 Gelsolin
"Gelsolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.
| Descriptor ID |
D018260
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| MeSH Number(s) |
D05.750.078.730.350 D12.644.360.381.437 D12.776.157.125.412.437 D12.776.220.525.350 D12.776.476.387.437
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| Concept/Terms |
Gelsolin- Gelsolin
- Serum Actin Inhibitory Protein
- Gelsolin Protein
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Below are MeSH descriptors whose meaning is more general than "Gelsolin".
Below are MeSH descriptors whose meaning is more specific than "Gelsolin".
This graph shows the total number of publications written about "Gelsolin" by people in Harvard Catalyst Profiles by year, and whether "Gelsolin" was a major or minor topic of these publication.
Below are the most recent publications written about "Gelsolin" by people in Profiles.
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DuBoff B, Götz J, Feany MB. Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron. 2012 Aug 23; 75(4):618-32.
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Chou SH, Lee PS, Konigsberg RG, Gallacci D, Chiou T, Arai K, Simmons S, Bauer D, Feske SK, Lo EH, Ning M. Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage. Stroke. 2011 Dec; 42(12):3624-7.
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Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP. Gelsolin-independent podosome formation in dendritic cells. PLoS One. 2011; 6(7):e21615.
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Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V. Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution. Am J Physiol Cell Physiol. 2011 Jun; 300(6):C1442-55.
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Vargas T, Martinez-Garcia A, Antequera D, Vilella E, Clarimon J, Mateo I, Sanchez-Juan P, Rodriguez-Rodriguez E, Frank A, Rosich-Estrago M, Lleo A, Molina-Porcel L, Blesa R, Gomez-Isla T, Combarros O, Bermejo-Pareja F, Valdivieso F, Bullido MJ, Carro E. IGF-I gene variability is associated with an increased risk for AD. Neurobiol Aging. 2011 Mar; 32(3):556.e3-11.
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Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 3; 29(21):3593-606.
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Kasza KE, Broedersz CP, Koenderink GH, Lin YC, Messner W, Millman EA, Nakamura F, Stossel TP, Mackintosh FC, Weitz DA. Actin filament length tunes elasticity of flexibly cross-linked actin networks. Biophys J. 2010 Aug 9; 99(4):1091-100.
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Lee PS, Bhan I, Thadhani R. The potential role of plasma gelsolin in dialysis-related protein-energy wasting. Blood Purif. 2010; 29(2):99-101.
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Ji L, Chauhan V, Mehta P, Wegiel J, Mehta S, Chauhan A. Relationship between proteolytically cleaved gelsolin and levels of amyloid-ß protein in the brains of Down syndrome subjects. J Alzheimers Dis. 2010; 22(2):609-17.
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Lee H, Ferrer JM, Nakamura F, Lang MJ, Kamm RD. Passive and active microrheology for cross-linked F-actin networks in vitro. Acta Biomater. 2010 Apr; 6(4):1207-18.
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