; 16(6):655-8.
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Greenblatt DJ, Shader RI. Drug abuse and the emergency room physician. Am J Psychiatry. 1974 May; 131(5):559-62.
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Shader RI, Harmatz JS, Salzman C. A new scale for clinical assessment in geriatric populations: Sandoz Clinical Assessment--Geriatric (SCAG). J Am Geriatr Soc. 1974 Mar; 22(3):107-13.
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Greenblatt DJ, Shader RI, Koch-Weser J. Letter: Safety of nitrazepam. Lancet. 1974 Feb 23; 1(7852):315.
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Shader RI, Jackson AH, Dodes LM. The antiaggressive effects of lithium in man. Psychopharmacologia. 1974; 40(1):17-24.
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Shader RI. The concept and phenomenology of depression, with special reference to the aged. Discussion. J Geriatr Psychiatry. 1974; 7(1):70-7.
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Salzman C, Shader RI. Psychopharmacology in the aged. Research considerations in geriatric psychopharmacology. J Geriatr Psychiatry. 1974; 7(2):165-84.
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Greenblatt DJ, Shader RI. Drug therapy. Anticholinergics. N Engl J Med. 1973 Jun 7; 288(23):1215-9.
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Jackson AH, Shader RI. Guidelines for the withdrawal of narcotic and general depressant drugs. Dis Nerv Syst. 1973 Mar; 34(3):162-6.
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Salzman C, Lieff J, Kochansky GE, Shader RI. The psychology of hallucinogenic drug discontinuers. Am J Psychiatry. 1972 Dec; 129(6):755-61.
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Greenblatt DJ, Shader RI. On the psychopharmacology of beta adrenergic blockade. Curr Ther Res Clin Exp. 1972 Sep; 14(9):615-25.
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Greenblatt DJ, Shader RI. Atropine overdose in three children. Br J Anaesth. 1972 Jul; 44(7):750.
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Salzman C, Kochansky GE, Shader RI. Rating scales for geriatric psychopharmacology--a review. Psychopharmacol Bull. 1972 Jul; 8(3):3-50.
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Greenblatt DJ, Shader RI. The clinical choice of sedative-hypnotics. Ann Intern Med. 1972 Jul; 77(1):91-100.
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Shader RI, Dimascio A, Harmatz JS. Single versus repeated dosage of the minor tranquilizer chlordiazepoxide (Librium). Am J Psychiatry. 1972 Jun; 128(12):1576-7.
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Gudeman JE, Shader RI, Hemenway TS. Methadone withdrawal in the treatment of heroin addiction. Dis Nerv Syst. 1972 May; 33(5):297-303.
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Salzman C, Shader RI, Kochansky GE, Cronin DM. Rating scales for psychotropic drug research with geriatric patients. I. Behavior ratings. J Am Geriatr Soc. 1972 May; 20(5):209-14.
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Gudeman JE, Shader RI, Ryan J, Rolde EJ. Preliminary experiences with the treatment of opiate addiction by methadone withdrawal. Conn Med. 1972 Mar; 36(3):137-42.
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Harmatz JS, Shader RI, Salzman C. Marihuana users and nonusers. Personality test differences. Arch Gen Psychiatry. 1972 Feb; 26(2):108-12.
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Shader RI. Sexual dysfunction associated with mesoridazine besylate (serentil). Psychopharmacologia. 1972; 27(3):293-4.
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Belfer ML, Shader RI, Carroll M, Harmatz JS. Alcoholism in women. Arch Gen Psychiatry. 1971 Dec; 25(6):540-4.
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Shader RI, Ebert MH, Harmatz JS. Langner's Psychiatric Impairment Scale: a short screening device. Am J Psychiatry. 1971 Nov; 128(5):596-601.
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Shader RI, Greenblatt DJ. Uses and toxicity of belladonna alkaloids and synthetic anticholinergics. Semin Psychiatry. 1971 Nov; 3(4):449-76.
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Shader RI, DiMascio A, Harmatz JS. Comparative effects of single and repeat dose administration of antianxiety agents. Psychopharmacol Bull. 1971 Oct; 7(4):27-8.
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Greenblatt DJ, Shader RI. Meprobamate: a study of irrational drug use. Am J Psychiatry. 1971 Apr; 127(10):1297-303.
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Shader RI, Grinspoon L, Harmatz JS, Ewalt JR. The therapist variable. Am J Psychiatry. 1971 Feb; 127(8):1009-12.
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Greenblatt DJ, Shader RI. Psychopharmacologic management of anxiety in the cardiac patient. Psychiatry Med. 1971 Jan; 2(1):55-66.
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DiMascio A, Shader RI. Drug administration schedules. Curr Psychiatr Ther. 1971; 11:94-9.
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Shader RI. Drugs in the management of anxiety. Curr Psychiatr Ther. 1971; 11:81-5.
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Greenblatt DJ, Shader RI. Adverse effects of LSD: a current perspective. Conn Med. 1970 Dec; 34(12):895-902.
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Meltzer HY, Grinspoon L, Shader RI. Serum creatine phosphokinase and aldolase activity in acute schizophrenic patients and their relatives. Compr Psychiatry. 1970 Nov; 11(6):552-8.
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Salzman C, Shader RI, Scott DA, Binstock W. Interviewer anger and patient dropout in walk-in clinic. Compr Psychiatry. 1970 May; 11(3):267-73.
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Shader RI, Grinspoon L. The effect of social feedback on chronic schizophrenic patients. Compr Psychiatry. 1970 Mar; 11(2):196-9.
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Appleton WS, Shader RI, DiMascio A. Ocular (pigmentary) effects of psychotropic drugs. Conn Med. 1970 Jan; 34(1):25-8.
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Dimascio A, Shader RI. Drug administration schedules. Am J Psychiatry. 1969 Dec; 126(6):796-801.
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DiMascio A, Gardos G, Harmatz J, Shader R. Tybamate: an examination of its actions in "high" and "low" anxious normals. Dis Nerv Syst. 1969 Nov; 30(11):758-63.
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Ebert MH, Shader RI. Cardiovascular effects of psychotropic drugs. Conn Med. 1969 Nov; 33(11):695-702.
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Pavy D, Grinspoon L, Shader RI. Word frequency measures of verbal disorders in schizophrenia. Dis Nerv Syst. 1969 Aug; 30(8):553-6.
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Gershon ES, Shader RI. Screening for aminoacidurias in psychiatric inpatients. Arch Gen Psychiatry. 1969 Jul; 21(1):82-8.
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DiMascio A, Shader RI, Harmatz J. Psychotropic drugs and induced hostility. Psychosomatics. 1969 May-Jun; 10(3):47-50.
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DiMascio A, Shader RI, Harmatz GS. Behavioral toxicity of psychotropic drugs. V. Effects on gross behavior patterns. Conn Med. 1969 Apr; 33(4):279-81.
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Shader RI, Levine FM. Staff-patient interaction patterns and opinions about mental illness. Soc Sci Med. 1969 Apr; 3(1):101-4.
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Greenblatt DJ, Shader RI, DiMascio A. Extrapyramidal side effects of psychotropic drugs. Conn Med. 1969 Mar; 33(3):197-201.
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Shader RI, Binstock WA, Ohly JI, Scott D. Biasing factors in diagnosis and disposition. Compr Psychiatry. 1969 Mar; 10(2):81-9.
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Blum RA, Livingston PB, Shader RI. Changes in cognition, attention and language in acute schizophrenia. Dis Nerv Syst. 1969 Jan; 30(1):31-6.
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Meltzer H, Shader R, Grinspoon L. The behavioral effects of nicotinamide adenine dinucleotide in chronic schizophrenia. Psychopharmacologia. 1969; 15(2):144-52.
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Salzman C, DiMascio A, Shader RI, Harmatz JS. Chlordiazepoxide, expectation and hostility. Psychopharmacologia. 1969; 14(1):38-45.
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Shader RI, Binstock WA, Scott D. Subjective determinants of drug prescription: a study of therapists' attitudes. Hosp Community Psychiatry. 1968 Dec; 19(12):384-7.
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Shader RI, DiMascio A. Endocrine effects of psychotropic drugs: VI. Male sexual function. Conn Med. 1968 Nov; 32(11):847-8.
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DiMascio A, Giller DR, Shader RI. Behavioral toxicity of psychotropic drugs. 3. Effects on perceptual and cognitive functions. IV. Effects on emotional (mood) states. Conn Med. 1968 Oct; 32(10):771-5.
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Belfer ML, Shader RI, Di Mascio A, Harmatz JS, Nahum JP. Stress and bronchitis. Br Med J. 1968 Sep 28; 3(5621):805-6.
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Shader RI, Belfer ML, DiMascio A. Endocrine effects of psychotropic drugs: V. Pituitary-thyroid axis. Conn Med. 1968 Sep; 32(9):679-84 passim.
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DiMascio A, Shader RI. Behavioral toxicity of psychotropic drugs. I. Definition. II. Toxic effects on psychomotor functions. Conn Med. 1968 Aug; 32(8):617-20.
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Shader RI, DiMascio A, Harmatz J. Characterological anxiety levels and premenstrual libido changes. Psychosomatics. 1968 Jul-Aug; 9(4):197-8.
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Shader RI, Giller DR, DiMascio A. Endocrine and metabolic effects of psychotropic drugs. IV. Hypothalamic-pituitary-adrenal axis. Conn Med. 1968 Jul; 32(7):539-43.
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Gardos G, DiMascio A, Salzman C, Shader RI. Differential actions of chlordiazepoxide and oxazepam on hostility. Arch Gen Psychiatry. 1968 Jun; 18(6):757-60.
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Shader RI, Binftock WA, Scott D. Psychiatrists' biases: who get drugs? Soc Sci Med. 1968 Jun; 2(2):213-6.
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Grinspoon L, Ewalt JR, Shader R. Psychotherapy and pharmacotherapy in chronic schizophrenia. Am J Psychiatry. 1968 Jun; 124(12):1645-52.
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Shader RI. Behavioral treatment of enuresis nocturna. Dis Nerv Syst. 1968 May; 29(5):334-5.
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Shader RI, Belfer ML, DiMascio A. Endocrine effects of psychotropic drugs. 3. Glucose metabolism. Conn Med. 1968 May; 32(5):389-94.
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Shader RI, Nahum JP, DiMascio A. Endocrine effects of psychotropic drugs. II. Amenorrhea. Conn Med. 1968 Apr; 32(4):303-5.
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Harmatz JS, DiMascio A, Shader RI. An investigation of the stimulating and mood-elevating properties of pipradol HCl administered to clinically normal volunteers. Curr Ther Res Clin Exp. 1968 Mar; 10(3):144-9.
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Shader RI, DiMascio A. Endocrine effects of psychotropic drugs. 1. Galactorrhea and gynecomastia. Conn Med. 1968 Feb; 32(2):106-8.
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DiMascio A, Shader RI, Salzman C, Harmatz JS. An evaluation of isoquinazepon (SAH-1123). Curr Ther Res Clin Exp. 1967 Oct; 9(10):517-21.
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Salzman C, Shader RI, DiMascio A. Collagen disease-like syndrome following administration of a benzodiazepine derivative. Dis Nerv Syst. 1967 Sep; 28(9):614-5.
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Grinspoon L, Ewalt JR, Shader R. Long-term treatment of chronic schizophrenia. A preliminary report. Int J Psychiatry. 1967 Aug; 4(2):116-28.
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Grinspoon L, Ewalt JR, Shader R. Long term therapy of chronic schizophrenia; a reply by the authors. Int J Psychiatry. 1967 Aug; 4(2):140-1.
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Shader RI, Kellam SG, Durell J. Social field events during the first week of hospitalization as predictors of treatment outcome for psychotic patients. J Nerv Ment Dis. 1967 Aug; 145(2):142-53.
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Shader RI, Grinspoon L. Schizophrenia, oligospermia, and the phenothiazines. Dis Nerv Syst. 1967 Apr; 28(4):240-4.
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Levine FM, Shader RI, Whitney N, Grinspoon L. The observers and the observed: the effects of doing ratings on staff-patient contact patterns. J Consult Psychol. 1966 Oct; 30(5):456-7.
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Ohler J, Grinspoon L, Shader R, Chatterjee S. Behavioral correlates of the guessing game. Side effects and double-blind studies. Arch Gen Psychiatry. 1966 Sep; 15(3):279-87.
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Durell J, Libow LS, Kellam SG, Shader RI. Interrelationships between regulation of thyroid gland function and psychosis. Res Publ Assoc Res Nerv Ment Dis. 1966; 43:387-99.
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Kellam SG, Durell J, Shader RI. Measurement of staff attitudes and the clinical course of patients on a psychiatric ward. Am J Psychother. 1966 Jan; 20(1):169-83.
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Shader RI. Effect on the liver of long-term tranquilizing medication. Am J Psychiatry. 1965 Dec; 122(6):707-8.
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GRINSPOON L, SHADER RI, CHATTERJEE S, COHLER J. SIDE EFFECTS AND DOUBLE-BLIND STUDIES. I. A CLINICAL COMPARISON BETWEEN THIORIDAZINE HYDROCHLORIDE AND A COMBINATION OF PHENOBARBITAL AND ATROPINE SULFATE. J Psychiatr Res. 1964 Dec; 33:247-56.
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SHADER RI, COHLER J, ELASHOFF R, GRINSPOON L. PHENOBARBITAL AND ATROPINE IN COMBINATION, AN ACTIVE CONTROL SUBSTANCE FOR PHENOTHIAZINE RESEARCH. J Psychiatr Res. 1964 Oct; 28:169-83.
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SHADER RI. SEXUAL DYSFUNCTION ASSOCIATED WITH THIORIDAZINE HYDROCHLORIDE. JAMA. 1964 Jun 15; 188:1007-9.