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Randy Lyanne Gollub, M.D., PH.D.

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Title
Associate Professor of Psychiatry
Institution
Massachusetts General Hospital
Department
Psychiatry
Address
Mass. General Hospital - East
Rm 9109
149 13th Street
Charlestown, MA 02129
Telephone
617/724-9602
Fax
617/726-4078
Other Positions
Title
Member of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
Institution
Mass Institute of Technology
Department
Health Sciences and Technology
Narrative
The work in my laboratory falls into two main domains:
1) Translational interface between the biomedical imaging technologies (particularly the development, calibration and validation of MRI acquisition and analysis methods) and their application to clinical neuroscience.
and
2) Study of the neural representation of acute and chronic pain and its modulation by acupuncture and placebo/expectation.
Publications
1. Hyman SE, Gollub RL. More serotonin: not as simple as it seems. Harv Rev Psychiatry. 1994 Nov-Dec; 2(4):222-4.
2. Gollub RL, Hyman SE. G proteins and second messengers in psychiatry. Harv Rev Psychiatry. 1995 May-Jun; 3(1):41-4.
3. Gollub RL, Rauch SL. Neuroimaging: issues of design, resolution, and interpretation. Harv Rev Psychiatry. 1996 Jan-Feb; 3(5):285-9.
4. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE, et al. Acute effects of cocaine on human brain activity and emotion. Neuron. 1997 Sep; 19(3):591-611.
5. Gollub RL, Breiter HC, Kantor H, Kennedy D, Gastfriend D, Mathew RT, Makris N, Guimaraes A, Riorden J, Campbell T, Foley M, Hyman SE, Rosen B, Weisskoff R, et al. Cocaine decreases cortical cerebral blood flow but does not obscure regional activation in functional magnetic resonance imaging in human subjects. J Cereb Blood Flow Metab. 1998 Jul; 18(7):724-34.
6. Elman I, Breiter HC, Gollub RL, Krause S, Kantor HL, Baumgartner WA, Gastfriend DR, Rosen BR, et al. Depressive symptomatology and cocaine-induced pituitary-adrenal axis activation in individuals with cocaine dependence. Drug Alcohol Depend. 1999 Aug 2; 56(1):39-45.
7. Gollub RL, Hui KK, Stefano GB. Acupuncture: pain management coupled to immune stimulation. Zhongguo Yao Li Xue Bao. 1999 Sep; 20(9):769-77.
8. Elman I, Krause S, Breiter HC, Gollub RL, Heintges J, Baumgartner WA, Rosen BR, Gastfriend DR. The validity of self-reported drug use in non-treatment seeking individuals with cocaine dependence: correlation with biochemical assays. Am J Addict. 2000; 9(3):216-21.
9. Hui KK, Liu J, Makris N, Gollub RL, Chen AJ, Moore CI, Kennedy DN, Rosen BR, Kwong KK. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapp. 2000; 9(1):13-25.
10. Lazar SW, Bush G, Gollub RL, Fricchione GL, Khalsa G, Benson H. Functional brain mapping of the relaxation response and meditation. Neuroreport. 2000 May 15; 11(7):1581-5.
11. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, Saper CB, Rauch SL. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry. 2000 Jul 15; 48(2):99-109.
12. Elman I, Krause S, Karlsgodt K, Schoenfeld DA, Gollub RL, Breiter HC, Gastfriend DR. Clinical outcomes following cocaine infusion in nontreatment-seeking individuals with cocaine dependence. Biol Psychiatry. 2001 Mar 15; 49(6):553-5.
13. Manoach DS, Halpern EF, Kramer TS, Chang Y, Goff DC, Rauch SL, Kennedy DN, Gollub RL. Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am J Psychiatry. 2001 Jun; 158(6):955-8.
14. Kong J, Ma L, Gollub RL, Wei J, Yang X, Li D, Weng X, Jia F, Wang C, Li F, Li R, Zhuang D. A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods. J Altern Complement Med. 2002 Aug; 8(4):411-9.
15. Kong J, Wang C, Kwong K, Vangel M, Chua E, Gollub R. The neural substrate of arithmetic operations and procedure complexity. Brain Res Cogn Brain Res. 2005 Mar; 22(3):397-405.
16. Kong J, Fufa DT, Gerber AJ, Rosman IS, Vangel MG, Gracely RH, Gollub RL. Psychophysical outcomes from a randomized pilot study of manual, electro, and sham acupuncture treatment on experimentally induced thermal pain. J Pain. 2005 Jan; 6(1):55-64.
17. Jovicich J, Czanner S, Greve D, Haley E, van der Kouwe A, Gollub R, Kennedy D, Schmitt F, Brown G, Macfall J, Fischl B, Dale A. Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data. Neuroimage. 2006 Apr 1; 30(2):436-43.
18. Murphy SN, Mendis ME, Grethe JS, Gollub RL, Kennedy D, Rosen BR. A web portal that enables collaborative use of advanced medical image processing and informatics tools through the Biomedical Informatics Research Network (BIRN). AMIA Annu Symp Proc. 2006; 579-83.
19. Kong J, Gollub RL, Rosman IS, Webb JM, Vangel MG, Kirsch I, Kaptchuk TJ. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci. 2006 Jan 11; 26(2):381-8.
20. Kong J, White NS, Kwong KK, Vangel MG, Rosman IS, Gracely RH, Gollub RL. Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Hum Brain Mapp. 2006 Sep; 27(9):715-21.
21. Kong J, Gollub RL, Webb JM, Kong JT, Vangel MG, Kwong K. Test-retest study of fMRI signal change evoked by electroacupuncture stimulation. Neuroimage. 2007 Feb 1; 34(3):1171-81.
22. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Gollub RL. Placebo analgesia: findings from brain imaging studies and emerging hypotheses. Rev Neurosci. 2007; 18(3-4):173-90.
23. Kong J, Kaptchuk TJ, Webb JM, Kong JT, Sasaki Y, Polich GR, Vangel MG, Kwong K, Rosen B, Gollub RL. Functional neuroanatomical investigation of vision-related acupuncture point specificity-A multisession fMRI study. Hum Brain Mapp. 2007 Nov 7.
24. Kong J, Gollub R, Huang T, Polich G, Napadow V, Hui K, Vangel M, Rosen B, Kaptchuk TJ. Acupuncture de qi, from qualitative history to quantitative measurement. J Altern Complement Med. 2007 Dec; 13(10):1059-70.
25. Pujol S, Kikinis R, Gollub R. Lowering the barriers inherent in translating advances in neuroimage analysis to clinical research applications. Acad Radiol. 2008 Jan; 15(1):114-8.
26. Dougherty DD, Kong J, Webb M, Bonab AA, Fischman AJ, Gollub RL. A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia. Behav Brain Res. 2008 May 2.
27. Magnotta VA, Adix ML, Caprahan A, Lim K, Gollub R, Andreasen NC. Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study. Psychiatry Res. 2008 Aug 30; 163(3):193-200.
28. Leyba L, Mayer AR, Gollub RL, Andreasen NC, Clark VP. Smoking status as a potential confound in the BOLD response of patients with schizophrenia. Schizophr Res. 2008 Sep; 104(1-3):79-84.
 
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