 Naphthalimides
"Naphthalimides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS.
| Descriptor ID |
D053644
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| MeSH Number(s) |
D02.478.480 D03.383.621.808.612 D03.438.531.460 D04.615.638.596
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Naphthalimides".
Below are MeSH descriptors whose meaning is more specific than "Naphthalimides".
This graph shows the total number of publications written about "Naphthalimides" by people in Harvard Catalyst Profiles by year, and whether "Naphthalimides" was a major or minor topic of these publication.
Below are the most recent publications written about "Naphthalimides" by people in Profiles.
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Xie SQ, Zhang YH, Li Q, Xu FH, Miao JW, Zhao J, Wang CJ. 3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway. Apoptosis. 2012 Jul; 17(7):725-34.
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Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One. 2012; 7(5):e36335.
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Bae S, Siu PM, Choudhury S, Ke Q, Choi JH, Koh YY, Kang PM. Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1374-81.
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Loving G, Imperiali B. Thiol-reactive derivatives of the solvatochromic 4-N,N-dimethylamino-1,8-naphthalimide fluorophore: a highly sensitive toolset for the detection of biomolecular interactions. Bioconjug Chem. 2009 Nov; 20(11):2133-41.
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Hess CN, Kou R, Johnson RP, Li GK, Michel T. ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase. J Biol Chem. 2009 Nov 20; 284(47):32209-24.
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Loving G, Imperiali B. A versatile amino acid analogue of the solvatochromic fluorophore 4-N,N-dimethylamino-1,8-naphthalimide: a powerful tool for the study of dynamic protein interactions. J Am Chem Soc. 2008 Oct 15; 130(41):13630-8.
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Gaines P, Lamoureux J, Marisetty A, Chi J, Berliner N. A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils. Exp Hematol. 2008 Jul; 36(7):832-44.
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Shakhnovich EA, Sturtevant D, Mekalanos JJ. Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae. Mol Microbiol. 2007 Dec; 66(6):1331-41.
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Shen QW, Zhu MJ, Tong J, Ren J, Du M. Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1395-403.
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Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ. Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2372-7.
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