 Ketotifen
"Ketotifen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
| Descriptor ID |
D007665
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| MeSH Number(s) |
D02.886.778.370 D03.383.621.370 D03.383.903.370
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| Concept/Terms |
Ketotifen- Ketotifen
- Ketotiphene
- Ketotiphen
- 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one
- Ketotifene
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Below are MeSH descriptors whose meaning is more general than "Ketotifen".
Below are MeSH descriptors whose meaning is more specific than "Ketotifen".
This graph shows the total number of publications written about "Ketotifen" by people in Harvard Catalyst Profiles by year, and whether "Ketotifen" was a major or minor topic of these publication.
Below are the most recent publications written about "Ketotifen" by people in Profiles.
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Wang J, Shi GP. Mast cell stabilization: novel medication for obesity and diabetes. Diabetes Metab Res Rev. 2011 Nov; 27(8):919-24.
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Da'as S, Teh EM, Dobson JT, Nasrallah GK, McBride ER, Wang H, Neuberg DS, Marshall JS, Lin TJ, Berman JN. Zebrafish mast cells possess an Fc?RI-like receptor and participate in innate and adaptive immune responses. Dev Comp Immunol. 2011 Jan; 35(1):125-34.
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Lambiase A, Micera A, Bonini S. Multiple action agents and the eye: do they really stabilize mast cells? Curr Opin Allergy Clin Immunol. 2009 Oct; 9(5):454-65.
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Torkildsen GL, Abelson MB, Gomes PJ. Bioequivalence of two formulations of ketotifen fumarate ophthalmic solution: a single-center, randomized, double-masked conjunctival allergen challenge investigation in allergic conjunctivitis. Clin Ther. 2008 Jul; 30(7):1272-82.
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Abelson MB, Ferzola NJ, McWhirter CL, Crampton HJ. Efficacy and safety of single- and multiple-dose ketotifen fumarate 0.025% ophthalmic solution in a pediatric population. Pediatr Allergy Immunol. 2004 Dec; 15(6):551-7.
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Greiner JV, Mundorf T, Dubiner H, Lonsdale J, Casey R, Parver L, Kapik BM, Shams NB, Abelson MB. Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis. Am J Ophthalmol. 2003 Dec; 136(6):1097-105.
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Yamada Y, Sannohe S, Saito N, Cui CH, Ueki S, Oyamada H, Kanda A, Yamaguchi K, Hamada K, Adachi T, Kayaba H, Chihara J. Effect of ketotifen on the production of reactive oxygen species from human eosinophils primed by eotaxin. Pharmacology. 2003 Nov; 69(3):138-41.
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Greiner JV, Minno G. A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model. Clin Ther. 2003 Jul; 25(7):1988-2005.
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Abelson MB, Chapin MJ, Kapik BM, Shams NB. Efficacy of ketotifen fumarate 0.025% ophthalmic solution compared with placebo in the conjunctival allergen challenge model. Arch Ophthalmol. 2003 May; 121(5):626-30.
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Ganz M, Koll E, Gausche J, Detjen P, Orfan N. Ketotifen fumarate and olopatadine hydrochloride in the treatment of allergic conjunctivitis: a real-world comparison of efficacy and ocular comfort. Adv Ther. 2003 Mar-Apr; 20(2):79-91.
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