 Presenilin-2
"Presenilin-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
| Descriptor ID |
D053766
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| MeSH Number(s) |
D12.776.543.696.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Presenilin-2".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-2".
This graph shows the total number of publications written about "Presenilin-2" by people in Harvard Catalyst Profiles by year, and whether "Presenilin-2" was a major or minor topic of these publication.
Below are the most recent publications written about "Presenilin-2" by people in Profiles.
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Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS. Dissociation between the processivity and total activity of ?-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations. Biochemistry. 2011 Oct 25; 50(42):9023-35.
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Bertram L, Lill CM, Tanzi RE. The genetics of Alzheimer disease: back to the future. Neuron. 2010 Oct 21; 68(2):270-81.
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Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, del Monte F. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 2010 Mar 16; 121(10):1216-26.
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Xia W. Exploring Alzheimer's disease in zebrafish. J Alzheimers Dis. 2010; 20(4):981-90.
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Dunys J, Sevalle J, Giaime E, Pardossi-Piquard R, Vitek MP, Renbaum P, Levy-Lahad E, Zhang YW, Xu H, Checler F, da Costa CA. p53-dependent control of transactivation of the Pen2 promoter by presenilins. J Cell Sci. 2009 Nov 1; 122(Pt 21):4003-8.
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Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP, Zhang Y, Wang JZ. Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am J Pathol. 2009 Apr; 174(4):1481-91.
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Yankner BA, Lu T. Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem. 2009 Feb 20; 284(8):4755-9.
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Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC. Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):979-84.
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Selkoe DJ, Wolfe MS. Presenilin: running with scissors in the membrane. Cell. 2007 Oct 19; 131(2):215-21.
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Manabe T, Ohe K, Katayama T, Matsuzaki S, Yanagita T, Okuda H, Bando Y, Imaizumi K, Reeves R, Tohyama M, Mayeda A. HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA. Genes Cells. 2007 Oct; 12(10):1179-91.
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