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Mutsuko Ohnishi, Ph.D., M.D.

TitleResearch Fellow in Oral Medicine, Infection, and Immunity (INT)
InstitutionHarvard School of Dental Medicine
DepartmentOral Med - Infection + Immunity
AddressHarvard School of Dental Medicine
Oral Med., Infection, & Immunity REB 315
188 Longwood Ave
Boston MA 02115
Phone617/432-5768

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ettahar A, Ferrigno O, Zhang MZ, Ohnishi M, Ferrand N, Prunier C, Levy L, Bourgeade MF, Bieche I, Romero DG, Colland F, Atfi A. Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-ß Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation. Cell Rep. 2013 Aug 15; 4(3):530-41.
    View in: PubMed
  2. Ohnishi M, Razzaque MS. Osteo-Renal Cross-Talk and Phosphate Metabolism by the FGF23-Klotho System. Contrib Nephrol. 2013; 180:1-13.
    View in: PubMed
  3. Hartman ML, Groppo F, Ohnishi M, Goodson JM, Hasturk H, Tavares M, Yaskell T, Floros C, Behbehani K, Razzaque MS. Can salivary phosphate levels be an early biomarker to monitor the evolvement of obesity? Contrib Nephrol. 2013; 180:138-48.
    View in: PubMed
  4. Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, Ma J, Gai W, Kuro-o M, Razzaque MS, Mohammadi M. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. J Biol Chem. 2012 Aug 17; 287(34):29134-46.
    View in: PubMed
  5. Goetz R, Ohnishi M, Ding X, Kurosu H, Wang L, Akiyoshi J, Ma J, Gai W, Sidis Y, Pitteloud N, Kuro-O M, Razzaque MS, Mohammadi M. Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands. Mol Cell Biol. 2012 May; 32(10):1944-54.
    View in: PubMed
  6. Ohnishi M, Kato S, Razzaque MS. Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese mice. Biochem Biophys Res Commun. 2011 Nov 25; 415(3):434-8.
    View in: PubMed
  7. Ohnishi M, Kato S, Akiyoshi J, Atfi A, Razzaque MS. Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions. FASEB J. 2011 Jun; 25(6):2031-9.
    View in: PubMed
  8. Ohnishi M, Razzaque MS. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J. 2010 Sep; 24(9):3562-71.
    View in: PubMed
  9. Ohnishi M, Nakatani T, Lanske B, Razzaque MS. In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels. Circ Cardiovasc Genet. 2009 Dec; 2(6):583-90.
    View in: PubMed
  10. Nakatani T, Ohnishi M, Razzaque MS. Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model. FASEB J. 2009 Nov; 23(11):3702-11.
    View in: PubMed
  11. Ohnishi M, Nakatani T, Lanske B, Razzaque MS. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int. 2009 Jun; 75(11):1166-72.
    View in: PubMed
  12. Nakatani T, Sarraj B, Ohnishi M, Densmore MJ, Taguchi T, Goetz R, Mohammadi M, Lanske B, Razzaque MS. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. FASEB J. 2009 Feb; 23(2):433-41.
    View in: PubMed
  13. Ogino S, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS. LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int J Cancer. 2008 Jun 15; 122(12):2767-73.
    View in: PubMed
  14. Nosho K, Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Zepf D, Yan L, Longtine JA, Fuchs CS, Ogino S. PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. Neoplasia. 2008 Jun; 10(6):534-41.
    View in: PubMed
  15. Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S. Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. BMC Cancer. 2008; 8:33.
    View in: PubMed
  16. Kawasaki T, Ohnishi M, Nosho K, Suemoto Y, Kirkner GJ, Meyerhardt JA, Fuchs CS, Ogino S. CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. Mod Pathol. 2008 Mar; 21(3):245-55.
    View in: PubMed
  17. Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Liu Z, Yamamoto H, Loda M, Fuchs CS, Ogino S. WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol. 2008 Feb; 21(2):150-8.
    View in: PubMed
  18. Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, Ogino S. IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. Neoplasia. 2007 Dec; 9(12):1091-8.
    View in: PubMed
  19. Ogino S, Hazra A, Tranah GJ, Kirkner GJ, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Meyerhardt JA, Hunter DJ, Fuchs CS. MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis. 2007 Sep; 28(9):1985-90.
    View in: PubMed
  20. Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Dehari R, Meyerhardt JA, Fuchs CS, Ogino S. Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. Neoplasia. 2007 Jul; 9(7):569-77.
    View in: PubMed
  21. Ogino S, Kawasaki T, Kirkner GJ, Ohnishi M, Fuchs CS. 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. BMC Cancer. 2007; 7:72.
    View in: PubMed
  22. Ohnishi M, Sakurai T, Heike Y, Yamazaki R, Kanda Y, Takaue Y, Mizoguchi H, Kawakami Y. Evaluation of cytomegalovirus-specific T-cell reconstitution in patients after various allogeneic haematopoietic stem cell transplantation using interferon-gamma-enzyme-linked immunospot and human leucocyte antigen tetramer assays with an immunodominant T-cell epitope. Br J Haematol. 2005 Nov; 131(4):472-9.
    View in: PubMed
  23. Hori A, Kami M, Ohnishi M, Murashige N, Kojima R, Takaue Y. Feasibility of early tapering of cyclosporine following reduced-intensity stem cell transplantation for advanced hematologic or solid malignancies. Haematologica. 2005 Jul; 90(7):1001-3.
    View in: PubMed
  24. Kojima R, Kami M, Hori A, Murashige N, Ohnishi M, Kim SW, Hamaki T, Kishi Y, Tsutsumi Y, Masauzi N, Heike Y, Mori S, Kobayashi K, Masuo S, Tanosaki R, Takaue Y. Reduced-intensity allogeneic hematopoietic stem-cell transplantation as an immunotherapy for metastatic colorectal cancer. Transplantation. 2004 Dec 27; 78(12):1740-6.
    View in: PubMed
  25. Nakai K, Mineishi S, Kami M, Saito T, Hori A, Kojima R, Imataki O, Hamaki T, Yoshihara S, Ohnishi M, Kim SW, Ando T, Fumitoh A, Kanda Y, Makimoto A, Tanosaki R, Kanai S, Heike Y, Ohnishi T, Kawano Y, Wakasugi H, Takaue Y. Antithymocyte globulin affects the occurrence of acute and chronic graft-versus-host disease after a reduced-intensity conditioning regimen by modulating mixed chimerism induction and immune reconstitution. Transplantation. 2003 Jun 27; 75(12):2135-43.
    View in: PubMed
  26. Kanda Y, Tanosaki R, Nakai K, Saito T, Ohnishi M, Niiya H, Chizuka A, Yakushijin K, Urahama N, Ueda K, Iijima K, Ando T, Matsubara H, Kami M, Makimoto A, Kobayashi Y, Tobinai K, Mineishi S, Takaue Y. Impact of stem cell source and conditioning regimen on erythrocyte recovery kinetics after allogeneic haematopoietic stem cell transplantation from an ABO-incompatible donor. Br J Haematol. 2002 Jul; 118(1):128-31.
    View in: PubMed
  27. Ohnishi M, Kanda Y, Takeuchi T, Won Kim S, Hori A, Niiya H, Chizuka A, Nakai K, Saito T, Makimoto A, Tanosaki R, Watanabe T, Kobayashi Y, Tobinai K, Takaue Y, Mineishi S. Limited efficacy of lamivudine against hepatitis B virus infection in allogeneic hematopoietic stem cell transplant recipients. Transplantation. 2002 Mar 15; 73(5):812-5.
    View in: PubMed
  28. Kanda Y, Mineishi S, Saito T, Saito A, Ohnishi M, Niiya H, Chizuka A, Nakai K, Takeuchi T, Matsubara H, Makimoto A, Tanosaki R, Kunitoh H, Tobinai K, Takaue Y. Response-oriented preemptive therapy against cytomegalovirus disease with low-dose ganciclovir: a prospective evaluation. Transplantation. 2002 Feb 27; 73(4):568-72.
    View in: PubMed
  29. Hishiya A, Ohnishi M, Tamura S, Nakamura F. Protein phosphatase 2C inactivates F-actin binding of human platelet moesin. J Biol Chem. 1999 Sep 17; 274(38):26705-12.
    View in: PubMed
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