Rebecca Aubrey Betensky, PH.D.
Title
Professor of Biostatistics
Institution
School of Public Health
Address
Harvard School of Public Health Bldg 2, Rm 421 655 Huntington Ave Boston, MA 02115
Other Positions
Title
Member of the Faculty of Health Sciences and Technology
Institution
Mass Institute of Technology
Department
Health Sciences and Technology
Title
Professor of Biostatistics
Department
Harvard School of Public Health
Publications
| 1. |
Gelman RS, Tormey DC, Betensky R, Mansour EG, Falkson HC, Falkson G, Creech RH, Haller DG, et al. Actual versus ideal weight in the calculation of surface area: effects on dose of 11 chemotherapy agents. Cancer Treat Rep. 1987 Oct; 71(10):907-11.
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| 2. |
Betensky RA. Conditional power calculations for early acceptance of H0 embedded in sequential tests. Stat Med. 1997 Feb 28; 16(4):465-77.
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| 3. |
Betensky RA. Early stopping to accept H(o) based on conditional power: approximations and comparisons. Biometrics. 1997 Sep; 53(3):794-806.
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| 4. |
Betensky RA. Sequential analysis of censored survival data from three treatment groups. Biometrics. 1997 Sep; 53(3):807-22.
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| 5. |
Betensky RA. Local estimation of smooth curves for longitudinal data. Stat Med. 1997 Nov 15; 16(21):2429-45.
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| 6. |
Betensky RA, Tierney C. An examination of methods for sample size recalculation during an experiment. Stat Med. 1997 Nov 30; 16(22):2587-98.
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| 7. |
Betensky RA. Multiple imputation for early stopping of a complex clinical trial. Biometrics. 1998 Mar; 54(1):229-42.
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| 8. |
Betensky RA. Construction of a continuous stopping boundary from an alpha spending function. Biometrics. 1998 Sep; 54(3):1061-71.
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| 9. |
Betensky RA, Calvelli T, Pahwa S. Predictive value of CD19 measurements for bacterial infections in children infected with human immunodeficiency virus. Clin Diagn Lab Immunol. 1999 Mar; 6(2):247-53.
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| 10. |
Betensky RA, Lindsey JC, Ryan LM, Wand MP. Local EM estimation of the hazard function for interval-censored data. Biometrics. 1999 Mar; 55(1):238-45.
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| 11. |
Betensky RA, Rabinowitz D. Maximally selected chi2 statistics for k x 2 tables. Biometrics. 1999 Mar; 55(1):317-20.
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| 12. |
Marschner IC, Betensky RA, DeGruttola V, Hammer SM, Kuritzkes DR, et al. Clinical trials using HIV-1 RNA-based primary endpoints: statistical analysis and potential biases. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1; 20(3):220-7.
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| 13. |
Betensky RA, Finkelstein DM, et al. A non-parametric maximum likelihood estimator for bivariate interval censored data. Stat Med. 1999 Nov 30; 18(22):3089-100.
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| 14. |
Betensky RA, Finkelstein DM, et al. An extension of Kendall's coefficient of concordance to bivariate interval censored data. Stat Med. 1999 Nov 30; 18(22):3101-9.
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| 15. |
Hundeiker C, Pineau T, Cassar G, Betensky RA, Gleichmann E, Esser C. Thymocyte development in Ah-receptor-deficient mice is refractory to TCDD-inducible changes. Int J Immunopharmacol. 1999 Dec; 21(12):841-59.
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| 16. |
Bebchuk JD, Betensky RA. Multiple imputation for simple estimation of the hazard function based on interval censored data. Stat Med. 2000 Feb 15; 19(3):405-19.
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| 17. |
Betensky RA, Talcott JA, Weeks JC. Binary data with two, non-nested sources of clustering: an analysis of physician recommendations for early prostate cancer treatment. Biostatistics. 2000 Jun; 1(2):219-30.
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| 18. |
Rabinowitz D, Betensky RA, Tsiatis AA, et al. Using conditional logistic regression to fit proportional odds models to interval censored data. Biometrics. 2000 Jun; 56(2):511-8.
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| 19. |
Betensky RA, Connick E, Devers J, Landay AL, Nokta M, Plaeger S, Rosenblatt H, Schmitz JL, Valentine F, Wara D, Weinberg A, Lederman HM. Shipment impairs lymphocyte proliferative responses to microbial antigens. Clin Diagn Lab Immunol. 2000 Sep; 7(5):759-63.
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| 20. |
Rabinowitz D, Betensky RA, et al. Approximating the distribution of maximally selected McNemar's statistics. Biometrics. 2000 Sep; 56(3):897-902.
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| 21. |
Betensky RA, Rabinowitz D. Simple approximations for the maximal transmission/disequilibrium test with a multi-allelic marker. Ann Hum Genet. 2000 Nov; 64(Pt 6):567-74.
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| 22. |
Betensky RA, Hudson JI, Jones CA, Hu F, Wang B, Chen C, Xu X. A computationally simple test of homogeneity of odds ratios for twin data. Genet Epidemiol. 2001 Feb; 20(2):228-38.
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| 23. |
Betensky RA, Schoenfeld DA. Nonparametric estimation in a cure model with random cure times. Biometrics. 2001 Mar; 57(1):282-6.
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| 24. |
Hudson JI, Laird NM, Betensky RA, Keck PE, Pope HG. Multivariate logistic regression for familial aggregation of two disorders. II. Analysis of studies of eating and mood disorders. Am J Epidemiol. 2001 Mar 1; 153(5):506-14.
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| 25. |
Hudson JI, Laird NM, Betensky RA. Multivariate logistic regression for familial aggregation of two disorders. I. Development of models and methods. Am J Epidemiol. 2001 Mar 1; 153(5):500-5.
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| 26. |
Ino Y, Betensky RA, Zlatescu MC, Sasaki H, Macdonald DR, Stemmer-Rachamimov AO, Ramsay DA, Cairncross JG, Louis DN. Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res. 2001 Apr; 7(4):839-45.
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| 27. |
Sasaki H, Zlatescu MC, Betensky RA, Ino Y, Cairncross JG, Louis DN. PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. Am J Pathol. 2001 Jul; 159(1):359-67.
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| 28. |
Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9110-5.
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| 29. |
Zlatescu MC, TehraniYazdi A, Sasaki H, Megyesi JF, Betensky RA, Louis DN, Cairncross JG. Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms. Cancer Res. 2001 Sep 15; 61(18):6713-5.
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| 30. |
Sasaki H, Zlatescu MC, Betensky RA, Johnk LB, Cutone AN, Cairncross JG, Louis DN. Histopathological-molecular genetic correlations in referral pathologist-diagnosed low-grade "oligodendroglioma". J Neuropathol Exp Neurol. 2002 Jan; 61(1):58-63.
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| 31. |
Betensky RA, Lindsey JC, Ryan LM, Wand MP. A local likelihood proportional hazards model for interval censored data. Stat Med. 2002 Jan 30; 21(2):263-75.
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| 32. |
Betensky RA, Finkelstein DM. Testing for dependence between failure time and visit compliance with interval-censored data. Biometrics. 2002 Mar; 58(1):58-63.
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| 33. |
Li Y, Betensky RA, Louis DN, Cairncross JG. The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power. Biometrics. 2002 Mar; 58(1):232-6.
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| 34. |
Rabinowitz D, Betensky RA. Testing for familial correlation in age-at-onset. Biostatistics. 2002 Mar; 3(1):77-85.
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| 35. |
Sasaki H, Betensky RA, Cairncross JG, Louis DN. DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis. Cancer Res. 2002 Mar 15; 62(6):1790-6.
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| 36. |
Betensky RA, Louis DN, Cairncross JG. Influence of unrecognized molecular heterogeneity on randomized clinical trials. J Clin Oncol. 2002 May 15; 20(10):2495-9.
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| 37. |
Lake S, Kammann E, Klar N, Betensky R. Sample size re-estimation in cluster randomization trials. Stat Med. 2002 May 30; 21(10):1337-50.
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| 38. |
Arboleda-Velasquez JF, Lopera F, Lopez E, Frosch MP, Sepulveda-Falla D, Gutierrez JE, Vargas S, Medina M, Martinez De Arrieta C, Lebo RV, Slaugenhaupt SA, Betensky RA, Villegas A, Arcos-Burgos M, Rivera D, Restrepo JC, Kosik KS. C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke. Neurology. 2002 Jul 23; 59(2):277-9.
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| 39. |
Bebchuk JD, Betensky RA. Local likelihood analysis of the latency distribution with interval censored intermediate events. Stat Med. 2002 Nov 30; 21(22):3475-91.
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| 40. |
Braaten KM, Betensky RA, de Leval L, Okada Y, Hochberg FH, Louis DN, Harris NL, Batchelor TT. BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma. Clin Cancer Res. 2003 Mar; 9(3):1063-9.
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| 41. |
Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH. Neurolymphomatosis. Neuro Oncol. 2003 Apr; 5(2):104-15.
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| 42. |
Betensky RA, Louis DN, Cairncross JG. Analysis of a molecular genetic neuro-oncology study with partially biased selection. Biostatistics. 2003 Apr; 4(2):167-78.
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| 43. |
Nutt CL, Mani DR, Betensky RA, Tamayo P, Cairncross JG, Ladd C, Pohl U, Hartmann C, McLaughlin ME, Batchelor TT, Black PM, von Deimling A, Pomeroy SL, Golub TR, Louis DN. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 2003 Apr 1; 63(7):1602-7.
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| 44. |
Bai H, Cviko A, Granter S, Yuan L, Betensky RA, Crum CP. Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. Hum Pathol. 2003 Jun; 34(6):559-64.
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| 45. |
Cai T, Betensky RA. Hazard regression for interval-censored data with penalized spline. Biometrics. 2003 Sep; 59(3):570-9.
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| 46. |
Baehring JM, Betensky RA, Batchelor TT. Malignant peripheral nerve sheath tumor: the clinical spectrum and outcome of treatment. Neurology. 2003 Sep 9; 61(5):696-8.
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| 47. |
Christian CK, Gustafson ML, Betensky RA, Daley J, Zinner MJ. The Leapfrog volume criteria may fall short in identifying high-quality surgical centers. Ann Surg. 2003 Oct; 238(4):447-55; discussion 455-7.
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| 48. |
Batchelor TT, Betensky RA, Esposito JM, Pham LD, Dorfman MV, Piscatelli N, Jhung S, Rhee D, Louis DN. Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res. 2004 Jan 1; 10(1 Pt 1):228-33.
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| 49. |
Fernandez-Teijeiro A, Betensky RA, Sturla LM, Kim JY, Tamayo P, Pomeroy SL. Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas. J Clin Oncol. 2004 Mar 15; 22(6):994-8.
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| 50. |
Rabbee N, Betensky RA. Power calculations for familial aggregation studies. Genet Epidemiol. 2004 May; 26(4):316-27.
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| 51. |
Megyesi JF, Kachur E, Lee DH, Zlatescu MC, Betensky RA, Forsyth PA, Okada Y, Sasaki H, Mizoguchi M, Louis DN, Cairncross JG. Imaging correlates of molecular signatures in oligodendrogliomas. Clin Cancer Res. 2004 Jul 1; 10(13):4303-6.
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| 52. |
Federschneider JM, Yuan L, Brodsky J, Breslin G, Betensky RA, Crum CP. The borderline or weakly positive Hybrid Capture II HPV test: a statistical and comparative (PCR) analysis. Am J Obstet Gynecol. 2004 Sep; 191(3):757-61.
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| 53. |
Plotkin SR, Betensky RA, Hochberg FH, Grossman SA, Lesser GJ, Nabors LB, Chon B, Batchelor TT. Treatment of relapsed central nervous system lymphoma with high-dose methotrexate. Clin Cancer Res. 2004 Sep 1; 10(17):5643-6.
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| 54. |
Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK. Somatic mitochondrial DNA mutations in single neurons and glia. Neurobiol Aging. 2005 Nov-Dec; 26(10):1343-55.
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| 55. |
Christian CK, Kwaan MR, Betensky RA, Breen EM, Zinner MJ, Bleday R. Risk factors for perineal wound complications following abdominoperineal resection. Dis Colon Rectum. 2005 Jan; 48(1):43-8.
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| 56. |
Nutt CL, Betensky RA, Brower MA, Batchelor TT, Louis DN, Stemmer-Rachamimov AO. YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas. Clin Cancer Res. 2005 Mar 15; 11(6):2258-64.
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| 57. |
Betensky RA, Nutt CL, Batchelor TT, Louis DN. Statistical considerations for immunohistochemistry panel development after gene expression profiling of human cancers. J Mol Diagn. 2005 May; 7(2):276-82.
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| 58. |
Shih HA, Betensky RA, Dorfman MV, Louis DN, Loeffler JS, Batchelor TT. Genetic analyses for predictors of radiation response in glioblastoma. Int J Radiat Oncol Biol Phys. 2005 Nov 1; 63(3):704-10.
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| 59. |
Baehring JM, Androudi S, Longtine JJ, Betensky RA, Sklar J, Foster CS, Hochberg FH. Analysis of clonal immunoglobulin heavy chain rearrangements in ocular lymphoma. Cancer. 2005 Aug 1; 104(3):591-7.
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| 60. |
Rosand J, Muzikansky A, Kumar A, Wisco JJ, Smith EE, Betensky RA, Greenberg SM. Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol. 2005 Sep; 58(3):459-62.
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| 61. |
Srouji SS, Mark A, Levine Z, Betensky RA, Hornstein MD, Ginsburg ES. Predicting in vitro fertilization live birth using stimulation day 6 estradiol, age, and follicle-stimulating hormone. Fertil Steril. 2005 Sep; 84(3):795-7.
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| 62. |
Christian CK, Gustafson ML, Betensky RA, Daley J, Zinner MJ. The volume-outcome relationship: don't believe everything you see. World J Surg. 2005 Oct; 29(10):1241-4.
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| 63. |
Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN. Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol. 2005 Nov; 64(11):948-55.
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| 64. |
Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN. In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation. Am J Pathol. 2005 Nov; 167(5):1379-87.
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| 65. |
Bianchetta MJ, Betensky RA, Cohen JB. Cell-surface MuSK self-association: a crucial role for the putative signal sequence. Biochemistry. 2005 Dec 13; 44(49):16229-38.
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| 66. |
Ferrante KL, Shefner J, Zhang H, Betensky R, O'Brien M, Yu H, Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress J, Ashburn C, Freiberg B, O'Neill C, Paladenech C, Walker T, Pestronk A, Abrams B, Florence J, Renna R, Schierbecker J, Malkus B, Cudkowicz M. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS. Neurology. 2005 Dec 13; 65(11):1834-6.
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| 67. |
Matthews AG, Betensky RA, Anton-Culver H, Bowen D, Griffin C, Isaacs C, Kasten C, Mineau G, Nayfield S, Schildkraut J, Strong L, Weber B, Finkelstein DM. Analysis of co-aggregation of cancer based on registry data. Community Genet. 2006; 9(2):87-92.
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| 68. |
Engler DA, Mohapatra G, Louis DN, Betensky RA. A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations. Biostatistics. 2006 Jul; 7(3):399-421.
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| 69. |
Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci. 2006 Jan 11; 26(2):365-71.
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| 70. |
Mohapatra G, Betensky RA, Miller ER, Carey B, Gaumont LD, Engler DA, Louis DN. Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization. J Mol Diagn. 2006 May; 8(2):268-76.
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| 71. |
Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MA. Family history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol. 2006 Jun 20; 47(12):2456-61.
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| 72. |
Betensky RA, Christian CK, Gustafson ML, Daley J, Zinner MJ. Hospital volume versus outcome: an unusual example of bivariate association. Biometrics. 2006 Jun; 62(2):598-604.
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| 73. |
Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res. 2006 Jun 1; 66(11):5618-23.
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| 74. |
Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J. Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes. J Neurol Sci. 2006 Sep 25; 247(2):208-16.
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| 75. |
Zhang B, Li Y, Betensky RA. Effects of unmeasured heterogeneity in the linear transformation model for censored data. Lifetime Data Anal. 2006 Jun; 12(2):191-203.
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| 76. |
Scholtens D, Betensky RA. A computationally simple bivariate survival estimator for efficacy and safety. Lifetime Data Anal. 2006 Sep; 12(3):365-87.
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| 77. |
Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 2006 Dec; 24(3):516-24.
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| 78. |
Houseman EA, Coull BA, Betensky RA. Feature-specific penalized latent class analysis for genomic data. Biometrics. 2006 Dec; 62(4):1062-70.
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| 79. |
Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL. Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. J Neuropathol Exp Neurol. 2006 Dec; 65(12):1181-8.
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| 80. |
Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN. Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. J Neuropathol Exp Neurol. 2006 Dec; 65(12):1149-56.
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| 81. |
Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci. 2007 Feb 21; 27(8):1973-80.
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| 82. |
Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN. Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin Cancer Res. 2007 Apr 1; 13(7):2038-45.
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| 83. |
Matthews AG, Finkelstein DM, Betensky RA. Multivariate logistic regression for familial aggregation in age at disease onset. Lifetime Data Anal. 2007 Jun; 13(2):191-209.
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| 84. |
Mandel M, Betensky RA. Testing goodness of fit of a uniform truncation model. Biometrics. 2007 Jun; 63(2):405-12.
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| 85. |
Gauthier SA, Mandel M, Guttmann CR, Glanz BI, Khoury SJ, Betensky RA, Weiner HL. Predicting short-term disability in multiple sclerosis. Neurology. 2007 Jun 12; 68(24):2059-65.
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| 86. |
Desantis SM, Houseman EA, Coull BA, Stemmer-Rachamimov A, Betensky RA. A penalized latent class model for ordinal data. Biostatistics. 2008 Apr; 9(2):249-62.
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| 87. |
Betensky RA, Louis DN, Cairncross JG. Tests of association under misclassification: application to histological sampling in oncology. Stat Med. 2007 Nov 20; 26(26):4808-16.
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| 88. |
Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV. Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int. 2008 Apr; 73(7):863-9.
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| 89. |
Snuderl M, Chi SN, De Santis SM, Stemmer-Rachamimov AO, Betensky RA, De Girolami U, Kieran MW. Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas. J Neuropathol Exp Neurol. 2008 Sep; 67(9):911-20.
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