 Azirines
"Azirines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.
| Descriptor ID |
D001389
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| MeSH Number(s) |
D03.383.097
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| Concept/Terms |
Azirines- Azirines
- Azacyclopropanes, Unsaturated
- Unsaturated Azacyclopropanes
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Below are MeSH descriptors whose meaning is more general than "Azirines".
Below are MeSH descriptors whose meaning is more specific than "Azirines".
This graph shows the total number of publications written about "Azirines" by people in Harvard Catalyst Profiles by year, and whether "Azirines" was a major or minor topic of these publication.
Below are the most recent publications written about "Azirines" by people in Profiles.
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Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26; 55(14):6554-65.
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Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23; 468(7327):1067-73.
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Hamouda AK, Chiara DC, Blanton MP, Cohen JB. Probing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor. Biochemistry. 2008 Dec 2; 47(48):12787-94.
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Hamouda AK, Sanghvi M, Sauls D, Machu TK, Blanton MP. Assessing the lipid requirements of the Torpedo californica nicotinic acetylcholine receptor. Biochemistry. 2006 Apr 4; 45(13):4327-37.
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Chiara DC, Trinidad JC, Wang D, Ziebell MR, Sullivan D, Cohen JB. Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist. Biochemistry. 2003 Jan 21; 42(2):271-83.
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Gallagher MJ, Chiara DC, Cohen JB. Interactions between 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel. Mol Pharmacol. 2001 Jun; 59(6):1514-22.
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Chiara DC, Kloczewiak MA, Addona GH, Yu JA, Cohen JB, Miller KW. Site of resting state inhibition of the nicotinic acetylcholine receptor by a hydrophobic inhibitor. Biochemistry. 2001 Jan 9; 40(1):296-304.
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Forman SA. A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step. Biochemistry. 1999 Nov 2; 38(44):14559-64.
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Husain SS, Forman SA, Kloczewiak MA, Addona GH, Olsen RW, Pratt MB, Cohen JB, Miller KW. Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. J Med Chem. 1999 Aug 26; 42(17):3300-7.
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Addona GH, Kloczewiak MA, Miller KW. Time-resolved photolabeling of membrane proteins: application to the nicotinic acetylcholine receptor. Anal Biochem. 1999 Feb 1; 267(1):135-40.
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