 Carboxylesterase
"Carboxylesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.
| Descriptor ID |
D043182
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| MeSH Number(s) |
D08.811.277.352.100.100
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| Concept/Terms |
Carboxylesterase- Carboxylesterase
- Isocarboxazid amidase
- amidase, Isocarboxazid
- Non-specific Esterase
- Esterase, Non-specific
- Non specific Esterase
- Nonspecific Esterase
- Esterase, Nonspecific
- Procaine Esterase
- Esterase, Procaine
- Ali-esterase
- Ali esterase
- B-esterase
- B esterase
- CAP-hydrolyzing Enzyme
- CAP hydrolyzing Enzyme
- Enzyme, CAP-hydrolyzing
- Capsaicin-Hydrolyzing Enzyme
- Capsaicin Hydrolyzing Enzyme
- Enzyme, Capsaicin-Hydrolyzing
- Carboxyesterase
- Carboxylate Esterase
- Esterase, Carboxylate
- Carboxylester Lipase
- Lipase, Carboxylester
- Carboxylesterase B
- Carboxylic Ester Hydrolase
- Ester Hydrolase, Carboxylic
- Hydrolase, Carboxylic Ester
- Naproxen Esterase
- Esterase, Naproxen
- Non-specific Carboxylesterase
- Carboxylesterase, Non-specific
- Non specific Carboxylesterase
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Below are MeSH descriptors whose meaning is more general than "Carboxylesterase".
Below are MeSH descriptors whose meaning is more specific than "Carboxylesterase".
This graph shows the total number of publications written about "Carboxylesterase" by people in Harvard Catalyst Profiles by year, and whether "Carboxylesterase" was a major or minor topic of these publication.
Below are the most recent publications written about "Carboxylesterase" by people in Profiles.
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Johansson BB, Torsvik J, Bjørkhaug L, Vesterhus M, Ragvin A, Tjora E, Fjeld K, Hoem D, Johansson S, Ræder H, Lindquist S, Hernell O, Cnop M, Saraste J, Flatmark T, Molven A, Njølstad PR. Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease. J Biol Chem. 2011 Oct 7; 286(40):34593-605.
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Wu D, Li Y, Song G, Zhang D, Shaw N, Liu ZJ. Crystal structure of human esterase D: a potential genetic marker of retinoblastoma. FASEB J. 2009 May; 23(5):1441-6.
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Yano H, Kayukawa S, Iida S, Nakagawa C, Oguri T, Sanda T, Ding J, Mori F, Ito A, Ri M, Inagaki A, Kusumoto S, Ishida T, Komatsu H, Inagaki H, Suzuki A, Ueda R. Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma. Cancer Sci. 2008 Nov; 99(11):2309-14.
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Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Goto H, Usui M, Nishioka K, Kato T, Takeuchi M. Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain-type creatine kinase as novel autoantigens. Mol Vis. 2008; 14:1094-104.
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Raeder H, Haldorsen IS, Ersland L, Grüner R, Taxt T, Søvik O, Molven A, Njølstad PR. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Diabetes. 2007 Feb; 56(2):444-9.
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Tyminski E, Leroy S, Terada K, Finkelstein DM, Hyatt JL, Danks MK, Potter PM, Saeki Y, Chiocca EA. Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan. Cancer Res. 2005 Aug 1; 65(15):6850-7.
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Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK. Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application. Mol Cancer Ther. 2004 Aug; 3(8):903-9.
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Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM. p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11). J Pharmacol Exp Ther. 2003 Feb; 304(2):699-705.
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Wrasidlo W, Schröder U, Bernt K, Hübener N, Shabat D, Gaedicke G, Lode H. Synthesis, hydrolytic activation and cytotoxicity of etoposide prodrugs. Bioorg Med Chem Lett. 2002 Feb 25; 12(4):557-60.
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Mziaut H, Korza G, Hand AR, Gerard C, Ozols J. Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. J Biol Chem. 1999 May 14; 274(20):14122-9.
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