 CADASIL
"CADASIL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)
| Descriptor ID |
D046589
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| MeSH Number(s) |
C10.228.140.300.275.249 C10.228.140.300.400.203 C10.228.140.300.510.200.175 C10.228.140.380.230.124 C14.907.253.329.249 C14.907.253.560.200.175 C16.320.129
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| Concept/Terms |
CADASIL- CADASIL
- Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
- Dementia, Hereditary Multi-Infarct Type
- Dementia, Hereditary Multi Infarct Type
- Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
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Below are MeSH descriptors whose meaning is more general than "CADASIL".
Below are MeSH descriptors whose meaning is more specific than "CADASIL".
This graph shows the total number of publications written about "CADASIL" by people in Harvard Catalyst Profiles by year, and whether "CADASIL" was a major or minor topic of these publication.
Below are the most recent publications written about "CADASIL" by people in Profiles.
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Louvi A, Artavanis-Tsakonas S. Notch and disease: a growing field. Semin Cell Dev Biol. 2012 Jun; 23(4):473-80.
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Chitnis T, Hollmann TJ. CADASIL mutation and Balo concentric sclerosis: a link between demyelination and ischemia? Neurology. 2012 Jan 17; 78(3):221-3.
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Lee JH, Bacskai BJ, Ayata C. Genetic animal models of cerebral vasculopathies. Prog Mol Biol Transl Sci. 2012; 105:25-55.
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Cavallari M, Falco T, Frontali M, Romano S, Bagnato F, Orzi F. Fractal analysis reveals reduced complexity of retinal vessels in CADASIL. PLoS One. 2011; 6(4):e19150.
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Rice CM, McGuone D, Kurian KM, Love S, Renowden SA, Giffin NJ. Autopsy-confirmed, co-existent CADASIL and multiple system atrophy. Parkinsonism Relat Disord. 2011 Jun; 17(5):390-2.
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Loder E, Cardona L. Evaluation for secondary causes of headache: the role of blood and urine testing. Headache. 2011 Feb; 51(2):338-45.
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Eikermann-Haerter K, Yuzawa I, Dilekoz E, Joutel A, Moskowitz MA, Ayata C. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression. Ann Neurol. 2011 Feb; 69(2):413-8.
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Ayata C. CADASIL: experimental insights from animal models. Stroke. 2010 Oct; 41(10 Suppl):S129-34.
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Jacqmin M, Hervé D, Viswanathan A, Guichard JP, During M, Dichgans M, Chabriat H. Confluent thalamic hyperintensities in CADASIL. Cerebrovasc Dis. 2010 Aug; 30(3):308-13.
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Brennan-Krohn T, Salloway S, Correia S, Dong M, de la Monte SM. Glial vascular degeneration in CADASIL. J Alzheimers Dis. 2010; 21(4):1393-402.
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