 Max L. Nibert, Ph.D., M.D.
| Title | Professor of Microbiology and Immunobiology |
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| Institution | Harvard Medical School |
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| Department | Microbiology and Immunobiology |
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| Address | Harvard Medical School
MBIB, Room 940
77 Avenue Louis Pasteur
Boston MA 02115
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| Phone | 617/432-4829 |
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| Fax | 617/738-7664 |
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 Mentoring Available: 09/15/11, Expires: 05/31/16 Student will participate on equal footing with other lab members in basic studies of dsRNA viruses that symbiotically infect important protozoan pathogens of humans, including Trichomonas vaginalis, Giardia lamblia, and Cryptosporidium parvum. Some areas of current interest and work include (a) developing genetic methods and tools for studies of these viruses, (b) dissecting the roles of these viruses and their genetic products in protozoan pathogenicity, (c) exploring the genetic diversity of these viruses in recent clinical isolates of the respective protozoa, (d) determining structures of the viral particles and protein products, and (e) searching for novel inhibitors of these viruses and their effects on their respective hosts. Autoproteolysis of Clostridium difficile Toxin B
Summer, 06/13/11 - 08/12/11 Structural Characterization of Reovirus Nonstructural Protein µNS Summer, 06/20/08 - 08/22/08 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Parent KN, Takagi Y, Cardone G, Olson NH, Ericsson M, Yang M, Lee Y, Asara JM, Fichorova RN, Baker TS, Nibert ML. Structure of a Protozoan Virus from the Human Genitourinary Parasite Trichomonas vaginalis. MBio. 2013; 4(2).
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Dunn SE, Li H, Cardone G, Nibert ML, Ghabrial SA, Baker TS. Three-dimensional Structure of Victorivirus HvV190S Suggests Coat Proteins in Most Totiviruses Share a Conserved Core. PLoS Pathog. 2013 Mar; 9(3):e1003225.
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Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T. Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Apr; 24(8):1196-207.
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Nibert ML, Tang J, Xie J, Collier AM, Ghabrial SA, Baker TS, Tao YJ. 3D Structures of Fungal Partitiviruses. Adv Virus Res. 2013; 86:59-85.
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Fichorova RN, Lee Y, Yamamoto HS, Takagi Y, Hayes GR, Goodman RP, Chepa-Lotrea X, Buck OR, Murray R, Kula T, Beach DH, Singh BN, Nibert ML. Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy. PLoS One. 2012; 7(11):e48418.
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Nibert ML, Takagi Y. Fibers come and go: differences in cell-entry components among related dsRNA viruses. Curr Opin Virol. 2013 Feb; 3(1):20-6.
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Ivanovic T, Boulant S, Ehrlich M, Demidenko AA, Arnold MM, Kirchhausen T, Nibert ML. Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking. Traffic. 2011 Sep; 12(9):1179-95.
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Demidenko AA, Lee J, Powers TR, Nibert ML. Effects of viscogens on RNA transcription inside reovirus particles. J Biol Chem. 2011 Aug 26; 286(34):29521-30.
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Yan X, Parent KN, Goodman RP, Tang J, Shou J, Nibert ML, Duncan R, Baker TS. Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber. J Virol. 2011 Aug; 85(15):7483-95.
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Li H, Havens WM, Nibert ML, Ghabrial SA. RNA sequence determinants of a coupled termination-reinitiation strategy for downstream open reading frame translation in Helminthosporium victoriae virus 190S and other victoriviruses (Family Totiviridae). J Virol. 2011 Jul; 85(14):7343-52.
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Goodman RP, Freret TS, Kula T, Geller AM, Talkington MW, Tang-Fernandez V, Suciu O, Demidenko AA, Ghabrial SA, Beach DH, Singh BN, Fichorova RN, Nibert ML. Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species (Family Totiviridae). J Virol. 2011 May; 85(9):4258-70.
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Goodman RP, Ghabrial SA, Fichorova RN, Nibert ML. Trichomonasvirus: a new genus of protozoan viruses in the family Totiviridae. Arch Virol. 2011 Jan; 156(1):171-9.
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Tang J, Pan J, Havens WM, Ochoa WF, Guu TS, Ghabrial SA, Nibert ML, Tao YJ, Baker TS. Backbone trace of partitivirus capsid protein from electron cryomicroscopy and homology modeling. Biophys J. 2010 Jul 21; 99(2):685-94.
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Tang J, Ochoa WF, Li H, Havens WM, Nibert ML, Ghabrial SA, Baker TS. Structure of Fusarium poae virus 1 shows conserved and variable elements of partitivirus capsids and evolutionary relationships to picobirnavirus. J Struct Biol. 2010 Dec; 172(3):363-71.
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Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 2010 May 14; 141(4):668-81.
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Miller CL, Arnold MM, Broering TJ, Hastings CE, Nibert ML. Localization of mammalian orthoreovirus proteins to cytoplasmic factory-like structures via nonoverlapping regions of microNS. J Virol. 2010 Jan; 84(2):867-82.
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Nibert ML, Woods KM, Upton SJ, Ghabrial SA. Cryspovirus: a new genus of protozoan viruses in the family Partitiviridae. Arch Virol. 2009; 154(12):1959-65.
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Schmitz AM, Morrison MF, Agunwamba AO, Nibert ML, Lesser CF. Protein interaction platforms: visualization of interacting proteins in yeast. Nat Methods. 2009 Jul; 6(7):500-2.
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Zhang L, Agosto MA, Ivanovic T, King DS, Nibert ML, Harrison SC. Requirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide. J Virol. 2009 Jul; 83(14):7004-14.
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Demidenko AA, Nibert ML. Probing the transcription mechanisms of reovirus cores with molecules that alter RNA duplex stability. J Virol. 2009 Jun; 83(11):5659-70.
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Pan J, Dong L, Lin L, Ochoa WF, Sinkovits RS, Havens WM, Nibert ML, Baker TS, Ghabrial SA, Tao YJ. Atomic structure reveals the unique capsid organization of a dsRNA virus. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4225-30.
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Ghabrial SA, Nibert ML. Victorivirus, a new genus of fungal viruses in the family Totiviridae. Arch Virol. 2009; 154(2):373-9.
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Lu X, McDonald SM, Tortorici MA, Tao YJ, Vasquez-Del Carpio R, Nibert ML, Patton JT, Harrison SC. Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure. 2008 Nov 12; 16(11):1678-88.
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Tang J, Ochoa WF, Sinkovits RS, Poulos BT, Ghabrial SA, Lightner DV, Baker TS, Nibert ML. Infectious myonecrosis virus has a totivirus-like, 120-subunit capsid, but with fiber complexes at the fivefold axes. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17526-31.
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Agosto MA, Myers KS, Ivanovic T, Nibert ML. A positive-feedback mechanism promotes reovirus particle conversion to the intermediate associated with membrane penetration. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10571-6.
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Ochoa WF, Havens WM, Sinkovits RS, Nibert ML, Ghabrial SA, Baker TS. Partitivirus structure reveals a 120-subunit, helix-rich capsid with distinctive surface arches formed by quasisymmetric coat-protein dimers. Structure. 2008 May; 16(5):776-86.
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Arnold MM, Murray KE, Nibert ML. Formation of the factory matrix is an important, though not a sufficient function of nonstructural protein mu NS during reovirus infection. Virology. 2008 Jun 5; 375(2):412-23.
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Ivanovic T, Agosto MA, Zhang L, Chandran K, Harrison SC, Nibert ML. Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. EMBO J. 2008 Apr 23; 27(8):1289-98.
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Nguyen CL, Eichwald C, Nibert ML, Münger K. Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin. J Virol. 2007 Dec; 81(24):13533-43.
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Agosto MA, Middleton JK, Freimont EC, Yin J, Nibert ML. Thermolabilizing pseudoreversions in reovirus outer-capsid protein micro 1 rescue the entry defect conferred by a thermostabilizing mutation. J Virol. 2007 Jul; 81(14):7400-9.
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Carvalho J, Arnold MM, Nibert ML. Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2. Virology. 2007 Aug 1; 364(2):301-16.
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Nibert ML. '2A-like' and 'shifty heptamer' motifs in penaeid shrimp infectious myonecrosis virus, a monosegmented double-stranded RNA virus. J Gen Virol. 2007 Apr; 88(Pt 4):1315-8.
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Miller CL, Arnold MM, Broering TJ, Eichwald C, Kim J, Dinoso JB, Nibert ML. Virus-derived platforms for visualizing protein associations inside cells. Mol Cell Proteomics. 2007 Jun; 6(6):1027-38.
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Murray KE, Nibert ML. Guanidine hydrochloride inhibits mammalian orthoreovirus growth by reversibly blocking the synthesis of double-stranded RNA. J Virol. 2007 May; 81(9):4572-84.
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Ivanovic T, Agosto MA, Chandran K, Nibert ML. A role for molecular chaperone Hsc70 in reovirus outer capsid disassembly. J Biol Chem. 2007 Apr 20; 282(16):12210-9.
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Middleton JK, Agosto MA, Severson TF, Yin J, Nibert ML. Thermostabilizing mutations in reovirus outer-capsid protein mu1 selected by heat inactivation of infectious subvirion particles. Virology. 2007 May 10; 361(2):412-25.
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Agosto MA, Ivanovic T, Nibert ML. Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16496-501.
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Zhang L, Chandran K, Nibert ML, Harrison SC. Reovirus mu1 structural rearrangements that mediate membrane penetration. J Virol. 2006 Dec; 80(24):12367-76.
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Coffey CM, Sheh A, Kim IS, Chandran K, Nibert ML, Parker JS. Reovirus outer capsid protein micro1 induces apoptosis and associates with lipid droplets, endoplasmic reticulum, and mitochondria. J Virol. 2006 Sep; 80(17):8422-38.
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Zhang X, Ji Y, Zhang L, Harrison SC, Marinescu DC, Nibert ML, Baker TS. Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution. Structure. 2005 Oct; 13(10):1545-57.
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Zhang X, Tang J, Walker SB, O'Hara D, Nibert ML, Duncan R, Baker TS. Structure of avian orthoreovirus virion by electron cryomicroscopy and image reconstruction. Virology. 2005 Dec 5; 343(1):25-35.
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Broering TJ, Arnold MM, Miller CL, Hurt JA, Joyce PL, Nibert ML. Carboxyl-proximal regions of reovirus nonstructural protein muNS necessary and sufficient for forming factory-like inclusions. J Virol. 2005 May; 79(10):6194-206.
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Nibert ML, Odegard AL, Agosto MA, Chandran K, Schiff LA. Putative autocleavage of reovirus mu1 protein in concert with outer-capsid disassembly and activation for membrane permeabilization. J Mol Biol. 2005 Jan 21; 345(3):461-74.
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Miller CL, Parker JS, Dinoso JB, Piggott CD, Perron MJ, Nibert ML. Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2. J Virol. 2004 Oct; 78(19):10291-302.
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Helander A, Miller CL, Myers KS, Neutra MR, Nibert ML. Protective immunoglobulin A and G antibodies bind to overlapping intersubunit epitopes in the head domain of type 1 reovirus adhesin sigma1. J Virol. 2004 Oct; 78(19):10695-705.
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Yin P, Keirstead ND, Broering TJ, Arnold MM, Parker JS, Nibert ML, Coombs KM. Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolates. Virol J. 2004; 1:6.
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Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell. 2004 Sep 3; 118(5):591-605.
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Odegard AL, Chandran K, Zhang X, Parker JS, Baker TS, Nibert ML. Putative autocleavage of outer capsid protein micro1, allowing release of myristoylated peptide micro1N during particle uncoating, is critical for cell entry by reovirus. J Virol. 2004 Aug; 78(16):8732-45.
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Nibert ML, Kim J. Conserved sequence motifs for nucleoside triphosphate binding unique to turreted reoviridae members and coltiviruses. J Virol. 2004 May; 78(10):5528-30.
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Kim J, Tao Y, Reinisch KM, Harrison SC, Nibert ML. Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces. Virus Res. 2004 Apr; 101(1):15-28.
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Broering TJ, Kim J, Miller CL, Piggott CD, Dinoso JB, Nibert ML, Parker JS. Reovirus nonstructural protein mu NS recruits viral core surface proteins and entering core particles to factory-like inclusions. J Virol. 2004 Feb; 78(4):1882-92.
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Hutchings AB, Helander A, Silvey KJ, Chandran K, Lucas WT, Nibert ML, Neutra MR. Secretory immunoglobulin A antibodies against the sigma1 outer capsid protein of reovirus type 1 Lang prevent infection of mouse Peyer's patches. J Virol. 2004 Jan; 78(2):947-57.
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Golden JW, Bahe JA, Lucas WT, Nibert ML, Schiff LA. Cathepsin S supports acid-independent infection by some reoviruses. J Biol Chem. 2004 Mar 5; 279(10):8547-57.
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Chandran K, Parker JS, Ehrlich M, Kirchhausen T, Nibert ML. The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry. J Virol. 2003 Dec; 77(24):13361-75.
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Kim J, Parker JS, Murray KE, Nibert ML. Nucleoside and RNA triphosphatase activities of orthoreovirus transcriptase cofactor mu2. J Biol Chem. 2004 Feb 6; 279(6):4394-403.
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Zhang X, Walker SB, Chipman PR, Nibert ML, Baker TS. Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A. Nat Struct Biol. 2003 Dec; 10(12):1011-8.
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Chandran K, Nibert ML. Animal cell invasion by a large nonenveloped virus: reovirus delivers the goods. Trends Microbiol. 2003 Aug; 11(8):374-82.
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Helander A, Silvey KJ, Mantis NJ, Hutchings AB, Chandran K, Lucas WT, Nibert ML, Neutra MR. The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces. J Virol. 2003 Jul; 77(14):7964-77.
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Tortorici MA, Broering TJ, Nibert ML, Patton JT. Template recognition and formation of initiation complexes by the replicase of a segmented double-stranded RNA virus. J Biol Chem. 2003 Aug 29; 278(35):32673-82.
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Nibert ML, Baker TS. CPV, a stable and symmetrical machine for mRNA synthesis. Structure. 2003 Jun; 11(6):605-7.
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Odegard AL, Chandran K, Liemann S, Harrison SC, Nibert ML. Disulfide bonding among micro 1 trimers in mammalian reovirus outer capsid: a late and reversible step in virion morphogenesis. J Virol. 2003 May; 77(9):5389-400.
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Miller CL, Broering TJ, Parker JS, Arnold MM, Nibert ML. Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminus. J Virol. 2003 Apr; 77(8):4566-76.
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Kim J, Zhang X, Centonze VE, Bowman VD, Noble S, Baker TS, Nibert ML. The hydrophilic amino-terminal arm of reovirus core shell protein lambda1 is dispensable for particle assembly. J Virol. 2002 Dec; 76(23):12211-22.
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Tao Y, Farsetta DL, Nibert ML, Harrison SC. RNA synthesis in a cage--structural studies of reovirus polymerase lambda3. Cell. 2002 Nov 27; 111(5):733-45.
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Chandran K, Farsetta DL, Nibert ML. Strategy for nonenveloped virus entry: a hydrophobic conformer of the reovirus membrane penetration protein micro 1 mediates membrane disruption. J Virol. 2002 Oct; 76(19):9920-33.
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Broering TJ, Parker JS, Joyce PL, Kim J, Nibert ML. Mammalian reovirus nonstructural protein microNS forms large inclusions and colocalizes with reovirus microtubule-associated protein micro2 in transfected cells. J Virol. 2002 Aug; 76(16):8285-97.
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Jané-Valbuena J, Breun LA, Schiff LA, Nibert ML. Sites and determinants of early cleavages in the proteolytic processing pathway of reovirus surface protein sigma3. J Virol. 2002 May; 76(10):5184-97.
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Parker JS, Broering TJ, Kim J, Higgins DE, Nibert ML. Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules. J Virol. 2002 May; 76(9):4483-96.
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Luongo CL, Zhang X, Walker SB, Chen Y, Broering TJ, Farsetta DL, Bowman VD, Baker TS, Nibert ML. Loss of activities for mRNA synthesis accompanies loss of lambda2 spikes from reovirus cores: an effect of lambda2 on lambda1 shell structure. Virology. 2002 Apr 25; 296(1):24-38.
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Middleton JK, Severson TF, Chandran K, Gillian AL, Yin J, Nibert ML. Thermostability of reovirus disassembly intermediates (ISVPs) correlates with genetic, biochemical, and thermodynamic properties of major surface protein mu1. J Virol. 2002 Feb; 76(3):1051-61.
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Nibert ML. Rotavirus translation control protein takes RNA to heart. Structure. 2002 Feb; 10(2):129-30.
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Liemann S, Chandran K, Baker TS, Nibert ML, Harrison SC. Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3. Cell. 2002 Jan 25; 108(2):283-95.
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Breun LA, Broering TJ, McCutcheon AM, Harrison SJ, Luongo CL, Nibert ML. Mammalian reovirus L2 gene and lambda2 core spike protein sequences and whole-genome comparisons of reoviruses type 1 Lang, type 2 Jones, and type 3 Dearing. Virology. 2001 Sep 1; 287(2):333-48.
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Chandran K, Zhang X, Olson NH, Walker SB, Chappell JD, Dermody TS, Baker TS, Nibert ML. Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein. J Virol. 2001 Jun; 75(11):5335-42.
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Olland AM, Jané-Valbuena J, Schiff LA, Nibert ML, Harrison SC. Structure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution. EMBO J. 2001 Mar 1; 20(5):979-89.
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Farsetta DL, Chandran K, Nibert ML. Transcriptional activities of reovirus RNA polymerase in recoated cores. Initiation and elongation are regulated by separate mechanisms. J Biol Chem. 2000 Dec 15; 275(50):39693-701.
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Gillian AL, Schmechel SC, Livny J, Schiff LA, Nibert ML. Reovirus protein sigmaNS binds in multiple copies to single-stranded RNA and shares properties with single-stranded DNA binding proteins. J Virol. 2000 Jul; 74(13):5939-48.
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Broering TJ, McCutcheon AM, Centonze VE, Nibert ML. Reovirus nonstructural protein muNS binds to core particles but does not inhibit their transcription and capping activities. J Virol. 2000 Jun; 74(12):5516-24.
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Reinisch KM, Nibert ML, Harrison SC. Structure of the reovirus core at 3.6 A resolution. Nature. 2000 Apr 27; 404(6781):960-7.
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Luongo CL, Reinisch KM, Harrison SC, Nibert ML. Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2. J Biol Chem. 2000 Jan 28; 275(4):2804-10.
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Chen D, Luongo CL, Nibert ML, Patton JT. Rotavirus open cores catalyze 5'-capping and methylation of exogenous RNA: evidence that VP3 is a methyltransferase. Virology. 1999 Dec 5; 265(1):120-30.
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McCutcheon AM, Broering TJ, Nibert ML. Mammalian reovirus M3 gene sequences and conservation of coiled-coil motifs near the carboxyl terminus of the microNS protein. Virology. 1999 Nov 10; 264(1):16-24.
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Harrison SJ, Farsetta DL, Kim J, Noble S, Broering TJ, Nibert ML. Mammalian reovirus L3 gene sequences and evidence for a distinct amino-terminal region of the lambda1 protein. Virology. 1999 May 25; 258(1):54-64.
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Chandran K, Walker SB, Chen Y, Contreras CM, Schiff LA, Baker TS, Nibert ML. In vitro recoating of reovirus cores with baculovirus-expressed outer-capsid proteins mu1 and sigma3. J Virol. 1999 May; 73(5):3941-50.
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Jané-Valbuena J, Nibert ML, Spencer SM, Walker SB, Baker TS, Chen Y, Centonze VE, Schiff LA. Reovirus virion-like particles obtained by recoating infectious subvirion particles with baculovirus-expressed sigma3 protein: an approach for analyzing sigma3 functions during virus entry. J Virol. 1999 Apr; 73(4):2963-73.
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Kothandaraman S, Hebert MC, Raines RT, Nibert ML. No role for pepstatin-A-sensitive acidic proteinases in reovirus infections of L or MDCK cells. Virology. 1998 Nov 25; 251(2):264-72.
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Chappell JD, Barton ES, Smith TH, Baer GS, Duong DT, Nibert ML, Dermody TS. Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck. J Virol. 1998 Oct; 72(10):8205-13.
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Luongo CL, Contreras CM, Farsetta DL, Nibert ML. Binding site for S-adenosyl-L-methionine in a central region of mammalian reovirus lambda2 protein. Evidence for activities in mRNA cap methylation. J Biol Chem. 1998 Sep 11; 273(37):23773-80.
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Dryden KA, Farsetta DL, Wang G, Keegan JM, Fields BN, Baker TS, Nibert ML. Internal/structures containing transcriptase-related proteins in top component particles of mammalian orthoreovirus. Virology. 1998 May 25; 245(1):33-46.
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Gillian AL, Nibert ML. Amino terminus of reovirus nonstructural protein sigma NS is important for ssRNA binding and nucleoprotein complex formation. Virology. 1998 Jan 5; 240(1):1-11.
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Nibert ML. Structure of mammalian orthoreovirus particles. Curr Top Microbiol Immunol. 1998; 233(Pt 1):1-30.
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Chandran K, Nibert ML. Protease cleavage of reovirus capsid protein mu1/mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle. J Virol. 1998 Jan; 72(1):467-75.
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Luongo CL, Dryden KA, Farsetta DL, Margraf RL, Severson TF, Olson NH, Fields BN, Baker TS, Nibert ML. Localization of a C-terminal region of lambda2 protein in reovirus cores. J Virol. 1997 Oct; 71(10):8035-40.
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Spencer SM, Sgro JY, Dryden KA, Baker TS, Nibert ML. IRIS explorer software for radial-depth cueing reovirus particles and other macromolecular structures determined by cryoelectron microscopy and image reconstruction. J Struct Biol. 1997 Oct; 120(1):11-21.
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Noble S, Nibert ML. Core protein mu2 is a second determinant of nucleoside triphosphatase activities by reovirus cores. J Virol. 1997 Oct; 71(10):7728-35.
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Noble S, Nibert ML. Characterization of an ATPase activity in reovirus cores and its genetic association with core-shell protein lambda1. J Virol. 1997 Mar; 71(3):2182-91.
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Nibert ML, Margraf RL, Coombs KM. Nonrandom segregation of parental alleles in reovirus reassortants. J Virol. 1996 Oct; 70(10):7295-300.
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Centonze VE, Chen Y, Severson TF, Borisy GG, Nibert ML. Visualization of individual reovirus particles by low-temperature, high-resolution scanning electron microscopy. J Struct Biol. 1995 Nov-Dec; 115(3):215-25.
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Nibert ML, Chappell JD, Dermody TS. Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein. J Virol. 1995 Aug; 69(8):5057-67.
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Tosteson MT, Nibert ML, Fields BN. Ion channels induced in lipid bilayers by subvirion particles of the nonenveloped mammalian reoviruses. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10549-52.
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Dryden KA, Wang G, Yeager M, Nibert ML, Coombs KM, Furlong DB, Fields BN, Baker TS. Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: analysis of virions and subviral particles by cryoelectron microscopy and image reconstruction. J Cell Biol. 1993 Sep; 122(5):1023-41.
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Dermody TS, Nibert ML, Wetzel JD, Tong X, Fields BN. Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J Virol. 1993 Apr; 67(4):2055-63.
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Nibert ML, Fields BN. A carboxy-terminal fragment of protein mu 1/mu 1C is present in infectious subvirion particles of mammalian reoviruses and is proposed to have a role in penetration. J Virol. 1992 Nov; 66(11):6408-18.
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Dermody TS, Schiff LA, Nibert ML, Coombs KM, Fields BN. The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: characterization of reovirus core protein sigma 2. J Virol. 1991 Nov; 65(11):5721-31.
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Nibert ML, Furlong DB, Fields BN. Mechanisms of viral pathogenesis. Distinct forms of reoviruses and their roles during replication in cells and host. J Clin Invest. 1991 Sep; 88(3):727-34.
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Nibert ML, Schiff LA, Fields BN. Mammalian reoviruses contain a myristoylated structural protein. J Virol. 1991 Apr; 65(4):1960-7.
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Dermody TS, Nibert ML, Bassel-Duby R, Fields BN. Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. J Virol. 1990 Oct; 64(10):4842-50.
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Dermody TS, Nibert ML, Bassel-Duby R, Fields BN. A sigma 1 region important for hemagglutination by serotype 3 reovirus strains. J Virol. 1990 Oct; 64(10):5173-6.
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Nibert ML, Dermody TS, Fields BN. Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1. J Virol. 1990 Jun; 64(6):2976-89.
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Fraser RD, Furlong DB, Trus BL, Nibert ML, Fields BN, Steven AC. Molecular structure of the cell-attachment protein of reovirus: correlation of computer-processed electron micrographs with sequence-based predictions. J Virol. 1990 Jun; 64(6):2990-3000.
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Nibert M, Heim S. Uterine leiomyoma cytogenetics. Genes Chromosomes Cancer. 1990 May; 2(1):3-13.
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Bodkin DK, Nibert ML, Fields BN. Proteolytic digestion of reovirus in the intestinal lumens of neonatal mice. J Virol. 1989 Nov; 63(11):4676-81.
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Schiff LA, Nibert ML, Fields BN. Characterization of a zinc blotting technique: evidence that a retroviral gag protein binds zinc. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4195-9.
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Jayasuriya AK, Nibert ML, Fields BN. Complete nucleotide sequence of the M2 gene segment of reovirus type 3 dearing and analysis of its protein product mu 1. Virology. 1988 Apr; 163(2):591-602.
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Furlong DB, Nibert ML, Fields BN. Sigma 1 protein of mammalian reoviruses extends from the surfaces of viral particles. J Virol. 1988 Jan; 62(1):246-56.
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Schiff LA, Nibert ML, Co MS, Brown EG, Fields BN. Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3. Mol Cell Biol. 1988 Jan; 8(1):273-83.
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Sturzenbecker LJ, Nibert M, Furlong D, Fields BN. Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle. J Virol. 1987 Aug; 61(8):2351-61.
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Bassel-Duby R, Nibert ML, Homcy CJ, Fields BN, Sawutz DG. Evidence that the sigma 1 protein of reovirus serotype 3 is a multimer. J Virol. 1987 Jun; 61(6):1834-41.
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