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Jeremie Boucher, Ph.D.

TitleInstructor in Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
Research 5th Flr
One Joslin Place
Boston MA 02215
Phone617/732-2400

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee KY, Yamamoto Y, Boucher J, Winnay JN, Gesta S, Cobb J, Blüher M, Kahn CR. Shox2 is a molecular determinant of depot-specific adipocyte function. Proc Natl Acad Sci U S A. 2013 Jul 9; 110(28):11409-14.
    View in: PubMed
  2. Bagchi M, Kim LA, Boucher J, Walshe TE, Kahn CR, D'Amore PA. Vascular endothelial growth factor is important for brown adipose tissue development and maintenance. FASEB J. 2013 Aug; 27(8):3257-71.
    View in: PubMed
  3. Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes. 2013 Mar; 62(3):864-74.
    View in: PubMed
  4. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26.
    View in: PubMed
  5. Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, Larsson NG, Kahn CR. Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance. Cell Metab. 2012 Dec 5; 16(6):765-76.
    View in: PubMed
  6. Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 2012 Sep 5; 16(3):336-47.
    View in: PubMed
  7. Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun. 2012; 3:902.
    View in: PubMed
  8. Lee KY, Gesta S, Boucher J, Wang XL, Kahn CR. The differential role of Hif1ß/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. Cell Metab. 2011 Oct 5; 14(4):491-503.
    View in: PubMed
  9. Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14608-13.
    View in: PubMed
  10. Macotela Y, Emanuelli B, Bång AM, Espinoza DO, Boucher J, Beebe K, Gall W, Kahn CR. Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One. 2011; 6(6):e21187.
    View in: PubMed
  11. Iffiú-Soltész Z, Mercader J, Daviaud D, Boucher J, Carpéné C. Increased primary amine oxidase expression and activity in white adipose tissue of obese and diabetic db-/- mice. J Neural Transm. 2011 Jul; 118(7):1071-7.
    View in: PubMed
  12. Boucher J, Macotela Y, Bezy O, Mori MA, Kriauciunas K, Kahn CR. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Sci Signal. 2010; 3(151):ra87.
    View in: PubMed
  13. Boucher J, Tseng YH, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem. 2010 May 28; 285(22):17235-45.
    View in: PubMed
  14. Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med. 2010 Apr; 16(4):438-45.
    View in: PubMed
  15. Macotela Y, Boucher J, Tran TT, Kahn CR. Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes. 2009 Apr; 58(4):803-12.
    View in: PubMed
  16. Dray C, Knauf C, Daviaud D, Waget A, Boucher J, Buléon M, Cani PD, Attané C, Guigné C, Carpéné C, Burcelin R, Castan-Laurell I, Valet P. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab. 2008 Nov; 8(5):437-45.
    View in: PubMed
  17. Emanuelli B, Macotela Y, Boucher J, Ronald Kahn C. SOCS-1 deficiency does not prevent diet-induced insulin resistance. Biochem Biophys Res Commun. 2008 Dec 12; 377(2):447-52.
    View in: PubMed
  18. Chavey C, Boucher J, Monthouël-Kartmann MN, Sage EH, Castan-Laurell I, Valet P, Tartare-Deckert S, Van Obberghen E. Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia. Obesity (Silver Spring). 2006 Nov; 14(11):1890-7.
    View in: PubMed
  19. Carpéné C, Daviaud D, Boucher J, Bour S, Visentin V, Grès S, Duffaut C, Fontana E, Testar X, Saulnier-Blache JS, Valet P. Short- and long-term insulin-like effects of monoamine oxidases and semicarbazide-sensitive amine oxidase substrates in cultured adipocytes. Metabolism. 2006 Oct; 55(10):1397-405.
    View in: PubMed
  20. Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes. 2006 Jul; 55(7):2032-41.
    View in: PubMed
  21. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D, Ayav A, Ziegler O, Carpene C, Saulnier-Blache JS, Valet P, Castan-Laurell I. TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J. 2006 Jul; 20(9):1528-30.
    View in: PubMed
  22. Gesta S, Blüher M, Yamamoto Y, Norris AW, Berndt J, Kralisch S, Boucher J, Lewis C, Kahn CR. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6676-81.
    View in: PubMed
  23. Boucher J, Castan-Laurell I, Daviaud D, Guigné C, Buléon M, Carpéné C, Saulnier-Blache JS, Valet P. Adipokine expression profile in adipocytes of different mouse models of obesity. Horm Metab Res. 2005 Dec; 37(12):761-7.
    View in: PubMed
  24. Castan-Laurell I, Boucher J, Dray C, Daviaud D, Guigné C, Valet P. Apelin, a novel adipokine over-produced in obesity: friend or foe? Mol Cell Endocrinol. 2005 Dec 21; 245(1-2):7-9.
    View in: PubMed
  25. Visentin V, Bour S, Boucher J, Prévot D, Valet P, Ordener C, Parini A, Carpéné C. Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide. Eur J Pharmacol. 2005 Oct 17; 522(1-3):139-46.
    View in: PubMed
  26. Visentin V, Boucher J, Bour S, Prévot D, Castan I, Carpéné C, Valet P. Influence of high-fat diet on amine oxidase activity in white adipose tissue of mice prone or resistant to diet-induced obesity. J Physiol Biochem. 2005 Jun; 61(2):343-52.
    View in: PubMed
  27. Boucher J, Quilliot D, Pradères JP, Simon MF, Grès S, Guigné C, Prévot D, Ferry G, Boutin JA, Carpéné C, Valet P, Saulnier-Blache JS. Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia. 2005 Mar; 48(3):569-77.
    View in: PubMed
  28. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, Castan-Laurell I, Tack I, Knibiehler B, Carpéné C, Audigier Y, Saulnier-Blache JS, Valet P. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology. 2005 Apr; 146(4):1764-71.
    View in: PubMed
  29. Boucher J, Daviaud D, Siméon-Remaud M, Carpéné C, Saulnier-Blache JS, Monsan P, Valet P. Effect of non-digestible gluco-oligosaccharides on glucose sensitivity in high fat diet fed mice. J Physiol Biochem. 2003 Sep; 59(3):169-73.
    View in: PubMed
  30. Ferry G, Tellier E, Try A, Grés S, Naime I, Simon MF, Rodriguez M, Boucher J, Tack I, Gesta S, Chomarat P, Dieu M, Raes M, Galizzi JP, Valet P, Boutin JA, Saulnier-Blache JS. Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J Biol Chem. 2003 May 16; 278(20):18162-9.
    View in: PubMed
  31. Boucher J, Castan-Laurell I, Le Lay S, Grujic D, Sibrac D, Krief S, Lafontan M, Lowell BB, Dugail I, Saulnier-Blache JS, Valet P. Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements. J Mol Endocrinol. 2002 Oct; 29(2):251-64.
    View in: PubMed
  32. Castan-Laurell I, Boucher J, Rey A, Sibrac D, Gesta S, Pagès C, Daviaud D, Simon MF, Lafontan M, Saulnier-Blachet JS, Valet P. [Development of nutritional obesity in transgenic mice with an adrenergic receptivity in adipose tissue comparable with that of humans]. Pathol Biol (Paris). 2002 Feb; 50(1):52-7.
    View in: PubMed
  33. Le Lay S, Boucher J, Rey A, Castan-Laurell I, Krief S, Ferré P, Valet P, Dugail I. Decreased resistin expression in mice with different sensitivities to a high-fat diet. Biochem Biophys Res Commun. 2001 Nov 30; 289(2):564-7.
    View in: PubMed
  34. Visentin V, Morin N, Fontana E, Prévot D, Boucher J, Castan I, Valet P, Grujic D, Carpéné C. Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J Pharmacol Exp Ther. 2001 Oct; 299(1):96-104.
    View in: PubMed
  35. Fontana E, Boucher J, Marti L, Lizcano JM, Testar X, Zorzano A, Carpéné C. Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells. Biochem J. 2001 Jun 15; 356(Pt 3):769-77.
    View in: PubMed
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