 Scleritis
"Scleritis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
| Descriptor ID |
D015423
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| MeSH Number(s) |
C11.790.500
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| Concept/Terms |
Necrotizing Scleritis- Necrotizing Scleritis
- Necrotizing Scleritides
- Scleritides, Necrotizing
- Scleritis, Necrotizing
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Below are MeSH descriptors whose meaning is more general than "Scleritis".
Below are MeSH descriptors whose meaning is more specific than "Scleritis".
This graph shows the total number of publications written about "Scleritis" by people in Harvard Catalyst Profiles by year, and whether "Scleritis" was a major or minor topic of these publication.
Below are the most recent publications written about "Scleritis" by people in Profiles.
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Durrani K, Zakka FR, Ahmed M, Memon M, Siddique SS, Foster CS. Systemic therapy with conventional and novel immunomodulatory agents for ocular inflammatory disease. Surv Ophthalmol. 2011 Nov-Dec; 56(6):474-510.
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Kroshinsky D, Stone JH, Nazarian RM. Case records of the Massachusetts General Hospital. Case 22-2011. A 79-year-old man with a rash, arthritis, and ocular erythema. N Engl J Med. 2011 Jul 21; 365(3):252-62.
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Siddique SS, Gonzalez-Gonzalez LA, Thakuria P, Chang PY, Foster CS. Scleral necrosis in a patient with congenital erythropoietic porphyria. Cornea. 2011 Jan; 30(1):97-9.
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Pujari SS, Kempen JH, Newcomb CW, Gangaputra S, Daniel E, Suhler EB, Thorne JE, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Foster CS. Cyclophosphamide for ocular inflammatory diseases. Ophthalmology. 2010 Feb; 117(2):356-65.
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Doctor P, Sultan A, Syed S, Christen W, Bhat P, Foster CS. Infliximab for the treatment of refractory scleritis. Br J Ophthalmol. 2010 May; 94(5):579-83.
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Bhat PV, Jakobiec FA, Kurbanyan K, Zhao T, Foster CS. Chronic herpes simplex scleritis: characterization of 9 cases of an underrecognized clinical entity. Am J Ophthalmol. 2009 Nov; 148(5):779-789.e2.
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Oono S, Kurimoto T, Oku H, Mimura O. Adult T-cell leukemia presenting with episcleritis and secondary glaucoma. Jpn J Ophthalmol. 2009 Jan; 53(1):70-1.
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Rudraraju M, Singh V, Cobb SH, Douglas D, Patel D, Shen J. Scleritis associated with hepatitis C: a case report and review of literature. Ann Ophthalmol (Skokie). 2008 Fall-Winter; 40(3-4):197-9.
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Jain V, Shome D, Natarajan S, Narverkar R. Surgically induced necrotizing scleritis after pterygium surgery with conjunctival autograft. Cornea. 2008 Jul; 27(6):720-1.
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Huynh N, Cervantes-Castaneda RA, Bhat P, Gallagher MJ, Foster CS. Biologic response modifier therapy for psoriatic ocular inflammatory disease. Ocul Immunol Inflamm. 2008 May-Jun; 16(3):89-93.
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