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Talal Amine Chatila, M.D.

TitleDenise and David Bunning Professor of Pediatrics in the Field of Allergy and Immunology
InstitutionChildren's Hospital Boston
DepartmentPediatrics
AddressChildren's Hospital
Karp 10
300 Longwood Ave
Boston MA 02115
Phone617/919-3529
Fax617/730-0528

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Williams CB, Chatila TA. Fox family ties. Cell Res. 2013 Apr; 23(4):452-4.
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  2. Noval Rivas M, Burton OT, Wise P, Zhang YQ, Hobson SA, Garcia Lloret M, Chehoud C, Kuczynski J, Desantis T, Warrington J, Hyde ER, Petrosino JF, Gerber GK, Bry L, Oettgen HC, Mazmanian SK, Chatila TA. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol. 2013 Jan; 131(1):201-12.
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  3. Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB. IL-10 Produced by Induced Regulatory T Cells (iTregs) Controls Colitis and Pathogenic Ex-iTregs during Immunotherapy. J Immunol. 2012 Dec 15; 189(12):5638-48.
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  4. Karaca E, Karakoc-Aydiner E, Bayrak OF, Keles S, Sevli S, Barlan IB, Yuksel A, Chatila TA, Ozen M. Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder. Gene. 2013 Jan 10; 512(2):189-93.
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  5. Quatromoni JG, Wang Y, Vo DD, Morris LF, Jazirehi AR, McBride W, Chatila T, Koya RC, Economou JS. T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFß) signaling mediate superior tumor regression in an animal model of adoptive cell therapy. J Transl Med. 2012; 10:127.
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  6. Chatila TA, Williams CB. Foxp3: shades of tolerance. Immunity. 2012 May 25; 36(5):693-4.
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  7. Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 Jun; 13(6):612-20.
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  8. Ooi AT, Ram S, Kuo A, Gilbert JL, Yan W, Pellegrini M, Nickerson DW, Chatila TA, Gomperts BN. Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation. Am J Transl Res. 2012; 4(2):219-28.
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  9. Rivas MN, Koh YT, Chen A, Nguyen A, Lee YH, Lawson G, Chatila TA. MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice. J Clin Invest. 2012 May 1; 122(5):1933-47.
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  10. Al-Herz W, Ragupathy R, Massaad MJ, Al-Attiyah R, Nanda A, Engelhardt KR, Grimbacher B, Notarangelo L, Chatila T, Geha RS. Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Clin Immunol. 2012 Jun; 143(3):266-72.
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  11. Peng IC, Chen Z, Sun W, Li YS, Marin TL, Hsu PH, Su MI, Cui X, Pan S, Lytle CY, Johnson DA, Blaeser F, Chatila T, Shyy JY. Glucagon regulates ACC activity in adipocytes through the CAMKKß/AMPK pathway. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1560-8.
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  12. Verbsky JW, Chatila TA. T-regulatory cells in primary immune deficiencies. Curr Opin Allergy Clin Immunol. 2011 Dec; 11(6):539-44.
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  13. Quatromoni JG, Morris LF, Donahue TR, Wang Y, McBride W, Chatila T, Economou JS. T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3. J Hematol Oncol. 2011; 4:48.
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  14. Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. 2011 Jul 22; 35(1):109-22.
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  15. Dasouki M, Okonkwo KC, Ray A, Folmsbeel CK, Gozales D, Keles S, Puck JM, Chatila T. Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening. Clin Immunol. 2011 Nov; 141(2):128-32.
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  16. Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011 May 20; 332(6032):974-7.
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  17. Mathias CB, Hobson SA, Garcia-Lloret M, Lawson G, Poddighe D, Freyschmidt EJ, Xing W, Gurish MF, Chatila TA, Oettgen HC. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J Allergy Clin Immunol. 2011 Mar; 127(3):795-805.e1-6.
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  18. McDonald DR, Massaad MJ, Johnston A, Keles S, Chatila T, Geha RS, Pai SY. Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1304-5.e3.
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  19. Freyschmidt EJ, Mathias CB, Diaz N, MacArthur DH, Laouar A, Manjunath N, Hofer MD, Wurbel MA, Campbell JJ, Chatila TA, Oettgen HC. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. J Immunol. 2010 Jul 15; 185(2):1295-302.
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  20. Tachdjian R, Al Khatib S, Schwinglshackl A, Kim HS, Chen A, Blasioli J, Mathias C, Kim HY, Umetsu DT, Oettgen HC, Chatila TA. In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol. 2010 May; 125(5):1128-1136.e8.
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  21. Liao G, Nayak S, Regueiro JR, Berger SB, Detre C, Romero X, de Waal Malefyt R, Chatila TA, Herzog RW, Terhorst C. GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. Int Immunol. 2010 Apr; 22(4):259-70.
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  22. McGhee SA, Chatila TA. DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction. Dis Markers. 2010; 29(3-4):151-6.
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  23. Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, Lopez-Herrera G, Chen A, Kim HS, Lloret MG, Schulze I, Ehl S, Thiel J, Pfeifer D, Veelken H, Niehues T, Siepermann K, Weinspach S, Reisli I, Keles S, Genel F, Kutukculer N, Kutuculer N, Camcioglu Y, Somer A, Karakoc-Aydiner E, Barlan I, Gennery A, Metin A, Degerliyurt A, Pietrogrande MC, Yeganeh M, Baz Z, Al-Tamemi S, Klein C, Puck JM, Holland SM, McCabe ER, Grimbacher B, Chatila TA. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009 Dec; 124(6):1289-302.e4.
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  24. Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J Neurosci. 2009 Oct 28; 29(43):13720-9.
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  25. Tachdjian R, Mathias C, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, Chatila TA. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med. 2009 Sep 28; 206(10):2191-204.
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  26. Dowden AM, Rullo OJ, Aziz N, Fasano MB, Chatila T, Ballas ZK. Idiopathic systemic capillary leak syndrome: novel therapy for acute attacks. J Allergy Clin Immunol. 2009 Nov; 124(5):1111-3.
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  27. Al Khatib S, Keles S, Garcia-Lloret M, Karakoc-Aydiner E, Reisli I, Artac H, Camcioglu Y, Cokugras H, Somer A, Kutukculer N, Yilmaz M, Ikinciogullari A, Yegin O, Yüksek M, Genel F, Kucukosmanoglu E, Baki A, Bahceciler NN, Rambhatla A, Nickerson DW, McGhee S, Barlan IB, Chatila T. Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome. J Allergy Clin Immunol. 2009 Aug; 124(2):342-8, 348.e1-5.
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  28. Chatila TA. Regulatory T cells: key players in tolerance and autoimmunity. Endocrinol Metab Clin North Am. 2009 Jun; 38(2):265-72, vii.
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  29. Chatila TA, Krogstad P. Crouching tigers, hidden dragons: the interplay of pathogens and hosts. Pediatr Res. 2009 May; 65(5 Pt 2):1R-2R.
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  30. Lee KH, Chatila TA, Ram RA, Thompson RF. Impaired memory of eyeblink conditioning in CaMKIV KO mice. Behav Neurosci. 2009 Apr; 123(2):438-42.
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  31. Haribhai D, Lin W, Edwards B, Ziegelbauer J, Salzman NH, Carlson MR, Li SH, Simpson PM, Chatila TA, Williams CB. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol. 2009 Mar 15; 182(6):3461-8.
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  32. Garcia-Lloret M, McGhee S, Chatila TA. Immunoglobulin replacement therapy in children. Immunol Allergy Clin North Am. 2008 Nov; 28(4):833-49, ix.
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  33. Chatila T. Molecular mechanisms of regulatory T cell development. J Clin Immunol. 2008 Nov; 28(6):625-30.
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  34. Chatila TA, Li N, Garcia-Lloret M, Kim HJ, Nel AE. T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets. J Allergy Clin Immunol. 2008 Apr; 121(4):812-23; quiz 824-5.
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  35. Chatila TA. Molecular mechanisms of regulatory T-cell development. Chem Immunol Allergy. 2008; 94:16-28.
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  36. Chatila T. The regulatory T cell transcriptosome: E pluribus unum. Immunity. 2007 Nov; 27(5):693-5.
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  37. Chatila TA. Extra-intestinal manifestations of gastro-intestinal allergy: effector and regulatory T cells in the balance. Clin Exp Allergy. 2007 Oct; 37(10):1417-8.
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  38. Li B, Samanta A, Song X, Iacono KT, Brennan P, Chatila TA, Roncador G, Banham AH, Riley JL, Wang Q, Shen Y, Saouaf SJ, Greene MI. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol. 2007 Jul; 19(7):825-35.
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  39. Haribhai D, Lin W, Relland LM, Truong N, Williams CB, Chatila TA. Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol. 2007 Mar 1; 178(5):2961-72.
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  40. Lin W, Haribhai D, Relland LM, Truong N, Carlson MR, Williams CB, Chatila TA. Regulatory T cell development in the absence of functional Foxp3. Nat Immunol. 2007 Apr; 8(4):359-68.
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  41. Caudy AA, Reddy ST, Chatila T, Atkinson JP, Verbsky JW. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol. 2007 Feb; 119(2):482-7.
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  42. Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006 Dec; 12(12):1410-6.
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  43. Blaeser F, Sanders MJ, Truong N, Ko S, Wu LJ, Wozniak DF, Fanselow MS, Zhuo M, Chatila TA. Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol. 2006 Dec; 26(23):9105-15.
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  44. Boyden ES, Katoh A, Pyle JL, Chatila TA, Tsien RW, Raymond JL. Selective engagement of plasticity mechanisms for motor memory storage. Neuron. 2006 Sep 21; 51(6):823-34.
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  45. Ko SW, Jia Y, Xu H, Yim SJ, Jang DH, Lee YS, Zhao MG, Toyoda H, Wu LJ, Chatila T, Kaang BK, Zhuo M. Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci. 2006 Apr; 23(8):2158-68.
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  46. Chatila TA. Role of regulatory T cells in human diseases. J Allergy Clin Immunol. 2005 Nov; 116(5):949-59; quiz 960.
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  47. Lin W, Truong N, Grossman WJ, Haribhai D, Williams CB, Wang J, Martín MG, Chatila TA. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol. 2005 Nov; 116(5):1106-15.
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  48. Blaeser F, Kelly M, Siegrist K, Storch GA, Buller RS, Whitlock J, Truong N, Chatila TA. Critical function of the CD40 pathway in parvovirus B19 infection revealed by a hypomorphic CD40 ligand mutation. Clin Immunol. 2005 Dec; 117(3):231-7.
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  49. Ko SW, Chatila T, Zhuo M. Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice. Mol Pain. 2005; 1:10.
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  50. Chatila TA, Smith JB. NF-kappaB and the innate immune response in the respiratory distress syndrome of the newborn: commentary on the article by Cheah et al. on page 616. Pediatr Res. 2005 May; 57(5 Pt 1):613-5.
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  51. Spertini F, Perret-Menoud V, Barbier N, Chatila T, Barbey C, Corthesy B. Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells. Immunology. 2004 Dec; 113(4):441-52.
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  52. Chatila TA. Interleukin-4 receptor signaling pathways in asthma pathogenesis. Trends Mol Med. 2004 Oct; 10(10):493-9.
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  53. Blaeser F, Bryce PJ, Ho N, Raman V, Dedeoglu F, Donaldson DD, Geha RS, Oettgen HC, Chatila TA. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200.
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  54. Wei F, Qiu CS, Liauw J, Robinson DA, Ho N, Chatila T, Zhuo M. Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nat Neurosci. 2002 Jun; 5(6):573-9.
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  55. Raman V, Clary R, Siegrist KL, Zehnbauer B, Chatila TA. Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis. Pediatrics. 2002 Jan; 109(1):E13.
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  56. Raman V, Blaeser F, Ho N, Engle DL, Williams CB, Chatila TA. Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. J Immunol. 2001 Dec 1; 167(11):6270-8.
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  57. Blaeser F, Toppari J, Heikinheimo M, Yan W, Wallace M, Ho N, Chatila TA. CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells. Am J Physiol Endocrinol Metab. 2001 Nov; 281(5):E931-7.
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  58. Raman V, Kim J, Sharkey A, Chatila T. Response of refractory Kawasaki disease to pulse steroid and cyclosporin A therapy. Pediatr Infect Dis J. 2001 Jun; 20(6):635-7.
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  59. Shenoy S, Mohanakumar T, Chatila T, Tersak J, Duffy B, Wang R, Thilenius AR, Russell JH. Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias. Clin Immunol. 2001 May; 99(2):266-75.
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  60. Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, Bowcock AM. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest. 2000 Dec; 106(12):R75-81.
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  61. Ho N, Liauw JA, Blaeser F, Wei F, Hanissian S, Muglia LM, Wozniak DF, Nardi A, Arvin KL, Holtzman DM, Linden DJ, Zhuo M, Muglia LJ, Chatila TA. Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci. 2000 Sep 1; 20(17):6459-72.
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  62. Youn HD, Chatila TA, Liu JO. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J. 2000 Aug 15; 19(16):4323-31.
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  63. Shenoy S, Arnold S, Chatila T. Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome. J Pediatr. 2000 May; 136(5):682-7.
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  64. Kung C, Pingel JT, Heikinheimo M, Klemola T, Varkila K, Yoo LI, Vuopala K, Poyhonen M, Uhari M, Rogers M, Speck SH, Chatila T, Thomas ML. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med. 2000 Mar; 6(3):343-5.
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  65. Blaeser F, Ho N, Prywes R, Chatila TA. Ca(2+)-dependent gene expression mediated by MEF2 transcription factors. J Biol Chem. 2000 Jan 7; 275(1):197-209.
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  66. Kraus MD, Shenoy S, Chatila T, Hess JL. Light microscopic, immunophenotypic, and molecular genetic study of autoimmune lymphoproliferative syndrome caused by fas mutation. Pediatr Dev Pathol. 2000 Jan-Feb; 3(1):101-9.
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  67. Lobo FM, Zanjani R, Ho N, Chatila TA, Fuleihan RL. Calcium-dependent activation of TNF family gene expression by Ca2+/calmodulin kinase type IV/Gr and calcineurin. J Immunol. 1999 Feb 15; 162(4):2057-63.
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  68. Chatila TA. Genetics of atopic diseases. Curr Opin Pediatr. 1998 Dec; 10(6):584-7.
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  69. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med. 1997 Dec 11; 337(24):1720-5.
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  70. Speck SH, Chatila T, Flemington E. Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene. Trends Microbiol. 1997 Oct; 5(10):399-405.
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  71. Chatila T, Ho N, Liu P, Liu S, Mosialos G, Kieff E, Speck SH. The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication. J Virol. 1997 Sep; 71(9):6560-7.
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  72. Melander Gradin H, Marklund U, Larsson N, Chatila TA, Gullberg M. Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. Mol Cell Biol. 1997 Jun; 17(6):3459-67.
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  73. Liu S, Liu P, Borras A, Chatila T, Speck SH. Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member. EMBO J. 1997 Jan 2; 16(1):143-53.
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  74. Morio T, Chatila T, Geha RS. HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. Int Immunol. 1997 Jan; 9(1):53-64.
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  75. Chatila T, Anderson KA, Ho N, Means AR. A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. J Biol Chem. 1996 Aug 30; 271(35):21542-8.
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  76. Ho N, Gullberg M, Chatila T. Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. J Exp Med. 1996 Jul 1; 184(1):101-12.
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  77. Jawahar S, Moody C, Chan M, Finberg R, Geha R, Chatila T. Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol. 1996 Mar; 103(3):408-13.
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  78. Tanner JE, Alfieri C, Chatila TA, Diaz-Mitoma F. Induction of interleukin-6 after stimulation of human B-cell CD21 by Epstein-Barr virus glycoproteins gp350 and gp220. J Virol. 1996 Jan; 70(1):570-5.
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  79. Castigli E, Irani AM, Geha RS, Chatila T. Defective expression of early activation genes in cartilage-hair hypoplasia (CHH) with severe combined immunodeficiency (SCID). Clin Exp Immunol. 1995 Oct; 102(1):6-10.
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  80. Trede NS, Tsytsykova AV, Chatila T, Goldfeld AE, Geha RS. Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B. J Immunol. 1995 Jul 15; 155(2):902-8.
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  81. Miranti CK, Ginty DD, Huang G, Chatila T, Greenberg ME. Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Mol Cell Biol. 1995 Jul; 15(7):3672-84.
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  82. Rothenberg ME, White FV, Chilmonczyk B, Chatila T. A syndrome involving immunodeficiency and multiple intestinal atresias. Immunodeficiency. 1995; 5(3):171-8.
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  83. Marklund U, Larsson N, Brattsand G, Osterman O, Chatila TA, Gullberg M. Serine 16 of oncoprotein 18 is a major cytosolic target for the Ca2+/calmodulin-dependent kinase-Gr. Eur J Biochem. 1994 Oct 1; 225(1):53-60.
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  84. Fuleihan R, Trede N, Chatila T, Geha RS. Superantigens activate HIV-1 gene expression in monocytic cells. Clin Immunol Immunopathol. 1994 Sep; 72(3):357-61.
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  85. Spertini F, Wang AV, Chatila T, Geha RS. Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells. J Immunol. 1994 Aug 15; 153(4):1593-602.
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  86. Morio T, Geha RS, Chatila TA. Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur J Immunol. 1994 Mar; 24(3):651-8.
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  87. Mosialos G, Hanissian SH, Jawahar S, Vara L, Kieff E, Chatila TA. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. J Virol. 1994 Mar; 68(3):1697-705.
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  88. Trede NS, Morio T, Scholl PR, Geha RS, Chatila T. Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes. Clin Immunol Immunopathol. 1994 Feb; 70(2):137-44.
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  89. Hanissian SH, Frangakis M, Bland MM, Jawahar S, Chatila TA. Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling. J Biol Chem. 1993 Sep 25; 268(27):20055-63.
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  90. Trede NS, Chatila T, Geha RS. Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells. Eur J Immunol. 1993 Sep; 23(9):2129-35.
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  91. Sancho J, Franco R, Chatila T, Hall C, Terhorst C. The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif. Eur J Immunol. 1993 Jul; 23(7):1636-42.
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  92. Trede NS, Castigli E, Geha RS, Chatila T. Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1. J Immunol. 1993 Jun 15; 150(12):5604-13.
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  93. Castigli E, Pahwa R, Good RA, Geha RS, Chatila TA. Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4728-32.
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  94. Castigli E, Chatila TA, Geha RS. A protein of the AP-1 family is a component of nuclear factor of activated T cells. J Immunol. 1993 Apr 15; 150(8 Pt 1):3284-90.
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  95. Fuleihan R, Ramesh N, Loh R, Jabara H, Rosen RS, Chatila T, Fu SM, Stamenkovic I, Geha RS. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2170-3.
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  96. Chatila T, Geha RS. Signal transduction by microbial superantigens via MHC class II molecules. Immunol Rev. 1993 Feb; 131:43-59.
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  97. Mourad W, al-Daccak R, Chatila T, Geha RS. Staphylococcal superantigens as inducers of signal transduction in MHC class II-positive cells. Semin Immunol. 1993 Feb; 5(1):47-55.
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  98. Castigli E, Geha RS, Chatila T. Severe combined immunodeficiency with selective T-cell cytokine genes. Pediatr Res. 1993 Jan; 33(1 Suppl):S20-2; discussion S22-3.
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  99. Fuleihan R, Spertini F, Geha RS, Chatila T. Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands. J Immunol. 1992 Sep 15; 149(6):1853-8.
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  100. Hanissian SH, Chatila T, Sahyoun NE. Association of neuronal pp60c-src with growth cone glycoproteins of rat brain. J Neurobiol. 1992 Sep; 23(7):803-13.
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  101. Spertini F, Chatila T, Geha RS. Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells. J Immunol. 1992 Jul 1; 149(1):65-70.
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  102. Spertini F, Chatila T, Geha RS. Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways. J Immunol. 1992 Apr 1; 148(7):2045-9.
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  103. Scholl PR, Trede N, Chatila TA, Geha RS. Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. J Immunol. 1992 Apr 1; 148(7):2237-41.
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  104. Sancho J, Silverman LB, Castigli E, Ahern D, Laudano AP, Terhorst C, Geha RS, Chatila TA. Developmental regulation of transmembrane signaling via the T cell antigen receptor/CD3 complex in human T lymphocytes. J Immunol. 1992 Mar 1; 148(5):1315-21.
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  105. Chatila T, Geha RS. Superantigens. Curr Opin Immunol. 1992 Feb; 4(1):74-8.
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  106. Chatila T, Scholl P, Ramesh N, Trede N, Fuleihan R, Morio T, Geha RS. Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1. Chem Immunol. 1992; 55:146-71.
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  107. Geha RS, Castigli E, Chatila T. Novel immune deficiencies: defective transcription of lymphokine genes. Clin Immunol Immunopathol. 1991 Nov; 61(2 Pt 2):S16-20.
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  108. Frangakis MV, Chatila T, Wood ER, Sahyoun N. Expression of a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in rat thymus. J Biol Chem. 1991 Sep 15; 266(26):17592-6.
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  109. Trede NS, Geha RS, Chatila T. Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands. J Immunol. 1991 Apr 1; 146(7):2310-5.
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  110. Fuleihan R, Mourad W, Geha RS, Chatila T. Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells. J Immunol. 1991 Mar 1; 146(5):1661-6.
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  111. Chatila T, Scholl P, Spertini F, Ramesh N, Trede N, Fuleihan R, Geha RS. Toxic shock syndrome toxin-1, toxic shock, and the immune system. Curr Top Microbiol Immunol. 1991; 174:63-79.
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  112. Geha RS, Castigli E, Chatila T. Novel immune deficiencies: defective transcription of lymphokine genes. Clin Exp Allergy. 1991 Jan; 21 Suppl 1:190-4.
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  113. Chatila T, Castigli E, Pahwa R, Pahwa S, Chirmule N, Oyaizu N, Good RA, Geha RS. Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):10033-7.
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  114. Mourad W, Geha RS, Chatila T. Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion. J Exp Med. 1990 Nov 1; 172(5):1513-6.
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  115. Wong RC, Remold-O'Donnell E, Vercelli D, Sancho J, Terhorst C, Rosen F, Geha R, Chatila T. Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C. J Immunol. 1990 Feb 15; 144(4):1455-60.
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  116. Sancho J, Chatila T, Wong RC, Hall C, Blumberg R, Alarcon B, Geha RS, Terhorst C. T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes. J Biol Chem. 1989 Dec 5; 264(34):20760-9.
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  117. Mourad W, Scholl P, Diaz A, Geha R, Chatila T. The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. J Exp Med. 1989 Dec 1; 170(6):2011-22.
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  118. Chatila TA, Geha RS, Arnaout MA. Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules. J Cell Biol. 1989 Dec; 109(6 Pt 2):3435-44.
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  119. Chatila T, Silverman L, Miller R, Geha R. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15; 143(4):1283-9.
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  120. Pahwa R, Chatila T, Pahwa S, Paradise C, Day NK, Geha R, Schwartz SA, Slade H, Oyaizu N, Good RA. Recombinant interleukin 2 therapy in severe combined immunodeficiency disease. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):5069-73.
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  121. Silverman LB, Wong RC, Remold-O'Donnell E, Vercelli D, Sancho J, Terhorst C, Rosen F, Geha R, Chatila T. Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. J Immunol. 1989 Jun 15; 142(12):4194-200.
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  122. Scholl P, Diez A, Mourad W, Parsonnet J, Geha RS, Chatila T. Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A. 1989 Jun; 86(11):4210-4.
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  123. Chatila T, Wong R, Young M, Miller R, Terhorst C, Geha RS. An immunodeficiency characterized by defective signal transduction in T lymphocytes. N Engl J Med. 1989 Mar 16; 320(11):696-702.
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  124. Schwartz D, Wong RC, Chatila T, Arnaout A, Miller R, Geha R. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact. J Clin Immunol. 1989 Mar; 9(2):151-8.
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  125. Chatila TA, Geha RS. Phosphorylation of T cell membrane proteins by activators of protein kinase C. J Immunol. 1988 Jun 15; 140(12):4308-14.
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  126. Chatila T, Wood N, Parsonnet J, Geha RS. Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells. J Immunol. 1988 Feb 15; 140(4):1250-5.
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  127. Chatila TA, Schwartz DH, Miller R, Geha RS. Requirement for mitogen, T cell-accessory cell contact, and interleukin 1 in the induction of resting T-cell proliferation. Clin Immunol Immunopathol. 1987 Aug; 44(2):235-47.
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  128. Umetsu DT, Katzen D, Chatila T, Miller R, Jabara HH, Maher M, Oettgen H, Terhorst C, Geha RS. Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. Clin Immunol Immunopathol. 1987 Apr; 43(1):48-64.
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