 Ferrochelatase
"Ferrochelatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
| Descriptor ID |
D005294
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| MeSH Number(s) |
D08.811.520.500 D12.776.157.427.374.375.957 D12.776.556.579.374.375.617 D12.776.575.562
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| Concept/Terms |
Ferrochelatase- Ferrochelatase
- Protoheme Ferro-Lyase
- Ferro-Lyase, Protoheme
- Protoheme Ferro Lyase
- Heme Synthetase
- Synthetase, Heme
- Porphyrin-Metal Chelatase
- Chelatase, Porphyrin-Metal
- Porphyrin Metal Chelatase
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Below are MeSH descriptors whose meaning is more general than "Ferrochelatase".
Below are MeSH descriptors whose meaning is more specific than "Ferrochelatase".
This graph shows the total number of publications written about "Ferrochelatase" by people in Harvard Catalyst Profiles by year, and whether "Ferrochelatase" was a major or minor topic of these publication.
Below are the most recent publications written about "Ferrochelatase" by people in Profiles.
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Wang Y, Langer NB, Shaw GC, Yang G, Li L, Kaplan J, Paw BH, Bloomer JR. Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Exp Hematol. 2011 Jul; 39(7):784-94.
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Chen W, Dailey HA, Paw BH. Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood. 2010 Jul 29; 116(4):628-30.
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Anand S, Honari G, Hasan T, Elson P, Maytin EV. Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin Cancer Res. 2009 May 15; 15(10):3333-43.
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Li C, Di Pierro E, Brancaleoni V, Cappellini MD, Steensma DP. A novel large deletion and three polymorphisms in the FECH gene associated with erythropoietic protoporphyria. Clin Chem Lab Med. 2009; 47(1):44-6.
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Caudill JS, Imran H, Porcher JC, Steensma DP. Congenital sideroblastic anemia associated with germline polymorphisms reducing expression of FECH. Haematologica. 2008 Oct; 93(10):1582-4.
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Steensma DP, Hecksel KA, Porcher JC, Lasho TL. Candidate gene mutation analysis in idiopathic acquired sideroblastic anemia (refractory anemia with ringed sideroblasts). Leuk Res. 2007 May; 31(5):623-8.
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Pawliuk R, Tighe R, Wise RJ, Mathews-Roth MM, Leboulch P. Prevention of murine erythropoietic protoporphyria-associated skin photosensitivity and liver disease by dermal and hepatic ferrochelatase. J Invest Dermatol. 2005 Jan; 124(1):256-62.
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Mathews-Roth MM. Erythropoietic protoporphyria: treatment with antioxidants and potential cure with gene therapy. Methods Enzymol. 2000; 319:479-84.
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Pawliuk R, Bachelot T, Wise RJ, Mathews-Roth MM, Leboulch P. Long-term cure of the photosensitivity of murine erythropoietic protoporphyria by preselective gene therapy. Nat Med. 1999 Jul; 5(7):768-73.
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Mathews-Roth MM, Michel JL, Wise RJ. Amelioration of the metabolic defect in erythropoietic protoporphyria by expression of human ferrochelatase in cultured cells. J Invest Dermatol. 1995 Apr; 104(4):497-9.
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