 Presenilin-1
"Presenilin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
| Descriptor ID |
D053764
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| MeSH Number(s) |
D12.776.543.696.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Presenilin-1".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-1".
This graph shows the total number of publications written about "Presenilin-1" by people in Harvard Catalyst Profiles by year, and whether "Presenilin-1" was a major or minor topic of these publication.
Below are the most recent publications written about "Presenilin-1" by people in Profiles.
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William CM, Andermann ML, Goldey GJ, Roumis DK, Reid RC, Shatz CJ, Albers MW, Frosch MP, Hyman BT. Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice. J Neurosci. 2012 Jun 6; 32(23):8004-11.
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Biscaro B, Lindvall O, Tesco G, Ekdahl CT, Nitsch RM. Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neurodegener Dis. 2012; 9(4):187-98.
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Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of ?-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med. 2012 Jul; 4(7):660-73.
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Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012 Apr 11; 32(15):5085-96.
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Frost JL, Liu B, Kleinschmidt M, Schilling S, Demuth HU, Lemere CA. Passive immunization against pyroglutamate-3 amyloid-ß reduces plaque burden in Alzheimer-like transgenic mice: a pilot study. Neurodegener Dis. 2012; 10(1-4):265-70.
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Lee S, Lemere CA, Frost JL, Shea TB. Dietary supplementation with S-adenosyl methionine delayed amyloid-ß and tau pathology in 3xTg-AD mice. J Alzheimers Dis. 2012; 28(2):423-31.
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Kim J, Jiang H, Park S, Eltorai AE, Stewart FR, Yoon H, Basak JM, Finn MB, Holtzman DM. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-ß amyloidosis. J Neurosci. 2011 Dec 7; 31(49):18007-12.
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Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y, Ayata C, Frosch MP, Greenberg SM, Bacskai BJ. Cerebrovascular lesions induce transient ß-amyloid deposition. Brain. 2011 Dec; 134(Pt 12):3697-707.
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Cai J, Chen Z, Ruan Q, Han S, Liu L, Qi X, Boye SL, Hauswirth WW, Grant MB, Boulton ME. ?-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. J Biol Chem. 2011 Dec 9; 286(49):42514-23.
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Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type ?-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J. 2011 Nov 30; 30(23):4815-24.
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