 Phencyclidine
"Phencyclidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
| Descriptor ID |
D010622
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| MeSH Number(s) |
D03.383.621.699
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| Concept/Terms |
Phencyclidine- Phencyclidine
- Angel Dust
- Dust, Angel
- 1-(1-Phenylcyclohexyl)piperidine
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Below are MeSH descriptors whose meaning is more general than "Phencyclidine".
Below are MeSH descriptors whose meaning is more specific than "Phencyclidine".
This graph shows the total number of publications written about "Phencyclidine" by people in Harvard Catalyst Profiles by year, and whether "Phencyclidine" was a major or minor topic of these publication.
Below are the most recent publications written about "Phencyclidine" by people in Profiles.
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Benneyworth MA, Roseman AS, Basu AC, Coyle JT. Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers. Neurosci Lett. 2011 Jan 25; 488(3):267-71.
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Benneyworth MA, Basu AC, Coyle JT. Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function. Psychopharmacology (Berl). 2011 Jan; 213(1):143-53.
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Carroll ME, Mach JL, La Nasa RM, Newman JL. Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys. Psychopharmacology (Berl). 2009 Nov; 207(1):85-98.
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Choi YK, Snigdha S, Shahid M, Neill JC, Tarazi FI. Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia. J Mol Neurosci. 2009 Jul; 38(3):227-35.
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Hamouda AK, Chiara DC, Blanton MP, Cohen JB. Probing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor. Biochemistry. 2008 Dec 2; 47(48):12787-94.
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Newman JL, Perry JL, Carroll ME. Effects of altering reinforcer magnitude and reinforcement schedule on phencyclidine (PCP) self-administration in monkeys using an adjusting delay task. Pharmacol Biochem Behav. 2008 Oct; 90(4):778-86.
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Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. J Neurosci. 2008 Mar 19; 28(12):2970-5.
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Newman JL, Perry JL, Carroll ME. Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Pharmacol Biochem Behav. 2007 Jun-Jul; 87(2):280-8.
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Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger JI, Faraone SV, Tsuang MT, Niculescu AB. Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5; 144B(2):129-58.
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Newman JL, Thorne JJ, Batulis DK, Carroll ME. Effects of menstrual cycle phase on the reinforcing effects of phencyclidine (PCP) in rhesus monkeys. Pharmacol Biochem Behav. 2006 Nov; 85(3):584-91.
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