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Seung-Joo Lee, PH.D.

TitleResearch Associate in Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressHarvard Medical School
Bcmp C2-223
240 Longwood Ave
Boston MA 02115
Phone617/432-3130
Fax617/432-3362

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Akabayov B, Akabayov SR, Lee SJ, Wagner G, Richardson CC. Impact of macromolecular crowding on DNA replication. Nat Commun. 2013 Mar 19; 4:1615.
    View in: PubMed
  2. Lee SJ, Zhu B, Akabayov B, Richardson CC. Zinc-binding Domain of the Bacteriophage T7 DNA Primase Modulates Binding to the DNA Template. J Biol Chem. 2012 Nov 9; 287(46):39030-40.
    View in: PubMed
  3. Tran NQ, Lee SJ, Akabayov B, Johnson DE, Richardson CC. Thioredoxin, the processivity factor, sequesters an exposed cysteine in the thumb domain of bacteriophage t7 DNA polymerase. J Biol Chem. 2012 Nov 16; 287(47):39732-41.
    View in: PubMed
  4. Kulczyk AW, Akabayov B, Lee SJ, Bostina M, Berkowitz SA, Richardson CC. An Interaction between DNA Polymerase and Helicase Is Essential for the High Processivity of the Bacteriophage T7 Replisome. J Biol Chem. 2012 Nov 9; 287(46):39050-60.
    View in: PubMed
  5. Zhang H, Lee SJ, Kulczyk AW, Zhu B, Richardson CC. Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication. J Biol Chem. 2012 Oct 5; 287(41):34273-87.
    View in: PubMed
  6. Zhang H, Lee SJ, Richardson CC. The roles of tryptophans in primer synthesis by the DNA primase of bacteriophage T7. J Biol Chem. 2012 Jul 6; 287(28):23644-56.
    View in: PubMed
  7. Zhu B, Lee SJ, Tan M, Wang ED, Richardson CC. Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8050-5.
    View in: PubMed
  8. Zhang H, Lee SJ, Richardson CC. Essential protein interactions within the replisome regulate DNA replication. Cell Cycle. 2011 Oct 15; 10(20):3413-4.
    View in: PubMed
  9. Lee SJ, Richardson CC. Choreography of bacteriophage T7 DNA replication. Curr Opin Chem Biol. 2011 Oct; 15(5):580-6.
    View in: PubMed
  10. Zhu B, Lee SJ, Richardson CC. Bypass of a nick by the replisome of bacteriophage T7. J Biol Chem. 2011 Aug 12; 286(32):28488-97.
    View in: PubMed
  11. Zhang H, Lee SJ, Zhu B, Tran NQ, Tabor S, Richardson CC. Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9372-7.
    View in: PubMed
  12. Akabayov B, Akabayov SR, Lee SJ, Tabor S, Kulczyk AW, Richardson CC. Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15033-8.
    View in: PubMed
  13. Lee SJ, Richardson CC. Molecular basis for recognition of nucleoside triphosphate by gene 4 helicase of bacteriophage T7. J Biol Chem. 2010 Oct 8; 285(41):31462-71.
    View in: PubMed
  14. Tran NQ, Lee SJ, Richardson CC, Tabor S. A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7. Mol Microbiol. 2010 Jul; 77(2):492-504.
    View in: PubMed
  15. Zhu B, Lee SJ, Richardson CC. Direct role for the RNA polymerase domain of T7 primase in primer delivery. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9099-104.
    View in: PubMed
  16. Lee SJ, Zhu B, Hamdan SM, Richardson CC. Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7. Nucleic Acids Res. 2010 Jul; 38(13):4372-83.
    View in: PubMed
  17. Zhu B, Lee SJ, Richardson CC. An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. J Biol Chem. 2009 Aug 28; 284(35):23842-51.
    View in: PubMed
  18. Lee SJ, Chowdhury K, Tabor S, Richardson CC. Rescue of bacteriophage T7 DNA polymerase of low processivity by suppressor mutations affecting gene 3 endonuclease. J Virol. 2009 Sep; 83(17):8418-27.
    View in: PubMed
  19. Akabayov B, Lee SJ, Akabayov SR, Rekhi S, Zhu B, Richardson CC. DNA recognition by the DNA primase of bacteriophage T7: a structure-function study of the zinc-binding domain. Biochemistry. 2009 Mar 3; 48(8):1763-73.
    View in: PubMed
  20. Lee SJ, Qimron U, Richardson CC. Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7. Proc Natl Acad Sci U S A. 2008 Jul 1; 105(26):8908-13.
    View in: PubMed
  21. Johnson DE, Takahashi M, Hamdan SM, Lee SJ, Richardson CC. Exchange of DNA polymerases at the replication fork of bacteriophage T7. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5312-7.
    View in: PubMed
  22. Lee SJ, Marintcheva B, Hamdan SM, Richardson CC. The C-terminal residues of bacteriophage T7 gene 4 helicase-primase coordinate helicase and DNA polymerase activities. J Biol Chem. 2006 Sep 1; 281(35):25841-9.
    View in: PubMed
  23. Marintcheva B, Hamdan SM, Lee SJ, Richardson CC. Essential residues in the C terminus of the bacteriophage T7 gene 2.5 single-stranded DNA-binding protein. J Biol Chem. 2006 Sep 1; 281(35):25831-40.
    View in: PubMed
  24. Qimron U, Lee SJ, Hamdan SM, Richardson CC. Primer initiation and extension by T7 DNA primase. EMBO J. 2006 May 17; 25(10):2199-208.
    View in: PubMed
  25. Lee SJ, Richardson CC. Acidic residues in the nucleotide-binding site of the bacteriophage T7 DNA primase. J Biol Chem. 2005 Jul 22; 280(29):26984-91.
    View in: PubMed
  26. Hamdan SM, Marintcheva B, Cook T, Lee SJ, Tabor S, Richardson CC. A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor. Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14):5096-101.
    View in: PubMed
  27. Lee SJ, Richardson CC. The linker region between the helicase and primase domains of the gene 4 protein of bacteriophage T7. Role in helicase conformation and activity. J Biol Chem. 2004 May 28; 279(22):23384-93.
    View in: PubMed
  28. Lee SJ, Richardson CC. Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7. Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20):12703-8.
    View in: PubMed
  29. Lee SJ, Richardson CC. Essential lysine residues in the RNA polymerase domain of the gene 4 primase-helicase of bacteriophage T7. J Biol Chem. 2001 Dec 28; 276(52):49419-26.
    View in: PubMed
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