Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Thomas Walz, PH.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Dept Cell Biology, C2416B
240 Longwood Ave
Boston MA 02115
Phone617/432-4090
Fax617/432-1144

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Molecular Electron Microscopy Facility (HMS) - Core services (1) and Instruments (4)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Tan D, Cai Y, Wang J, Zhang J, Menon S, Chou HT, Ferro-Novick S, Reinisch KM, Walz T. The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19432-7.
    View in: PubMed
  2. Peisley A, Wu B, Yao H, Walz T, Hur S. RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent, Ubiquitin-Independent Manner. Mol Cell. 2013 Sep 12; 51(5):573-83.
    View in: PubMed
  3. Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H. Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Rep. 2013 Jul 25; 4(2):327-39.
    View in: PubMed
  4. Wang J, Menon S, Yamasaki A, Chou HT, Walz T, Jiang Y, Ferro-Novick S. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9800-5.
    View in: PubMed
  5. Schenk AD, Philippsen A, Engel A, Walz T. A pipeline for comprehensive and automated processing of electron diffraction data in IPLT. J Struct Biol. 2013 May; 182(2):173-85.
    View in: PubMed
  6. Etzkorn M, Raschle T, Hagn F, Gelev V, Rice AJ, Walz T, Wagner G. Cell-free Expressed Bacteriorhodopsin in Different Soluble Membrane Mimetics: Biophysical Properties and NMR Accessibility. Structure. 2013 Mar 5; 21(3):394-401.
    View in: PubMed
  7. Wu B, Peisley A, Richards C, Yao H, Zeng X, Lin C, Chu F, Walz T, Hur S. Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5. Cell. 2013 Jan 17; 152(1-2):276-89.
    View in: PubMed
  8. Peisley A, Jo MH, Lin C, Wu B, Orme-Johnson M, Walz T, Hohng S, Hur S. Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments. Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49):E3340-9.
    View in: PubMed
  9. Kumar M, Habel JE, Shen YX, Meier WP, Walz T. High-density reconstitution of functional water channels into vesicular and planar block copolymer membranes. J Am Chem Soc. 2012 Nov 14; 134(45):18631-7.
    View in: PubMed
  10. Lu C, Mi LZ, Schürpf T, Walz T, Springer TA. Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor. J Biol Chem. 2012 Nov 2; 287(45):38244-53.
    View in: PubMed
  11. Rahmeh AA, Morin B, Schenk AD, Liang B, Heinrich BS, Brusic V, Walz T, Whelan SP. Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus. Proc Natl Acad Sci U S A. 2012 Sep 4; 109(36):14628-33.
    View in: PubMed
  12. Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 2012 Jul 20; 150(2):339-50.
    View in: PubMed
  13. Aponte-Santamaría C, Briones R, Schenk AD, Walz T, de Groot BL. Molecular driving forces defining lipid positions around aquaporin-0. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9887-92.
    View in: PubMed
  14. Zhou YF, Eng ET, Zhu J, Lu C, Walz T, Springer TA. Sequence and structure relationships within von Willebrand factor. Blood. 2012 Jul 12; 120(2):449-58.
    View in: PubMed
  15. Chen X, Yu Y, Mi LZ, Walz T, Springer TA. Molecular basis for complement recognition by integrin aXß2. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4586-91.
    View in: PubMed
  16. Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA. Structural specializations of a(4)ß(7), an integrin that mediates rolling adhesion. J Cell Biol. 2012 Jan 9; 196(1):131-46.
    View in: PubMed
  17. Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T, Hur S. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21010-5.
    View in: PubMed
  18. Djerf Severinsson EA, Trinks C, Gréen H, Abdiu A, Hallbeck AL, Stål O, Walz TM. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28; 414(3):563-8.
    View in: PubMed
  19. Zhou YF, Eng ET, Nishida N, Lu C, Walz T, Springer TA. A pH-regulated dimeric bouquet in the structure of von Willebrand factor. EMBO J. 2011 Oct 5; 30(19):4098-111.
    View in: PubMed
  20. Eng ET, Smagghe BJ, Walz T, Springer TA. Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. J Biol Chem. 2011 Oct 7; 286(40):35218-26.
    View in: PubMed
  21. Mi LZ, Lu C, Li Z, Nishida N, Walz T, Springer TA. Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nat Struct Mol Biol. 2011 Sep; 18(9):984-9.
    View in: PubMed
  22. Tung SY, Hong JY, Walz T, Moazed D, Liou GG. Chromatin affinity-precipitation using a small metabolic molecule: its application to analysis of O-acetyl-ADP-ribose. Cell Mol Life Sci. 2012 Feb; 69(4):641-50.
    View in: PubMed
  23. Chiu PL, Kelly DF, Walz T. The use of trehalose in the preparation of specimens for molecular electron microscopy. Micron. 2011 Dec; 42(8):762-72.
    View in: PubMed
  24. Norville JE, Kelly DF, Knight TF, Belcher AM, Walz T. Fast and easy protocol for the purification of recombinant S-layer protein for synthetic biology applications. Biotechnol J. 2011 Jul; 6(7):807-11.
    View in: PubMed
  25. Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA. Latent TGF-ß structure and activation. Nature. 2011 Jun 16; 474(7351):343-9.
    View in: PubMed
  26. Trinks C, Severinsson EA, Holmlund B, Gréen A, Gréen H, Jönsson JI, Hallbeck AL, Walz TM. The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells. Biochem Biophys Res Commun. 2011 Jul 8; 410(3):422-7.
    View in: PubMed
  27. Ferron F, Li Z, Danek EI, Luo D, Wong Y, Coutard B, Lantez V, Charrel R, Canard B, Walz T, Lescar J. The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog. 2011 May; 7(5):e1002030.
    View in: PubMed
  28. Yip CK, Walz T. Molecular structure and flexibility of the yeast coatomer as revealed by electron microscopy. J Mol Biol. 2011 May 20; 408(5):825-31.
    View in: PubMed
  29. Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat Struct Mol Biol. 2011 Mar; 18(3):316-22.
    View in: PubMed
  30. Lupardus PJ, Skiniotis G, Rice AJ, Thomas C, Fischer S, Walz T, Garcia KC. Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Ra cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure. 2011 Jan 12; 19(1):45-55.
    View in: PubMed
  31. Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP. Molecular architecture of the vesicular stomatitis virus RNA polymerase. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20075-80.
    View in: PubMed
  32. Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP. Assembly of a functional Machupo virus polymerase complex. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20069-74.
    View in: PubMed
  33. Yip CK, Berscheminski J, Walz T. Molecular architecture of the TRAPPII complex and implications for vesicle tethering. Nat Struct Mol Biol. 2010 Nov; 17(11):1298-304.
    View in: PubMed
  34. Lees JA, Yip CK, Walz T, Hughson FM. Molecular organization of the COG vesicle tethering complex. Nat Struct Mol Biol. 2010 Nov; 17(11):1292-7.
    View in: PubMed
  35. Wang L, Yang JK, Kabaleeswaran V, Rice AJ, Cruz AC, Park AY, Yin Q, Damko E, Jang SB, Raunser S, Robinson CV, Siegel RM, Walz T, Wu H. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol. 2010 Nov; 17(11):1324-9.
    View in: PubMed
  36. Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010 Aug 20; 142(4):556-67.
    View in: PubMed
  37. Chen X, Xie C, Nishida N, Li Z, Walz T, Springer TA. Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14727-32.
    View in: PubMed
  38. Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell. 2010 Jun 11; 38(5):768-74.
    View in: PubMed
  39. Kelly DF, Dukovski D, Walz T. Strategy for the use of affinity grids to prepare non-His-tagged macromolecular complexes for single-particle electron microscopy. J Mol Biol. 2010 Jul 23; 400(4):675-81.
    View in: PubMed
  40. Kelly DF, Lake RJ, Middelkoop TC, Fan HY, Artavanis-Tsakonas S, Walz T. Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy. PLoS One. 2010; 5(5):e10532.
    View in: PubMed
  41. Hite RK, Li Z, Walz T. Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals. EMBO J. 2010 May 19; 29(10):1652-8.
    View in: PubMed
  42. Trinks C, Djerf EA, Hallbeck AL, Jönsson JI, Walz TM. The pan-ErbB receptor tyrosine kinase inhibitor canertinib induces ErbB-independent apoptosis in human leukemia (HL-60 and U-937) cells. Biochem Biophys Res Commun. 2010 Feb 26; 393(1):6-10.
    View in: PubMed
  43. Schenk AD, Hite RK, Engel A, Fujiyoshi Y, Walz T. Electron crystallography and aquaporins. Methods Enzymol. 2010; 483:91-119.
    View in: PubMed
  44. Hite RK, Schenk AD, Li Z, Cheng Y, Walz T. Collecting electron crystallographic data of two-dimensional protein crystals. Methods Enzymol. 2010; 481:251-82.
    View in: PubMed
  45. Kelly DF, Dukovski D, Walz T. A practical guide to the use of monolayer purification and affinity grids. Methods Enzymol. 2010; 481:83-107.
    View in: PubMed
  46. Won EY, Cha K, Byun JS, Kim DU, Shin S, Ahn B, Kim YH, Rice AJ, Walz T, Kwon BS, Cho HS. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. J Biol Chem. 2010 Mar 19; 285(12):9202-10.
    View in: PubMed
  47. Raschle T, Hiller S, Yu TY, Rice AJ, Walz T, Wagner G. Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J Am Chem Soc. 2009 Dec 16; 131(49):17777-9.
    View in: PubMed
  48. Ren Y, Yip CK, Tripathi A, Huie D, Jeffrey PD, Walz T, Hughson FM. A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell. 2009 Dec 11; 139(6):1119-29.
    View in: PubMed
  49. Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, MacDonald ME. Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet. 2010 Feb 15; 19(4):573-83.
    View in: PubMed
  50. Li Z, Hite RK, Cheng Y, Walz T. Evaluation of imaging plates as recording medium for images of negatively stained single particles and electron diffraction patterns of two-dimensional crystals. J Electron Microsc (Tokyo). 2010; 59(1):53-63.
    View in: PubMed
  51. Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, Moazed D. An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol Cell. 2009 Apr 24; 34(2):155-67.
    View in: PubMed
  52. Dukovski D, Li Z, Kelly DF, Mack E, Walz T. Structural and functional studies on the stalk of the transferrin receptor. Biochem Biophys Res Commun. 2009 Apr 17; 381(4):712-6.
    View in: PubMed
  53. Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell. 2009 Mar 6; 136(5):876-90.
    View in: PubMed
  54. Raunser S, Mathai JC, Abeyrathne PD, Rice AJ, Zeidel ML, Walz T. Oligomeric structure and functional characterization of the urea transporter from Actinobacillus pleuropneumoniae. J Mol Biol. 2009 Apr 3; 387(3):619-27.
    View in: PubMed
  55. Raunser S, Magnani R, Huang Z, Houtz RL, Trievel RC, Penczek PA, Walz T. Rubisco in complex with Rubisco large subunit methyltransferase. Proc Natl Acad Sci U S A. 2009 Mar 3; 106(9):3160-5.
    View in: PubMed
  56. Walz T, Fujiyoshi Y, Engel A. The AQP structure and functional implications. Handb Exp Pharmacol. 2009; (190):31-56.
    View in: PubMed
  57. Raunser S, Walz T. Electron crystallography as a technique to study the structure on membrane proteins in a lipidic environment. Annu Rev Biophys. 2009; 38:89-105.
    View in: PubMed
  58. Cheng Y, Walz T. The advent of near-atomic resolution in single-particle electron microscopy. Annu Rev Biochem. 2009; 78:723-42.
    View in: PubMed
  59. Mi LZ, Grey MJ, Nishida N, Walz T, Lu C, Springer TA. Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs. Biochemistry. 2008 Sep 30; 47(39):10314-23.
    View in: PubMed
  60. Skiniotis G, Lupardus PJ, Martick M, Walz T, Garcia KC. Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol Cell. 2008 Sep 5; 31(5):737-48.
    View in: PubMed
  61. Kelly DF, Abeyrathne PD, Dukovski D, Walz T. The Affinity Grid: a pre-fabricated EM grid for monolayer purification. J Mol Biol. 2008 Oct 3; 382(2):423-33.
    View in: PubMed
  62. Ng AK, Zhang H, Tan K, Li Z, Liu JH, Chan PK, Li SM, Chan WY, Au SW, Joachimiak A, Walz T, Wang JH, Shaw PC. Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J. 2008 Oct; 22(10):3638-47.
    View in: PubMed
  63. Stahlberg H, Walz T. Molecular electron microscopy: state of the art and current challenges. ACS Chem Biol. 2008 May 16; 3(5):268-81.
    View in: PubMed
  64. Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN. Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa. J Biol Chem. 2008 Jul 4; 283(27):18655-64.
    View in: PubMed
  65. Hartley DM, Zhao C, Speier AC, Woodard GA, Li S, Li Z, Walz T. Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation. J Biol Chem. 2008 Jun 13; 283(24):16790-800.
    View in: PubMed
  66. Kelly DF, Dukovski D, Walz T. Monolayer purification: a rapid method for isolating protein complexes for single-particle electron microscopy. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4703-8.
    View in: PubMed
  67. Strunk JJ, Gregor I, Becker Y, Li Z, Gavutis M, Jaks E, Lamken P, Walz T, Enderlein J, Piehler J. Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domain. J Mol Biol. 2008 Mar 28; 377(3):725-39.
    View in: PubMed
  68. Engel A, Fujiyoshi Y, Gonen T, Walz T. Junction-forming aquaporins. Curr Opin Struct Biol. 2008 Apr; 18(2):229-35.
    View in: PubMed
  69. Onishi M, Liou GG, Buchberger JR, Walz T, Moazed D. Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol Cell. 2007 Dec 28; 28(6):1015-28.
    View in: PubMed
  70. Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, Chen JS, Yoon HJ, Wall JS, Huang Z, Penczek PA, Gould KL, Walz T. Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell. 2007 Dec 14; 28(5):871-85.
    View in: PubMed
  71. Li Z, Strunk JJ, Lamken P, Piehler J, Walz T. The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling. J Mol Biol. 2008 Mar 28; 377(3):715-24.
    View in: PubMed
  72. Hite RK, Gonen T, Harrison SC, Walz T. Interactions of lipids with aquaporin-0 and other membrane proteins. Pflugers Arch. 2008 Jul; 456(4):651-61.
    View in: PubMed
  73. Gonen T, Hite RK, Cheng Y, Petre BM, Kistler J, Walz T. Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20. J Mol Biol. 2008 Feb 15; 376(2):380-92.
    View in: PubMed
  74. Hite RK, Raunser S, Walz T. Revival of electron crystallography. Curr Opin Struct Biol. 2007 Aug; 17(4):389-95.
    View in: PubMed
  75. Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D. Structural basis of Dscam isoform specificity. Nature. 2007 Sep 27; 449(7161):487-91.
    View in: PubMed
  76. Scheuring S, Buzhynskyy N, Jaroslawski S, Gonçalves RP, Hite RK, Walz T. Structural models of the supramolecular organization of AQP0 and connexons in junctional microdomains. J Struct Biol. 2007 Dec; 160(3):385-94.
    View in: PubMed
  77. Norville JE, Kelly DF, Knight TF, Belcher AM, Walz T. 7A projection map of the S-layer protein sbpA obtained with trehalose-embedded monolayer crystals. J Struct Biol. 2007 Dec; 160(3):313-23.
    View in: PubMed
  78. Kelly DF, Lake RJ, Walz T, Artavanis-Tsakonas S. Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless. Proc Natl Acad Sci U S A. 2007 Jun 5; 104(23):9591-6.
    View in: PubMed
  79. Skiniotis G, Moazed D, Walz T. Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex. J Biol Chem. 2007 Jul 20; 282(29):20804-8.
    View in: PubMed
  80. Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC. Structural insight into pre-B cell receptor function. Science. 2007 Apr 13; 316(5822):291-4.
    View in: PubMed
  81. Ohi MD, Ren L, Wall JS, Gould KL, Walz T. Structural characterization of the fission yeast U5.U2/U6 spliceosome complex. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3195-200.
    View in: PubMed
  82. Ruch C, Skiniotis G, Steinmetz MO, Walz T, Ballmer-Hofer K. Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat Struct Mol Biol. 2007 Mar; 14(3):249-50.
    View in: PubMed
  83. Park HH, Logette E, Raunser S, Cuenin S, Walz T, Tschopp J, Wu H. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell. 2007 Feb 9; 128(3):533-46.
    View in: PubMed
  84. Cheng Y, Walz T. Reconstructing the endocytotic machinery. Methods Cell Biol. 2007; 79:463-87.
    View in: PubMed
  85. Viadiu H, Gonen T, Walz T. Projection map of aquaporin-9 at 7 A resolution. J Mol Biol. 2007 Mar 16; 367(1):80-8.
    View in: PubMed
  86. Nishida N, Walz T, Springer TA. Structural transitions of complement component C3 and its activation products. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19737-42.
    View in: PubMed
  87. Buzhynskyy N, Hite RK, Walz T, Scheuring S. The supramolecular architecture of junctional microdomains in native lens membranes. EMBO Rep. 2007 Jan; 8(1):51-5.
    View in: PubMed
  88. Kim YG, Raunser S, Munger C, Wagner J, Song YL, Cygler M, Walz T, Oh BH, Sacher M. The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering. Cell. 2006 Nov 17; 127(4):817-30.
    View in: PubMed
  89. Gonen T, Walz T. The structure of aquaporins. Q Rev Biophys. 2006 Nov; 39(4):361-96.
    View in: PubMed
  90. Cheng Y, Boll W, Kirchhausen T, Harrison SC, Walz T. Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9.
    View in: PubMed
  91. Nishida N, Xie C, Shimaoka M, Cheng Y, Walz T, Springer TA. Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity. 2006 Oct; 25(4):583-94.
    View in: PubMed
  92. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60.
    View in: PubMed
  93. Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science. 2006 Jun 9; 312(5779):1526-30.
    View in: PubMed
  94. Crampton DJ, Ohi M, Qimron U, Walz T, Richardson CC. Oligomeric states of bacteriophage T7 gene 4 primase/helicase. J Mol Biol. 2006 Jul 14; 360(3):667-77.
    View in: PubMed
  95. Nakagawa T, Cheng Y, Sheng M, Walz T. Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins. Biol Chem. 2006 Feb; 387(2):179-87.
    View in: PubMed
  96. Smith DM, Kafri G, Cheng Y, Ng D, Walz T, Goldberg AL. ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell. 2005 Dec 9; 20(5):687-98.
    View in: PubMed
  97. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005 Dec 1; 438(7068):633-8.
    View in: PubMed
  98. Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T. Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol. 2006 Feb 3; 355(5):1048-65.
    View in: PubMed
  99. Cheng Y, Zak O, Aisen P, Harrison SC, Walz T. Single particle reconstruction of the human apo-transferrin-transferrin receptor complex. J Struct Biol. 2005 Dec; 152(3):204-10.
    View in: PubMed
  100. Hiroaki Y, Tani K, Kamegawa A, Gyobu N, Nishikawa K, Suzuki H, Walz T, Sasaki S, Mitsuoka K, Kimura K, Mizoguchi A, Fujiyoshi Y. Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol. 2006 Jan 27; 355(4):628-39.
    View in: PubMed
  101. Morikawa M, Fryer JD, Sullivan PM, Christopher EA, Wahrle SE, DeMattos RB, O'Dell MA, Fagan AM, Lashuel HA, Walz T, Asai K, Holtzman DM. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):66-76.
    View in: PubMed
  102. Liou GG, Tanny JC, Kruger RG, Walz T, Moazed D. Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell. 2005 May 20; 121(4):515-27.
    View in: PubMed
  103. Skiniotis G, Boulanger MJ, Garcia KC, Walz T. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol. 2005 Jun; 12(6):545-51.
    View in: PubMed
  104. Walz T. How cholesterol-dependent cytolysins bite holes into membranes. Mol Cell. 2005 May 13; 18(4):393-4.
    View in: PubMed
  105. Viadiu H, Stemmann O, Kirschner MW, Walz T. Domain structure of separase and its binding to securin as determined by EM. Nat Struct Mol Biol. 2005 Jun; 12(6):552-3.
    View in: PubMed
  106. Schmidt M, Haas W, Crosas B, Santamaria PG, Gygi SP, Walz T, Finley D. The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol. 2005 Apr; 12(4):294-303.
    View in: PubMed
  107. Nakagawa T, Cheng Y, Ramm E, Sheng M, Walz T. Structure and different conformational states of native AMPA receptor complexes. Nature. 2005 Feb 3; 433(7025):545-9.
    View in: PubMed
  108. Ohi MD, Vander Kooi CW, Rosenberg JA, Ren L, Hirsch JP, Chazin WJ, Walz T, Gould KL. Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Mol Cell Biol. 2005 Jan; 25(1):451-60.
    View in: PubMed
  109. Nakagawa T, Futai K, Lashuel HA, Lo I, Okamoto K, Walz T, Hayashi Y, Sheng M. Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron. 2004 Oct 28; 44(3):453-67.
    View in: PubMed
  110. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 2; 432(7017):573-9.
    View in: PubMed
  111. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 2; 432(7017):649-53.
    View in: PubMed
  112. Gonen T, Cheng Y, Kistler J, Walz T. Aquaporin-0 membrane junctions form upon proteolytic cleavage. J Mol Biol. 2004 Sep 24; 342(4):1337-45.
    View in: PubMed
  113. Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE, Byfield S, Felici A, Flanders KC, Walz TM, Roberts AB, Aplan PD, Balis FM, Letterio JJ. Loss of Smad3 in acute T-cell lymphoblastic leukemia. N Engl J Med. 2004 Aug 5; 351(6):552-9.
    View in: PubMed
  114. Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004 May 13; 429(6988):193-7.
    View in: PubMed
  115. Ray SS, Nowak RJ, Strokovich K, Brown RH, Walz T, Lansbury PT. An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis. Biochemistry. 2004 May 4; 43(17):4899-905.
    View in: PubMed
  116. Luo BH, Strokovich K, Walz T, Springer TA, Takagi J. Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J Biol Chem. 2004 Jun 25; 279(26):27466-71.
    View in: PubMed
  117. Ohi M, Li Y, Cheng Y, Walz T. Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online. 2004; 6:23-34.
    View in: PubMed
  118. Cheng Y, Zak O, Aisen P, Harrison SC, Walz T. Structure of the human transferrin receptor-transferrin complex. Cell. 2004 Feb 20; 116(4):565-76.
    View in: PubMed
  119. Kheterpal I, Lashuel HA, Hartley DM, Walz T, Lansbury PT, Wetzel R. Abeta protofibrils possess a stable core structure resistant to hydrogen exchange. Biochemistry. 2003 Dec 9; 42(48):14092-8.
    View in: PubMed
  120. Lashuel HA, Hartley DM, Petre BM, Wall JS, Simon MN, Walz T, Lansbury PT. Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol. 2003 Sep 26; 332(4):795-808.
    View in: PubMed
  121. Takagi J, Strokovich K, Springer TA, Walz T. Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J. 2003 Sep 15; 22(18):4607-15.
    View in: PubMed
  122. Wang L, Lashuel HA, Walz T, Colon W. Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):15947-52.
    View in: PubMed
  123. Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, Lansbury PT. Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol. 2002 Oct 4; 322(5):1089-102.
    View in: PubMed
  124. Takagi J, Petre BM, Walz T, Springer TA. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell. 2002 Sep 6; 110(5):599-11.
    View in: PubMed
  125. Leggett DS, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker RT, Walz T, Ploegh H, Finley D. Multiple associated proteins regulate proteasome structure and function. Mol Cell. 2002 Sep; 10(3):495-507.
    View in: PubMed
  126. Lashuel HA, Hartley D, Petre BM, Walz T, Lansbury PT. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature. 2002 Jul 18; 418(6895):291.
    View in: PubMed
  127. Cascio P, Call M, Petre BM, Walz T, Goldberg AL. Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J. 2002 Jun 3; 21(11):2636-45.
    View in: PubMed
  128. Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T. Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10704-9.
    View in: PubMed
  129. Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y. Structural determinants of water permeation through aquaporin-1. Nature. 2000 Oct 5; 407(6804):599-605.
    View in: PubMed
  130. Mitsuoka K, Murata K, Walz T, Hirai T, Agre P, Heymann JB, Engel A, Fujiyoshi Y. The structure of aquaporin-1 at 4.5-A resolution reveals short alpha-helices in the center of the monomer. J Struct Biol. 1999 Dec 1; 128(1):34-43.
    View in: PubMed
  131. Walz T, Jamieson SJ, Bowers CM, Bullough PA, Hunter CN. Projection structures of three photosynthetic complexes from Rhodobacter sphaeroides: LH2 at 6 A, LH1 and RC-LH1 at 25 A. J Mol Biol. 1998 Oct 2; 282(4):833-45.
    View in: PubMed
  132. Hasler L, Walz T, Tittmann P, Gross H, Kistler J, Engel A. Purified lens major intrinsic protein (MIP) forms highly ordered tetragonal two-dimensional arrays by reconstitution. J Mol Biol. 1998 Jun 19; 279(4):855-64.
    View in: PubMed
  133. Hasler L, Heymann JB, Engel A, Kistler J, Walz T. 2D crystallization of membrane proteins: rationales and examples. J Struct Biol. 1998; 121(2):162-71.
    View in: PubMed
  134. Cabiaux V, Oberg KA, Pancoska P, Walz T, Agre P, Engel A. Secondary structures comparison of aquaporin-1 and bacteriorhodopsin: a Fourier transform infrared spectroscopy study of two-dimensional membrane crystals. Biophys J. 1997 Jul; 73(1):406-17.
    View in: PubMed
  135. Walz T, Hirai T, Murata K, Heymann JB, Mitsuoka K, Fujiyoshi Y, Smith BL, Agre P, Engel A. The three-dimensional structure of aquaporin-1. Nature. 1997 Jun 5; 387(6633):624-7.
    View in: PubMed
  136. Walz T, Ghosh R. Two-dimensional crystallization of the light-harvesting I-reaction centre photounit from Rhodospirillum rubrum. J Mol Biol. 1997 Jan 17; 265(2):107-11.
    View in: PubMed
  137. Walz T, Tittmann P, Fuchs KH, Müller DJ, Smith BL, Agre P, Gross H, Engel A. Surface topographies at subnanometer-resolution reveal asymmetry and sidedness of aquaporin-1. J Mol Biol. 1996 Dec 20; 264(5):907-18.
    View in: PubMed
  138. Karrasch S, Typke D, Walz T, Miller M, Tsiotis G, Engel A. Highly ordered two-dimensional crystals of photosystem I reaction center from Synechococcus sp.: functional and structural analyses. J Mol Biol. 1996 Sep 27; 262(3):336-48.
    View in: PubMed
  139. Tsiotis G, Walz T, Spyridaki A, Lustig A, Engel A, Ghanotakis D. Tubular crystals of a photosystem II core complex. J Mol Biol. 1996 Jun 7; 259(2):241-8.
    View in: PubMed
  140. Egesten A, Calafat J, Knol EF, Janssen H, Walz TM. Subcellular localization of transforming growth factor-alpha in human eosinophil granulocytes. Blood. 1996 May 1; 87(9):3910-8.
    View in: PubMed
  141. Walz T, Typke D, Smith BL, Agre P, Engel A. Projection map of aquaporin-1 determined by electron crystallography. Nat Struct Biol. 1995 Sep; 2(9):730-2.
    View in: PubMed
  142. Walz T, Häner M, Wu XR, Henn C, Engel A, Sun TT, Aebi U. Towards the molecular architecture of the asymmetric unit membrane of the mammalian urinary bladder epithelium: a closed "twisted ribbon" structure. J Mol Biol. 1995 May 19; 248(5):887-900.
    View in: PubMed
  143. Walz TM, Malm C, Nishikawa BK, Wasteson A. Transforming growth factor-alpha (TGF-alpha) in human bone marrow: demonstration of TGF-alpha in erythroblasts and eosinophilic precursor cells and of epidermal growth factor receptors in blastlike cells of myelomonocytic origin. Blood. 1995 May 1; 85(9):2385-92.
    View in: PubMed
  144. Walz T, Smith BL, Agre P, Engel A. The three-dimensional structure of human erythrocyte aquaporin CHIP. EMBO J. 1994 Jul 1; 13(13):2985-93.
    View in: PubMed
  145. Wu XR, Lin JH, Walz T, Häner M, Yu J, Aebi U, Sun TT. Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem. 1994 May 6; 269(18):13716-24.
    View in: PubMed
  146. Walz T, Smith BL, Zeidel ML, Engel A, Agre P. Biologically active two-dimensional crystals of aquaporin CHIP. J Biol Chem. 1994 Jan 21; 269(3):1583-6.
    View in: PubMed
  147. Dolder M, Walz T, Hefti A, Engel A. Human erythrocyte band 3. Solubilization and reconstitution into two-dimensional crystals. J Mol Biol. 1993 May 5; 231(1):119-32.
    View in: PubMed
  148. Dolder M, Walz T, Hefti A, Engel A. Reconstitution of human erythrocyte band 3 into two-dimensional crystals. Soc Gen Physiol Ser. 1993; 48:63-76.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Walz's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_