James Hutchinson Ware, Ph.D.
Title
Frederick Mosteller Professor of Biostatistics
Institution
School of Public Health
Address
Harvard School of Public Health Bldg 2, Room 417 655 Huntington Ave Boston, MA 02115
Other Positions
Title
Honorary Associate and Former Master of Cabot House
Institution
Faculty of Arts & Sciences
Title
Dean for Academic Affairs, Emeritus
Institution
School of Public Health
Publications
| 1. |
Ware JH, Lipsitz S, Speizer FE. Issues in the analysis of repeated categorical outcomes. Stat Med. 1988 Jan-Feb; 7(1-2):95-107.
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| 2. |
Dockery DW, Speizer FE, Ferris BG, Ware JH, Louis TA, Spiro A. Cumulative and reversible effects of lifetime smoking on simple tests of lung function in adults. Am Rev Respir Dis. 1988 Feb; 137(2):286-92.
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| 3. |
Kinney PL, Ware JH, Spengler JD. A critical evaluation of acute ozone epidemiology results. Arch Environ Health. 1988 Mar-Apr; 43(2):168-73.
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| 4. |
el Samani EF, Willett WC, Ware JH. Association of malnutrition and diarrhea in children aged under five years. A prospective follow-up study in a rural Sudanese community. Am J Epidemiol. 1988 Jul; 128(1):93-105.
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| 5. |
Stone PH, Ware JH, DeWood MA, Gore JM, Eich RH, Pietro DA, Parisi AF, Nesto RW, Boden WE, Sharma SC. The efficacy of the addition of nifedipine in patients with mixed angina compared to patients with classic exertional angina: a multicenter, randomized, double-blind, placebo-controlled clinical trial. Am Heart J. 1988 Oct; 116(4):961-71.
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| 6. |
Day R, Ware JH, Wartenberg D, Zelen M. An investigation of a reported cancer cluster in Randolph, Massachusetts. J Clin Epidemiol. 1989; 42(2):137-50.
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| 7. |
el Samani FZ, Willett WC, Ware JH. Predictors of simple diarrhoea in children under 5 years--a study of a Sudanese rural community. Soc Sci Med. 1989; 29(9):1065-70.
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| 8. |
Kinney PL, Ware JH, Spengler JD, Dockery DW, Speizer FE, Ferris BG. Short-term pulmonary function change in association with ozone levels. Am Rev Respir Dis. 1989 Jan; 139(1):56-61.
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| 9. |
Dockery DW, Speizer FE, Stram DO, Ware JH, Spengler JD, Ferris BG. Effects of inhalable particles on respiratory health of children. Am Rev Respir Dis. 1989 Mar; 139(3):587-94.
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| 10. |
Spiegelman D, Maurer LH, Ware JH, Perry MC, Chahinian AP, Comis R, Eaton W, Zimmer B, Green M, et al. Prognostic factors in small-cell carcinoma of the lung: an analysis of 1,521 patients. J Clin Oncol. 1989 Mar; 7(3):344-54.
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| 11. |
Chahinian AP, Propert KJ, Ware JH, Zimmer B, Perry MC, Hirsh V, Skarin A, Kopel S, Holland JF, Comis RL, et al. A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the Cancer and Leukemia Group B. J Clin Oncol. 1989 Aug; 7(8):993-1002.
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| 12. |
Hasabelnaby NA, Ware JH, Fuller WA. Indoor air pollution and pulmonary performance: investigating errors in exposure assessment. Stat Med. 1989 Sep; 8(9):1109-26; discussion 1137-8.
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| 13. |
Brunekreef B, Dockery DW, Speizer FE, Ware JH, Spengler JD, Ferris BG. Home dampness and respiratory morbidity in children. Am Rev Respir Dis. 1989 Nov; 140(5):1363-7.
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| 14. |
O'Rourke PP, Crone RK, Vacanti JP, Ware JH, Lillehei CW, Parad RB, Epstein MF. Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study. Pediatrics. 1989 Dec; 84(6):957-63.
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| 15. |
Halperin M, DeMets DL, Ware JH. Early methodological developments for clinical trials at the National Heart, Lung and Blood Institute. Stat Med. 1990 Aug; 9(8):881-92; discussion 903-6.
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| 16. |
Ware JH, Dockery DW, Louis TA, Xu XP, Ferris BG, Speizer FE. Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults. Am J Epidemiol. 1990 Oct; 132(4):685-700.
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| 17. |
Brunekreef B, Kinney PL, Ware JH, Dockery D, Speizer FE, Spengler JD, Ferris BG. Sensitive subgroups and normal variation in pulmonary function response to air pollution episodes. Environ Health Perspect. 1991 Jan; 90:189-93.
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| 18. |
Neas LM, Dockery DW, Ware JH, Spengler JD, Speizer FE, Ferris BG. Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children. Am J Epidemiol. 1991 Jul 15; 134(2):204-19.
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| 19. |
Laird NM, Donnelly C, Ware JH. Longitudinal studies with continuous responses. Stat Methods Med Res. 1992; 1(3):225-47.
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| 20. |
Wilcox LS, Martinez-Schnell B, Peterson HB, Ware JH, Hughes JM. Menstrual function after tubal sterilization. Am J Epidemiol. 1992 Jun 15; 135(12):1368-81.
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| 21. |
Xu X, Dockery DW, Ware JH, Speizer FE, Ferris BG. Effects of cigarette smoking on rate of loss of pulmonary function in adults: a longitudinal assessment. Am Rev Respir Dis. 1992 Nov; 146(5 Pt 1):1345-8.
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| 22. |
Ware JH. Analysis of longitudinal data: choosing and interpreting regression models. Eur Respir J. 1993 Mar; 6(3):325-7.
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| 23. |
Ware JH, Spengler JD, Neas LM, Samet JM, Wagner GR, Coultas D, Ozkaynak H, Schwab M. Respiratory and irritant health effects of ambient volatile organic compounds. The Kanawha County Health Study. Am J Epidemiol. 1993 Jun 15; 137(12):1287-301.
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| 24. |
Gold DR, Rotnitzky A, Damokosh AI, Ware JH, Speizer FE, Ferris BG, Dockery DW. Race and gender differences in respiratory illness prevalence and their relationship to environmental exposures in children 7 to 14 years of age. Am Rev Respir Dis. 1993 Jul; 148(1):10-8.
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| 25. |
Wang X, Dockery DW, Wypij D, Gold DR, Speizer FE, Ware JH, Ferris BG. Pulmonary function growth velocity in children 6 to 18 years of age. Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1502-8.
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| 26. |
Dockery DW, Pope CA, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG, Speizer FE. An association between air pollution and mortality in six U.S. cities. N Engl J Med. 1993 Dec 9; 329(24):1753-9.
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| 27. |
Fineberg HV, Green GM, Ware JH, Anderson BL. Changing public health training needs: professional education and the paradigm of public health. Annu Rev Public Health. 1994; 15:237-57.
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| 28. |
Gold DR, Wypij D, Wang X, Speizer FE, Pugh M, Ware JH, Ferris BG, Dockery DW. Gender- and race-specific effects of asthma and wheeze on level and growth of lung function in children in six U.S. cities. Am J Respir Crit Care Med. 1994 May; 149(5):1198-208.
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| 29. |
Neas LM, Dockery DW, Ware JH, Spengler JD, Ferris BG, Speizer FE, et al. Concentration of indoor particulate matter as a determinant of respiratory health in children. Am J Epidemiol. 1994 Jun 1; 139(11):1088-99.
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| 30. |
Wang X, Wypij D, Gold DR, Speizer FE, Ware JH, Ferris BG, Dockery DW. A longitudinal study of the effects of parental smoking on pulmonary function in children 6-18 years. Am J Respir Crit Care Med. 1994 Jun; 149(6):1420-5.
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| 31. |
Schwartz J, Dockery DW, Neas LM, Wypij D, Ware JH, Spengler JD, Koutrakis P, Speizer FE, Ferris BG. Acute effects of summer air pollution on respiratory symptom reporting in children. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 1):1234-42.
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| 32. |
Wang-Clow F, Lange M, Laird NM, Ware JH. A simulation study of estimators for rates of change in longitudinal studies with attrition. Stat Med. 1995 Feb 15; 14(3):283-97.
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| 33. |
Ware JH, DiBenedetto AJ, Pittman RN. Localization of tissue plasminogen activator mRNA in the developing rat cerebellum and effects of inhibiting tissue plasminogen activator on granule cell migration. J Neurobiol. 1995 Sep; 28(1):9-22.
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| 34. |
Dockery DW, Cunningham J, Damokosh AI, Neas LM, Spengler JD, Koutrakis P, Ware JH, Raizenne M, Speizer FE. Health effects of acid aerosols on North American children: respiratory symptoms. Environ Health Perspect. 1996 May; 104(5):500-5.
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| 35. |
Raizenne M, Neas LM, Damokosh AI, Dockery DW, Spengler JD, Koutrakis P, Ware JH, Speizer FE. Health effects of acid aerosols on North American children: pulmonary function. Environ Health Perspect. 1996 May; 104(5):506-14.
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| 36. |
Gold DR, Wang X, Wypij D, Speizer FE, Ware JH, Dockery DW. Effects of cigarette smoking on lung function in adolescent boys and girls. N Engl J Med. 1996 Sep 26; 335(13):931-7.
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| 37. |
Ware JH, Weiss S. Statistical issues in longitudinal research on respiratory health. Am J Respir Crit Care Med. 1996 Dec; 154(6 Pt 2):S212-6.
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| 38. |
Weiss ST, Ware JH, et al. Overview of issues in the longitudinal analysis of respiratory data. Am J Respir Crit Care Med. 1996 Dec; 154(6 Pt 2):S208-11.
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| 39. |
Rijcken B, Schouten JP, Weiss ST, Ware JH. ERS/ATS workshop on longitudinal analysis of pulmonary function data, Barcelona, September 1995. Eur Respir J. 1997 Mar; 10(3):758-63.
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| 40. |
Ware JH, Antman EM. Equivalence trials. N Engl J Med. 1997 Oct 16; 337(16):1159-61.
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| 41. |
Rogan WJ, Ragan NB, Damokosh AI, Davoli C, Shaffer TR, Jones RL, Wilkens S, Heenehan MC, Ware JH, Henretig F. Recall of a lead-contaminated vitamin and mineral supplement in a clinical trial. Pharmacoepidemiol Drug Saf. 1999 Aug; 8(5):343-50.
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| 42. |
Ware JH. Particulate air pollution and mortality--clearing the air. N Engl J Med. 2000 Dec 14; 343(24):1798-9.
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| 43. |
Rogan WJ, Dietrich KN, Ware JH, Dockery DW, Salganik M, Radcliffe J, Jones RL, Ragan NB, Chisolm JJ, Rhoads GG. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med. 2001 May 10; 344(19):1421-6.
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| 44. |
Rogan WJ, Ware JH. Exposure to lead in children--how low is low enough? N Engl J Med. 2003 Apr 17; 348(16):1515-6.
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| 45. |
Ware JH. The National Emphysema Treatment Trial--how strong is the evidence? N Engl J Med. 2003 May 22; 348(21):2055-6.
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| 46. |
Ware JH. Interpreting incomplete data in studies of diet and weight loss. N Engl J Med. 2003 May 22; 348(21):2136-7.
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| 47. |
Rogan WJ, Ware JH. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. J Pediatr. 2003 Nov; 143(5):687-8.
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| 48. |
Levkoff SE, Chen H, Coakley E, Herr EC, Oslin DW, Katz I, Bartels SJ, Maxwell J, Olsen E, Miles KM, Constantino G, Ware JH. Design and sample characteristics of the PRISM-E multisite randomized trial to improve behavioral health care for the elderly. J Aging Health. 2004 Feb; 16(1):3-27.
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| 49. |
Peterson KE, Salganik M, Campbell C, Rhoads GG, Rubin J, Berger O, Ware JH, Rogan W. Effect of succimer on growth of preschool children with moderate blood lead levels. Environ Health Perspect. 2004 Feb; 112(2):233-7.
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| 50. |
Dietrich KN, Ware JH, Salganik M, Radcliffe J, Rogan WJ, Rhoads GG, Fay ME, Davoli CT, Denckla MB, Bornschein RL, Schwarz D, Dockery DW, Adubato S, Jones RL. Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics. 2004 Jul; 114(1):19-26.
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| 51. |
Bartels SJ, Coakley EH, Zubritsky C, Ware JH, Miles KM, Areán PA, Chen H, Oslin DW, Llorente MD, Costantino G, Quijano L, McIntyre JS, Linkins KW, Oxman TE, Maxwell J, Levkoff SE. Improving access to geriatric mental health services: a randomized trial comparing treatment engagement with integrated versus enhanced referral care for depression, anxiety, and at-risk alcohol use. Am J Psychiatry. 2004 Aug; 161(8):1455-62.
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| 52. |
Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F. Physical activity, including walking, and cognitive function in older women. JAMA. 2004 Sep 22; 292(12):1454-61.
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| 53. |
Glass TA, Berkman LF, Hiltunen EF, Furie K, Glymour MM, Fay ME, Ware J. The Families In Recovery From Stroke Trial (FIRST): primary study results. Psychosom Med. 2004 Nov-Dec; 66(6):889-97.
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| 54. |
Chen A, Dietrich KN, Ware JH, Radcliffe J, Rogan WJ. IQ and blood lead from 2 to 7 years of age: are the effects in older children the residual of high blood lead concentrations in 2-year-olds? Environ Health Perspect. 2005 May; 113(5):597-601.
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| 55. |
Ware JH, Sánchez BN. Bias in cross-sectional and longitudinal estimates of pulmonary function decline: a different perspective. COPD. 2005 Dec; 2(4):393-4.
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| 56. |
Chen H, Coakley EH, Cheal K, Maxwell J, Costantino G, Krahn DD, Malgady RG, Durai UN, Quijano LM, Zaman S, Miller CJ, Ware JH, Chung H, Aoyama C, Van Stone WW, Levkoff SE. Satisfaction with mental health services in older primary care patients. Am J Geriatr Psychiatry. 2006 Apr; 14(4):371-9.
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| 57. |
Stone GW, McLaurin BT, Cox DA, Bertrand ME, Lincoff AM, Moses JW, White HD, Pocock SJ, Ware JH, Feit F, Colombo A, Aylward PE, Cequier AR, Darius H, Desmet W, Ebrahimi R, Hamon M, Rasmussen LH, Rupprecht HJ, Hoekstra J, Mehran R, Ohman EM. Bivalirudin for patients with acute coronary syndromes. N Engl J Med. 2006 Nov 23; 355(21):2203-16.
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| 58. |
Ware JH. The limitations of risk factors as prognostic tools. N Engl J Med. 2006 Dec 21; 355(25):2615-7.
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| 59. |
Kirchner JE, Zubritsky C, Cody M, Coakley E, Chen H, Ware JH, Oslin DW, Sanchez HA, Durai UN, Miles KM, Llorente MD, Costantino G, Levkoff S. Alcohol consumption among older adults in primary care. J Gen Intern Med. 2007 Jan; 22(1):92-7.
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| 60. |
Stone GW, Bertrand ME, Moses JW, Ohman EM, Lincoff AM, Ware JH, Pocock SJ, McLaurin BT, Cox DA, Jafar MZ, Chandna H, Hartmann F, Leisch F, Strasser RH, Desaga M, Stuckey TD, Zelman RB, Lieber IH, Cohen DJ, Mehran R, White HD. Routine upstream initiation vs deferred selective use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: the ACUITY Timing trial. JAMA. 2007 Feb 14; 297(6):591-602.
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| 61. |
Stone GW, White HD, Ohman EM, Bertrand ME, Lincoff AM, McLaurin BT, Cox DA, Pocock SJ, Ware JH, Feit F, Colombo A, Manoukian SV, Lansky AJ, Mehran R, Moses JW. Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. Lancet. 2007 Mar 17; 369(9565):907-19.
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| 62. |
Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med. 2007 Nov 22; 357(21):2189-94.
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| 63. |
Stone GW, Ware JH, Bertrand ME, Lincoff AM, Moses JW, Ohman EM, White HD, Feit F, Colombo A, McLaurin BT, Cox DA, Manoukian SV, Fahy M, Clayton TC, Mehran R, Pocock SJ. Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management: one-year results from the ACUITY trial. JAMA. 2007 Dec 5; 298(21):2497-506.
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| 64. |
Gao P, Ware JH, Mehta C. Sample size re-estimation for adaptive sequential design in clinical trials. J Biopharm Stat. 2008; 18(6):1184-96.
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| 65. |
Ware JH, Cai T. Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929). Stat Med. 2008 Jan 30; 27(2):185-7.
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| 66. |
Gao P, Ware JH. Assessing non-inferiority: a combination approach. Stat Med. 2008 Feb 10; 27(3):392-406.
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| 67. |
Krieger N, Chen JT, Ware JH, Kaddour A. Race/ethnicity and breast cancer estrogen receptor status: impact of class, missing data, and modeling assumptions. Cancer Causes Control. 2008 Dec; 19(10):1305-18.
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| 68. |
Drazen JM, D'Agostino RB, Ware JH, Morrissey S, Curfman GD. Ezetimibe and cancer--an uncertain association. N Engl J Med. 2008 Sep 25; 359(13):1398-9.
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| 69. |
Barrero LH, Katz JN, Perry MJ, Krishnan R, Ware JH, Dennerlein JT. Work pattern causes bias in self-reported activity duration: a randomised study of mechanisms and implications for exposure assessment and epidemiology. Occup Environ Med. 2009 Jan; 66(1):38-44.
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| 70. |
Lincoff AM, Steinhubl SR, Manoukian SV, Chew D, Pollack CV, Feit F, Ware JH, Bertrand ME, Ohman EM, Desmet W, Cox DA, Mehran R, Stone GW. Influence of timing of clopidogrel treatment on the efficacy and safety of bivalirudin in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention: an analysis of the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. JACC Cardiovasc Interv. 2008 Dec; 1(6):639-48.
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| 71. |
Mehta C, Gao P, Bhatt DL, Harrington RA, Skerjanec S, Ware JH. Optimizing trial design: sequential, adaptive, and enrichment strategies. Circulation. 2009 Feb 3; 119(4):597-605.
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| 72. |
Ropper AH, Gorson KC, Gooch CL, Weinberg DH, Pieczek A, Ware JH, Kershen J, Rogers A, Simovic D, Schratzberger P, Kirchmair R, Losordo D. Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial. Ann Neurol. 2009 Apr; 65(4):386-93.
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| 73. |
Mehran R, Pocock SJ, Stone GW, Clayton TC, Dangas GD, Feit F, Manoukian SV, Nikolsky E, Lansky AJ, Kirtane A, White HD, Colombo A, Ware JH, Moses JW, Ohman EM. Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. Eur Heart J. 2009 Jun; 30(12):1457-66.
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| 74. |
Pocock SJ, Ware JH. Translating statistical findings into plain English. Lancet. 2009 Jun 6; 373(9679):1926-8.
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| 75. |
Lewinn KZ, Stroud LR, Molnar BE, Ware JH, Koenen KC, Buka SL. Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ. Int J Epidemiol. 2009 May 7.
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| 76. |
Ebrahimi R, Dyke C, Mehran R, Manoukian SV, Feit F, Cox DA, Gersh BJ, Ohman EM, White HD, Moses JW, Ware JH, Lincoff AM, Stone GW. Outcomes following pre-operative clopidogrel administration in patients with acute coronary syndromes undergoing coronary artery bypass surgery: the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. J Am Coll Cardiol. 2009 May 26; 53(21):1965-72.
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