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Joren Christian Madsen, D.PHIL., M.D.

TitleProfessor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
Surgery, Bulfinch 119
55 Fruit St
Boston MA 02114
Phone617/724-1130
Fax617/724-8834

 Mentoring 
 current student opportunities
Available: 12/01/12, Expires: 06/01/14

When hearts are transplanted into miniature swine or nonhuman primates treated with a tolerance induction protocol, they all reject. In contrast, when hearts are co-transplanted with kidneys from the same donors, the hearts all accept permanently. The explanation and implications of this finding for the induction of tolerance to human heart transplant recipients are the focus of this proposal.

The mechanism by which a heart is protected from both acute and chronic rejection by the tolerant state induced following a kidney allograft is unknown. Our previous work shows that based on our previous work, we hypothesize that host thymus-derived regulatory T cells, generated by cells or antigens in the donor kidney, are responsible for the induction of tolerance to cardiac allografts in heart/kidney recipients. The corollary is that regulatory T cells are present in tolerant recipients bearing long-term cardiac allografts but are not present in chronically immunosuppressed recipients bearing long-term cardiac allografts. We will test these hypotheses by performing experiments with four specific aims.

Aim 1. Determine the in vitro characteristics of regulatory T cells from tolerant heart/kidney recipients.

Aim 2. Determine the role of regulatory T cells in the induction and maintenance phase of tolerance in heart/kidney recipients.

Aim 3. Determine how a state of tolerance modifies the effects of intragraft cytokine excess in heart/kidney recipients.

Aim 4. Compare the in vitro parameters of transplant immunity in animals bearing allogeneic heart transplants prolonged by tolerance induction vs. chronic immunosuppression.

The student will be intimately involved in all aspects of these studies including experimental design, large animal surgery, in vitro assays, data analysis and manuscript preparation.

 completed student projects
The Role of the Renal Tubular Epithelial Cell in Kidney-Induced Cardiac Allograft Tolerance
Summer, 06/11/12 - 08/17/12

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Akiyoshi T, Hirohashi T, Alessandrini A, Chase CM, Farkash EA, Neal Smith R, Madsen JC, Russell PS, Colvin RB. Role of complement and NK cells in antibody mediated rejection. Hum Immunol. 2012 Dec; 73(12):1226-32.
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  2. Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol. 2012 Jun 15; 188(12):6063-70.
    View in: PubMed
  3. Benichou G, Tonsho M, Tocco G, Nadazdin O, Madsen JC. Innate immunity and resistance to tolerogenesis in allotransplantation. Front Immunol. 2012; 3:73.
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  4. Millington T, Koulmanda M, Ng C, Boskovic S, Nadazdin OM, Benichou G, Zheng XX, Strom TB, Madsen JC. Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates. J Heart Lung Transplant. 2012 Apr; 31(4):427-35.
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  5. Liu W, Xiao X, Demirci G, Madsen J, Li XC. Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms. J Immunol. 2012 Mar 15; 188(6):2703-11.
    View in: PubMed
  6. Nadazdin O, Boskovic S, Wee SL, Sogawa H, Koyama I, Colvin RB, Smith RN, Tocco G, O'Connor DH, Karl JA, Madsen JC, Sachs DH, Kawai T, Cosimi AB, Benichou G. Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates. J Immunol. 2011 Nov 1; 187(9):4589-97.
    View in: PubMed
  7. Song JJ, Kim SS, Liu Z, Madsen JC, Mathisen DJ, Vacanti JP, Ott HC. Enhanced in vivo function of bioartificial lungs in rats. Ann Thorac Surg. 2011 Sep; 92(3):998-1005; discussion 1005-6.
    View in: PubMed
  8. Veillette GR, Sahara H, Meltzer AJ, Weiss MJ, Iwamoto Y, Kim KM, Rosengard BR, Allan JS, Houser SL, Sachs DH, Benichou G, Madsen JC. Autoimmune sensitization to cardiac myosin leads to acute rejection of cardiac allografts in miniature swine. Transplantation. 2011 Jun 15; 91(11):1187-91.
    View in: PubMed
  9. Nadazdin O, Boskovic S, Murakami T, Tocco G, Smith RN, Colvin RB, Sachs DH, Allan J, Madsen JC, Kawai T, Cosimi AB, Benichou G. Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med. 2011 Jun 8; 3(86):86ra51.
    View in: PubMed
  10. Russell PS, Chase CM, Madsen JC, Hirohashi T, Cornell LD, Sproule TJ, Colvin RB, Roopenian DC. Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts. Transplantation. 2011 Apr 27; 91(8):847-52.
    View in: PubMed
  11. Miyajima M, Chase CM, Alessandrini A, Farkash EA, Della Pelle P, Benichou G, Graham JA, Madsen JC, Russell PS, Colvin RB. Early acceptance of renal allografts in mice is dependent on foxp3(+) cells. Am J Pathol. 2011 Apr; 178(4):1635-45.
    View in: PubMed
  12. Benichou G, Yamada Y, Aoyama A, Madsen JC. Natural killer cells in rejection and tolerance of solid organ allografts. Curr Opin Organ Transplant. 2011 Feb; 16(1):47-53.
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  13. Millington TM, Madsen JC. Innate immunity and cardiac allograft rejection. Kidney Int Suppl. 2010 Dec; (119):S18-21.
    View in: PubMed
  14. Dey BR, Chung SS, Spitzer TR, Zheng H, Macgillivray TE, Seldin DC, McAfee S, Ballen K, Attar E, Wang T, Shin J, Newton-Cheh C, Moore S, Sanchorawala V, Skinner M, Madsen JC, Semigran MJ. Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure. Transplantation. 2010 Oct 27; 90(8):905-11.
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  15. Graham JA, Fray M, de Haseth S, Lee KM, Lian MM, Chase CM, Madsen JC, Markmann J, Benichou G, Colvin RB, Cosimi AB, Deng S, Kim J, Alessandrini A. Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition. J Biol Chem. 2010 Oct 22; 285(43):32852-9.
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  16. Mehra MR, Crespo-Leiro MG, Dipchand A, Ensminger SM, Hiemann NE, Kobashigawa JA, Madsen J, Parameshwar J, Starling RC, Uber PA. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. J Heart Lung Transplant. 2010 Jul; 29(7):717-27.
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  17. Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G. Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. Am J Transplant. 2010 Jun; 10(6):1375-84.
    View in: PubMed
  18. Nadazdin O, Abrahamian G, Boskovic S, Smith RN, Schoenfeld DA, Madsen JC, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Stem cell mobilization and collection for induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys. J Surg Res. 2011 Jun 15; 168(2):294-300.
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  19. Hirohashi T, Uehara S, Chase CM, DellaPelle P, Madsen JC, Russell PS, Colvin RB. Complement independent antibody-mediated endarteritis and transplant arteriopathy in mice. Am J Transplant. 2010 Mar; 10(3):510-7.
    View in: PubMed
  20. Abbasi R, Abdou Y, Abu-Zayyad T, Adams J, Aguilar JA, Ahlers M, Andeen K, Auffenberg J, Bai X, Baker M, Barwick SW, Bay R, Bazo Alba JL, Beattie K, Beatty JJ, Bechet S, Becker JK, Becker KH, Benabderrahmane ML, Berdermann J, Berghaus P, Berley D, Bernardini E, Bertrand D, Besson DZ, Bissok M, Blaufuss E, Boersma DJ, Bohm C, Botner O, Bradley L, Braun J, Breder D, Carson M, Castermans T, Chirkin D, Christy B, Clem J, Cohen S, Cowen DF, D'Agostino MV, Danninger M, Day CT, De Clercq C, Demirörs L, Depaepe O, Descamps F, Desiati P, de Vries-Uiterweerd G, DeYoung T, Díaz-Vélez JC, Dreyer J, Dumm JP, Duvoort MR, Edwards WR, Ehrlich R, Eisch J, Ellsworth RW, Engdegård O, Euler S, Evenson PA, Fadiran O, Fazely AR, Feusels T, Filimonov K, Finley C, Foerster MM, Fox BD, Franckowiak A, Franke R, Gaisser TK, Gallagher J, Ganugapati R, Gerhardt L, Gladstone L, Goldschmidt A, Goodman JA, Gozzini R, Grant D, Griesel T, Gross A, Grullon S, Gunasingha RM, Gurtner M, Ha C, Hallgren A, Halzen F, Han K, Hanson K, Hasegawa Y, Helbing K, Herquet P, Hickford S, Hill GC, Hoffman KD, Homeier A, Hoshina K, Hubert D, Huelsnitz W, Hülss JP, Hulth PO, Hultqvist K, Hussain S, Imlay RL, Inaba M, Ishihara A, Jacobsen J, Japaridze GS, Johansson H, Joseph JM, Kampert KH, Kappes A, Karg T, Karle A, Kelley JL, Kemming N, Kenny P, Kiryluk J, Kislat F, Klein SR, Knops S, Kohnen G, Kolanoski H, Köpke L, Koskinen DJ, Kowalski M, Kowarik T, Krasberg M, Krings T, Kroll G, Kuehn K, Kuwabara T, Labare M, Lafebre S, Laihem K, Landsman H, Lauer R, Lehmann R, Lennarz D, Lundberg J, Lünemann J, Madsen J, Majumdar P, Maruyama R, Mase K, Matis HS, McParland CP, Meagher K, Merck M, Mészáros P, Meures T, Middell E, Milke N, Miyamoto H, Montaruli T, Morse R, Movit SM, Nahnhauer R, Nam JW, Niessen P, Nygren DR, Odrowski S, Olivas A, Olivo M, Ono M, Panknin S, Patton S, Paul L, Pérez de los Heros C, Petrovic J, Piegsa A, Pieloth D, Pohl AC, Porrata R, Potthoff N, Price PB, Prikockis M, Przybylski GT, Rawlins K, Redl P, Resconi E, Rhode W, Ribordy M, Rizzo A, Rodrigues JP, Roth P, Rothmaier F, Rott C, Roucelle C, Rutledge D, Ruzybayev B, Ryckbosch D, Sander HG, Sarkar S, Schatto K, Schlenstedt S, Schmidt T, Schneider D, Schukraft A, Schulz O, Schunck M, Seckel D, Semburg B, Seo SH, Sestayo Y, Seunarine S, Silvestri A, Slipak A, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Stephens G, Stezelberger T, Stokstad RG, Stoufer MC, Stoyanov S, Strahler EA, Straszheim T, Sullivan GW, Swillens Q, Taboada I, Tamburro A, Tarasova O, Tepe A, Ter-Antonyan S, Terranova C, Tilav S, Toale PA, Tooker J, Tosi D, Turcan D, van Eijndhoven N, Vandenbroucke J, Van Overloop A, van Santen J, Voigt B, Walck C, Waldenmaier T, Wallraff M, Walter M, Wendt C, Westerhoff S, Whitehorn N, Wiebe K, Wiebusch CH, Wiedemann A, Wikström G, Williams DR, Wischnewski R, Wissing H, Woschnagg K, Xu C, Xu XW, Yodh G, Yoshida S. Extending the search for neutrino point sources with IceCube above the horizon. Phys Rev Lett. 2009 Nov 27; 103(22):221102.
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  21. Graham JA, Wilkinson RA, Hirohashi T, Chase CM, Colvin RB, Madsen JC, Fishman JA, Russell PS. Viral infection induces de novo lesions of coronary allograft vasculopathy through a natural killer cell-dependent pathway. Am J Transplant. 2009 Nov; 9(11):2479-84.
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  22. Millington TM, Madsen JC. Innate immunity in heart transplantation. Curr Opin Organ Transplant. 2009 Oct; 14(5):571-6.
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  23. White JK, Jagannath A, Titus J, Yoneyama R, Madsen J, Agnihotri AK. Funnel-tipped aortic cannula for reduction of atheroemboli. Ann Thorac Surg. 2009 Aug; 88(2):551-7.
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  24. Stevens LM, Madsen JC, Isselbacher EM, Khairy P, MacGillivray TE, Hilgenberg AD, Agnihotri AK. Surgical management and long-term outcomes for acute ascending aortic dissection. J Thorac Cardiovasc Surg. 2009 Dec; 138(6):1349-57.e1.
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  25. Abbasi R, Abdou Y, Ackermann M, Adams J, Ahlers M, Andeen K, Auffenberg J, Bai X, Baker M, Barwick SW, Bay R, Bazo Alba JL, Beattie K, Beatty JJ, Bechet S, Becker JK, Becker KH, Benabderrahmane ML, Berdermann J, Berghaus P, Berley D, Bernardini E, Bertrand D, Besson DZ, Bissok M, Blaufuss E, Boersma DJ, Bohm C, Bolmont J, Böser S, Botner O, Bradley L, Braun J, Breder D, Burgess T, Castermans T, Chirkin D, Christy B, Clem J, Cohen S, Cowen DF, D'Agostino MV, Danninger M, Day CT, De Clercq C, Demirörs L, Depaepe O, Descamps F, Desiati P, de Vries-Uiterweerd G, Deyoung T, Diaz-Velez JC, Dreyer J, Dumm JP, Duvoort MR, Edwards WR, Ehrlich R, Eisch J, Ellsworth RW, Engdegård O, Euler S, Evenson PA, Fadiran O, Fazely AR, Feusels T, Filimonov K, Finley C, Foerster MM, Fox BD, Franckowiak A, Franke R, Gaisser TK, Gallagher J, Ganugapati R, Gerhardt L, Gladstone L, Goldschmidt A, Goodman JA, Gozzini R, Grant D, Griesel T, Gross A, Grullon S, Gunasingha RM, Gurtner M, Ha C, Hallgren A, Halzen F, Han K, Hanson K, Hasegawa Y, Heise J, Helbing K, Herquet P, Hickford S, Hill GC, Hoffman KD, Hoshina K, Hubert D, Huelsnitz W, Hülss JP, Hulth PO, Hultqvist K, Hussain S, Imlay RL, Inaba M, Ishihara A, Jacobsen J, Japaridze GS, Johansson H, Joseph JM, Kampert KH, Kappes A, Karg T, Karle A, Kelley JL, Kenny P, Kiryluk J, Kislat F, Klein SR, Klepser S, Knops S, Kohnen G, Kolanoski H, Köpke L, Kowalski M, Kowarik T, Krasberg M, Kuehn K, Kuwabara T, Labare M, Lafebre S, Laihem K, Landsman H, Lauer R, Leich H, Lennarz D, Lucke A, Lundberg J, Lünemann J, Madsen J, Majumdar P, Maruyama R, Mase K, Matis HS, McParland CP, Meagher K, Merck M, Mészáros P, Middell E, Milke N, Miyamoto H, Mohr A, Montaruli T, Morse R, Movit SM, Münich K, Nahnhauer R, Nam JW, Niessen P, Nygren DR, Odrowski S, Olivas A, Olivo M, Ono M, Panknin S, Patton S, Pérez de Los Heros C, Petrovic J, Piegsa A, Pieloth D, Pohl AC, Porrata R, Potthoff N, Price PB, Prikockis M, Przybylski GT, Rawlins K, Redl P, Resconi E, Rhode W, Ribordy M, Rizzo A, Rodrigues JP, Roth P, Rothmaier F, Rott C, Roucelle C, Rutledge D, Ryckbosch D, Sander HG, Sarkar S, Satalecka K, Schlenstedt S, Schmidt T, Schneider D, Schukraft A, Schulz O, Schunck M, Seckel D, Semburg B, Seo SH, Sestayo Y, Seunarine S, Silvestri A, Slipak A, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Stephens G, Stezelberger T, Stokstad RG, Stoufer MC, Stoyanov S, Strahler EA, Straszheim T, Sulanke KH, Sullivan GW, Swillens Q, Taboada I, Tarasova O, Tepe A, Ter-Antonyan S, Terranova C, Tilav S, Tluczykont M, Toale PA, Tosi D, Turcan D, van Eijndhoven N, Vandenbroucke J, Van Overloop A, Voigt B, Walck C, Waldenmaier T, Walter M, Wendt C, Westerhoff S, Whitehorn N, Wiebusch CH, Wiedemann A, Wikström G, Williams DR, Wischnewski R, Wissing H, Woschnagg K, Xu XW, Yodh G, Yoshida S. Limits on a muon flux from neutralino annihilations in the sun with the IceCube 22-string detector. Phys Rev Lett. 2009 May 22; 102(20):201302.
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  26. Weiss MJ, Guenther DA, Mezrich JD, Sahara H, Ng CY, Meltzer AJ, Sayre JK, Cochrane ME, Pujara AC, Houser SL, Sachs DH, Rosengard BR, Allan JS, Benichou G, Madsen JC. The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts. Am J Transplant. 2009 Jan; 9(1):105-13.
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  27. Aoyama A, Ng CY, Millington TM, Boskovic S, Murakami T, Wain JC, Houser SL, Madsen JC, Kawai T, Allan JS. Comparison of lung and kidney allografts in induction of tolerance by a mixed-chimerism approach in cynomolgus monkeys. Transplant Proc. 2009 Jan-Feb; 41(1):429-30.
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  28. Ng CY, Madsen JC, Rosengard BR, Allan JS. Immunosuppression for lung transplantation. Front Biosci. 2009; 14:1627-41.
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  29. Meltzer AJ, Weiss MJ, Veillette GR, Sahara H, Ng CY, Cochrane ME, Houser SL, Sachs DH, Rosengard BR, Madsen JC, Wain JC, Allan JS. Repetitive gastric aspiration leads to augmented indirect allorecognition after lung transplantation in miniature swine. Transplantation. 2008 Dec 27; 86(12):1824-9.
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  30. Traum AZ, Kawai T, Vacanti JP, Sachs DH, Cosimi AB, Madsen JC. The need for tolerance in pediatric organ transplantation. Pediatrics. 2008 Jun; 121(6):1258-60.
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  31. Madsen JC. Sirolimus as primary immunosuppression is effective in attenuating progression of cardiac-allograft vasculopathy. Nat Clin Pract Cardiovasc Med. 2008 Jun; 5(6):300-1.
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  32. Cowan SW, Fiser SM, Albrecht M, Fifer M, Vlahakes GJ, Madsen JC. Management of coronary artery compression caused by recurrent aortic root abscess. J Card Surg. 2008 May-Jun; 23(3):195-7.
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  33. Hoerbelt R, Benjamin CL, Shoji T, Houser SL, Muniappan A, Hasse RS, Ledgerwood LG, Allan JS, Sachs DH, Madsen JC. The effects of tolerance on allograft damage caused by the innate immune system. Transplantation. 2008 Feb 15; 85(3):314-22.
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  34. Weiss MJ, Madsen JC, Rosengard BR, Allan JS. Mechanisms of chronic rejection in cardiothoracic transplantation. Front Biosci. 2008; 13:2980-8.
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  35. Shoji T, Sahara H, Muniappan A, Guenther DA, Wain JC, Houser SL, Bravard MA, Pujara AC, Hasse RS, Sachs DH, Madsen JC, Allan JS. Operational tolerance to class I disparate lungs can be induced despite pretransplant immunization with class I allopeptides. Transplantation. 2007 Dec 15; 84(11):1467-73.
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  36. Kitchens WH, Chase CM, Uehara S, Cornell LD, Colvin RB, Russell PS, Madsen JC. Macrophage depletion suppresses cardiac allograft vasculopathy in mice. Am J Transplant. 2007 Dec; 7(12):2675-82.
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  37. Dormond O, Madsen JC, Briscoe DM. The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. J Biol Chem. 2007 Aug 10; 282(32):23679-86.
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  38. Benichou G, Kant CD, Madsen J, Tocco G. Modulation of alloreactivity to MHC-derived peptides and transplantation tolerance. Front Biosci. 2007; 12:4239-47.
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  39. Houser S, Muniappan A, Allan J, Sachs D, Madsen J. Cardiac allograft vasculopathy: real or a normal morphologic variant? J Heart Lung Transplant. 2007 Feb; 26(2):167-73.
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  40. Uehara S, Chase CM, Cornell LD, Madsen JC, Russell PS, Colvin RB. Chronic cardiac transplant arteriopathy in mice: relationship of alloantibody, C4d deposition and neointimal fibrosis. Am J Transplant. 2007 Jan; 7(1):57-65.
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  41. Hoerbelt R, Benjamin LC, Shoji T, Johnston DR, Muniappan A, Guenther DA, Allan JS, Houser SL, Madsen JC. Effects of tolerance induction on the actions of interferon-gamma on porcine cardiac allografts. Transplant Proc. 2006 Dec; 38(10):3196-8.
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  42. Uehara S, Chase CM, Colvin RB, Madsen JC, Russell PS. T-cell depletion eliminates the development of cardiac allograft vasculopathy in mice rendered tolerant by the induction of mixed chimerism. Transplant Proc. 2006 Dec; 38(10):3169-71.
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  43. Shoji T, Sahara H, Muniappan A, Guenther DA, Houser SL, Pujara AC, Bravard MA, Wain JC, Sachs DH, Madsen JC, Allan JS. An MHC class II disparity raises the threshold for tolerance induction in pulmonary allografts in miniature swine. Transplant Proc. 2006 Dec; 38(10):3268-70.
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  44. Sahara H, Shoji T, Ng CY, Weiss MJ, Muniappan A, Guenther DA, Houser SL, Pujara AC, Sayre JK, Wain JC, Sachs DH, Madsen JC, Allan JS. The role of indirect recognition of MHC class I and II allopeptides in a fully mismatched miniature swine model of lung transplantation. Transplant Proc. 2006 Dec; 38(10):3256-8.
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  45. Sahara H, Weiss MJ, Ng CY, Houser SL, Pujara AC, Sayre JK, Wain JC, Sachs DH, Madsen JC, Allan JS. Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Transplant Proc. 2006 Dec; 38(10):3253-5.
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  46. Achterberg A, Ackermann M, Adams J, Ahrens J, Andeen K, Atlee DW, Bahcall JN, Bai X, Baret B, Bartelt M, Barwick SW, Bay R, Beattie K, Becka T, Becker JK, Becker KH, Berghaus P, Berley D, Bernardini E, Bertrand D, Besson DZ, Blaufuss E, Boersma DJ, Bohm C, Bolmont J, Böser S, Botner O, Bouchta A, Braun J, Burgess C, Burgess T, Castermans T, Chirkin D, Christy B, Clem J, Cowen DF, D'Agostino MV, Davour A, Day CT, De Clercq C, Demirörs L, Descamps F, Desiati P, Deyoung T, Diaz-Velez JC, Dreyer J, Dumm JP, Duvoort MR, Edwards WR, Ehrlich R, Eisch J, Ellsworth RW, Evenson PA, Fadiran O, Fazely AR, Feser T, Filimonov K, Fox BD, Gaisser TK, Gallagher J, Ganugapati R, Geenen H, Gerhardt L, Goldschmidt A, Goodman JA, Gozzini R, Grullon S, Gross A, Gunasingha RM, Gurtner M, Hallgren A, Halzen F, Han K, Hanson K, Hardtke D, Hardtke R, Harenberg T, Hart JE, Hauschildt T, Hays D, Heise J, Helbing K, Hellwig M, Herquet P, Hill GC, Hodges J, Hoffman KD, Hommez B, Hoshina K, Hubert D, Hughey B, Hulth PO, Hultqvist K, Hundertmark S, Hülss JP, Ishihara A, Jacobsen J, Japaridze GS, Jones A, Joseph JM, Kampert KH, Karle A, Kawai H, Kelley JL, Kestel M, Kitamura N, Klein SR, Klepser S, Kohnen G, Kolanoski H, Köpke L, Krasberg M, Kuehn K, Landsman H, Leich H, Liubarsky I, Lundberg J, Madsen J, Mase K, Matis HS, McCauley T, McParland CP, Meli A, Messarius T, Mészáros P, Miyamoto H, Mokhtarani A, Montaruli T, Morey A, Morse R, Movit SM, Münich K, Nahnhauer R, Nam JW, Niessen P, Nygren DR, Ogelman H, Olbrechts P, Olivas A, Patton S, Peña-Garay C, Pérez de Los Heros C, Piegsa A, Pieloth D, Pohl AC, Porrata R, Pretz J, Price PB, Przybylski GT, Rawlins K, Razzaque S, Refflinghaus F, Resconi E, Rhode W, Ribordy M, Rizzo A, Robbins S, Roth P, Rott C, Rutledge D, Ryckbosch D, Sander HG, Sarkar S, Schlenstedt S, Schmidt T, Schneider D, Seckel D, Seo SH, Seunarine S, Silvestri A, Smith AJ, Solarz M, Song C, Sopher JE, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Steffen P, Stezelberger T, Stokstad RG, Stoufer MC, Stoyanov S, Strahler EA, Straszheim T, Sulanke KH, Sullivan GW, Sumner TJ, Taboada I, Tarasova O, Tepe A, Thollander L, Tilav S, Toale PA, Turcan D, van Eijndhoven N, Vandenbroucke J, Van Overloop A, Voigt B, Wagner W, Walck C, Waldmann H, Walter M, Wang YR, Wendt C, Wiebusch CH, Wikström G, Williams DR, Wischnewski R, Wissing H, Woschnagg K, Xu XW, Yodh G, Yoshida S, Zornoza JD. Limits on the high-energy gamma and neutrino fluxes from the SGR 1806-20 giant flare of 27 December 2004 with the AMANDA-II detector. Phys Rev Lett. 2006 Dec 1; 97(22):221101.
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  47. Weiss MJ, Ng CY, Madsen JC. Tolerance, xenotransplantation: future therapies. Surg Clin North Am. 2006 Oct; 86(5):1277-96, viii.
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  48. Dormond O, Madsen JC. Invited commentary. Ann Thorac Surg. 2006 May; 81(5):1736-7.
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  49. Kitchens WH, Uehara S, Chase CM, Colvin RB, Russell PS, Madsen JC. The changing role of natural killer cells in solid organ rejection and tolerance. Transplantation. 2006 Mar 27; 81(6):811-7.
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  50. Akins CW, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE, LaMuraglia GM, Cambria RP. Late results of combined carotid and coronary surgery using actual versus actuarial methodology. Ann Thorac Surg. 2005 Dec; 80(6):2091-7.
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  51. Hoerbelt R, Johnston DR, Shoji T, Houser SL, Hasse RS, Ledgerwood LG, Iribarne A, Allan JS, Sayegh MH, Sachs DH, Madsen JC. Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine. Transplantation. 2005 Nov 15; 80(9):1275-82.
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  52. Schwarze ML, Houser SL, Muniappan A, Allan JS, Menard MT, McMorrow I, Maloney ME, Madsen JC. Effects of mycophenolate mofetil on cardiac allograft survival and cardiac allograft vasculopathy in miniature swine. Ann Thorac Surg. 2005 Nov; 80(5):1787-93.
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  53. Akins CW, Bitondo JM, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE. Early and late results of the surgical correction of cardiac prosthetic paravalvular leaks. J Heart Valve Dis. 2005 Nov; 14(6):792-9; discussion 799-800.
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  54. Uehara S, Chase CM, Kitchens WH, Rose HS, Colvin RB, Russell PS, Madsen JC. NK cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts. J Immunol. 2005 Sep 1; 175(5):3424-30.
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  55. Smith RN, Brousaides N, Grazette L, Saidman S, Semigran M, Disalvo T, Madsen J, Dec GW, Perez-Atayde AR, Collins AB. C4d deposition in cardiac allografts correlates with alloantibody. J Heart Lung Transplant. 2005 Sep; 24(9):1202-10.
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  56. Johnston DR, Muniappan A, Hoerbelt R, Guenther DA, Shoji T, Houser SL, Sachs DH, Madsen JC. Heart and en-bloc thymus transplantation in miniature swine. J Thorac Cardiovasc Surg. 2005 Aug; 130(2):554-9.
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  57. Wong DR, Agnihotri AK, Hung JW, Vlahakes GJ, Akins CW, Hilgenberg AD, Madsen JC, MacGillivray TE, Picard MH, Torchiana DF. Long-term survival after surgical revascularization for moderate ischemic mitral regurgitation. Ann Thorac Surg. 2005 Aug; 80(2):570-7.
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  58. Shoji T, Wain JC, Houser SL, Benjamin LC, Johnston DR, Hoerbelt R, Hasse RS, Lee RS, Muniappan A, Guenther DA, Bravard MA, Ledgerwood LG, Sachs DH, Sayegh MH, Madsen JC, Allan JS. Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine. Am J Transplant. 2005 Jul; 5(7):1626-34.
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  59. Mezrich JD, Benjamin LC, Sachs JA, Houser SL, Vagefi PA, Sachs DH, Madsen JC, Yamada K. Role of the thymus and kidney graft in the maintenance of tolerance to heart grafts in miniature swine. Transplantation. 2005 Jun 27; 79(12):1663-73.
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  60. Guenther DA, Madsen JC. Advances in strategies for inducing central tolerance in organ allograft recipients. Pediatr Transplant. 2005 Jun; 9(3):277-81.
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  61. Shoji T, Muniappan A, Guenther DA, Wain JC, Houser SL, Hoerbelt R, Benjamin LC, Hasse RS, Bravard MA, Sachs DH, Madsen JC, Allan JS. Long-term acceptance of porcine pulmonary allografts without chronic rejection. Transplant Proc. 2005 Jan-Feb; 37(1):72-4.
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  62. Schroeder C, Allan JS, Nguyen BN, Wu G, Zhang T, Azimzadeh AM, Madsen JC, Schuurman HJ, Sachs DH, Pierson RN. Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood. Transplant Proc. 2005 Jan-Feb; 37(1):512-3.
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  63. Uehara S, Chase CM, Colvin RB, Russell PS, Madsen JC. Further evidence that NK cells may contribute to the development of cardiac allograft vasculopathy. Transplant Proc. 2005 Jan-Feb; 37(1):70-1.
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  64. Akins CW, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE. Aortic valve replacement in patients with previous cardiac surgery. J Card Surg. 2004 Jul-Aug; 19(4):308-12.
    View in: PubMed
  65. Hoerbelt R, Muniappan A, Madsen JC, Allan JS. New strategies for the treatment of chronic rejection. Curr Opin Investig Drugs. 2004 May; 5(5):489-98.
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  66. Mezrich J, Yamada K, Sachs DH, Madsen JC. Regulatory T cells generated by the kidney may mediate the beneficial immune effects of combining kidney with heart transplantation. Surgery. 2004 May; 135(5):473-8.
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  67. Houser SL, Benjamin LC, Wain JC, Madsen JC, Allan JS. Constitutive expression of major histocompatibility complex class II antigens in pulmonary epithelium and endothelium varies among different species. Transplantation. 2004 Feb 27; 77(4):605-7.
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  68. Hoerbelt R, Madsen JC. Feasibility of xeno-transplantation. Surg Clin North Am. 2004 Feb; 84(1):289-307.
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  69. Houser SL, McMorrow IM, LeGuern C, Schwarze ML, Fuchimoto Y, Sachs DH, Madsen JC. Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine. J Heart Lung Transplant. 2004 Jan; 23(1):50-60.
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  70. Menard MT, Schwarze ML, Allan JS, Johnston DR, Mawulawde K, Shimizu A, Yamada K, Houser SL, Allison KS, Sachs DH, Madsen JC. Composite "thymoheart" transplantation improves cardiac allograft survival. Am J Transplant. 2004 Jan; 4(1):79-86.
    View in: PubMed
  71. Mezrich JD, Kesselheim JA, Johnston DR, Yamada K, Sachs DH, Madsen JC. The role of regulatory cells in miniature swine rendered tolerant to cardiac allografts by donor kidney cotransplantation. Am J Transplant. 2003 Sep; 3(9):1107-15.
    View in: PubMed
  72. Mezrich JD, Yamada K, Lee RS, Mawulawde K, Benjamin LC, Schwarze ML, Maloney ME, Amoah HC, Houser SL, Sachs DH, Madsen JC. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population. Transplantation. 2003 Aug 27; 76(4):625-31.
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  73. Mezrich JD, Haller GW, Arn JS, Houser SL, Madsen JC, Sachs DH. Histocompatible miniature swine: an inbred large-animal model. Transplantation. 2003 Mar 27; 75(6):904-7.
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  74. Mezrich JD, Yamada K, Lee RS, Mawulawde K, Benjamin LC, Schwarze ML, Maloney ME, Amoah HC, Houser SL, Sachs DH, Madsen JC. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal cell population. Transplantation(Rapid Communication). 2003; 76:625-31.
  75. Mezrich JD, Kesselheim JA, Johnston DR, Yamada K, Sachs DH, Madsen JC. The role of regulatory T cells in miniature swine rendered tolerant to cardiac allografts. American Journal of Transplantation. 2003; 3:1107-15.
  76. Mezrich JD, Haller GW, Arn JS, Houser SL, Madsen JC, Sachs DH. Histocompatible miniature swine: an inbred large animal model . Transplantation. 2003; 75:904-7.
  77. Akins CW, Hilgenberg AD, Vlahakes GJ, MacGillivray TE, Torchiana DF, Madsen JC. Results of bioprosthetic versus mechanical aortic valve replacement performed with concomitant coronary artery bypass grafting. Ann Thorac Surg. 2002 Oct; 74(4):1098-106.
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  78. Ohuchi H, Madsen JC, Neragi-Miandoab S, Vlahakes GJ. A novel technique for en bloc, vascularized, composite thymic, and cardiac co-transplantation1. Transplantation. 2002 Aug 15; 74(3):403-5.
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  79. Kawai T, Cosimi AB, Wee SL, Houser S, Andrews D, Sogawa H, Phelan J, Boskovic S, Nadazdin O, Abrahamian G, Colvin RB, Sach DH, Madsen JC. Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys. Transplantation. 2002 Jun 15; 73(11):1757-64.
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  80. Mezrich JD, Sachs DH, Madsen JC. Combined heart and kidney transplantation: are two organs better than one? J Heart Lung Transplant. 2002 Jun; 21(6):714-6.
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  81. Allan JS, Madsen JC. Recent advances in the immunology of chronic rejection. Curr Opin Nephrol Hypertens. 2002 May; 11(3):315-21.
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  82. Johnston DR, Sayegh MH, Madsen JC. Overcoming cardiac allograft vasculopathy (CAV) by inducing tolerance. Front Biosci. 2002 May 1; 7:e116-8.
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  83. Allan JS, Wain JC, Schwarze ML, Houser SL, Benjamin LC, Madsen JC, Sachs DH. Modeling chronic lung allograft rejection in miniature swine. Transplantation. 2002 Feb 15; 73(3):447-53.
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  84. Bitondo JM, Daggett WM, Torchiana DF, Akins CW, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE, Agnihotri AK. Endoscopic versus open saphenous vein harvest: a comparison of postoperative wound complications. Ann Thorac Surg. 2002 Feb; 73(2):523-8.
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  85. Benjamin LC, Allan JS, Madsen JC. Cytokines in immunity and allograft rejection. Crit Rev Immunol. 2002; 22(4):269-79.
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  86. Bitondo JM, Daggett WM, Torchiana DF, Akins CW, Hilgenberg AD, Vlahakes GJ, Madsen JC, MacGillivray TE, Agnihotri AK. Endoscopic versus open saphenous vein harvest: A comparison of post-operative wound infections. Annals of Thoracic Surgery. 2002.
  87. Grünenfelder J, Akins CW, Hilgenberg AD, Vlahakes GJ, Torchiana DF, Madsen JC, MacGillivray TE. Long-term results and determinants of mortality after surgery for native and prosthetic valve endocarditis. J Heart Valve Dis. 2001 Nov; 10(6):694-702.
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  88. Madsen JC. Tailoring tolerance to prevent chronic rejection. Transplantation. 2001 Oct 27; 72(8 Suppl):S10-2.
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  89. Massicot-Fisher J, Noel P, Madsen JC. Recommendations of the National Heart, Lung and Blood Institute Heart and Lung Tolerance Working Group. Transplantation. 2001 Oct 27; 72(8):1467-70.
    View in: PubMed
  90. Fuchimoto Y, Gleit ZL, Huang CA, Kitamura H, Schwarze ML, Menard MT, Mawulawde K, Madsen JC, Sachs DH. Skin-specific alloantigens in miniature swine. Transplantation. 2001 Jul 15; 72(1):122-6.
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  91. Womer KL, Lee RS, Madsen JC, Sayegh MH. Tolerance and chronic rejection. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):727-38.
    View in: PubMed
  92. Allan JS, Rose GA, Choo JK, Arn JS, Vesga L, Mawulawde K, Slisz JK, Allison K, Madsen JC. Morphometric analysis of miniature swine hearts as potential human xenografts. Xenotransplantation. 2001 May; 8(2):90-3.
    View in: PubMed
  93. Lee RS, Yamada K, Houser SL, Womer KL, Maloney ME, Rose HS, Sayegh MH, Madsen JC. Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3276-81.
    View in: PubMed
  94. Lee RS, Rusche JR, Maloney ME, Sachs DH, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogeneic T cell responses. J Immunol. 2001 Feb 1; 166(3):1572-82.
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  95. Allan JS, Wain JC, Schwarze ML, Houser SL, Madsen JC, Sachs DH. Obliterative bronchiolitis develops in miniature swine transplanted across a minor histocompatibility barrier. Transplant Proc. 2001 Feb-Mar; 33(1-2):358-9.
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  96. Lee RS, Yamada K, Houser SL, Womer KL, Maloney ME, Rose HS, Sayegh MH, Madsen JC. Indirect allorecognition promotes the development of cardiac allograft vasculopathy. Transplant Proc. 2001 Feb-Mar; 33(1-2):308-10.
    View in: PubMed
  97. Lee RS, Rusche JR, Maloney ME, Sachs DH, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogeneic T cell responses. Transplant Proc. 2001 Feb-Mar; 33(1-2):88-9.
    View in: PubMed
  98. Lee RS, KazuhikoY, Houser SL, Wormer KL, Maloney ME, Rose HS, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogenic T cell responses. Journal of Immunology. 2001; 166:1572-1582.
  99. Massicot-Fisher J, Noel P, Madsen JC. Recommendations of the NHLBI heart and lung tolerance working group. Transplantation. 2001; 72:1467-70.
  100. Mathes DW, Yaremchuk MJ, Isselbacher EM, Madsen JC. Successful in situ treatment of an infected ascending aortic graft. Ann Thorac Surg. 2000 Oct; 70(4):1410-2.
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  101. Schwarze ML, Menard MT, Fuchimoto Y, Huang CA, Houser S, Mawulawde K, Allison KS, Sachs DH, Madsen JC. Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine. Ann Thorac Surg. 2000 Jul; 70(1):131-8; discussion 138-9.
    View in: PubMed
  102. Yamada K, Mawulawde K, Menard MT, Shimizu A, Aretz HT, Choo JK, Allison KS, Slisz JK, Sachs DH, Madsen JC. Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: the effect of augmentation of donor antigen load. J Thorac Cardiovasc Surg. 2000 Apr; 119(4 Pt 1):709-19.
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  103. Lee RS, Yamada K, Womer KL, Pillsbury EP, Allison KS, Marolewski AE, Geng D, Thall AD, Arn JS, Sachs DH, Sayegh MH, Madsen JC. Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses. J Immunol. 2000 Mar 15; 164(6):3434-44.
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  104. Schwarze ML, Menard MT, Fuchimoto Y, Huang CA, Houser S, Mawulawde K, Allison KS, Sachs DH, and Madsen JC. Mixed hematopoietic chimerism induces long term tolerance to cardiac allografts in miniature swine. The Annals of Thoracic Surgery. 2000; 70:131-139.
  105. Lee RS, Yamada K, Womer KL, Pillsbury EP, Allison KS, Marolewski AL, Geng D, Thall AD, Arn JS, Sachs DH, Sayegh MH, Madsen JC. Blockade of CD28-B7 but not CD40-CD154 prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses. The Journal of Immunology. 2000; 164:3434-3444.
  106. Pins MR, Ferrell MA, Madsen JC, Piubello Q, Dickersin GR, Fletcher CD. Epithelioid and spindle-celled leiomyosarcoma of the heart. Report of 2 cases and review of the literature. Arch Pathol Lab Med. 1999 Sep; 123(9):782-8.
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  107. Yamada K, Choo JK, Allan JS, Erhorn AE, Menard MT, Mawulawde K, Slisz JK, Aretz HT, Shimizu A, Sachs DH, Madsen JC. The effect of thymectomy on tolerance induction and cardiac allograft vasculopathy in a miniature swine heart/kidney transplantation model. Transplantation. 1999 Aug 27; 68(4):485-91.
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  108. Allan JS, Rose GA, Choo JK, Arn JS, Vesga L, Mawulawde K, Slisz JK, Allison K, Madsen JC. Morphometric analyses to predict appropriate donor size for swine-to-human cardiac xenotransplantation. Transplant Proc. 1999 Feb-Mar; 31(1-2):975-7.
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  109. Yamada K, Menard MT, Mawulawde K, Slisz JK, Choo JK, Erhorn AE, Sachs DH, Madsen JC. The effects of heart/kidney versus double heart transplantation on tolerance induction and prevention of cardiac allograft vasculopathy. Transplant Proc. 1999 Feb-Mar; 31(1-2):108.
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  110. Allan JS, Slisz JK, Vesga L, Arn JS, Yamada K, Sachs DH, Madsen JC. Enhanced efficacy of repeated anti-CD8 monoclonal antibody therapy by high-dose cyclosporine treatment. Transplant Proc. 1998 Dec; 30(8):4062-3.
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  111. Lambrigts D, Menard MT, Alexandre GP, Franssen C, Meurisse M, Van Calster P, Coignoul F, Mawulawde K, Choo JK, Yamada K, Erhorn AE, Slisz JK, Chiotellis P, Aretz HT, Sachs DH, Madsen JC. Creation of the "thymoheart" allograft: implantation of autologous thymus into the heart prior to procurement. Transplantation. 1998 Sep 27; 66(6):810-4.
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  112. Akins CW, Buckley MJ, Daggett WM, Hilgenberg AD, Vlahakes GJ, Torchiana DF, Madsen JC. Risk of reoperative valve replacement for failed mitral and aortic bioprostheses. Ann Thorac Surg. 1998 Jun; 65(6):1545-51; discussion 1551-2.
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  113. Madsen JC, Daggett WM. Repair of postinfarction ventricular septal defects. Semin Thorac Cardiovasc Surg. 1998 Apr; 10(2):117-27.
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  114. Madsen JC, Yamada K, Allan JS, Choo JK, Erhorn AE, Pins MR, Vesga L, Slisz JK, Sachs DH. Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine. Transplantation. 1998 Feb 15; 65(3):304-13.
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  115. Madsen JC, Yamada K, Allan JS, Choo JK, Erhorn AE, Pins MR, Vesga L, Slisz JK, Sachs DH. Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility class I-disparate miniature swine. Transplantation (Rapid Communication). 1998; 65:304-313.
  116. Akins CW, Buckley MJ, Daggett WM, Hilgenberg AD, Vlahakes GJ, Torchiana DF, Madsen JC. Risk of reoperative valve replacement for failed miral and aortic bioprostheses. Annals of Thoracic Surgery. 1998; 65:1545-52.
  117. Choo JK, Seebach JD, Nickeleit V, Shimizu A, Lei H, Sachs DH, Madsen JC. Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity. Transplantation. 1997 Nov 15; 64(9):1315-22.
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  118. Allan JS, Choo JK, Vesga L, Arn JS, Pins MR, Sachs DH, Madsen JC. Cardiac allograft vasculopathy is abrogated by anti-CD8 monoclonal antibody therapy. Ann Thorac Surg. 1997 Oct; 64(4):1019-25.
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  119. Akins CW, Daggett WM, Vlahakes GJ, Hilgenberg AD, Torchiana DF, Madsen JC, Buckley MJ. Cardiac operations in patients 80 years old and older. Ann Thorac Surg. 1997 Sep; 64(3):606-14; discussion 614-5.
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  120. Akins CW, Daggett WM, Vlahakes GJ, Hilgenberg AD, Torchiana DF, Madsen JC, Buckley MJ. Cardiac surgery in patients 80 years old and older. Annals of Thoracic Surgery. 1997; 64.
  121. Hilgenberg AD, Akins CW, Logan DL, Vlahakes GJ, Buckley MJ, Madsen JC, Torchiana DF. Composite aortic root replacement with direct coronary artery implantation. Ann Thorac Surg. 1996 Oct; 62(4):1090-5.
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  122. Madsen JC, Sachs DH, Fallon JT, Weissman NJ. Cardiac allograft vasculopathy in partially inbred miniature swine. I. Time course, pathology, and dependence on immune mechanisms. J Thorac Cardiovasc Surg. 1996 Jun; 111(6):1230-9.
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  123. Hajjar RJ, Rose GA, Madsen JC, Levine RA, DeSanctis RW. Extrapericardial cardiac tamponade after blunt chest trauma. Am Heart J. 1995 Sep; 130(3 Pt 1):620-1.
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  124. Madsen JC, Mathisen DJ, Grillo HC. Cervical exenteration. Semin Thorac Cardiovasc Surg. 1992 Oct; 4(4):292-9.
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  125. Pearson TC, Madsen JC, Larsen CP, Morris PJ, Wood KJ. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation. 1992 Sep; 54(3):475-83.
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  126. Pearson TC, Madsen JC, Wood KJ. Effect of anti-CD4 monoclonal antibody dosage when combined with donor antigen for the induction of transplantation tolerance. Transplant Proc. 1991 Feb; 23(1 Pt 1):565-6.
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  127. Madsen JC. An immunogenetic analysis of immunological unresponsiveness using recipient cells transfected with donor MHC genes. 1991.
  128. Pearson TC, Madsen JC, Morris PJ, Wood KJ. The induction of transplantation tolerance using donor antigen and CD4 monoclonal antibody. Transplant Proc. 1990 Aug; 22(4):1955-6.
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  129. Madsen JC, Wood KJ, Morris PJ. Effects of anti-L3T4 and anti-LYT2 monoclonal antibody therapy on cardiac allograft survival in presensitized recipients. Transplant Proc. 1989 Feb; 21(1 Pt 1):1022.
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  130. Madsen JC, Wood KJ, Superina RA, Morris PJ. Induction of immunological unresponsiveness using recipient cells transfected with donor class I or class II MHC genes. Transplant Proc. 1989 Feb; 21(1 Pt 1):477.
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  131. Madsen JC, Superina RA, Wood KJ, Morris PJ. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature. 1988 Mar 10; 332(6160):161-4.
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  132. Madsen JC, Peugh WN, Wood KJ, Morris PJ. The effect of anti-L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts. Transplantation. 1987 Dec; 44(6):849-52.
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  133. Madsen JC, Wood KJ, Morris PJ. Effects of anti-L3T4 and anti-Lyt 2 monoclonal antibodies on murine cardiac allograft rejection. Transplant Proc. 1987 Oct; 19(5):3991-2.
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  134. Madsen JC, Wood KJ, Morris PJ. The effect of anti-L3T4 and anti-Lyt 2 monoclonal antibodies on murine cardiac allograft rejection. Transplantation Proceedings. 1987; 19:3991-3992.
  135. Stromeyer CF, Kronauer RE, Madsen JC, Klein SA. Opponent-movement mechanisms in human vision. J Opt Soc Am A. 1984 Aug; 1(8):876-84.
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  136. Stromeyer CF, Kronauer RE, Madsen JC. Adaptive processes controlling sensitivity of short-wave cone pathways to different spatial frequencies. Vision Res. 1984; 24(8):827-34.
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  137. Stromeyer CF, Kronauer RE, Madsen JC, Klein S. Opponent movement mechanisms in human vision. Journal of the Optical Society of America. 1984; 81:876-884.
  138. Stromeyer CF, Kronauer RE, Madsen JC, Cohen MA. Spatial adaptation of short-wavelength pathways in humans. Science. 1980 Feb 1; 207(4430):555-7.
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  139. Stromeyer CF, Kronauer RE, Madsen JC. Response saturation of short-wavelength cone pathways controlled by color-opponent mechanisms. Vision Res. 1979; 19(9):1025-40.
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  140. Stromeyer CF, Kronauer RE, Madsen JC. Apparent saturation of blue-sensitive cones occurs at a color-opponent stage. Science. 1978 Oct 13; 202(4364):217-9.
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  141. Stromeyer CF, Madsen JC, Klein S, Zeevi YY. Movement-selective mechanisms in human vision sensitive to high spatial frequencies. J Opt Soc Am. 1978 Jul; 68(7):1002-5.
    View in: PubMed
  142. Stromeyer CF, Madsen JC, Klein S. Direction of selective adaptation with very slow motion. Journal of the Optical Society of America. 1978; 69:1350-1354.
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