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Institution

Amin Iskandar Kassis, Ph.D.

TitleProfessor of Radiology, Emeritus
InstitutionHarvard Medical School
DepartmentEmeritus
AddressHarvard Medical School
Radiology, Armenise Bldg
200 Longwood Ave
Boston MA 02115
Phone617/398-2400
Fax617/398-2469

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ngwa W, Korideck H, Kassis AI, Kumar R, Sridhar S, Makrigiorgos GM, Cormack RA. In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds. Nanomedicine. 2013 Jan; 9(1):25-7.
    View in: PubMed
  2. Balagurumoorthy P, Xu X, Wang K, Adelstein SJ, Kassis AI. Effect of distance between decaying (125)I and DNA on Auger-electron induced double-strand break yield. Int J Radiat Biol. 2012 Dec; 88(12):998-1008.
    View in: PubMed
  3. Mamlouk O, Balagurumoorthy P, Wang K, Adelstein SJ, Kassis AI. Bystander effect in tumor cells produced by Iodine-125 labeled human lymphocytes. Int J Radiat Biol. 2012 Dec; 88(12):1019-27.
    View in: PubMed
  4. Pospisil P, Korideck H, Wang K, Yang Y, Iyer LK, Kassis AI. Computational and biological evaluation of quinazolinone prodrug for targeting pancreatic cancer. Chem Biol Drug Des. 2012 Jun; 79(6):926-34.
    View in: PubMed
  5. Yang Y, Adelstein SJ, Kassis AI. Target discovery from data mining approaches. Drug Discov Today. 2012 Feb; 17 Suppl:S16-23.
    View in: PubMed
  6. Yang Y, Wang K, Li W, Adelstein SJ, Kassis AI. Human placental alkaline phosphatase-mediated hydrolysis correlates tightly with the electrostatic contribution from tail group. Chem Biol Drug Des. 2011 Dec; 78(6):923-31.
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  7. Balagurumoorthy P, Adelstein SJ, Kassis AI. Novel method for quantifying radiation-induced single-strand-break yields in plasmid DNA highlights 10-fold discrepancy. Anal Biochem. 2011 Oct 15; 417(2):242-6.
    View in: PubMed
  8. Yang Y, Adelstein SJ, Kassis AI. General approach to identifying potential targets for cancer imaging by integrated bioinformatics analysis of publicly available genomic profiles. Mol Imaging. 2011 Apr; 10(2):123-34.
    View in: PubMed
  9. Yang Y, Adelstein SJ, Kassis AI. Integrated bioinformatics analysis for cancer target identification. Methods Mol Biol. 2011; 719:527-45.
    View in: PubMed
  10. Kassis AI. Molecular and cellular radiobiological effects of Auger emitting radionuclides. Radiat Prot Dosimetry. 2011 Feb; 143(2-4):241-7.
    View in: PubMed
  11. Zhu X, Palmer MR, Makrigiorgos GM, Kassis AI. Solid-tumor radionuclide therapy dosimetry: new paradigms in view of tumor microenvironment and angiogenesis. Med Phys. 2010 Jun; 37(6):2974-84.
    View in: PubMed
  12. Yang S Y, Adelstein J, Kassis AI. Putative molecular signatures for the imaging of prostate cancer. Expert Rev Mol Diagn. 2010 Jan; 10(1):65-74.
    View in: PubMed
  13. Yang Y, Adelstein SJ, Kassis AI. Target discovery from data mining approaches. Drug Discov Today. 2009 Feb; 14(3-4):147-54.
    View in: PubMed
  14. Singh A, Yang Y, Adelstein SJ, Kassis AI. Synthesis and application of molecular probe for detection of hydroxyl radicals produced by Na(125)I and gamma-rays in aqueous solution. Int J Radiat Biol. 2008 Dec; 84(12):1001-10.
    View in: PubMed
  15. Rebischung C, Hoffmann D, Stefani L, Desruet MD, Wang K, Adelstein SJ, Artignan X, Vincent F, Gauchez AS, Zhang H, Fagret D, Vuillez J, Kassis AI, Balosso J. First human treatment of resistant neoplastic meningitis by intrathecal administration of MTX plus (125)IUdR. Int J Radiat Biol. 2008 Dec; 84(12):1123-9.
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  16. Balagurumoorthy P, Wang K, Adelstein SJ, Kassis AI. DNA double-strand breaks induced by decay of (123)I-labeled Hoechst 33342: role of DNA topology. Int J Radiat Biol. 2008 Dec; 84(12):976-83.
    View in: PubMed
  17. Howell RW, Martin RF, Nikjoo H, Pomplun E, Terrissol M, Watanable R, Yasui L, Kassis AI, Adelstein SJ. Meeting overview. Int J Radiat Biol. 2008 Dec; 84(12):957-8.
    View in: PubMed
  18. Yang Y, Pospisil P, Iyer LK, Adelstein SJ, Kassis AI. Integrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer. PLoS One. 2008; 3(11):e3661.
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  19. Kassis AI. Therapeutic radionuclides: biophysical and radiobiologic principles. Semin Nucl Med. 2008 Sep; 38(5):358-66.
    View in: PubMed
  20. Balagurumoorthy P, Adelstein SJ, Kassis AI. Method to eliminate linear DNA from mixture containing nicked circular, supercoiled, and linear plasmid DNA. Anal Biochem. 2008 Oct 1; 381(1):172-4.
    View in: PubMed
  21. Balagurumoorthy P, Chen K, Adelstein SJ, Kassis AI. Auger electron-induced double-strand breaks depend on DNA topology. Radiat Res. 2008 Jul; 170(1):70-82.
    View in: PubMed
  22. Kassis AI, Korideck H, Wang K, Pospisil P, Adelstein SJ. Novel prodrugs for targeting diagnostic and therapeutic radionuclides to solid tumors. Molecules. 2008; 13(2):391-404.
    View in: PubMed
  23. Sgouros G, Knox SJ, Joiner MC, Morgan WF, Kassis AI. MIRD continuing education: Bystander and low dose-rate effects: are these relevant to radionuclide therapy? J Nucl Med. 2007 Oct; 48(10):1683-91.
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  24. Wang K, Adelstein SJ, Kassis AI. DMSO increases radioiodination yield of radiopharmaceuticals. Appl Radiat Isot. 2008 Jan; 66(1):50-9.
    View in: PubMed
  25. Singh A, Chen K, Adelstein SJ, Kassis AI. Synthesis of coumarin-polyamine-based molecular probe for the detection of hydroxyl radicals generated by gamma radiation. Radiat Res. 2007 Aug; 168(2):233-42.
    View in: PubMed
  26. Wang K, Kirichian AM, Aowad AF, Adelstein SJ, Kassis AI. Evaluation of chemical, physical, and biologic properties of tumor-targeting radioiodinated quinazolinone derivative. Bioconjug Chem. 2007 May-Jun; 18(3):754-64.
    View in: PubMed
  27. Pospisil P, Wang K, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors. Cancer Res. 2007 Mar 1; 67(5):2197-205.
    View in: PubMed
  28. Yasui LS, Chen K, Wang K, Jones TP, Caldwell J, Guse D, Kassis AI. Using Hoechst 33342 to target radioactivity to the cell nucleus. Radiat Res. 2007 Feb; 167(2):167-75.
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  29. Chen K, Aowad AF, Adelstein SJ, Kassis AI. Molecular-docking-guided design, synthesis, and biologic evaluation of radioiodinated quinazolinone prodrugs. J Med Chem. 2007 Feb 22; 50(4):663-73.
    View in: PubMed
  30. Chen K, Wang K, Kirichian AM, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy. Mol Cancer Ther. 2006 Dec; 5(12):3001-13.
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  31. Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AI. Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure. Nucl Med Biol. 2006 Nov; 33(8):1055-63.
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  32. Balagurumoorthy P, Chen K, Bash RC, Adelstein SJ, Kassis AI. Mechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst. Radiat Res. 2006 Aug; 166(2):333-44.
    View in: PubMed
  33. Pospisil P, Iyer LK, Adelstein SJ, Kassis AI. A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics. 2006; 7:354.
    View in: PubMed
  34. Kishikawa H, Wang K, Adelstein SJ, Kassis AI. Inhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123. Radiat Res. 2006 Jun; 165(6):688-94.
    View in: PubMed
  35. Kassis AI. Radiotargeting agents for cancer therapy. Expert Opin Drug Deliv. 2005 Nov; 2(6):981-91.
    View in: PubMed
  36. Semnani ES, Wang K, Adelstein SJ, Kassis AI. 5-[123I/125I]iodo-2'-deoxyuridine in metastatic lung cancer: radiopharmaceutical formulation affects targeting. J Nucl Med. 2005 May; 46(5):800-6.
    View in: PubMed
  37. Kassis AI, Adelstein SJ. Radiobiologic principles in radionuclide therapy. J Nucl Med. 2005 Jan; 46 Suppl 1:4S-12S.
    View in: PubMed
  38. Urashima T, Wang K, Adelstein SJ, Kassis AI. Activation of diverse pathways to apoptosis by (125)IdUrd and gamma-photon exposure. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):867-74.
    View in: PubMed
  39. Chen K, Adelstein SJ, Kassis AI. Molecular simulation of ligand-binding with DNA: implications for 125I-labeled pharmaceutical design. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):921-6.
    View in: PubMed
  40. Kassis AI. The amazing world of auger electrons. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):789-803.
    View in: PubMed
  41. Kassis AI, Kirichian AM, Wang K, Semnani ES, Adelstein SJ. Therapeutic potential of 5-[125I]iodo-2'-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):941-6.
    View in: PubMed
  42. Kassis AI. In vivo validation of the bystander effect. Hum Exp Toxicol. 2004 Feb; 23(2):71-3.
    View in: PubMed
  43. Bodei L, Kassis AI, Adelstein SJ, Mariani G. Radionuclide therapy with iodine-125 and other auger-electron-emitting radionuclides: experimental models and clinical applications. Cancer Biother Radiopharm. 2003 Dec; 18(6):861-77.
    View in: PubMed
  44. Kassis AI. Cancer therapy with Auger electrons: are we almost there? J Nucl Med. 2003 Sep; 44(9):1479-81.
    View in: PubMed
  45. Adelstein SJ, Kassis AI, Bodei L, Mariani G. Radiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy. Cancer Biother Radiopharm. 2003 Jun; 18(3):301-16.
    View in: PubMed
  46. Xue LY, Butler NJ, Makrigiorgos GM, Adelstein SJ, Kassis AI. Bystander effect produced by radiolabeled tumor cells in vivo. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13765-70.
    View in: PubMed
  47. Ho NH, Harapanhalli RS, Dahman BA, Chen K, Wang K, Adelstein SJ, Kassis AI. Synthesis and biologic evaluation of a radioiodinated quinazolinone derivative for enzyme-mediated insolubilization therapy. Bioconjug Chem. 2002 Mar-Apr; 13(2):357-64.
    View in: PubMed
  48. Kundra V, Mannting F, Jones AG, Kassis AI. Noninvasive monitoring of somatostatin receptor type 2 chimeric gene transfer. J Nucl Med. 2002 Mar; 43(3):406-12.
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  49. Ho N, Tumeh PC, Kassis AI. Synthesis and biologic studies of iodinated (125I/127I) ethidium. Nucl Med Biol. 2001 Nov; 28(8):983-90.
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  50. Walicka MA, Adelstein SJ, Kassis AI. Chemical modification of 5-[125I]iodo-2'-deoxyuridine toxicity in mammalian cells in vitro. Int J Radiat Biol. 2001 May; 77(5):625-30.
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  51. Goharderakhshan RZ, Grossfeld GD, Kassis A, Shinohara K, Roach M, Carroll PR. Additional treatments and reimbursement rates associated with prostate cancer treatment for patients undergoing radical prostatectomy, interstitial brachytherapy, and external beam radiotherapy. Urology. 2000 Oct 1; 56(4):622-6.
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  52. Walicka MA, Ding Y, Adelstein SJ, Kassis AI. Morphological transformation of C3H 10T1/2 cells by 99mTc-cardiolite. J Nucl Med. 2000 Sep; 41(9):1545-51.
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  53. Mariani G, Bodei L, Adelstein SJ, Kassis AI. Emerging roles for radiometabolic therapy of tumors based on auger electron emission. J Nucl Med. 2000 Sep; 41(9):1519-21.
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  54. Kassis AI, Walicka MA, Adelstein SJ. Double-strand break yield following 125I decay--effects of DNA conformation. Acta Oncol. 2000; 39(6):721-6.
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  55. Kassis AI, Dahman BA, Adelstein SJ. In vivo therapy of neoplastic meningitis with methotrexate and 5. Acta Oncol. 2000; 39(6):731-7.
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  56. Walicka MA, Ding Y, Roy AM, Harapanhalli RS, Adelstein SJ, Kassis AI. Cytotoxicity of [125I]iodoHoechst 33342: contribution of scavengeable effects. Int J Radiat Biol. 1999 Dec; 75(12):1579-87.
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  57. Kassis AI, Harapanhalli RS, Adelstein SJ. Strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125: direct compared to indirect effects. Radiat Res. 1999 Nov; 152(5):530-8.
    View in: PubMed
  58. Kassis AI, Harapanhalli RS, Adelstein SJ. Comparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125. Radiat Res. 1999 Feb; 151(2):167-76.
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  59. Maulik G, Kassis AI, Savvides P, Makrigiorgos GM. Fluoresceinated phosphoethanolamine for flow-cytometric measurement of lipid peroxidation. Free Radic Biol Med. 1998 Oct; 25(6):645-53.
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  60. Walicka MA, Vaidyanathan G, Zalutsky MR, Adelstein SJ, Kassis AI. Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. Radiat Res. 1998 Sep; 150(3):263-8.
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  61. Kassis AI, Wen PY, Van den Abbeele AD, Baranowska-Kortylewicz J, Makrigiorgos GM, Metz KR, Matalka KZ, Cook CU, Sahu SK, Black PM, Adelstein SJ. 5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats. J Nucl Med. 1998 Jul; 39(7):1148-54.
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  62. Harapanhalli RS, Roy AM, Adelstein SJ, Kassis AI. [125I/127I/131I]Iodorhodamine: synthesis, cellular localization, and biodistribution in athymic mice bearing human tumor xenografts and comparison with [99mTc]hexakis(2-methoxyisobutylisonitrile). J Med Chem. 1998 Jun 4; 41(12):2111-7.
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  63. Harapanhalli RS, Matalka KZ, Jones PL, Mahmood A, Adelstein SJ, Kassis AI. Lysine-directed conjugation of ethidium homodimer to B72.3 antibody: retention of immunoreactivity but altered tumor targeting. Nucl Med Biol. 1998 Apr; 25(3):267-78.
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  64. Walicka MA, Adelstein SJ, Kassis AI. Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: double-strand breaks. Radiat Res. 1998 Feb; 149(2):134-41.
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  65. Walicka MA, Adelstein SJ, Kassis AI. Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: clonogenic survival. Radiat Res. 1998 Feb; 149(2):142-6.
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  66. Chakrabarti S, Kassis AI, Slayter HS, Bump EA, Sahu SK, Makrigiorgos GM. Continuous detection of radiation or metal generated hydroxyl radicals within core chromatin particles. Int J Radiat Biol. 1998 Jan; 73(1):53-63.
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  67. Anderson LL, Lau CC, Gracely EJ, Berkowitz RS, Kassis AI. Enhancement of 131I-mediated cytotoxicity by caffeine. Gynecol Oncol. 1997 May; 65(2):253-7.
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  68. Sahu SK, Kortylewicz ZP, Baranowska-Kortylewicz J, Taube RA, Adelstein SJ, Kassis AI. Strand breaks after the decay of iodine-125 in proximity to plasmid pBR322 DNA. Radiat Res. 1997 Apr; 147(4):401-8.
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  69. Sahu SK, Wen PY, Foulon CF, Nagel JS, Black PM, Adelstein SJ, Kassis AI. Intrathecal 5-[125I]iodo-2'-deoxyuridine in a rat model of leptomeningeal metastases. J Nucl Med. 1997 Mar; 38(3):386-90.
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  70. Makrigiorgos GM, Kassis AI, Mahmood A, Bump EA, Savvides P. Novel fluorescein-based flow-cytometric method for detection of lipid peroxidation. Free Radic Biol Med. 1997; 22(1-2):93-100.
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  71. Harapanhalli RS, McLaughlin LW, Howell RW, Rao DV, Adelstein SJ, Kassis AI. [125I/127I]iodoHoechst 33342: synthesis, DNA binding, and biodistribution. J Med Chem. 1996 Nov 22; 39(24):4804-9.
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  72. Chakrabarti S, Mahmood A, Kassis AI, Bump EA, Jones AG, Makrigiorgos GM. Generation of hydroxyl radicals by nucleohistone-bound metal-adriamycin complexes. Free Radic Res. 1996 Sep; 25(3):207-20.
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  73. Kassis AI, Adelstein SJ, Mariani G. Radiolabeled nucleoside analogs in cancer diagnosis and therapy. Q J Nucl Med. 1996 Sep; 40(3):301-19.
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  74. Kassis AI, Tumeh SS, Wen PY, Baranowska-Kortylewicz J, Van den Abbeele AD, Zimmerman RE, Carvalho PA, Garada BM, DeSisto WC, Bailey NO, Castronovo FP, Mariani G, Black PM, Adelstein SJ. Intratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patient with a brain tumor. J Nucl Med. 1996 Apr; 37(4 Suppl):19S-22S.
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  75. Mariani G, Collecchi P, Baldassarri S, Di Luca L, Buralli S, Fontanini G, Baranowska-Kortylewicz J, Adelstein SJ, Kassis AI. Tumor uptake and mitotic activity pattern of 5-[125I]iodo-2'- deoxyuridine after intravesical infusion in patients with bladder cancer. J Nucl Med. 1996 Apr; 37(4 Suppl):16S-19S.
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  76. Mariani G, Di Sacco S, Volterrani D, Di Luca L, Buralli S, Di Stefano R, Baranowska-Kortylewicz J, Bonora D, Matteucci F, Ricci S, Bellina CR, Falcone A, Salvadori PA, Mosca F, Adelstein SJ, Kassis AI. Tumor targeting by intra-arterial infusion of 5-[123I]iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer. J Nucl Med. 1996 Apr; 37(4 Suppl):22S-25S.
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  77. Foulon CF, Adelstein SJ, Kassis AI. Kit formulation for the preparation of radiolabeled iododeoxyuridine by demetallation. J Nucl Med. 1996 Apr; 37(4 Suppl):1S-3S.
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  78. Kassis AI, Adelstein SJ. Preclinical animal studies with radioiododeoxyuridine. J Nucl Med. 1996 Apr; 37(4 Suppl):10S-12S.
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  79. Kassis AI, Jones PL, Matalka KZ, Adelstein SJ. Antibody-dependent signal amplification in tumor xenografts after pretreatment with biotinylated monoclonal antibody and avidin or streptavidin. J Nucl Med. 1996 Feb; 37(2):343-52.
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  80. Van den Abbeele AD, Tutrone RF, Berman RM, Baranowska-Kortylewicz J, Barclay PD, Richie JP, Adelstein SJ, Kassis AI. Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer. J Nucl Med. 1996 Feb; 37(2):315-20.
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  81. Adelstein SJ, Kassis AI. Strand breaks in plasmid DNA following positional changes of Auger-electron-emitting radionuclides. Acta Oncol. 1996; 35(7):797-801.
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  82. Chakrabarti S, Makrigiorgos GM, O'Brien K, Bump E, Kassis AI. Measurement of hydroxyl radicals catalyzed in the immediate vicinity of DNA by metal-bleomycin complexes. Free Radic Biol Med. 1996; 20(6):777-83.
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  83. Mariani G, Di Sacco S, Bonini R, Di Luca L, Buralli S, Bonora D, Ricci S, Baranowska-Kortylewicz J, Adelstein SJ, Falcone A, Kassis AI. Biochemical modulation by 5-fluorouracil and 1-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'deoxyuridine in patients with liver metastases from colorectal cancer. Acta Oncol. 1996; 35(7):941-5.
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  84. Kassis AI, Adelstein SJ. 5-[125]iodo-2'-deoxyuridine in the radiotherapy of solid CNS tumors in rats. Acta Oncol. 1996; 35(7):935-9.
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  85. Muto MG, Kassis AI. Monoclonal antibodies used in the detection and treatment of epithelial ovarian cancer. Cancer. 1995 Nov 15; 76(10 Suppl):2016-27.
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  86. Foulon CF, Zhang YZ, Adelstein SJ, Kassis AI. Instantaneous preparation of radiolabeled 5-iodo-2'-deoxyuridine. Appl Radiat Isot. 1995 Oct; 46(10):1039-46.
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  87. Gangopadhyay A, Saravis CA, van den Abbeele AD, Kassis AI. pI-dependent isolation of antibody isoforms by semipreparative isoelectric focusing. Q J Nucl Med. 1995 Jun; 39(2):129-33.
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  88. Makrigiorgos GM, Bump E, Huang C, Baranowska-Kortylewicz J, Kassis AI. A fluorimetric method for the detection of copper-mediated hydroxyl free radicals in the immediate proximity of DNA. Free Radic Biol Med. 1995 Apr; 18(4):669-78.
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  89. Sahu SK, Kassis AI, Makrigiorgos GM, Baranowska-Kortylewicz J, Adelstein SJ. The effects of indium-111 decay on pBR322 DNA. Radiat Res. 1995 Feb; 141(2):193-8.
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  90. Howell RW, Kassis AI, Adelstein SJ, Rao DV, Wright HA, Hamm RN, Turner JE, Sastry KS. Radiotoxicity of platinum-195m-labeled trans-platinum (II) in mammalian cells. Radiat Res. 1994 Oct; 140(1):55-62.
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  91. Makrigiorgos GM, Bump E, Huang C, Baranowska-Kortylewicz J, Kassis AI. Accessibility of nucleic acid-complexed biomolecules to hydroxyl radicals correlates with their conformation: a fluorescence polarization spectroscopy study. Int J Radiat Biol. 1994 Sep; 66(3):247-57.
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  92. Makrigiorgos GM, Folkard M, Huang C, Bump E, Baranowska-Kortylewicz J, Sahu SK, Michael BD, Kassis AI. Quantification of radiation-induced hydroxyl radicals within nucleohistones using a molecular fluorescent probe. Radiat Res. 1994 May; 138(2):177-85.
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  93. Gangopadhyay A, Saravis CA, Kassis AI. Semipreparative isoelectrophoresis of DTPA-conjugated antibody leads to isolation of antibody isoforms with different immunoreactivities. J Nucl Biol Med. 1994 Mar; 38(1):61-7.
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  94. Speidel MT, Holmquist B, Kassis AI, Humm JL, Berman RM, Atcher RW, Hines JJ, Macklis RM. Morphological, biochemical, and molecular changes in endothelial cells after alpha-particle irradiation. Radiat Res. 1993 Dec; 136(3):373-81.
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  95. Baranowska-Kortylewicz J, Kassis AI. Labeling of sulfhydryl groups in intact mammalian cells with coumarins. Bioconjug Chem. 1993 Jul-Aug; 4(4):305-7.
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  96. Baranowska-Kortylewicz J, Kassis AI. Labeling of immunoglobulins with bifunctional, sulfhydryl-selective, and photoreactive coumarins. Bioconjug Chem. 1993 Jul-Aug; 4(4):300-4.
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  97. Makrigiorgos GM, Baranowska-Kortylewicz J, Bump E, Sahu SK, Berman RM, Kassis AI. A method for detection of hydroxyl radicals in the vicinity of biomolecules using radiation-induced fluorescence of coumarin. Int J Radiat Biol. 1993 Apr; 63(4):445-58.
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  98. Kinsey BM, Kassis AI. Synthesis and biological activity of 125I/127I-phenylboronic acid derivatives. Nucl Med Biol. 1993 Jan; 20(1):13-22.
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  99. Muto MG, Finkler NJ, Kassis AI, Howes AE, Anderson LL, Lau CC, Zurawski VR, Weadock K, Tumeh SS, Lavin P, et al. Intraperitoneal radioimmunotherapy of refractory ovarian carcinoma utilizing iodine-131-labeled monoclonal antibody OC125. Gynecol Oncol. 1992 Jun; 45(3):265-72.
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  100. Kassis AI. The MIRD approach: remembering the limitations. J Nucl Med. 1992 May; 33(5):781-2.
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  101. Khawli LA, Kassis AI. m-[125I]iodoaniline: a useful reagent for radiolabeling biotin. Int J Rad Appl Instrum B. 1992 Apr; 19(3):297-301.
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  102. Khawli LA, van den Abbeele AD, Kassis AI. N-(m-[125I]iodophenyl)maleimide: an agent for high yield radiolabeling of antibodies. Int J Rad Appl Instrum B. 1992 Apr; 19(3):289-95.
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  103. Makrigiorgos GM, Berman RM, Baranowska-Kortylewicz J, Bump E, Humm JL, Adelstein SJ, Kassis AI. DNA damage produced in V79 cells by DNA-incorporated iodine-123: a comparison with iodine-125. Radiat Res. 1992 Mar; 129(3):309-14.
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  104. Kassis AI, Adelstein SJ. Does nonuniformity of dose have implications for radiation protection? J Nucl Med. 1992 Mar; 33(3):384-7.
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  105. Baranowska-Kortylewicz J, Makrigiorgos GM, Van den Abbeele AD, Berman RM, Adelstein SJ, Kassis AI. 5-[123I]iodo-2'-deoxyuridine in the radiotherapy of an early ascites tumor model. Int J Radiat Oncol Biol Phys. 1991 Nov; 21(6):1541-51.
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  106. Kassis AI. Optimizing antibodies for use in nuclear medicine. J Nucl Med. 1991 Sep; 32(9):1751-3.
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  107. Kassis AI, Guptill WE, Taube RA, Adelstein SJ. Radiotoxicity of 5-[125I]iodo-2'-deoxyuridine in mammalian cells following treatment with 5-fluoro-2'-deoxyuridine. J Nucl Biol Med. 1991 Jul-Sep; 35(3):167-73.
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  108. Janicek MJ, Van den Abbeele AD, DeSisto WC, Kassis AI, Holman BL, Tumeh SS, Hollenberg NK. Embolization of platelets after endothelial injury to the aorta in rabbits. Assessment with 111indium-labeled platelets and angiography. Invest Radiol. 1991 Jul; 26(7):655-9.
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  109. Mariani G, Ito S, Nayak RC, Baranowska-Kortylewicz J, Venkateshan CN, Van den Abbeele AD, Eisenbarth GS, Adelstein SJ, Kassis AI. Capping and internalization of a monoclonal antibody-surface antigen complex: a possible mode of interaction of monoclonal antibodies and tumor cells. J Nucl Biol Med. 1991 Apr-Jun; 35(2):111-9.
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  110. Van den Abbeele AD, Aaronson RA, Daher S, Taube RA, Adelstein SJ, Kassis AI. Antigen-binding site protection during radiolabeling leads to a higher immunoreactive fraction. J Nucl Med. 1991 Jan; 32(1):116-22.
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  111. Adelstein SJ, Kassis AI, Baranowska-Kortylewicz J, van den Abbeele AD, Mariani G, Ito S. Potential for tumor therapy with iodine-125 labeled immunoglobulins. Int J Rad Appl Instrum B. 1991; 18(1):43-4.
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  112. Tumeh SS, Carvalho PA, van den Abbeele AD, Maguire JH, Rauh DA, Neptune M, Kassis AI. Detection of focal infection by 111In-human polyclonal IgG. J Nucl Biol Med. 1991 Jan-Mar; 35(1):4-9.
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  113. Kassis AI. 5-123I/125I-iodo-2'-deoxyuridine for cancer diagnosis and therapy. J Nucl Med Allied Sci. 1990 Oct-Dec; 34(4):299-303.
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  114. Janicek MJ, Van den Abbeele AD, Hollenberg NK, Kassis AI, Holman BL, Tumeh SS. Platelet activation and aggregation after endothelial injury. Assessment with indium-111-labeled platelets and angiography. Invest Radiol. 1990 Sep; 25(9):988-93.
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  115. Kassis AI, Van den Abbeele AD, Wen PY, Baranowska-Kortylewicz J, Aaronson RA, DeSisto WC, Lampson LA, Black PM, Adelstein SJ. Specific uptake of the auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnostic and therapeutic implications in humans. Cancer Res. 1990 Aug 15; 50(16):5199-203.
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  116. Makrigiorgos GM, Adelstein SJ, Kassis AI. Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates. JAMA. 1990 Aug 1; 264(5):592-5.
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  117. Makrigiorgos GM, Ito S, Baranowska-Kortylewicz J, Vinter DW, Iqbal A, Van den Abbeele AD, Adelstein SJ, Kassis AI. Inhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implications. J Nucl Med. 1990 Aug; 31(8):1358-63.
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  118. Muto MG, Finkler NJ, Kassis AI, Lepisto EM, Knapp RC. Human anti-murine antibody responses in ovarian cancer patients undergoing radioimmunotherapy with the murine monoclonal antibody OC-125. Gynecol Oncol. 1990 Aug; 38(2):244-8.
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  119. Whaley JM, Kassis AI, Kinsey BM, Adelstein SJ, Little JB. Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells. Int J Radiat Biol. 1990 Jun; 57(6):1087-103.
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  120. van den Abbeele AD, Aaronson RA, Taube RA, Adelstein SJ, Kassis AI. Preadsorption of radiolabeled monoclonal antibodies to liver and spleen tissues leads to higher tumor-to-normal-tissue ratios. J Nucl Med Allied Sci. 1990 Apr-Jun; 34(2):94-102.
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  121. Livni E, Ito S, Kassis AI, Elmaleh DR. (3H/14C)beta-methylheptadecanoic acid subcellular distribution and lipid incorporation in mouse heart. Lipids. 1990 Apr; 25(4):238-40.
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  122. Kinsey BM, Fayad F, Venkateshan CN, Adelstein SJ, Kassis AI. Synthesis and biological activity of the intercalating agent 3-acetamido-5-[123/125I]iodo-6-aminoacridine. Int J Rad Appl Instrum B. 1990; 17(3):341-6.
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  123. Makrigiorgos G, Adelstein SJ, Kassis AI. Auger electron emitters: insights gained from in vitro experiments. Radiat Environ Biophys. 1990; 29(2):75-91.
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  124. Baranowska-Kortylewicz J, Berman RM, Kaldany A, Eisenbarth GS, Kassis AI. Immunoradiometric assay for antibodies recognizing antigenic gangliosides. J Nucl Med Allied Sci. 1990 Jan-Mar; 34(1):34-41.
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  125. Baranowska-Kortylewicz J, Adelstein SJ, Kassis AI. 5-iodo-2'-deoxyuridine-protein conjugates: synthesis and enzymatic degradation. Sel Cancer Ther. 1990; 6(1):1-13.
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  126. Mariani G, Kassis AI, Adelstein SJ. Antibody internalization by tumor cells: implications for tumor diagnosis and therapy. J Nucl Med Allied Sci. 1990 Jan-Mar; 34(1):51-4.
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  127. Makrigiorgos GM, Adelstein SJ, Kassis AI. Limitations of conventional internal dosimetry at the cellular level. J Nucl Med. 1989 Nov; 30(11):1856-64.
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  128. Kinsey BM, Van den Abbeele AD, Adelstein SJ, Kassis AI. Absence of preferential uptake of [125I]iododihydrorhodamine 123 by four human tumor xenografts. Cancer Res. 1989 Nov 1; 49(21):5986-8.
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  129. Muto MG, Lepisto EM, Van den Abbeele AD, Knapp RC, Kassis AI. Influence of human antimurine antibody on CA 125 levels in patients with ovarian cancer undergoing radioimmunotherapy or immunoscintigraphy with murine monoclonal antibody OC 125. Am J Obstet Gynecol. 1989 Nov; 161(5):1206-12.
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  130. Finkler NJ, Muto MG, Kassis AI, Weadock K, Tumeh SS, Zurawski VR, Knapp RC. Intraperitoneal radiolabeled OC 125 in patients with advanced ovarian cancer. Gynecol Oncol. 1989 Sep; 34(3):339-44.
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  131. Makrigiorgos GM, Kassis AI, Baranowska-Kortylewicz J, McElvany KD, Welch MJ, Sastry KS, Adelstein SJ. Radiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: a comparison with 5-[125I]iodo-2'-deoxyuridine. Radiat Res. 1989 Jun; 118(3):532-44.
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  132. Kassis AI, Fayad F, Kinsey BM, Sastry KS, Adelstein SJ. Radiotoxicity of an 125I-labeled DNA intercalator in mammalian cells. Radiat Res. 1989 May; 118(2):283-94.
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  133. Weadock KS, Anderson LL, Kassis AI. A simple remote system for the high-level radioiodination of monoclonal antibodies. J Nucl Med Allied Sci. 1989 Jan-Mar; 33(1):37-41.
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  134. Mariani G, Abbeele AD, Venkateshan CN, Kaldany A, Ito S, Adelstein SJ, Kassis AI. Monoclonal antibody internalization by tumor cells: an experimental model for potential radioimmunotherapy applications. Int J Rad Appl Instrum B. 1989; 16(2):147-50.
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  135. Khawli LA, Kassis AI. Synthesis of 125I labeled N-succinimidyl p-iodobenzoate for use in radiolabeling antibodies. Int J Rad Appl Instrum B. 1989; 16(7):727-33.
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  136. Van den Abbeele AD, Aaronson RA, Adelstein SJ, Kassis AI. Does the in vitro testing of the immunoreactivity of an antibody reflect its in vivo behavior? J Nucl Med Allied Sci. 1988 Oct-Dec; 32(4):260-7.
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  137. Macklis RM, Kaplan WD, Ferrara JL, Kinsey BM, Kassis AI, Burakoff SJ. Biodistribution studies of anti-Thy 1.2 IgM immunoconjugates: implications for radioimmunotherapy. Int J Radiat Oncol Biol Phys. 1988 Aug; 15(2):383-9.
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  138. Macklis RM, Kinsey BM, Kassis AI, Ferrara JL, Atcher RW, Hines JJ, Coleman CN, Adelstein SJ, Burakoff SJ. Radioimmunotherapy with alpha-particle-emitting immunoconjugates. Science. 1988 May 20; 240(4855):1024-6.
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  139. Baranowska-Kortylewicz J, Kinsey BM, Layne WW, Kassis AI. Radioiododemercuration: a simple synthesis of 5-[123/125/127I]iodo-2'-deoxyuridine. Int J Rad Appl Instrum A. 1988; 39(4):335-41.
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  140. Kinsey BM, Macklis RM, Ferrara JM, Layne WW, Burakoff SJ, Kassis AI. Efficient conjugation of DTPA to an IgM monoclonal antibody in ascites fluid. Int J Rad Appl Instrum B. 1988; 15(3):285-92.
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  141. Kinsey BM, Kassis AI, Fayad F, Layne WW, Adelstein SJ. Synthesis and biological studies of iodinated (127/125I) derivatives of rhodamine 123. J Med Chem. 1987 Oct; 30(10):1757-61.
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  142. Kassis AI, Fayad F, Kinsey BM, Sastry KS, Taube RA, Adelstein SJ. Radiotoxicity of 125I in mammalian cells. Radiat Res. 1987 Aug; 111(2):305-18.
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  143. Layne WW, Kassis AI, Van den Abbeele A, Kinsey BM, Adelstein SJ. HPLC analysis of the dissociation and recombination of rabbit immunoglobulin G. J Immunol Methods. 1987 Feb 11; 96(2):195-9.
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  144. Kassis AI, Taube RA. Efficient radiolabeling of mammalian cells using 111In-tagged liposomes. Int J Rad Appl Instrum B. 1987; 14(1):33-5.
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  145. Adelstein SJ, Kassis AI. Radiobiologic implications of the microscopic distribution of energy from radionuclides. Int J Rad Appl Instrum B. 1987; 14(3):165-9.
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  146. Kassis AI, Sastry KS, Adelstein SJ. Kinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes. Radiat Res. 1987 Jan; 109(1):78-89.
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  147. Huberman MS, Lokich JJ, Hill T, Kaldany A, Kassis A, Price T, Moore C, Davis S, Kasulis P, Monaco AP, et al. Non-human primate (baboon) anti-carcinoembryonic antigen antibody infusion in patients with metastatic adenocarcinoma. A phase I study. Cancer Immunol Immunother. 1986; 23(2):137-42.
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  148. Kassis AI, Harris CR, Adelstein SJ, Ruth TJ, Lambrecht R, Wolf AP. The in vitro radiobiology of astatine-211 decay. Radiat Res. 1986 Jan; 105(1):27-36.
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  149. Kassis AI, Adelstein SJ. Chemotoxicity of indium-111 oxine in mammalian cells. J Nucl Med. 1985 Feb; 26(2):187-90.
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  150. Kassis AI, Sastry KS, Adelstein SJ. Intracellular distribution and radiotoxicity of chromium-51 in mammalian cells: Auger-electron dosimetry. J Nucl Med. 1985 Jan; 26(1):59-67.
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  151. Jones AG, Abrams MJ, Davison A, Brodack JW, Toothaker AK, Adelstein SJ, Kassis AI. Biological studies of a new class of technetium complexes: the hexakis(alkylisonitrile)technetium(I) cations. Int J Nucl Med Biol. 1984; 11(3-4):225-34.
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  152. Kassis AI, Adelstein SJ, Haydock C, Sastry KS. Thallium-201: an experimental and a theoretical radiobiological approach to dosimetry. J Nucl Med. 1983 Dec; 24(12):1164-75.
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  153. Kassis AI, Adelstein SJ, Wolf AP, Fowler JG, Shiue CY. Transient toxicity of 2-deoxy-2-[18F]fluoro-D-glucose in mammalian cells: concise communication. J Nucl Med. 1983 Nov; 24(11):1055-9.
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  154. Kassis AI, Adelstein SJ, Haydock C, Sastry KS, McElvany KD, Welch MJ. Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells. Radiat Res. 1982 May; 90(2):362-73.
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  155. Kassis AI, Adelstein SJ, Haydock C, Sastry KS. Radiotoxicity of 75Se and 35S: theory and application to a cellular model. Radiat Res. 1980 Dec; 84(3):407-25.
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  156. Kassis AI, Adelstein SJ. A rapid and reproducible method for the separation of cells from radioactive media. J Nucl Med. 1980 Jan; 21(1):88-90.
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  157. Kassis AI, Warren KS, Mahmoud AA. Antibody-dependent complement-mediated killing of schistosomula in intraperitoneal diffusion chambers in mice. J Immunol. 1979 Oct; 123(4):1659-62.
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  158. Kassis AI, Aikawa M, Mahmoud AF. Mouse antibody-dependent eosinophil and macrophage adherence and damage to schistosomula of Schistosoma mansoni. J Immunol. 1979 Feb; 122(2):398-405.
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  159. Kassis AI, Warren KS, Mahmoud AA. The Schistosoma haematobium egg granuloma. Cell Immunol. 1978 Jul; 38(2):310-8.
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  160. Kassis AI, Tanner CE. Echinococcus multilocularis: complement's role in vivo in hydatid disease. Exp Parasitol. 1977 Dec; 43(2):390-5.
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  161. Kassis AI, Tanner CE. Host serum proteins in Echinococcus multilocularis: complement activation via the classical pathway. Immunology. 1977 Jul; 33(1):1-9.
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  162. Kassis AI, Tanner CE. Novel approach to the treatment of hydatid disease. Nature. 1976 Aug 12; 262(5569):588-9.
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  163. Kassis AI, Goh SL, Tanner CE. Lesions induced by complement in vitro on the protoscoleces of Echinococcus multilocularis: a study by electron microscopy. Int J Parasitol. 1976 Jun; 6(3):199-211.
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  164. Kassis AI, Tanner CE. The role of complement in hydatid disease: in vitro studies. Int J Parasitol. 1976 Feb; 6(1):25-35.
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