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Michael W. Retsky, Ph.D.

TitleResearch Associate
InstitutionHarvard School of Public Health
DepartmentEH - Molecular+Integrative Phys Sci Prog
AddressHarvard School of Public Health
Sph1-1312
665 Huntington Ave
Boston MA 02115
Phone2036750017

 Overview 
 overview
Michael Retsky divides his activities between cancer research at HSPH and electron beam technology at a small business. (See US patent 7282727 for an example of Retsky’s involvement with electron beam technology. This invention was a patriotic reaction after 9-11 terrorist attack. It describes a "Star Wars" type ballistic missile defense. This directed energy weapon can produce trillion watt/cm2 electron energy bursts at a rate of 1 per second for weeks that could destroy a very large number of missiles and decoys within 1000 km. This rapid fire ability is allowed within Antiballistic Treaties and is far outside the capability of all other ballistic missile defenses. See http://www.google.com/patents/US7282727 ).

He is co-PI of a 3 year $600k breast cancer grant from Komen Foundation.

Retsky was apparently the first person to use low dose metronomic chemotherapy in 1994-1996 for treatment of stage IIIc colon cancer as described in the following two papers:

Retsky M, Metronomic Chemotherapy was Originally Designed and first used in 1994 for Early Stage Cancer - why is it Taking so Long to Proceed? Journal of Bioequivalence and Bioavailability, May 2011, Editorial http://www.omicsonline.org/0975-0851/JBB-Editorial6.pdf

MW Retsky; How long should adjuvant chemotherapy be given in early stage colon cancer? Clinical and Experimental Pathology. 3:1 2013.
http://www.omicsonline.org/2161-0681/2161-0681-3-136.digital/2161-0681-3-136.html


He is on the Board of Directors of Colon Cancer Alliance (www.ccalliance.org) and Editor-in-Chief of Journal of Bioequivalence and Bioavailability.

He is Honorary Faculty, University College London, UK and Professor Adj at UANL, Monterrey, Mexico.

Email contact michael.retsky@gmail.com and mretsky@hsph.harvard.edu
phone 203-675-0017.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Retsky M, Demicheli R, Hrushesky WJ, Forget P, De Kock M, Gukas I, Rogers RA, Baum M, Sukhatme V, Vaidya JS. Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review. Curr Med Chem. 2013; 20(33):4163-76.
    View in: PubMed
  2. Retsky M, Demicheli R, Hrushesky WJ, Forget P, De Kock M, Gukas I, Rogers RA, Baum M, Pachmann K, Vaidya JS. Promising development from translational or perhaps anti-translational research in breast cancer. Clin Transl Med. 2012; 1(1):17.
    View in: PubMed
  3. Retsky M, Rogers R, Demicheli R, Hrushesky WJ, Gukas I, Vaidya JS, Baum M, Forget P, Dekock M, Pachmann K. NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup. Breast Cancer Res Treat. 2012 Jul; 134(2):881-8.
    View in: PubMed
  4. Baum M, Thornton H, Gøtzsche PC, Bewley S, Jørgensen KJ, Barratt A, Ross N, Woloshin S, Schwartz L, Musiello T, Blennerhassett M, Napoli M, Baines CJ, Vaidya JS, Williams N, Havercroft D, Zahl PH, Retsky M, Kaplan RM, Dixon-Woods M, Berry DA, Isaacson K, Brahams D, Pryke M, Tindall G, Bender DA, Marshall T. Breast cancer awareness month. Still awaiting screening facts. BMJ. 2010; 341:c6152.
    View in: PubMed
  5. Retsky M, Demicheli R, Hrushesky W, Baum M, Gukas I. Surgery triggers outgrowth of latent distant disease in breast cancer: an inconvenient truth? Cancers (Basel). 2010; 2(2):305-37.
    View in: PubMed
  6. Retsky, M.; Demicheli, R.; Hrushesky, W.; Baum, M.; Gukas, I. Cancers. Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth?. 2010; 2:305-337.
  7. Retsky MW. Guest Editor's Concluding Remarks-Advances in Usage of ANN, Discussion of an Unsolved Problem, and Some Differences between Papers Written by Engineers and by Physicians. Sensors (Basel). 2009; 9(10):8126-9.
    View in: PubMed
  8. Retsky M. Comments on John D. Keen and James E. Keen, What is the point: will screening mammography save my life? BMC Medical Informatics and Decision Making, 2009. BMC Med Inform Decis Mak. 2009; 9:20.
    View in: PubMed
  9. Retsky M. New concepts in breast cancer emerge from analyzing clinical data using numerical algorithms. Int J Environ Res Public Health. 2009 Jan; 6(1):329-48.
    View in: PubMed
  10. Retsky, M. Int. J. Environ. Res. Public Health. New Concepts in Breast Cancer Emerge from Analyzing Clinical Data Using Numerical Algorithms. 2009; 6(1):329-348.
  11. Retsky MW, Hrushesky WJ, Gukas ID. Hypothesis: primary antiangiogenic method proposed to treat early stage breast cancer. BMC Cancer. 2009; 9:7.
    View in: PubMed
  12. Demicheli R, Biganzoli E, Boracchi P, Greco M, Retsky MW. Recurrence dynamics does not depend on the recurrence site. Breast Cancer Res. 2008; 10(5):R83.
    View in: PubMed
  13. Retsky MW, Demicheli R, Hrushesky WJ, Baum M, Gukas ID. Dormancy and surgery-driven escape from dormancy help explain some clinical features of breast cancer. APMIS. 2008 Jul-Aug; 116(7-8):730-41.
    View in: PubMed
  14. Demicheli R, Retsky MW, Hrushesky WJ, Baum M, Gukas ID. The effects of surgery on tumor growth: a century of investigations. Ann Oncol. 2008 Nov; 19(11):1821-8.
    View in: PubMed
  15. Demicheli R, Retsky MW, Hrushesky WJ, Baum M. Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures. Nat Clin Pract Oncol. 2007 Dec; 4(12):699-710.
    View in: PubMed
  16. Demicheli R, Retsky MW, Hrushesky WJ, Baum M, Gukas ID, Jatoi I. Racial disparities in breast cancer outcome: insights into host-tumor interactions. Cancer. 2007 Nov 1; 110(9):1880-8.
    View in: PubMed
  17. Hrushesky WJ, Retsky M, Baum M, Demicheli R. Re: Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer. J Natl Cancer Inst. 2007 Jul 4; 99(13):1053; author reply 1053-4.
    View in: PubMed
  18. Demicheli R, Hrushesky WJ, Retsky MW, Bonadonna G, Valagussa P. Comment to "Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and intact primary tumor" by G V Babiera, R Rao, L Feng, F Meric-Bernstam, H M Kuerer, S E Singletary, K K Hunt, M I Ross, K M Gwyn, B W Feig, F C Ames, G N Horthobagyi. Ann Surg Oncol 2006;13:776-782. Ann Surg Oncol. 2007 Apr; 14(4):1519-20.
    View in: PubMed
  19. Retsky MW, Demicheli R, Gukas ID, Hrushesky WJ. Enhanced surgery-induced angiogenesis among premenopausal women might partially explain excess breast cancer mortality of blacks compared to whites: an hypothesis. Int J Surg. 2007 Oct; 5(5):300-4.
    View in: PubMed
  20. Demicheli R, Biganzoli E, Boracchi P, Greco M, Hrushesky WJ, Retsky MW. Allometric scaling law questions the traditional mechanical model for axillary lymph node involvement in breast cancer. J Clin Oncol. 2006 Sep 20; 24(27):4391-6.
    View in: PubMed
  21. Demicheli R, Bonadonna G, Greco M, Hrushesky WJ, Moliterni A, Retsky MW, Valagussa P, Zambetti M. Comment to Anderson WF, Jatoi I, Devesa SS: distinct breast cancer incidence and prognostic patterns in the NCI'S SEER program: suggesting a possible link between etiology and outcome. Breast Cancer Res Treat 90:127-137, 2005. Breast Cancer Res Treat. 2006 Jun; 97(3):341-3.
    View in: PubMed
  22. Retsky MW, Demicheli R, Hrushesky WJ. Screening and breast cancer. N Engl J Med. 2006 Feb 16; 354(7):767-9; author reply 767-9.
    View in: PubMed
  23. Retsky MW, Hrushesky W, Baum M. Sociodemographic determinants of cancer treatment health literacy. Cancer. 2006 Feb 1; 106(3):726-7; author reply 727.
    View in: PubMed
  24. Retsky M, Demicheli R, Hrushesky WJ. Authors respond to controversy surrounding breast cancer study. Int J Surg. 2005; 3(4):235-9.
    View in: PubMed
  25. Retsky M, Demicheli R, Hrushesky WJ. Does surgery induce angiogenesis in breast cancer? Indirect evidence from relapse pattern and mammography paradox. Int J Surg. 2005; 3(3):179-87.
    View in: PubMed
  26. Demicheli R, Bonadonna G, Valagussa P, Retsky MW, Hrushesky WJ, Baum M. Comment to Jatoi et al. report. Breast Cancer Res Treat. 2005 Sep; 93(1):1-2.
    View in: PubMed
  27. Demicheli R, Miceli R, Moliterni A, Zambetti M, Hrushesky WJ, Retsky MW, Valagussa P, Bonadonna G. Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process. Ann Oncol. 2005 Sep; 16(9):1449-57.
    View in: PubMed
  28. Baum M, Demicheli R, Hrushesky W, Retsky M. Does surgery unfavourably perturb the "natural history" of early breast cancer by accelerating the appearance of distant metastases? Eur J Cancer. 2005 Mar; 41(4):508-15.
    View in: PubMed
  29. Retsky M, Demicheli R, Hrushesky W, Speer J, Swartzendruber D, Wardwell R. Recent translational research: computational studies of breast cancer. Breast Cancer Res. 2005; 7(1):37-40.
    View in: PubMed
  30. Demicheli R, Bonadonna G, Hrushesky WJ, Retsky MW, Valagussa P. Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour. Breast Cancer Res. 2004; 6(6):R689-96.
    View in: PubMed
  31. Retsky M. Universal law of tumor growth. J Theor Biol. 2004 Aug 7; 229(3):289.
    View in: PubMed
  32. Retsky M, Bonadonna G, Demicheli R, Folkman J, Hrushesky W, Valagussa P. Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients. Breast Cancer Res. 2004; 6(4):R372-4.
    View in: PubMed
  33. Demicheli R, Retsky MW. Comment on "The process of metastasisation for breast cancer" by J. Engel, R. Eckel, J. Kerr et al. Eur J Cancer. 2004 Mar; 40(4):619-20; author reply 621-3.
    View in: PubMed
  34. Demicheli R, Bonadonna G, Hrushesky WJ, Retsky MW, Valagussa P. Menopausal status dependence of early mortality reduction due to diagnosis of smaller breast cancers (T1 v T2-T3): relevance to screening. J Clin Oncol. 2004 Jan 1; 22(1):102-7.
    View in: PubMed
  35. Retsky M, Demicheli R, Hrushesky W. Breast cancer screening: controversies and future directions. Curr Opin Obstet Gynecol. 2003 Feb; 15(1):1-8.
    View in: PubMed
  36. Retsky M, Demicheli R, Hrushesky W. Breast cancer screening for women aged 40-49 years: screening may not be the benign process usually thought. J Natl Cancer Inst. 2001 Oct 17; 93(20):1572.
    View in: PubMed
  37. Retsky M, Demicheli R, Hrushesky W. Wounding from biopsy and breast-cancer progression. Lancet. 2001 Mar 31; 357(9261):1048.
    View in: PubMed
  38. Retsky M, Demicheli R, Hrushesky W. Premenopausal status accelerates relapse in node positive breast cancer: hypothesis links angiogenesis, screening controversy. Breast Cancer Res Treat. 2001 Feb; 65(3):217-24.
    View in: PubMed
  39. Demicheli R, Retsky MW, Swartzendruber DE, Bonadonna G. Proposal for a new model of breast cancer metastatic development. Ann Oncol. 1997 Nov; 8(11):1075-80.
    View in: PubMed
  40. Retsky MW, Demicheli R, Swartzendruber DE, Bame PD, Wardwell RH, Bonadonna G, Speer JF, Valagussa P. Computer simulation of a breast cancer metastasis model. Breast Cancer Res Treat. 1997 Sep; 45(2):193-202.
    View in: PubMed
  41. Stewart TH, Retsky MW, Tsai SC, Verma S. Dose response in the treatment of breast cancer. Lancet. 1994 Feb 12; 343(8894):402-4.
    View in: PubMed
  42. Retsky MW, Swartzendruber DE, Bame PD, Wardwell RH. Computer model challenges breast cancer treatment strategy. Cancer Invest. 1994; 12(6):559-67.
    View in: PubMed
  43. Swartzendruber DE, Retsky MW, Wardwell RH, Bame PD. An alternative approach for treatment of breast cancer. Breast Cancer Res Treat. 1994; 32(3):319-25.
    View in: PubMed
  44. Retsky MW, Swartzendruber DE, Bame PD, Wardwell RH. A new paradigm for breast cancer. Recent Results Cancer Res. 1993; 127:13-22.
    View in: PubMed
  45. Retsky MW, Swartzendruber DE, Wardwell RH, Bame PD. Is Gompertzian or exponential kinetics a valid description of individual human cancer growth? Med Hypotheses. 1990 Oct; 33(2):95-106.
    View in: PubMed
  46. Retsky M, Swartzendruber D, Wardwell R, Bame P, Petrosky V. Re: Larry Norton, a Gompertzian model of human breast cancer growth. Cancer Res. 1989 Nov 15; 49(22):6443-4.
    View in: PubMed
  47. Retsky MW, Wardwell RH, Swartzendruber DE, Headley DL. Prospective computerized simulation of breast cancer: comparison of computer predictions with nine sets of biological and clinical data. Cancer Res. 1987 Sep 15; 47(18):4982-7.
    View in: PubMed
  48. Speer JF, Petrosky VE, Retsky MW, Wardwell RH. A stochastic numerical model of breast cancer growth that simulates clinical data. Cancer Res. 1984 Sep; 44(9):4124-30.
    View in: PubMed
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