 Pentoxifylline
"Pentoxifylline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
| Descriptor ID |
D010431
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| MeSH Number(s) |
D03.438.759.758.824.651.700
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pentoxifylline".
Below are MeSH descriptors whose meaning is more specific than "Pentoxifylline".
This graph shows the total number of publications written about "Pentoxifylline" by people in Harvard Catalyst Profiles by year, and whether "Pentoxifylline" was a major or minor topic of these publication.
Below are the most recent publications written about "Pentoxifylline" by people in Profiles.
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Lell B, Köhler C, Wamola B, Olola CH, Kivaya E, Kokwaro G, Wypij D, Mithwani S, Taylor TE, Kremsner PG, Newton CR. Pentoxifylline as an adjunct therapy in children with cerebral malaria. Malar J. 2010; 9:368.
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Giuliari GP, Sadaka A, Hinkle DM, Simpson ER. Current treatments for radiation retinopathy. Acta Oncol. 2011 Jan; 50(1):6-13.
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Kreth S, Ledderose C, Luchting B, Weis F, Thiel M. Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways. Shock. 2010 Jul; 34(1):10-6.
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Gordon PH, Corcia P, Lacomblez L, Pochigaeva K, Abitbol JL, Cudkowicz M, Leigh PN, Meininger V. Defining survival as an outcome measure in amyotrophic lateral sclerosis. Arch Neurol. 2009 Jun; 66(6):758-61.
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Creager MA, Pande RL, Hiatt WR. A randomized trial of iloprost in patients with intermittent claudication. Vasc Med. 2008 Feb; 13(1):5-13.
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Costelli P, Almendro V, Figueras MT, Reffo P, Penna F, Aragno M, Mastrocola R, Boccuzzi G, Busquets S, Bonelli G, Lopez Soriano FJ, Argilés JM, Baccino FM. Modulations of the calcineurin/NF-AT pathway in skeletal muscle atrophy. Biochim Biophys Acta. 2007 Jul; 1770(7):1028-36.
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Lindhorst S, Cudkowicz M. Is pentoxifylline safe and effective in patients with amyotrophic lateral sclerosis? Nat Clin Pract Neurol. 2006 Jul; 2(7):364-5.
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Ebrahimi F, Hajrasouliha AR, Tavakoli S, Sadeghipour H, Ghasemi M, Rofoui BR, Ahmadi SH, Dehpour AR. Pentoxifylline improves reoxygenation-induced contractile recovery through a nitric oxide-dependent mechanism in rat papillary muscles. J Cardiovasc Pharmacol. 2006 Apr; 47(4):571-7.
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Ray A, Gulati K, Anand S, Vijayan VK. Pharmacological studies on mechanisms of aminophylline-induced seizures in rats. Indian J Exp Biol. 2005 Oct; 43(10):849-53.
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Ciraulo DA, Sarid-Segal O, Knapp CM, Ciraulo AM, LoCastro J, Bloch DA, Montgomery MA, Leiderman DB, Elkashef A. Efficacy screening trials of paroxetine, pentoxifylline, riluzole, pramipexole and venlafaxine in cocaine dependence. Addiction. 2005 Mar; 100 Suppl 1:12-22.
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