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Zdravka Ognyanova Medarova, PH.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Martinos Center for Biomedical Imaging, Rm. 2301
149 13th Street
Charlestown MA 02129
Phone617/726-1223
Fax617/726-7422

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ghosh SK, Yigit MV, Uchida M, Ross AW, Barteneva N, Moore A, Medarova Z. Sequence-dependent combination therapy with doxorubicin and a survivin-specific small interfering RNA nanodrug demonstrates efficacy in models of adenocarcinoma. Int J Cancer. 2014 Apr 1; 134(7):1758-66.
    View in: PubMed
  2. Ghosh SK, Pantazopoulos P, Medarova Z, Moore A. Expression of Underglycosylated MUC1 Antigen in Cancerous and Adjacent Normal Breast Tissues. Clin Breast Cancer. 2013 Apr; 13(2):109-18.
    View in: PubMed
  3. Ghosh SK, Uchida M, Yoo B, Ross AW, Gendler SJ, Gong J, Moore A, Medarova Z. Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model. Int J Cancer. 2013 Apr 15; 132(8):1860-7.
    View in: PubMed
  4. Uppal R, Medarova Z, Farrar CT, Dai G, Moore A, Caravan P. Molecular imaging of fibrin in a breast cancer xenograft mouse model. Invest Radiol. 2012 Oct; 47(10):553-8.
    View in: PubMed
  5. Wang P, Yigit MV, Ran C, Ross A, Wei L, Dai G, Medarova Z, Moore A. A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection. Diabetes. 2012 Dec; 61(12):3247-54.
    View in: PubMed
  6. Yigit MV, Ghosh SK, Kumar M, Petkova V, Kavishwar A, Moore A, Medarova Z. Context-dependent differences in miR-10b breast oncogenesis can be targeted for the prevention and arrest of lymph node metastasis. Oncogene. 2013 Mar 21; 32(12):1530-8.
    View in: PubMed
  7. Yigit MV, Medarova Z. In vivo and ex vivo applications of gold nanoparticles for biomedical SERS imagingi. Am J Nucl Med Mol Imaging. 2012; 2(2):232-41.
    View in: PubMed
  8. Yigit MV, Moore A, Medarova Z. Magnetic nanoparticles for cancer diagnosis and therapy. Pharm Res. 2012 May; 29(5):1180-8.
    View in: PubMed
  9. Medarova Z, Greiner DL, Ifediba M, Dai G, Bolotin E, Castillo G, Bogdanov A, Kumar M, Moore A. Imaging the pancreatic vasculature in diabetes models. Diabetes Metab Res Rev. 2011 Nov; 27(8):767-72.
    View in: PubMed
  10. Wang P, Medarova Z, Moore A. Molecular imaging: a promising tool to monitor islet transplantation. J Transplant. 2011; 2011:202915.
    View in: PubMed
  11. Kavishwar A, Medarova Z, Moore A. Unique sphingomyelin patches are targets of a beta-cell-specific antibody. J Lipid Res. 2011 Sep; 52(9):1660-71.
    View in: PubMed
  12. Wang P, Yigit MV, Medarova Z, Wei L, Dai G, Schuetz C, Moore A. Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation. Diabetes. 2011 Feb; 60(2):565-71.
    View in: PubMed
  13. Yigit MV, Zhu L, Ifediba MA, Zhang Y, Carr K, Moore A, Medarova Z. Noninvasive MRI-SERS imaging in living mice using an innately bimodal nanomaterial. ACS Nano. 2011 Feb 22; 5(2):1056-66.
    View in: PubMed
  14. Kumar M, Yigit M, Dai G, Moore A, Medarova Z. Image-guided breast tumor therapy using a small interfering RNA nanodrug. Cancer Res. 2010 Oct 1; 70(19):7553-61.
    View in: PubMed
  15. Ghosh SK, Kim P, Zhang XA, Yun SH, Moore A, Lippard SJ, Medarova Z. A novel imaging approach for early detection of prostate cancer based on endogenous zinc sensing. Cancer Res. 2010 Aug 1; 70(15):6119-27.
    View in: PubMed
  16. Ifediba MA, Medarova Z, Ng SW, Yang J, Moore A. siRNA delivery to CNS cells using a membrane translocation peptide. Bioconjug Chem. 2010 May 19; 21(5):803-6.
    View in: PubMed
  17. Tsai S, Shameli A, Yamanouchi J, Clemente-Casares X, Wang J, Serra P, Yang Y, Medarova Z, Moore A, Santamaria P. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity. 2010 Apr 23; 32(4):568-80.
    View in: PubMed
  18. Kumar M, Medarova Z, Pantazopoulos P, Dai G, Moore A. Novel membrane-permeable contrast agent for brain tumor detection by MRI. Magn Reson Med. 2010 Mar; 63(3):617-24.
    View in: PubMed
  19. Ran C, Xu X, Raymond SB, Ferrara BJ, Neal K, Bacskai BJ, Medarova Z, Moore A. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28; 131(42):15257-61.
    View in: PubMed
  20. Medarova Z, Moore A. MRI in diabetes: first results. AJR Am J Roentgenol. 2009 Aug; 193(2):295-303.
    View in: PubMed
  21. Medarova Z, Moore A. MRI as a tool to monitor islet transplantation. Nat Rev Endocrinol. 2009 Aug; 5(8):444-52.
    View in: PubMed
  22. Medarova Z, Vallabhajosyula P, Tena A, Evgenov N, Pantazopoulos P, Tchipashvili V, Weir G, Sachs D, Moore A. In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates. Transplantation. 2009 Jun 15; 87(11):1659-66.
    View in: PubMed
  23. Medarova Z, Rashkovetsky L, Pantazopoulos P, Moore A. Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging. Cancer Res. 2009 Feb 1; 69(3):1182-9.
    View in: PubMed
  24. Moore A, Medarova Z. Imaging of siRNA delivery and silencing. Methods Mol Biol. 2009; 487:93-110.
    View in: PubMed
  25. Medarova Z, Kumar M, Ng SW, Moore A. Development and application of a dual-purpose nanoparticle platform for delivery and imaging of siRNA in tumors. Methods Mol Biol. 2009; 555:1-13.
    View in: PubMed
  26. Medarova Z, Kumar M, Ng SW, Yang J, Barteneva N, Evgenov NV, Petkova V, Moore A. Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets. Transplantation. 2008 Nov 15; 86(9):1170-7.
    View in: PubMed
  27. Medarova Z, Moore A. Non-invasive detection of transplanted pancreatic islets. Diabetes Obes Metab. 2008 Nov; 10 Suppl 4:88-97.
    View in: PubMed
  28. Medarova Z, Tsai S, Evgenov N, Santamaria P, Moore A. In vivo imaging of a diabetogenic CD8+ T cell response during type 1 diabetes progression. Magn Reson Med. 2008 Apr; 59(4):712-20.
    View in: PubMed
  29. Erdogan S, Medarova ZO, Roby A, Moore A, Torchilin VP. Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes. J Magn Reson Imaging. 2008 Mar; 27(3):574-80.
    View in: PubMed
  30. Medarova Z, Tsai S, Evgenov N, Santamaria P, Moore A. In vivo Imaging of a Diabetogenic CD8+ T cell Response During Type 1 Diabetes Progression. Magn Res Med. 2008; 59(4):712-720.
  31. Erdogan S*, Medarova Z*, Roby A, Moore A, Torchilin V. Enhanced tumor magnetic resonance imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes. J Magn Res Imaging. 2008; 27(3):574-580.
  32. Medarova Z, Castillo G, Dai G, Bolotin E, Bogdanov A, Moore A. Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes. Diabetes. 2007 Nov; 56(11):2677-82.
    View in: PubMed
  33. Medarova Z, Pham W, Farrar C, Petkova V, Moore A. In vivo imaging of siRNA delivery and silencing in tumors. Nat Med. 2007 Mar; 13(3):372-7.
    View in: PubMed
  34. Ran C, Pantazopoulos P, Medarova Z, Moore A. Synthesis and testing of beta-cell specific Streptozotocin-derived near infrared imaging probes. Angew Chem. 2007; 46(47):8998-9001.
  35. Ran C, Pantazopoulos P, Medarova Z, Moore A. Synthesis and testing of beta-cell-specific streptozotocin-derived near-infrared imaging probes. Angew Chem Int Ed Engl. 2007; 46(47):8998-9001.
    View in: PubMed
  36. Medarova Z, Moore A. Cellular and Molecular Imaging of the Diabetic Pancreas. Molecular and Cellular MR Imaging, Michael M.J.J. Modo and Jeff W.M. Bulte. 2007.
  37. Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore A. In vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes. 2006 Sep; 55(9):2419-28.
    View in: PubMed
  38. Medarova Z, Pham W, Kim Y, Dai G, Moore A. In vivo imaging of tumor response to therapy using a dual-modality imaging strategy. Int J Cancer. 2006 Jun 1; 118(11):2796-802.
    View in: PubMed
  39. Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore A. In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc. 2006; 1(1):429-35.
    View in: PubMed
  40. Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A. In vivo imaging of islet transplantation. Nat Med. 2006 Jan; 12(1):144-8.
    View in: PubMed
  41. Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. Neuroimage. 2005 Oct 15; 28(1):287-92.
    View in: PubMed
  42. Medarova Z, Bonner-Weir S, Lipes M, Moore A. Imaging beta-cell death with a near-infrared probe. Diabetes. 2005 Jun; 54(6):1780-8.
    View in: PubMed
  43. Pham W, Medarova Z, Moore A. Synthesis and application of a water-soluble near-infrared dye for cancer detection using optical imaging. Bioconjug Chem. 2005 May-Jun; 16(3):735-40.
    View in: PubMed
  44. Moore A, Medarova Z, Potthast A, Dai G. In vivo targeting of underglycosylated MUC-1 tumor antigen using a multimodal imaging probe. Cancer Res. 2004 Mar 1; 64(5):1821-7.
    View in: PubMed
  45. Moore A, Medarova Z. Approaches for imaging the diabetic pancreas: first results. Curr Med Chem-Immun, Endoc & Metab Agents. 2004; 4:315-332.
  46. Medarova Z, Moore A. Imaging of pancreatic cancer: a promise for early diagnosis through targeted strategies. Cancer Ther. 2004; 2:329-344.
  47. Medarova Z, Briles WE, Taylor RL. Resistance, susceptibility, and immunity to cecal coccidiosis: effects of B complex and alloantigen system L. Poult Sci. 2003 Jul; 82(7):1113-7.
    View in: PubMed
  48. Medarova Z, Briles WE, Taylor RL, Jr. Immunological functions of avian alloantigens. Recent Res. Dev. Infect. Immun. 2003; 1:145-166.
  49. Medarova Z, Briles WE, Taylor RL, Jr . Alloantigen system L affects antibody responses. Int. J. Poult. Sci. 2003; 2(1):23-27.
  50. Medarova Z, Briles WE, Taylor RL. Alloantigen system L affects the outcome of rous sarcomas. Exp Biol Med (Maywood). 2002 Mar; 227(3):158-63.
    View in: PubMed
  51. Medarova Z, Briles WE, Taylor RL, Jr. Alloantigen system L affects the outcome of Rous sarcomas. Exp. Biol. Med. 2002; 227(3):158-163.
  52. Medarova Z. The effects of erythrocyte alloantigen L on the avian immune response. 2002.
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