 Camptothecin
"Camptothecin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
| Descriptor ID |
D002166
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| MeSH Number(s) |
D03.132.151
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Camptothecin".
Below are MeSH descriptors whose meaning is more specific than "Camptothecin".
This graph shows the total number of publications written about "Camptothecin" by people in Harvard Catalyst Profiles by year, and whether "Camptothecin" was a major or minor topic of these publication.
Below are the most recent publications written about "Camptothecin" by people in Profiles.
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Meyerhardt JA, Ancukiewicz M, Abrams TA, Schrag D, Enzinger PC, Chan JA, Kulke MH, Wolpin BM, Goldstein M, Blaszkowsky L, Zhu AX, Elliott M, Regan E, Jain RK, Duda DG. Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer. PLoS One. 2012; 7(6):e38231.
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Hoshino H, Ishii Y, Hasegawa H, Endo T, Ochiai H, Hoshino Y, Matsunaga A, Shigeta K, Seo Y, Hoshino G, Kitagawa Y. [FOLFIRI with bevacizumab chemotherapy for a patient with recurrence of rectal cancer under haemodialysis for chronic renal failure]. Gan To Kagaku Ryoho. 2012 Jun; 39(6):983-6.
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Jeon GS, Kim KY, Hwang YJ, Jung MK, An S, Ouchi M, Ouchi T, Kowall N, Lee J, Ryu H. Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of ?-H2AX and DNA damage responses in Huntington's disease. Mol Neurobiol. 2012 Jun; 45(3):550-63.
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Conti RM, Rosenthal MB, Polite BN, Bach PB, Shih YC. Infused chemotherapy use in the elderly after patent expiration. Am J Manag Care. 2012 May; 18(5):e173-8.
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Mariani M, Zannoni GF, Sioletic S, Sieber S, Martino C, Martinelli E, Coco C, Scambia G, Shahabi S, Ferlini C. Gender influences the class III and V ß-tubulin ability to predict poor outcome in colorectal cancer. Clin Cancer Res. 2012 May 15; 18(10):2964-75.
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Wolinsky JB, Yohe ST, Colson YL, Grinstaff MW. Functionalized hydrophobic poly(glycerol-co-e-caprolactone) depots for controlled drug release. Biomacromolecules. 2012 Feb 13; 13(2):406-11.
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Meyerhardt JA, Li L, Sanoff HK, Carpenter W, Schrag D. Effectiveness of bevacizumab with first-line combination chemotherapy for Medicare patients with stage IV colorectal cancer. J Clin Oncol. 2012 Feb 20; 30(6):608-15.
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Tang W, Fu YP, Figueroa JD, Malats N, Garcia-Closas M, Chatterjee N, Kogevinas M, Baris D, Thun M, Hall JL, De Vivo I, Albanes D, Porter-Gill P, Purdue MP, Burdett L, Liu L, Hutchinson A, Myers T, Tardón A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Black A, Jacobs EJ, Diver WR, Gapstur SM, Virtamo J, Hunter DJ, Fraumeni JF, Chanock SJ, Silverman DT, Rothman N, Prokunina-Olsson L. Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer. Hum Mol Genet. 2012 Apr 15; 21(8):1918-30.
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Ogino S, Shima K, Meyerhardt JA, McCleary NJ, Ng K, Hollis D, Saltz LB, Mayer RJ, Schaefer P, Whittom R, Hantel A, Benson AB, Spiegelman D, Goldberg RM, Bertagnolli MM, Fuchs CS. Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803. Clin Cancer Res. 2012 Feb 1; 18(3):890-900.
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Thomas F, Motsinger-Reif AA, Hoskins JM, Dvorak A, Roy S, Alyasiri A, Myerson RJ, Fleshman JW, Tan BR, McLeod HL. Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer. Br J Cancer. 2011 Nov 22; 105(11):1654-62.
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