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Last Name
Institution

David Clapham, M.D., PH.D.

TitleAldo R. Castaneda Professor of Cardiovascular Research
InstitutionChildren's Hospital Boston
DepartmentNeurobiology
AddressCardiovascular Research
Enders 1309
320 Longwood Ave
Boston MA 02115
Phone617/919-2680
Fax617/731-0787
Other Positions
TitleAldo R. Castaneda Professor of Cardiovascular Research
InstitutionChildren's Hospital Boston
DepartmentPediatrics


 Mentoring 
 completed student projects
External Calcium Modulates TRPC5 Activity
Summer, 06/20/05 - 08/15/05
A Study of Transient Receptor Channels (trp) in C Elegans
Summer, 05/20/99 - 09/01/99
Characterization of human STIM and Orai, putative regulators of cytosolic calcium signaling
Full Time, 09/15/06 - 03/30/07

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Miki K, Clapham DE. Rheotaxis guides Mammalian sperm. Curr Biol. 2013 Mar 18; 23(6):443-52.
    View in: PubMed
  2. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na(+) Channels to Adapt to Metabolic State. Cell. 2013 Feb 14; 152(4):778-90.
    View in: PubMed
  3. Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods Enzymol. 2013; 525:59-83.
    View in: PubMed
  4. Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, Decaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel NavRh. Cell Res. 2013 Mar; 23(3):409-22.
    View in: PubMed
  5. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. Cell. 2012 Oct 12; 151(2):372-83.
    View in: PubMed
  6. Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS One. 2012; 7(10):e46865.
    View in: PubMed
  7. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110.
    View in: PubMed
  8. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62.
    View in: PubMed
  9. Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012 Jun 7; 486(7401):130-4.
    View in: PubMed
  10. Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7888-92.
    View in: PubMed
  11. Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012 Apr; 15(4):565-73.
    View in: PubMed
  12. Doerner JF, Febvay S, Clapham DE. Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nat Commun. 2012; 3:990.
    View in: PubMed
  13. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):E225-33.
    View in: PubMed
  14. Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A. 2011 Dec 6; 108(49):19492-7.
    View in: PubMed
  15. Krapivinsky G, Krapivinsky L, Stotz SC, Manasian Y, Clapham DE. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19234-9.
    View in: PubMed
  16. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 3; 479(7371):67-73.
    View in: PubMed
  17. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 1; 108(44):18114-9.
    View in: PubMed
  18. Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annu Rev Physiol. 2012; 74:453-75.
    View in: PubMed
  19. Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14342-7.
    View in: PubMed
  20. Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol. 2012 Jan; 29(1):91-100.
    View in: PubMed
  21. Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol. 2011; 704:173-83.
    View in: PubMed
  22. Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan; 2(1):153.
    View in: PubMed
  23. Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010 Sep; 62(3):381-404.
    View in: PubMed
  24. Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MS, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nat Struct Mol Biol. 2010 Jul; 17(7):869-75.
    View in: PubMed
  25. Febvay S, Marini DM, Belcher AM, Clapham DE. Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Lett. 2010 Jun 9; 10(6):2211-9.
    View in: PubMed
  26. Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselkorn R, Hawkes K, Hayes JM, Hille B, Hökfelt T, House JS, Hout M, Hunten DM, Izquierdo IA, Jagendorf AT, Janzen DH, Jeanloz R, Jencks CS, Jury WA, Kaback HR, Kailath T, Kay P, Kay SA, Kennedy D, Kerr A, Kessler RC, Khush GS, Kieffer SW, Kirch PV, Kirk K, Kivelson MG, Klinman JP, Klug A, Knopoff L, Kornberg H, Kutzbach JE, Lagarias JC, Lambeck K, Landy A, Langmuir CH, Larkins BA, Le Pichon XT, Lenski RE, Leopold EB, Levin SA, Levitt M, Likens GE, Lippincott-Schwartz J, Lorand L, Lovejoy CO, Lynch M, Mabogunje AL, Malone TF, Manabe S, Marcus J, Massey DS, McWilliams JC, Medina E, Melosh HJ, Meltzer DJ, Michener CD, Miles EL, Mooney HA, Moore PB, Morel FM, Mosley-Thompson ES, Moss B, Munk WH, Myers N, Nair GB, Nathans J, Nester EW, Nicoll RA, Novick RP, O'Connell JF, Olsen PE, Opdyke ND, Oster GF, Ostrom E, Pace NR, Paine RT, Palmiter RD, Pedlosky J, Petsko GA, Pettengill GH, Philander SG, Piperno DR, Pollard TD, Price PB, Reichard PA, Reskin BF, Ricklefs RE, Rivest RL, Roberts JD, Romney AK, Rossmann MG, Russell DW, Rutter WJ, Sabloff JA, Sagdeev RZ, Sahlins MD, Salmond A, Sanes JR, Schekman R, Schellnhuber J, Schindler DW, Schmitt J, Schneider SH, Schramm VL, Sederoff RR, Shatz CJ, Sherman F, Sidman RL, Sieh K, Simons EL, Singer BH, Singer MF, Skyrms B, Sleep NH, Smith BD, Snyder SH, Sokal RR, Spencer CS, Steitz TA, Strier KB, Südhof TC, Taylor SS, Terborgh J, Thomas DH, Thompson LG, Tjian RT, Turner MG, Uyeda S, Valentine JW, Valentine JS, Van Etten JL, van Holde KE, Vaughan M, Verba S, von Hippel PH, Wake DB, Walker A, Walker JE, Watson EB, Watson PJ, Weigel D, Wessler SR, West-Eberhard MJ, White TD, Wilson WJ, Wolfenden RV, Wood JA, Woodwell GM, Wright HE, Wu C, Wunsch C, Zoback ML. Climate change and the integrity of science. Science. 2010 May 7; 328(5979):689-90.
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  27. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16; 141(2):331-43.
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  28. Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science. 2009 Oct 2; 326(5949):144-7.
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  29. Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15750-5.
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  30. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72.
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  31. Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal. 2009; 2(70):ra21.
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  32. Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol. 2009 May; 133(5):525-46.
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  33. Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7642-7.
    View in: PubMed
  34. Clapham DE. A STIMulus Package puts orai calcium channels to work. Cell. 2009 Mar 6; 136(5):814-6.
    View in: PubMed
  35. Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc. 2009; 4(2):174-96.
    View in: PubMed
  36. Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31; 322(5902):756-60.
    View in: PubMed
  37. Cai X, Clapham DE. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One. 2008; 3(10):e3569.
    View in: PubMed
  38. Brauchi S, Krapivinsky G, Krapivinsky L, Clapham DE. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8304-8.
    View in: PubMed
  39. Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008; 3(5):e2082.
    View in: PubMed
  40. Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. J Physiol. 2008 May 15; 586(10):2477-86.
    View in: PubMed
  41. Rama S, Krapivinsky G, Clapham DE, Medina I. The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Mol Cell Neurosci. 2008 Jun; 38(2):183-8.
    View in: PubMed
  42. Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol. 2008; 52(5-6):607-13.
    View in: PubMed
  43. Clapham DE. Calcium signaling. Cell. 2007 Dec 14; 131(6):1047-58.
    View in: PubMed
  44. Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M. The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology. 2007 Dec; 153(Pt 12):4027-38.
    View in: PubMed
  45. Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6.
    View in: PubMed
  46. Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem. 2007 Jun 29; 282(26):18945-52.
    View in: PubMed
  47. Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7688-92.
    View in: PubMed
  48. Clapham DE. SnapShot: mammalian TRP channels. Cell. 2007 Apr 6; 129(1):220.
    View in: PubMed
  49. Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1219-23.
    View in: PubMed
  50. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006 Dec 15; 127(6):1137-50.
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  51. Krapivinsky G, Mochida S, Krapivinsky L, Cibulsky SM, Clapham DE. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron. 2006 Nov 9; 52(3):485-96.
    View in: PubMed
  52. Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem. 2006 Oct 6; 281(40):29897-904.
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  53. Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J. 2006 Jul 12; 25(13):2978-88.
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  54. Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. J Biol Chem. 2006 Aug 4; 281(31):22085-91.
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  55. Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35.
    View in: PubMed
  56. Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. Nature. 2006 Apr 27; 440(7088):1213-6.
    View in: PubMed
  57. Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006 Feb 9; 439(7077):737-40.
    View in: PubMed
  58. Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47.
    View in: PubMed
  59. Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res. 2006 Feb 3; 98(2):245-53.
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  60. Clapham DE, Garbers DL. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. Pharmacol Rev. 2005 Dec; 57(4):451-4.
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  61. Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev. 2005 Dec; 57(4):509-26.
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  62. Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev. 2005 Dec; 57(4):427-50.
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  63. Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci. 2005 Sep 28; 25(39):8924-37.
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  64. Desai BN, Clapham DE. TRP channels and mice deficient in TRP channels. Pflugers Arch. 2005 Oct; 451(1):11-8.
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  65. Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005 Jul; 37(7):739-44.
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  66. Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol. 2005 Apr; 25(7):2632-43.
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  67. Zhuang ZY, Xu H, Clapham DE, Ji RR. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci. 2004 Sep 22; 24(38):8300-9.
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  68. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 2004 Aug 19; 43(4):563-74.
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  69. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004 Aug; 6(8):709-20.
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  70. Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA. The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10566-71.
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  71. Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Curr Opin Neurobiol. 2004 Jun; 14(3):362-9.
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  72. Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol. 2004 Mar; 2(3):E50.
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  73. Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004 Jan 22; 427(6972):360-4.
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  74. Khositseth, A, Clapham DE, and Ackerman, M. Intracellular signaling and regulation of cardiac ion channels. Cardiac Electrophysiology. 2004; 33-41.
  75. 80. Ackerman, M, and Clapham DE. Excitability and Conduction. The Molecular Basis of Heart Disease. 2004; 311-335.
  76. Clapham DE. Symmetry, selectivity, and the 2003 Nobel Prize. Cell. 2003 Dec 12; 115(6):641-6.
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  77. Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem. 2004 Mar 5; 279(10):9532-8.
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  78. Clapham DE. TRP channels as cellular sensors. Nature. 2003 Dec 4; 426(6966):517-24.
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  79. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6.
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  80. Clapham DE, Montell C, Schultz G, Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev. 2003 Dec; 55(4):591-6.
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  81. Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25):14864-8.
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  82. Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron. 2003 Nov 13; 40(4):775-84.
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  83. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci. 2003 Aug; 6(8):837-45.
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  84. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem. 2003 Oct 3; 278(40):39014-9.
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  85. Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell. 2003 Apr; 4(4):561-74.
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  86. Wei X, Henke VG, Strübing C, Brown EB, Clapham DE. Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J. 2003 Feb; 84(2 Pt 1):1317-27.
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  87. Catterall, WA, Chandy, KG, Clapham, DE, Gutman, GA, Hofmann, F, Harmar, AJ, Abernethy, DR, and M. Spedding. International Union of Pharmacology: Approaches to the nomenclature of voltage-gated ion channels. Pharmacological Reviews. 2003; 55:572-574.
  88. Sandler VM, Wang S, Angelo K, Lo HG, Breakefield XO, Clapham DE. Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. J Neurosci Methods. 2002 Dec 15; 121(2):211-9.
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  89. Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol. 2002 Dec; 120(6):845-53.
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  90. Clapham DE. Sorting out MIC, TRP, and CRAC ion channels. J Gen Physiol. 2002 Aug; 120(2):217-20.
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  91. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 2002 Jul 11; 418(6894):181-6.
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  92. Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol. 2002 May; 4(5):329-36.
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  93. Clapham DE. Signal transduction. Hot and cold TRP ion channels. Science. 2002 Mar 22; 295(5563):2228-9.
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  94. Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. Gene. 2002 Feb 6; 284(1-2):241-50.
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  95. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002 Feb; 9(2):229-31.
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  96. Roberson, C, and Clapham, DE. . G protein-coupled receptor signaling through ion channels. GPCRs in the CNS- The GPCR Superfamily. 2002; 108-123.
  97. Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. Science. 2001 Dec 14; 294(5550):2372-5.
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  98. Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12527-31.
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  99. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11; 413(6856):603-9.
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  100. Clapham D, Michel T, Seidman C. In memorium. J Mol Cell Cardiol. 2001 Aug; 33(8):1393-4.
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  101. Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol. 2001 Jun 15; 37(8):2136-43.
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  102. Clapham DE, Runnels LW, Strübing C. The TRP ion channel family. Nat Rev Neurosci. 2001 Jun; 2(6):387-96.
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  103. Lindroth AM, Saarikoski P, Flygh G, Clapham D, Grönroos R, Thelander M, Ronne H, von Arnold S. Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta. Plant Mol Biol. 2001 Jun; 46(3):335-46.
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  104. O'Connell PJ, Klyachko VA, Badminton MN, Thomson AW, Jackson MB, Clapham DE, Ahern GP. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. J Immunol. 2001 May 15; 166(10):6126-33.
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  105. Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature. 2001 Apr 5; 410(6829):705-9.
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  106. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 2001 Mar; 29(3):645-55.
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  107. Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science. 2001 Feb 9; 291(5506):1043-7.
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  108. Corey S, Clapham DE. The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). J Biol Chem. 2001 Apr 6; 276(14):11409-13.
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  109. Clapham D. How to lose your hippocampus by working on chloride channels. Neuron. 2001 Jan; 29(1):1-3.
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  110. Clapham DE. . Intracellular calcium signaling. Roger Eckert Memorial Lecture. 2001.
  111. Jelacic TM, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. J Biol Chem. 2000 Nov 17; 275(46):36211-6.
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  112. Medina I, Krapivinsky G, Arnold S, Kovoor P, Krapivinsky L, Clapham DE. A switch mechanism for G beta gamma activation of I(KACh). J Biol Chem. 2000 Sep 22; 275(38):29709-16.
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  113. Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. J Neurosci. 2000 Aug 1; 20(15):5608-15.
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  114. Franco-Obregón A, Wang HW, Clapham DE. Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. Biophys J. 2000 Jul; 79(1):202-14.
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  115. Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. J Biol Chem. 2000 Apr 28; 275(17):12363-6.
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  116. Sabala I, Elfstrand M, Farbos I, Clapham D, von Arnold S. Tissue-specific expression of Pa18, a putative lipid transfer protein gene, during embryo development in Norway spruce (Picea abies). Plant Mol Biol. 2000 Feb; 42(3):461-78.
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  117. Clapham DE. Remembering Eva Neer. Cell. 2000.
  118. Clapham DE. More pieces of the K+ ion channel puzzle. Nat Struct Biol. 1999 Sep; 6(9):807-10.
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  119. Wang H, Clapham DE. Conformational changes of the in situ nuclear pore complex. Biophys J. 1999 Jul; 77(1):241-7.
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  120. Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol. 1999 Jun; 19(6):4113-20.
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  121. Clapham DE. Unlocking family secrets: K+ channel transmembrane domains. Cell. 1999 May 28; 97(5):547-50.
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  122. Jelacic TM, Sims SM, Clapham DE. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. J Membr Biol. 1999 May 15; 169(2):123-9.
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  123. Arnold DB, Clapham DE. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron. 1999 May; 23(1):149-57.
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  124. Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Ann N Y Acad Sci. 1999 Apr 30; 868:386-98.
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  125. Strübing C, Clapham DE. Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. J Gen Physiol. 1999 Feb; 113(2):239-48.
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  126. Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. J Biol Chem. 1999 Jan 22; 274(4):2571-82.
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  127. Nemec J, Wickman K, Clapham DE. Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophys J. 1999 Jan; 76(1 Pt 1):246-52.
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  128. Ackerman, M, and Clapham DE. G proteins and ion channels. Cardiac Electrophysiology. 1999; 112-118.
  129. Navarro, B, Corey, S, Kennedy, M, and Clapham DE. G-protein-gated potassium channels: Implications for the weaver mouse. Potassium Ion Channels: Molecular Structure, Function, and Diseases. 1999; 46:295-320.
  130. Franco-Obregón A, Clapham DE. Touch channels sense blood pressure. Neuron. 1998 Dec; 21(6):1224-6.
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  131. Corey S, Clapham DE. Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. J Biol Chem. 1998 Oct 16; 273(42):27499-504.
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  132. Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. J Biol Chem. 1998 Jul 3; 273(27):16946-52.
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  133. Clapham DE. Not so funny anymore: pacing channels are cloned. Neuron. 1998 Jul; 21(1):5-7.
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  134. Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nat Neurosci. 1998 Jun; 1(2):114-8.
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  135. Clapham DE. The list of potential volume-sensitive chloride currents continues to swell (and shrink). J Gen Physiol. 1998 May; 111(5):623-4.
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  136. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem. 1998 May 1; 273(18):10811-4.
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  137. Clapham DE. At last, the structure of an ion-selective channel. Nat Struct Biol. 1998 May; 5(5):342-4.
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  138. Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K+ channel with unique pore properties. Neuron. 1998 May; 20(5):995-1005.
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  139. Lorenz E, Alekseev AE, Krapivinsky GB, Carrasco AJ, Clapham DE, Terzic A. Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. Mol Cell Biol. 1998 Mar; 18(3):1652-9.
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  140. Corey S, Krapivinsky G, Krapivinsky L, Clapham DE. Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. J Biol Chem. 1998 Feb 27; 273(9):5271-8.
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  141. Lee MA, Dunn RC, Clapham DE, Stehno-Bittel L. Calcium regulation of nuclear pore permeability. Cell Calcium. 1998 Feb-Mar; 23(2-3):91-101.
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  142. Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron. 1998 Jan; 20(1):103-14.
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  143. Clapham DE. Some like it hot: spicing up ion channels. Nature. 1997 Oct 23; 389(6653):783-4.
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  144. Perez-Terzic C, Jaconi M, Clapham DE. Nuclear calcium and the regulation of the nuclear pore complex. Bioessays. 1997 Sep; 19(9):787-92.
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  145. Jaconi M, Pyle J, Bortolon R, Ou J, Clapham D. Calcium release and influx colocalize to the endoplasmic reticulum. Curr Biol. 1997 Aug 1; 7(8):599-602.
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  146. Ackerman MJ, Clapham DE. Ion channels--basic science and clinical disease. N Engl J Med. 1997 May 29; 336(22):1575-86.
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  147. Perez-Terzic C, Stehno-Bittel L, Clapham DE. Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. Cell Calcium. 1997 Apr; 21(4):275-82.
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  148. Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Icln gene. Genomics. 1997 Mar 15; 40(3):402-8.
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  149. Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. Genomics. 1997 Mar 15; 40(3):395-401.
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  150. Clapham DE, Neer EJ. G protein beta gamma subunits. Annu Rev Pharmacol Toxicol. 1997; 37:167-203.
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  151. Clapham DE. The molecular control of cardiac ion channels. Heart Vessels. 1997; Suppl 12:168-9.
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  152. Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science. 1996 Sep 27; 273(5283):1875-7.
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  153. Clapham DE. Intracellular signalling: more jobs for G beta gamma. Curr Biol. 1996 Jul 1; 6(7):814-6.
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  154. Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE. Nonselective and G betagamma-insensitive weaver K+ channels. Science. 1996 Jun 28; 272(5270):1950-3.
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  155. Clapham DE. TRP is cracked but is CRAC TRP? Neuron. 1996 Jun; 16(6):1069-72.
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  156. Saarikoski P, Clapham D, von Arnold S. A wound-inducible gene from Salix viminalis coding for a trypsin inhibitor. Plant Mol Biol. 1996 Jun; 31(3):465-78.
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  157. Aleksandrov A, Velimirovic B, Clapham DE. Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. Biophys J. 1996 Jun; 70(6):2680-7.
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  158. Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron. 1996 Feb; 16(2):423-9.
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  159. Clapham DE. The G-protein nanomachine. Nature. 1996 Jan 25; 379(6563):297-9.
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  160. Velimirovic BM, Gordon EA, Lim NF, Navarro B, Clapham DE. The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. FEBS Lett. 1996 Jan 22; 379(1):31-7.
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  161. Stehno-Bittel L, Perez-Terzic C, Luckhoff A, Clapham DE. Nuclear ion channels and regulation of the nuclear pore. Soc Gen Physiol Ser. 1996; 51:195-207.
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  162. Kennedy ME, Nemec J, Clapham DE. Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. Neuropharmacology. 1996; 35(7):831-9.
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  163. Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. Biochem J. 1995 Dec 15; 312 ( Pt 3):955-9.
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  164. Stehno-Bittel L, Perez-Terzic C, Clapham DE. Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. Science. 1995 Dec 15; 270(5243):1835-8.
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  165. Stehno-Bittel L, Krapivinsky G, Krapivinsky L, Perez-Terzic C, Clapham DE. The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. J Biol Chem. 1995 Dec 15; 270(50):30068-74.
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  166. Krapivinsky G, Krapivinsky L, Wickman K, Clapham DE. G beta gamma binds directly to the G protein-gated K+ channel, IKACh. J Biol Chem. 1995 Dec 8; 270(49):29059-62.
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  167. Krapivinsky G, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. J Biol Chem. 1995 Dec 1; 270(48):28777-9.
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  168. Wickman K, Clapham DE. Ion channel regulation by G proteins. Physiol Rev. 1995 Oct; 75(4):865-85.
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  169. Clapham DE. Intracellular calcium. Replenishing the stores. Nature. 1995 Jun 22; 375(6533):634-5.
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  170. Wickman KD, Clapham DE. G-protein regulation of ion channels. Curr Opin Neurobiol. 1995 Jun; 5(3):278-85.
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  171. Krapivinsky G, Gordon EA, Wickman K, Velimirovic B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995 Mar 9; 374(6518):135-41.
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  172. Hedin KE, Appleby MW, Clapham DE. Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. Immunology. 1995 Feb; 84(2):183-92.
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  173. Clapham DE. Calcium signaling. Cell. 1995 Jan 27; 80(2):259-68.
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  174. Stehno-Bittel L, Lückhoff A, Clapham DE. Calcium release from the nucleus by InsP3 receptor channels. Neuron. 1995 Jan; 14(1):163-7.
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  175. Clapham DE, Sneyd J. Intracellular calcium waves. Adv Second Messenger Phosphoprotein Res. 1995; 30:1-24.
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  176. Clapham DE. Signal transduction. Why testicles are cool. Nature. 1994 Sep 8; 371(6493):109-10.
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  177. Lückhoff A, Clapham DE. Calcium channels activated by depletion of internal calcium stores in A431 cells. Biophys J. 1994 Jul; 67(1):177-82.
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  178. Wickman KD, Iñiguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 1994 Mar 17; 368(6468):255-7.
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  179. Krapivinsky GB, Ackerman MJ, Gordon EA, Krapivinsky LD, Clapham DE. Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. Cell. 1994 Feb 11; 76(3):439-48.
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  180. Ackerman MJ, Wickman KD, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. J Gen Physiol. 1994 Feb; 103(2):153-79.
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  181. Girard S, Clapham DE. Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes. Methods Cell Biol. 1994; 40:263-84.
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  182. Clapham DE. Direct G protein activation of ion channels? Annu Rev Neurosci. 1994; 17:441-64.
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  183. Stehno-Bittel L, Amundson J, Clapham D. G-protein-mediated pathways assayed by electrophysiology and confocal microscopy. Methods Enzymol. 1994; 238:321-35.
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  184. Ackerman MJ, Krapivinsky GB, Gordon E, Krapivinsky L, Clapham DC. Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes. Jpn J Physiol. 1994; 44 Suppl 2:S17-24.
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  185. Clapham DE. Mutations in G protein-linked receptors: novel insights on disease. Cell. 1993 Dec 31; 75(7):1237-9.
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  186. Chris Bliton, James Lechleiter, and David Clapham. Confocal imaging system for visible and ultraviolet light. 1993.
  187. Atri A, Amundson J, Clapham D, Sneyd J. A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte. Biophys J. 1993 Oct; 65(4):1727-39.
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  188. Clapham DE, Neer EJ. New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature. 1993 Sep 30; 365(6445):403-6.
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  189. Hedin KE, Duerson K, Clapham DE. Specificity of receptor-G protein interactions: searching for the structure behind the signal. Cell Signal. 1993 Sep; 5(5):505-18.
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  190. Clapham DE. Cellular calcium. A mysterious new influx factor? Nature. 1993 Aug 26; 364(6440):763-4.
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  191. Clapham DE. Reply. Trends Cardiovasc Med. 1993 Jul-Aug; 3(4):114.
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  192. Duerson K, Carroll R, Clapham D. Alpha-helical distorting substitution disrupt coupling between m3 muscarinic receptor and G proteins. FEBS Lett. 1993 Jun 7; 324(1):103-8.
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  193. Amundson J, Clapham D. Calcium waves. Curr Opin Neurobiol. 1993 Jun; 3(3):375-82.
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  194. Girard S, Clapham D. Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx. Science. 1993 Apr 9; 260(5105):229-32.
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  195. Sneyd J, Girard S, Clapham D. Calcium wave propagation by calcium-induced calcium release: an unusual excitable system. Bull Math Biol. 1993 Mar; 55(2):315-44.
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  196. Ackerman MJ, Clapham DE. Cardiac chloride channels. Trends Cardiovasc Med. 1993 Jan-Feb; 3(1):23-8.
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  197. Clapham DE, Lechleiter JD, Girard S. Intracellular waves observed by confocal microscopy from Xenopus oocytes. Adv Second Messenger Phosphoprotein Res. 1993; 28:161-5.
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  198. Lechleiter JD, Clapham DE. Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes. Cell. 1992 Apr 17; 69(2):283-94.
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  199. Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. Nature. 1992 Mar 19; 356(6366):238-41.
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  200. Girard S, Lückhoff A, Lechleiter J, Sneyd J, Clapham D. Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes. Biophys J. 1992 Feb; 61(2):509-17.
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  201. Lückhoff A, Clapham DE. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. Nature. 1992 Jan 23; 355(6358):356-8.
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  202. Lechleiter JD, Clapham DE. Spiral waves and intracellular calcium signalling. J Physiol Paris. 1992; 86(1-3):123-8.
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  203. Neer EJ, Clapham DE. Signal transduction through G proteins in the cardiac myocyte. Trends Cardiovasc Med. 1992 Jan-Feb; 2(1):6-11.
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  204. Wallert MA, Ackerman MJ, Kim D, Clapham DE. Two novel cardiac atrial K+ channels, IK.AA and IK.PC. J Gen Physiol. 1991 Nov; 98(5):921-39.
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  205. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Proc Natl Acad Sci U S A. 1991 Sep 1; 88(17):7892-5.
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  206. Tabares L, Mazzanti M, Clapham DE. Chloride channels in the nuclear membrane. J Membr Biol. 1991 Jul; 123(1):49-54.
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  207. Lechleiter J, Girard S, Clapham D, Peralta E. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. Nature. 1991 Apr 11; 350(6318):505-8.
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  208. Lechleiter J, Girard S, Peralta E, Clapham D. Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes. Science. 1991 Apr 5; 252(5002):123-6.
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  209. Lechleiter J, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. EMBO J. 1990 Dec; 9(13):4381-90.
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  210. Lewis DL, Lechleiter JD, Kim D, Nanavati C, Clapham DE. Intracellular regulation of ion channels in cell membranes. Mayo Clin Proc. 1990 Aug; 65(8):1127-43.
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  211. Clapham DE. Arachidonic acid and its metabolites in the regulation of G-protein gated K+ channels in atrial myocytes. Biochem Pharmacol. 1990 Mar 1; 39(5):813-5.
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  212. Nanavati C, Clapham DE, Ito H, Kurachi Y. A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel. Soc Gen Physiol Ser. 1990; 45:29-41.
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  213. Lechleiter J, Peralta E, Clapham D. Diverse functions of muscarinic acetylcholine receptor subtypes. Trends Pharmacol Sci. 1989 Dec; Suppl:34-8.
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  214. Lewis DL, Clapham DE. Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. Pflugers Arch. 1989 Aug; 414(4):492-4.
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  215. Kim D, Clapham DE. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science. 1989 Jun 9; 244(4909):1174-6.
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  216. Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature. 1989 Feb 9; 337(6207):557-60.
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  217. Clapham DE, Kim D. G protein activation mechanisms of the cardiac K+ channel, iK.ACh. Soc Gen Physiol Ser. 1989; 44:55-68.
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  218. Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5814-8.
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  219. Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. Circ Res. 1988 Jun; 62(6):1059-64.
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  220. Clapham D, Neer E. Activation of atrial muscarinic-gated K+ channels by beta gamma-subunits of G proteins. Am J Physiol. 1988 Jun; 254(6 Pt 2):H1224.
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  221. Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. Hypertension. 1988 Jun; 11(6 Pt 2):563-72.
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  222. Neer EJ, Clapham DE. Roles of G protein subunits in transmembrane signalling. Nature. 1988 May 12; 333(6169):129-34.
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  223. Fish RD, Sperti G, Colucci WS, Clapham DE. Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circ Res. 1988 May; 62(5):1049-54.
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  224. Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature. 1988 Jan 14; 331(6152):168-70.
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  225. Clapham DE, Logothetis DE. Delayed rectifier K+ current in embryonic chick heart ventricle. Am J Physiol. 1988 Jan; 254(1 Pt 2):H192-7.
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  226. Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 1987 Jan 22-28; 325(6102):321-6.
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  227. Bormann J, Clapham DE. gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. Proc Natl Acad Sci U S A. 1985 Apr; 82(7):2168-72.
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  228. Clapham DE, Neher E. Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. J Physiol. 1984 Aug; 353:541-64.
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  229. Ypey DL, Clapham DE. Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. Proc Natl Acad Sci U S A. 1984 May; 81(10):3083-7.
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  230. Clapham DE, Neher E. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. J Physiol. 1984 Feb; 347:255-77.
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  231. Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. Biophys J. 1984 Jan; 45(1):40-2.
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  232. Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. J Membr Biol. 1982; 67(1):63-71.
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  233. Clapham DE, Shrier A, DeHaan RL. Junctional resistance and action potential delay between embryonic heart cell aggregates. J Gen Physiol. 1980 Jun; 75(6):633-54.
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  234. Ypey DL, Clapham DE, DeHaan RL. Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. J Membr Biol. 1979 Dec 12; 51(1):75-96.
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  235. David E. Clapham. A whole tissue model of the heart cell aggregate: electrical coupling between cells, membrane impedance, and the role of the extracellular space. 1979.
  236. Clapham DE, De Felice LJ. The theoretical small signal impedance of the frog node, Rana pipiens. Pflugers Arch. 1976 Nov 5; 366(2-3):273-6.
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