Title Assistant Professor of Ophthalmology Institution Massachusetts Eye and Ear Infirmary Address Massachusetts Eye & Ear Infrm
5th Flr 563C
243 Charles St
Boston MA 02114
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Overview
Mentoring
Available: 01/01/24, Expires: 06/30/25
1 in 3000 people suffer from retinitis pigmentosa (RP), a group of inherited retinal degenerative disorders (IRDs), and no treatment is yet available. Recent progress in CRISPR/Cas9 mediated genome editing makes it possible to permanently edit DNA sequences as a new treatment for IRDs. In collaboration with multiple CRISPR pioneers at Harvard University and Broad Institute, we have developed several CRISPR/Cas9 gene editing therapies for a few subtypes of recessive and dominant RP. The goal of this project is to develop novel CRISPR/Cas9-based therapies to treat one of the most common IRDs. The student will be involved in understanding the molecular basis of IRDs, characterizing mouse models for IRDs, and performing CRISPR/Cas9 gene editing experiments in cells and animals.
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